PharmaCoNets of Clofarabine (SPCN: 50.07 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Clofarabinehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Clofarabinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Clofarabinehsa00240Pyrimidine metabolism8.44E-044P31350, P21589, P32320, P04183RRM2, NT5E, CDA, TK1More
Clofarabinehsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Clofarabinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Clofarabinehsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Clofarabinehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Clofarabinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Clofarabinehsa00983Drug metabolism - other enzymes3.83E-044P04183, P32320, P31350, P05164TK1, CDA, RRM2, MPOMore
Clofarabinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Clofarabinehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Clofarabinehsa03040Spliceosome8.05E-049Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIHMore
Clofarabinehsa04020Calcium signaling pathway9.34E-037P27987, P21796, P45880, Q13557, P19174, P0DP23, P05141ITPKB, VDAC1, VDAC2, CAMK2D, PLCG1, CALM1, SLC25A5More
Clofarabinehsa04022cGMP-PKG signaling pathway2.26E-038Q14814, Q99941, P18848, P05141, P21796, P45880, P0DP23, P01042MEF2D, CREBL1, ATF4, SLC25A5, VDAC1, VDAC2, CALM1, KNG1More
Clofarabinehsa04064NF-kappa B signaling pathway1.98E-037P10415, P51617, Q04759, Q9UDY8, Q13315, P24522, P09341BCL2, IRAK1, PRKCQ, MALT1, ATM, GADD45A, CXCL1More
Clofarabinehsa04070Phosphatidylinositol signaling system1.32E-025P19174, P0DP23, O14986, P23743, P27987PLCG1, CALM1, PIP5K1B, DGKA, ITPKBMore
Clofarabinehsa04071Sphingolipid signaling pathway1.87E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Clofarabinehsa04115p53 signaling pathway3.35E-035P24522, Q13315, P31350, O95067, P10415GADD45A, ATM, RRM2, CCNB2, BCL2More
Clofarabinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Clofarabinehsa04141Protein processing in endoplasmic reticulum6.42E-038P18848, P30101, Q15437, Q15436, Q99941, P11142, P07900, P08238ATF4, PDIA3, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, HSP90AB1More
Clofarabinehsa04145Phagosome1.73E-036Q15080, P68371, P05164, P78380, P35443, P13765NCF4, TUBB2C, MPO, OLR1, THBS4, HLA-DOBMore
Clofarabinehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Clofarabinehsa04151PI3K-Akt signaling pathway1.24E-0212P62753, P27348, P07900, P08238, P62873, P63218, Q16363, P22105, P14784, Q99941, P18848, P30279RPS6, YWHAQ, HSP90AA1, HSP90AB1, GNB1, GNG5, LAMA4, TNXB, IL2RB, CREBL1, ATF4, CCND2More
Clofarabinehsa04217Necroptosis7.73E-0412P01375, P48023, P42224, Q14765, P07900, P08238, P15104, P05141, Q99878, Q13557, P21796, P45880TNF, FASLG, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, H2AC14, CAMK2D, VDAC1, VDAC2More
Clofarabinehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Clofarabinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Clofarabinehsa04612Antigen processing and presentation4.72E-024P13765, P48382, P26715, P26717HLA-DOB, RFX5, KLRC1, KLRC2More
Clofarabinehsa04613Neutrophil extracellular trap formation7.32E-0313O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Clofarabinehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Clofarabinehsa04657IL-17 signaling pathway2.40E-037O00463, Q16539, P49841, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, MMP9, ANAPC5, LCN2, TNFMore
Clofarabinehsa04659Th17 cell differentiation3.71E-026P19174, P42224, P14784, P07900, P08238, P07766PLCG1, STAT1, IL2RB, HSP90AA1, HSP90AB1, CD3EMore
Clofarabinehsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Clofarabinehsa04664Fc epsilon RI signaling pathway2.20E-036P01375, Q16539, P42338, Q9UQC2, P07948, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5More
Clofarabinehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Clofarabinehsa04713Circadian entrainment4.76E-024P0DP23, Q13557, P62873, P63218CALM1, CAMK2D, GNB1, GNG5More
Clofarabinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Clofarabinehsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Clofarabinehsa04725Cholinergic synapse5.23E-036P62873, P63218, P50151, P18848, Q13557, P42338GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CBMore
Clofarabinehsa04727GABAergic synapse2.26E-035P62873, P63218, P50151, P15104, P46459GNB1, GNG5, GNG10, GLUL, NSFMore
Clofarabinehsa04728Dopaminergic synapse1.87E-026P62873, P63218, Q99941, P18848, Q13557, P0DP23GNB1, GNG5, CREBL1, ATF4, CAMK2D, CALM1More
Clofarabinehsa04740Olfactory transduction9.79E-033P62873, Q13557, P0DP23GNB1, CAMK2D, CALM1More
Clofarabinehsa04744Phototransduction1.42E-022P62873, P0DP23GNB1, CALM1More
Clofarabinehsa04750Inflammatory mediator regulation of TRP channels1.61E-025Q13557, P19174, P24723, P0DP23, P01042CAMK2D, PLCG1, PRKCH, CALM1, KNG1More
Clofarabinehsa04915Estrogen signaling pathway1.87E-026Q99941, P18848, P07900, P08238, P11142, P0DP23CREBL1, ATF4, HSP90AA1, HSP90AB1, HSPA8, CALM1More
Clofarabinehsa04925Aldosterone synthesis and secretion3.35E-024Q99941, P18848, P0DP23, Q13557CREBL1, ATF4, CALM1, CAMK2DMore
Clofarabinehsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P49407PIK3CB, GNG5, GNG10, VEGFC, ARRB1More
Clofarabinehsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Clofarabinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Clofarabinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Clofarabinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Clofarabinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Clofarabinehsa05010Alzheimer disease4.56E-029P19404, P13073, P0DP23, P18848, Q71U36, Q13509, P05141, P21796, P45880NDUFV2, COX4I1, CALM1, ATF4, TUBA1A, TUBB3, SLC25A5, VDAC1, VDAC2More
Clofarabinehsa05012Parkinson disease6.70E-0411P19404, P13073, P05141, P21796, P45880, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509NDUFV2, COX4I1, SLC25A5, VDAC1, VDAC2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Clofarabinehsa05016Huntington disease9.64E-0310P19404, P13073, Q13547, P30876, P62487, P05141, P21796, P45880, Q71U36, Q13509NDUFV2, COX4I1, HDAC1, POLR2B, POLR2G, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3More
Clofarabinehsa05020Prion disease9.64E-0310P11142, P19404, P13073, P18848, P05141, P21796, P45880, Q71U36, Q13509, Q99941HSPA8, NDUFV2, COX4I1, ATF4, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3, CREBL1More
Clofarabinehsa05022Pathways of neurodegeneration - multiple diseases1.36E-0212Q71U36, Q13509, P19404, P13073, P21796, P18848, P19174, P05141, P45880, P20333, P0DP23, Q13557TUBA1A, TUBB3, NDUFV2, COX4I1, VDAC1, ATF4, PLCG1, SLC25A5, VDAC2, TNFRSF1B, CALM1, CAMK2DMore
Clofarabinehsa05031Amphetamine addiction6.57E-035P0DP23, Q13557, Q99941, P18848, Q13547CALM1, CAMK2D, CREBL1, ATF4, HDAC1More
Clofarabinehsa05034Alcoholism1.27E-027Q99941, P18848, Q13547, P0DP23, P62873, P63218, O60814CREBL1, ATF4, HDAC1, CALM1, GNB1, GNG5, H2BC12More
Clofarabinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Clofarabinehsa05134Legionellosis3.35E-024P11215, P68104, P11142, P19875ITGAM, EEF1A1, HSPA8, CXCL2More
Clofarabinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Clofarabinehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Clofarabinehsa05152Tuberculosis1.95E-025P48382, P10415, P13765, Q9UDY8, P51617RFX5, BCL2, HLA-DOB, MALT1, IRAK1More
Clofarabinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Clofarabinehsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Clofarabinehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-027P42224, P62873, P63218, P19875, P19174, P07948, P0DP23STAT1, GNB1, GNG5, CXCL2, PLCG1, LYN, CALM1More
Clofarabinehsa05169Epstein-Barr virus infection4.48E-039Q13547, P42338, P07948, P30101, Q13761, O75293, P30279, P42224, P07766HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CCND2, STAT1, CD3EMore
Clofarabinehsa05200Pathways in cancer1.93E-0317Q16363, P07900, P08238, P42224, P19174, P43246, P20585, Q13547, P30279, P62873, P63218, P78417, O75293, P0DP23, Q13557, P14784, P01042LAMA4, HSP90AA1, HSP90AB1, STAT1, PLCG1, MSH2, MSH3, HDAC1, CCND2, GNB1, GNG5, GSTO1, GADD45B, CALM1, CAMK2D, IL2RB, KNG1More
Clofarabinehsa05202Transcriptional misregulation in cancer1.63E-0315Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P35226, P05164, P08246, Q9C0K0, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, BCL11B, GADD45AMore
Clofarabinehsa05203Viral carcinogenesis2.22E-0310Q99941, P18848, P06746, P07948, P30279, P27348, P29083, Q7KZF4, Q13547, O60814CREBL1, ATF4, POLB, LYN, CCND2, YWHAQ, GTF2E1, SND1, HDAC1, H2BC12More
Clofarabinehsa05214Glioma1.76E-024P0DP23, Q13557, P19174, O75293CALM1, CAMK2D, PLCG1, GADD45BMore
Clofarabinehsa05221Acute myeloid leukemia3.29E-023P14923, Q15744, P05164JUP, CEBPE, MPOMore
Clofarabinehsa05310Asthma3.01E-022P13765, P12724HLA-DOB, RNASE3More
Clofarabinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Clofarabinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Clofarabinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Clofarabinehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Clofarabine (SDC: 4.54)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P04183TK1Thymidine kinase, cytosolicPredicted00.27170.16370.16530.6286
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P11142HSPA8Heat shock cognate 71 kDa proteinPredicted00.96820.07730.67291.3115
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)