PharmaCoNets of Clofazimine (SPCN: 27.93 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Clofaziminehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Clofaziminehsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Clofaziminehsa00190Oxidative phosphorylation3.50E-022Q16718, Q13488NDUFA5, TCIRG1More
Clofaziminehsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Clofaziminehsa00230Purine metabolism3.95E-023Q7LG56, P51828, Q9Y227RRM2B, ADCY7, ENTPD4More
Clofaziminehsa00240Pyrimidine metabolism2.84E-022Q7LG56, Q9Y227RRM2B, ENTPD4More
Clofaziminehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Clofaziminehsa00600Sphingolipid metabolism3.01E-022Q9BX95, P06280SGPP1, GLAMore
Clofaziminehsa00620Pyruvate metabolism4.20E-022P40926, P14550MDH2, AKR1A1More
Clofaziminehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Clofaziminehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Clofaziminehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Clofaziminehsa01100Metabolic pathways4.56E-0211P15144, P32320, P06280, P24666, P33121, P42330, Q13093, Q9NY28, Q9BX95, P09960, Q16718ANPEP, CDA, GLA, ACP1, ACSL1, AKR1C3, PLA2G7, GALNT8, SGPP1, LTA4H, NDUFA5More
Clofaziminehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Clofaziminehsa03010Ribosome3.56E-0614P62753, P42677, P32969, P40429, P62917, P46776, Q9H0U6, Q07020, P62910, Q02878, P36578, P05386, P62249, P23396RPS6, RPS27, RPL9, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL32, RPL6, RPL4, RPLP1, RPS16, RPS3More
Clofaziminehsa03013RNA transport8.19E-047Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Clofaziminehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Clofaziminehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Clofaziminehsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Clofaziminehsa03060Protein export3.40E-042P37108, Q15005SRP14, SPCS2More
Clofaziminehsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Clofaziminehsa04020Calcium signaling pathway6.50E-046Q96DU7, P45880, Q13557, P21860, P51828, P23634ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4More
Clofaziminehsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Clofaziminehsa04024cAMP signaling pathway1.53E-024P49019, P22694, P20020, P48058HCAR3, PRKACB, ATP2B1, GRIA4More
Clofaziminehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Clofaziminehsa04061Viral protein interaction with cytokine and cytokine receptor1.32E-026P09341, P25024, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Clofaziminehsa04062Chemokine signaling pathway6.73E-039P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITKMore
Clofaziminehsa04064NF-kappa B signaling pathway7.24E-038O00463, P14778, Q04759, P07948, P06239, P24522, P09341, Q06643TRAF5, IL1R1, PRKCQ, LYN, LCK, GADD45A, CXCL1, LTBMore
Clofaziminehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Clofaziminehsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Clofaziminehsa04145Phagosome2.75E-024Q15080, P14598, P68371, Q13488NCF4, NCF1, TUBB2C, TCIRG1More
Clofaziminehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Clofaziminehsa04217Necroptosis1.70E-025P01568, Q13489, P08238, O43633, Q08752IFNA21, BIRC3, HSP90AB1, CHMP2A, PPIDMore
Clofaziminehsa04261Adrenergic signaling in cardiomyocytes3.98E-024P51828, Q99941, Q13557, P23634ADCY7, CREBL1, CAMK2D, ATP2B4More
Clofaziminehsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Clofaziminehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Clofaziminehsa04612Antigen processing and presentation1.75E-026P13765, P01730, P26715, P26717, Q13241, P01732HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8AMore
Clofaziminehsa04640Hematopoietic cell lineage1.60E-0410P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P09564, P13765ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOBMore
Clofaziminehsa04650Natural killer cell mediated cytotoxicity2.23E-049P17252, P06239, O60880, P20963, Q13241, P26718, O14931, P26717, P26715PRKCA, LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Clofaziminehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Clofaziminehsa04658Th1 and Th2 cell differentiation2.44E-0711Q04759, P07766, P20963, P09693, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Clofaziminehsa04659Th17 cell differentiation4.63E-0611Q04759, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Clofaziminehsa04660T cell receptor signaling pathway8.91E-049Q04759, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239PRKCQ, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Clofaziminehsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Clofaziminehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Clofaziminehsa04713Circadian entrainment1.69E-023P17252, P48058, P22694PRKCA, GRIA4, PRKACBMore
Clofaziminehsa04714Thermogenesis3.16E-023P22694, P33121, Q16718PRKACB, ACSL1, NDUFA5More
Clofaziminehsa04721Synaptic vesicle cycle1.14E-022Q13488, P31645TCIRG1, SLC6A4More
Clofaziminehsa04723Retrograde endocannabinoid signaling1.20E-034P17252, P48058, P22694, Q16718PRKCA, GRIA4, PRKACB, NDUFA5More
Clofaziminehsa04724Glutamatergic synapse1.31E-023P48058, P22694, P17252GRIA4, PRKACB, PRKCAMore
Clofaziminehsa04726Serotonergic synapse2.62E-023P22694, P17252, P31645PRKACB, PRKCA, SLC6A4More
Clofaziminehsa04750Inflammatory mediator regulation of TRP channels3.74E-023P01584, P51828, Q13557IL1B, ADCY7, CAMK2DMore
Clofaziminehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Clofaziminehsa04911Insulin secretion8.21E-045P51828, P22694, P17252, Q99941, Q13557ADCY7, PRKACB, PRKCA, CREBL1, CAMK2DMore
Clofaziminehsa04913Ovarian steroidogenesis1.28E-022P42330, P22694AKR1C3, PRKACBMore
Clofaziminehsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Clofaziminehsa04918Thyroid hormone synthesis2.32E-035P22694, P51828, P17252, P02768, P05543PRKACB, ADCY7, PRKCA, ALB, SERPINA7More
Clofaziminehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Clofaziminehsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Clofaziminehsa04925Aldosterone synthesis and secretion1.13E-047Q99941, P51828, P17252, Q13557, P22694, P20020, P23634CREBL1, ADCY7, PRKCA, CAMK2D, PRKACB, ATP2B1, ATP2B4More
Clofaziminehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Clofaziminehsa04934Cushing syndrome3.48E-034Q99941, P51828, O15169, Q13557CREBL1, ADCY7, AXIN1, CAMK2DMore
Clofaziminehsa04961Endocrine and other factor-regulated calcium reabsorption9.85E-053P20020, P17252, P22694ATP2B1, PRKCA, PRKACBMore
Clofaziminehsa04962Vasopressin-regulated water reabsorption6.61E-032P22694, Q13561PRKACB, DCTN2More
Clofaziminehsa04970Salivary secretion7.14E-033P22694, P20020, P17252PRKACB, ATP2B1, PRKCAMore
Clofaziminehsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Clofaziminehsa04972Pancreatic secretion1.48E-032P20020, P17252ATP2B1, PRKCAMore
Clofaziminehsa04976Bile secretion1.51E-032P22694, P08183PRKACB, ABCB1More
Clofaziminehsa05010Alzheimer disease4.71E-0415Q92542, O15239, P05496, P13073, P12074, O75460, P01584, P18848, O15169, P67870, P05141, P12236, P45880, P28070, P43686NCSTN, NDUFA1, ATP5G1, COX4I1, COX6A1, ERN1, IL1B, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, VDAC2, PSMB4, PSMC4More
Clofaziminehsa05012Parkinson disease2.14E-027O15239, P13073, P05141, P12236, P18848, P28070, P43686NDUFA1, COX4I1, SLC25A5, SLC25A6, ATF4, PSMB4, PSMC4More
Clofaziminehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Clofaziminehsa05017Spinocerebellar ataxia4.66E-024P28070, P43686, P05141, P12236PSMB4, PSMC4, SLC25A5, SLC25A6More
Clofaziminehsa05020Prion disease9.98E-0516P01584, P46531, P11142, O15239, P05496, P13073, P12074, P18848, P05141, P12236, P45880, P28070, P43686, P67870, P51636, Q99941IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, SLC25A6, VDAC2, PSMB4, PSMC4, CSNK2B, CAV2, CREBL1More
Clofaziminehsa05022Pathways of neurodegeneration - multiple diseases5.20E-0415P67870, O15239, Q16718, P13073, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, O15169, Q08752, P28070, P43686CSNK2B, NDUFA1, NDUFA5, COX4I1, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, AXIN1, PPID, PSMB4, PSMC4More
Clofaziminehsa05031Amphetamine addiction1.69E-023P48058, P22694, P17252GRIA4, PRKACB, PRKCAMore
Clofaziminehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Clofaziminehsa05110Vibrio cholerae infection3.01E-022P17252, P22694PRKCA, PRKACBMore
Clofaziminehsa05146Amoebiasis9.73E-036P09341, P14778, P27930, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSGMore
Clofaziminehsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Clofaziminehsa05171Coronavirus disease - COVID-191.08E-0413P23396, P62753, P62249, P42677, P40429, P36578, Q02878, P62917, P32969, Q07020, P46776, P62910, P05386RPS3, RPS6, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL8, RPL9, RPL18, RPL27A, RPL32, RPLP1More
Clofaziminehsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Clofaziminehsa05224Breast cancer3.88E-023P46531, Q9UM47, O15169NOTCH1, NOTCH3, AXIN1More
Clofaziminehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.73E-036P07766, P20963, P09693, P06239, Q04759, P01730CD3E, CD247, CD3G, LCK, PRKCQ, CD4More
Clofaziminehsa05332Graft-versus-host disease3.93E-023P13765, P26715, Q13241HLA-DOB, KLRC1, KLRD1More
Clofaziminehsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Clofaziminehsa05415Diabetic cardiomyopathy2.75E-024P17252, P14598, Q15080, Q16718PRKCA, NCF1, NCF4, NDUFA5More

Community members of Clofazimine (SDC: 2.95)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Reported10.13960.505501.0809
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
O14786NRP1NeuropilinNone1Predicted10.38340.20260.51531.1123
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P17707AMD1SNoneadenosylmethionine decarboxylase proenzymePredicted00.80270.05050.16450.6667
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P16389KCNA2Potassium voltageNonegated channel subfamily A member 2Predicted00.01310.083500.1736
P17658KCNA6Potassium voltageNonegated channel subfamily A member 6Predicted00.28270.078500.2984
Q9ULS6KCNS2Potassium voltageNonegated channel subfamily S member 2Predicted00.19550.041200.1801
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)