PharmaCoNets of Clodronic-acid (SPCN: 11.22 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Clodronic-acidhsa00010Glycolysis / Gluconeogenesis2.17E-023P04075, P04406, P60174ALDOA, GAPDH, TPI1More
Clodronic-acidhsa00020Citrate cycle (TCA cycle)3.65E-022O75390, P40926CS, MDH2More
Clodronic-acidhsa00051Fructose and mannose metabolism2.48E-022P60174, P04075TPI1, ALDOAMore
Clodronic-acidhsa01200Carbon metabolism1.20E-024P04075, P04406, P60174, P40926ALDOA, GAPDH, TPI1, MDH2More
Clodronic-acidhsa01230Biosynthesis of amino acids1.28E-023P60174, P04406, P04075TPI1, GAPDH, ALDOAMore
Clodronic-acidhsa03010Ribosome7.17E-0615P62753, P32969, P30050, P40429, P62906, P62917, P46776, Q9H0U6, Q07020, P61513, P36578, P27635, P05386, P62249, P23396RPS6, RPL9, RPL12, RPL13A, RPL10A, RPL8, RPL27A, MRPL18, RPL18, RPL37A, RPL4, RPL10, RPLP1, RPS16, RPS3More
Clodronic-acidhsa03013RNA transport4.75E-026P62826, Q9UBU9, P63279, P68104, P11940, P20042RAN, NXF1, UBE2I, EEF1A1, PABPC1, EIF2S2More
Clodronic-acidhsa03030DNA replication3.59E-022P49005, P33993POLD2, MCM7More
Clodronic-acidhsa03040Spliceosome1.54E-026P17844, Q13435, P51991, P61978, Q15365, P11142DDX5, SF3B2, HNRPA3, HNRPK, PCBP1, HSPA8More
Clodronic-acidhsa04071Sphingolipid signaling pathway4.56E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Clodronic-acidhsa04141Protein processing in endoplasmic reticulum2.71E-027P18848, Q15436, P11142, Q9NXW2, Q9H3Z4, Q9NR31, P14625ATF4, SEC23A, HSPA8, DNAJB12, DNAJC5, SAR1A, HSP90B1More
Clodronic-acidhsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Clodronic-acidhsa04612Antigen processing and presentation2.40E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Clodronic-acidhsa04613Neutrophil extracellular trap formation3.61E-0213O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Clodronic-acidhsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Clodronic-acidhsa04657IL-17 signaling pathway3.91E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Clodronic-acidhsa04658Th1 and Th2 cell differentiation1.12E-028Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Clodronic-acidhsa04660T cell receptor signaling pathway3.76E-0311P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Clodronic-acidhsa04714Thermogenesis4.75E-026Q92618, Q15418, P62753, P13073, Q7KZN9, O15239ZNF516, RPS6KA1, RPS6, COX4I1, COX15, NDUFA1More
Clodronic-acidhsa04920Adipocytokine signaling pathway4.87E-022Q15831, P20333STK11, TNFRSF1BMore
Clodronic-acidhsa05010Alzheimer disease1.31E-0210O15239, P13073, Q00535, P01584, P18848, O15169, P67870, P05141, P28070, P43686NDUFA1, COX4I1, CDK5, IL1B, ATF4, AXIN1, CSNK2B, SLC25A5, PSMB4, PSMC4More
Clodronic-acidhsa05020Prion disease1.09E-0210P01584, P46531, P11142, O15239, P13073, P18848, P05141, P28070, P43686, P67870IL1B, NOTCH1, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5, PSMB4, PSMC4, CSNK2BMore
Clodronic-acidhsa05022Pathways of neurodegeneration - multiple diseases6.24E-0312P67870, O15239, P13073, P18848, P05141, P20333, Q00535, O15169, P01584, Q13557, P28070, P43686CSNK2B, NDUFA1, COX4I1, ATF4, SLC25A5, TNFRSF1B, CDK5, AXIN1, IL1B, CAMK2D, PSMB4, PSMC4More
Clodronic-acidhsa05134Legionellosis2.00E-024P01584, Q9NR31, P68104, P11142IL1B, SAR1A, EEF1A1, HSPA8More
Clodronic-acidhsa05140Leishmaniasis1.87E-027P13612, O75015, P13765, O60603, P01375, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4More
Clodronic-acidhsa05146Amoebiasis3.91E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Clodronic-acidhsa05171Coronavirus disease - COVID-196.10E-0515P01584, P23396, P62753, P62249, P40429, P62906, P36578, P62917, P32969, P27635, P30050, Q07020, P46776, P61513, P05386IL1B, RPS3, RPS6, RPS16, RPL13A, RPL10A, RPL4, RPL8, RPL9, RPL10, RPL12, RPL18, RPL27A, RPL37A, RPLP1More
Clodronic-acidhsa05202Transcriptional misregulation in cancer3.00E-0213P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Clodronic-acidhsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Clodronic-acidhsa05321Inflammatory bowel disease3.16E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Clodronic-acidhsa05332Graft-versus-host disease3.46E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More

Community members of Clodronic-acid (SDC: 2.44)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)