PharmaCoNets of Clemastine (SPCN: 44.84 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Clemastinehsa00190Oxidative phosphorylation3.92E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Clemastinehsa00500Starch and sucrose metabolism1.79E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Clemastinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Clemastinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Clemastinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Clemastinehsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Clemastinehsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Clemastinehsa00970Aminoacyl-tRNA biosynthesis7.90E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Clemastinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Clemastinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Clemastinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Clemastinehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Clemastinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Clemastinehsa03013RNA transport2.99E-024P38919, P37198, P35658, P55884EIF4A3, NUP62, NUP214, EIF3BMore
Clemastinehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Clemastinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Clemastinehsa03030DNA replication5.00E-021P27694RPA1More
Clemastinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Clemastinehsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Clemastinehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Clemastinehsa04120Ubiquitin mediated proteolysis4.81E-034Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Clemastinehsa04145Phagosome2.57E-024Q15080, P14598, Q13488, O60603NCF4, NCF1, TCIRG1, TLR2More
Clemastinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Clemastinehsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Clemastinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Clemastinehsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Clemastinehsa04512ECM-receptor interaction2.93E-022P07359, P08514GP1BA, ITGA2BMore
Clemastinehsa04514Cell adhesion molecules1.22E-022P23229, P30511ITGA6, HLA-FMore
Clemastinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Clemastinehsa04610Complement and coagulation cascades9.49E-043P09871, P0C0L4, P20023C1S, C4A, CR2More
Clemastinehsa04611Platelet activation5.13E-044P08514, Q15746, Q8WYR1, P07359ITGA2B, MYLK, PIK3R5, GP1BAMore
Clemastinehsa04613Neutrophil extracellular trap formation1.42E-0615P16109, P11215, Q13547, P04908, Q99878, Q93077, P58876, P62807, Q16778, O60814, P68431, P08514, P07359, O43315, Q16539SELP, ITGAM, HDAC1, H2AC4; H2AC8, H2AC14, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ITGA2B, GP1BA, AQP9, MAPK14More
Clemastinehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Clemastinehsa04640Hematopoietic cell lineage2.84E-037P07359, P08514, P21926, P20023, P07766, P01730, P09564GP1BA, ITGA2B, CD9, CR2, CD3E, CD4, CD7More
Clemastinehsa04650Natural killer cell mediated cytotoxicity1.35E-039P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Clemastinehsa04660T cell receptor signaling pathway2.78E-027P01375, Q08881, P20963, Q13191, P06239, Q16539, P49841TNF, ITK, CD247, CBLB, LCK, MAPK14, GSK3BMore
Clemastinehsa04662B cell receptor signaling pathway4.53E-033P20023, Q8WV28, P11912CR2, BLNK, CD79AMore
Clemastinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Clemastinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Clemastinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Clemastinehsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Clemastinehsa04730Long-term depression5.00E-021Q14344GNA13More
Clemastinehsa04810Regulation of actin cytoskeleton2.68E-022P23229, Q14344ITGA6, GNA13More
Clemastinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Clemastinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Clemastinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Clemastinehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Clemastinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Clemastinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Clemastinehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Clemastinehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Clemastinehsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Clemastinehsa05133Pertussis4.94E-021P0C0L4C4AMore
Clemastinehsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Clemastinehsa05140Leishmaniasis5.18E-046P14598, P42224, O60603, P25963, P29350, Q15080NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4More
Clemastinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Clemastinehsa05144Malaria2.07E-024P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Clemastinehsa05150Staphylococcus aureus infection2.54E-036P09871, Q14532, P16109, P59665, P59666, P49913C1S, KRT32, SELP, DEFA1; DEFA1B, DEFA3, CAMPMore
Clemastinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Clemastinehsa05163Human cytomegalovirus infection3.94E-0310P01375, P30511, P63218, P50151, Q14344, P49841, P14778, P25025, Q16539, O00463TNF, HLA-F, GNG5, GNG10, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Clemastinehsa05168Herpes simplex virus 1 infection6.00E-0416P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF140, ZNF189, ZNF212More
Clemastinehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Clemastinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Clemastinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Clemastinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Clemastinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Clemastinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Clemastinehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Clemastinehsa05323Rheumatoid arthritis2.00E-023Q13488, P10747, O60603TCIRG1, CD28, TLR2More
Clemastinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Clemastinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Clemastinehsa05340Primary immunodeficiency9.68E-055P01730, P11912, Q8WV28, P07766, P06239CD4, CD79A, BLNK, CD3E, LCKMore
Clemastinehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Clemastinehsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Clemastine (SDC: 4.91)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P27694RPA1Replication protein A 70 kDa DNANonebinding subunitPredicted00.22730.17560.27460.7395
O14786NRP1NeuropilinNone1Predicted10.38340.20260.51531.1123
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P12271RLBP1RetinaldehydeNonebinding protein 1Predicted00.0840.106200.2543
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)