PharmaCoNets of Clarithromycin (SPCN: 38.28 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Clarithromycinhsa00010Glycolysis / Gluconeogenesis3.09E-032P51648, P28332ALDH3A2, ADH6More
Clarithromycinhsa00052Galactose metabolism6.39E-042P06280, O43451GLA, MGAMMore
Clarithromycinhsa00053Ascorbate and aldarate metabolism4.51E-021P51648ALDH3A2More
Clarithromycinhsa00071Fatty acid degradation3.09E-032P28332, P51648ADH6, ALDH3A2More
Clarithromycinhsa00310Lysine degradation7.50E-042Q96KQ7, P51648EHMT2, ALDH3A2More
Clarithromycinhsa00330Arginine and proline metabolism4.51E-021P51648ALDH3A2More
Clarithromycinhsa00340Histidine metabolism3.03E-021P51648ALDH3A2More
Clarithromycinhsa00350Tyrosine metabolism4.51E-021P28332ADH6More
Clarithromycinhsa00380Tryptophan metabolism4.51E-021P51648ALDH3A2More
Clarithromycinhsa00410beta-Alanine metabolism3.03E-021P51648ALDH3A2More
Clarithromycinhsa00500Starch and sucrose metabolism1.75E-032O43451, P06737MGAM, PYGLMore
Clarithromycinhsa00515Mannose type O-glycan biosynthesis1.52E-021O75072FCMDMore
Clarithromycinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Clarithromycinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Clarithromycinhsa00600Sphingolipid metabolism4.56E-023Q9BX95, Q06136, P06280SGPP1, FVT1, GLAMore
Clarithromycinhsa00620Pyruvate metabolism2.08E-032P51648, P28332ALDH3A2, ADH6More
Clarithromycinhsa00730Thiamine metabolism1.50E-042P05186, P24666ALPL, ACP1More
Clarithromycinhsa00830Retinol metabolism1.08E-023Q9BPW9, O75911, P11712DHRS9, DHRS3, CYP2C9More
Clarithromycinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Clarithromycinhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Clarithromycinhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Clarithromycinhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Clarithromycinhsa03013RNA transport1.91E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Clarithromycinhsa03015mRNA surveillance pathway4.36E-023Q9BZI7, O43809, Q9H307UPF3B, NUDT21, PNNMore
Clarithromycinhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Clarithromycinhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Clarithromycinhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Clarithromycinhsa04064NF-kappa B signaling pathway1.86E-0315P10415, Q13489, O00463, Q13546, P14778, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, P24522, P09341, P19875, Q06643BCL2, BIRC3, TRAF5, RIPK1, IL1R1, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, GADD45A, CXCL1, CXCL2, LTBMore
Clarithromycinhsa04071Sphingolipid signaling pathway5.28E-059P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, BCL2, GAB2More
Clarithromycinhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Clarithromycinhsa04140Autophagy - animal3.72E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Clarithromycinhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Clarithromycinhsa04145Phagosome3.16E-022Q71U36, P68371TUBA1A, TUBB2CMore
Clarithromycinhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Clarithromycinhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Clarithromycinhsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Clarithromycinhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Clarithromycinhsa04371Apelin signaling pathway1.94E-035P63218, Q14344, Q13485, P84022, Q16566GNG5, GNA13, SMAD4, SMAD3, CAMK4More
Clarithromycinhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Clarithromycinhsa04540Gap junction8.97E-032P68371, Q71U36TUBB2C, TUBA1AMore
Clarithromycinhsa04612Antigen processing and presentation2.84E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Clarithromycinhsa04613Neutrophil extracellular trap formation1.54E-0419O60603, P05164, P08246, Q9UM07, Q92769, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Clarithromycinhsa04640Hematopoietic cell lineage1.64E-0312P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P09564, P13765, P01375ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNFMore
Clarithromycinhsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Clarithromycinhsa04657IL-17 signaling pathway4.48E-035P07900, P49841, P14780, P01375, P01584HSP90AA1, GSK3B, MMP9, TNF, IL1BMore
Clarithromycinhsa04658Th1 and Th2 cell differentiation1.80E-0512Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Clarithromycinhsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Clarithromycinhsa04660T cell receptor signaling pathway3.83E-0514P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Clarithromycinhsa04668TNF signaling pathway4.96E-026O00463, Q13546, Q13489, Q16539, Q13077, P14780TRAF5, RIPK1, BIRC3, MAPK14, TRAF1, MMP9More
Clarithromycinhsa04672Intestinal immune network for IgA production1.66E-023P10747, P13765, P13612CD28, HLA-DOB, ITGA4More
Clarithromycinhsa04724Glutamatergic synapse1.84E-023O15399, P63218, Q9NSB8GRIN2D, GNG5, HOMER2More
Clarithromycinhsa04730Long-term depression1.63E-022Q14344, P07948GNA13, LYNMore
Clarithromycinhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Clarithromycinhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Clarithromycinhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Clarithromycinhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Clarithromycinhsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Clarithromycinhsa04927Cortisol synthesis and secretion1.66E-023Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Clarithromycinhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Clarithromycinhsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Clarithromycinhsa04940Type I diabetes mellitus3.64E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Clarithromycinhsa04970Salivary secretion4.92E-024P07550, P22694, Q14643, P49913ADRB2, PRKACB, ITPR1, CAMPMore
Clarithromycinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Clarithromycinhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Clarithromycinhsa05010Alzheimer disease2.57E-025O15399, Q9NZJ5, Q13564, Q71U36, P21796GRIN2D, EIF2AK3, APPBP1, TUBA1A, VDAC1More
Clarithromycinhsa05012Parkinson disease1.68E-037O15239, P13073, P05141, P18848, Q13557, Q71U36, P68371NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D, TUBA1A, TUBB2CMore
Clarithromycinhsa05014Amyotrophic lateral sclerosis1.56E-026O15399, Q9NZJ5, Q71U36, P21796, P43243, P84103GRIN2D, EIF2AK3, TUBA1A, VDAC1, MATR3, SFRS3More
Clarithromycinhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Clarithromycinhsa05020Prion disease5.31E-0411P13591, P01584, P11142, O15239, P13073, O15399, Q9NZJ5, P18848, P05141, P21796, Q71U36NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, GRIN2D, EIF2AK3, ATF4, SLC25A5, VDAC1, TUBA1AMore
Clarithromycinhsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Clarithromycinhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Clarithromycinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.40E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Clarithromycinhsa05132Salmonella infection1.05E-023Q13489, Q71U36, P68371BIRC3, TUBA1A, TUBB2CMore
Clarithromycinhsa05134Legionellosis6.38E-046P01584, P11215, P68104, P11142, P09341, P19875IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Clarithromycinhsa05144Malaria4.92E-024O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Clarithromycinhsa05146Amoebiasis1.80E-0512P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Clarithromycinhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Clarithromycinhsa05166Human T-cell leukemia virus 1 infection3.68E-026P27824, P30279, P21796, P84022, Q13485, Q13042CANX, CCND2, VDAC1, SMAD3, SMAD4, CDC16More
Clarithromycinhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Clarithromycinhsa05202Transcriptional misregulation in cancer2.85E-0416Q15532, P41732, P14780, P27930, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, Q92769, P12980, P24522SS18, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC2, LYL1, GADD45AMore
Clarithromycinhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Clarithromycinhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Clarithromycinhsa05217Basal cell carcinoma2.01E-024Q13635, P04628, Q9UJU2, P24522PTCH1, WNT1, LEF1, GADD45AMore
Clarithromycinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Clarithromycinhsa05310Asthma1.66E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Clarithromycinhsa05321Inflammatory bowel disease1.14E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Clarithromycinhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Clarithromycinhsa05323Rheumatoid arthritis1.58E-025P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Clarithromycinhsa05332Graft-versus-host disease2.03E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Clarithromycinhsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore

Community members of Clarithromycin (SDC: 3.20)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P24666ACP1Low molecular weight phosphotyrosine protein phosphatasePredicted00.07040.10480.23610.481
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
Q9UM07PADI4ProteinNonearginine deiminase typeNone4Predicted10.14880.27780.42671.0567
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q9UIG8SLCO3A1Solute carrier organic anion transporter family member 3A1Predicted00.04050.006900.034
Q96BD0SLCO4A1Solute carrier organic anion transporter family member 4A1Predicted00.06690.00400.0415
P09958FURINFurinPredicted10.15690.07500.2286
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)