PharmaCoNets of Clidinium (SPCN: 19.92 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Clidiniumhsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Clidiniumhsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Clidiniumhsa03060Protein export4.22E-022P37108, Q15005SRP14, SPCS2More
Clidiniumhsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Clidiniumhsa04061Viral protein interaction with cytokine and cytokine receptor2.60E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Clidiniumhsa04064NF-kappa B signaling pathway4.09E-035P01584, P67870, P63279, Q8NHW4, Q9NQC7IL1B, CSNK2B, UBE2I, CCL4L2, CYLDMore
Clidiniumhsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Clidiniumhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Clidiniumhsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Clidiniumhsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Clidiniumhsa04613Neutrophil extracellular trap formation1.23E-035P11215, Q13547, P58876, Q16778, O60814ITGAM, HDAC1, H2BC5, HIST2H2BE, H2BC12More
Clidiniumhsa04623Cytosolic DNA-sensing pathway1.54E-022P01584, Q8NHW4IL1B, CCL4L2More
Clidiniumhsa04659Th17 cell differentiation4.38E-024P42224, P14784, P40189, P08238STAT1, IL2RB, IL6ST, HSP90AB1More
Clidiniumhsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Clidiniumhsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Clidiniumhsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Clidiniumhsa04932Non-alcoholic fatty liver disease1.24E-026O43521, O75460, P01584, P13073, P12074, O15239BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1More
Clidiniumhsa05010Alzheimer disease2.21E-0210O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4More
Clidiniumhsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Clidiniumhsa05163Human cytomegalovirus infection2.89E-027P0DP23, Q8NHW4, Q08828, P23458, P01584, P61073, Q13651CALM1, CCL4L2, ADCY1, JAK1, IL1B, CXCR4, IL10RAMore
Clidiniumhsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Clidiniumhsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Clidiniumhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Clidiniumhsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Clidiniumhsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Clidiniumhsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Clidiniumhsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Clidiniumhsa05418Fluid shear stress and atherosclerosis3.73E-024P42338, P14598, P0DP23, P08238PIK3CB, NCF1, CALM1, HSP90AB1More
Umeclidiniumhsa00040Pentose and glucuronate interconversions3.01E-021P15121AKR1B1More
Umeclidiniumhsa00190Oxidative phosphorylation8.33E-044Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Umeclidiniumhsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Umeclidiniumhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Umeclidiniumhsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Umeclidiniumhsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Umeclidiniumhsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Umeclidiniumhsa00790Folate biosynthesis3.01E-021P15121AKR1B1More
Umeclidiniumhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Umeclidiniumhsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Umeclidiniumhsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Umeclidiniumhsa03013RNA transport1.39E-0412O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1More
Umeclidiniumhsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Umeclidiniumhsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Umeclidiniumhsa03050Proteasome1.21E-021P28074PSMB5More
Umeclidiniumhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Umeclidiniumhsa04064NF-kappa B signaling pathway2.35E-024P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Umeclidiniumhsa04130SNARE interactions in vesicular transport1.52E-021P23763VAMP1More
Umeclidiniumhsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Umeclidiniumhsa04142Lysosome2.45E-039Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Umeclidiniumhsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Umeclidiniumhsa04145Phagosome2.07E-028P60709, Q15075, Q15080, P14598, Q13509, Q13488, Q99437, P25774ACTB, EEA1, NCF4, NCF1, TUBB3, TCIRG1, ATP6V0B, CTSSMore
Umeclidiniumhsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Umeclidiniumhsa04213Longevity regulating pathway - multiple species2.82E-023Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Umeclidiniumhsa04217Necroptosis3.73E-022P42229, Q9BTM1STAT5A, H2AFJMore
Umeclidiniumhsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Umeclidiniumhsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Umeclidiniumhsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Umeclidiniumhsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Umeclidiniumhsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Umeclidiniumhsa04750Inflammatory mediator regulation of TRP channels4.01E-024P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Umeclidiniumhsa04915Estrogen signaling pathway3.17E-025Q08828, P51828, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Umeclidiniumhsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Umeclidiniumhsa04932Non-alcoholic fatty liver disease1.39E-026O43521, O75460, P01584, P13073, P12074, O95298BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2More
Umeclidiniumhsa04970Salivary secretion4.78E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Umeclidiniumhsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Umeclidiniumhsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Umeclidiniumhsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Umeclidiniumhsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Umeclidiniumhsa05110Vibrio cholerae infection6.26E-045Q13488, Q99437, P17252, P19174, P60709TCIRG1, ATP6V0B, PRKCA, PLCG1, ACTBMore
Umeclidiniumhsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Umeclidiniumhsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Umeclidiniumhsa05140Leishmaniasis4.75E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Umeclidiniumhsa05150Staphylococcus aureus infection4.02E-036P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Umeclidiniumhsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Umeclidiniumhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Umeclidiniumhsa05163Human cytomegalovirus infection3.31E-027P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RAMore
Umeclidiniumhsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Umeclidiniumhsa05223Non-small cell lung cancer3.99E-024P17252, O43524, P19174, O75293PRKCA, FOXO3, PLCG1, GADD45BMore
Umeclidiniumhsa05231Choline metabolism in cancer3.99E-024P19174, P23743, O14494, P17252PLCG1, DGKA, PLPP1, PRKCAMore
Umeclidiniumhsa05415Diabetic cardiomyopathy3.94E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore

Community members of Clidinium (SDC: 3.72)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)