| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Cladribine | hsa00010 | Glycolysis / Gluconeogenesis | 4.41E-02 | 4 | P04075, P06733, P04406, P60174 | ALDOA, ENO1, GAPDH, TPI1 | More | | | Cladribine | hsa00030 | Pentose phosphate pathway | 1.95E-02 | 3 | P51854, P08237, P37837 | TKTL1, PFKM, TALDO1 | More | | | Cladribine | hsa00051 | Fructose and mannose metabolism | 2.21E-02 | 3 | O14772, P60174, P04075 | FPGT, TPI1, ALDOA | More | | | Cladribine | hsa00052 | Galactose metabolism | 4.27E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Cladribine | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Cladribine | hsa00140 | Steroid hormone biosynthesis | 2.78E-02 | 1 | P22680 | CYP7A1 | More | | | Cladribine | hsa00230 | Purine metabolism | 5.16E-04 | 4 | Q7LG56, P31350, P21589, Q9Y227 | RRM2B, RRM2, NT5E, ENTPD4 | More | | | Cladribine | hsa00240 | Pyrimidine metabolism | 3.21E-11 | 7 | Q7LG56, P31350, Q9Y227, P21589, P32320, P04183, P04818 | RRM2B, RRM2, ENTPD4, NT5E, CDA, TK1, TYMS | More | | | Cladribine | hsa00480 | Glutathione metabolism | 4.50E-02 | 1 | P31350 | RRM2 | More | | | Cladribine | hsa00500 | Starch and sucrose metabolism | 6.17E-03 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Cladribine | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Cladribine | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Cladribine | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Cladribine | hsa00630 | Glyoxylate and dicarboxylate metabolism | 5.34E-03 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Cladribine | hsa00670 | One carbon pool by folate | 3.40E-02 | 1 | P04818 | TYMS | More | | | Cladribine | hsa00730 | Thiamine metabolism | 2.27E-02 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Cladribine | hsa00750 | Vitamin B6 metabolism | 4.45E-02 | 1 | O00764 | PDXK | More | | | Cladribine | hsa00760 | Nicotinate and nicotinamide metabolism | 4.50E-02 | 1 | P21589 | NT5E | More | | | Cladribine | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Cladribine | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Cladribine | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Cladribine | hsa00983 | Drug metabolism - other enzymes | 3.93E-06 | 4 | P04183, P32320, P31350, P05164 | TK1, CDA, RRM2, MPO | More | | | Cladribine | hsa01040 | Biosynthesis of unsaturated fatty acids | 4.28E-02 | 1 | P22307 | SCP2 | More | | | Cladribine | hsa01100 | Metabolic pathways | 1.29E-03 | 33 | Q9Y234, P35790, P31350, Q16772, P15144, P30041, O14732, P21589, P04183, Q02153, Q16774, P20839, P00918, P10768, P55809, P06280, Q9Y6K0, P08237, P21399, Q9UHK6, P51854, P04818, Q86VZ5, Q9BVK2, P15907, Q9UBX8, O96024, P37837, P50213, P43490, Q969G6, Q13029, Q9NVH6 | LIPT1, CHKA, RRM2, GSTA3, ANPEP, PRDX6, IMPA2, NT5E, TK1, GUCY1B3, GUK1, IMPDH1, CA2, ESD, OXCT1, GLA, CEPT1, PFKM, ACO1, AMACR, TKTL1, TYMS, SGMS1, ALG8, ST6GAL1, B4GALT6, B3GALT4, TALDO1, IDH3A, PBEF1, RFK, PRDM2, TMLHE | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9Y234 | LIPT1 | Lipoyltransferase 1, mitochondrial | 0.778 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P35790 | CHKA | Choline kinase alpha | -0.856 | | P31350 | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 | P31350 | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 | 1 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q16772 | GSTA3 | Glutathione S-transferase A3 | -0.768 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P15144 | ANPEP | Aminopeptidase N | 0.846 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P30041 | PRDX6 | Peroxiredoxin-6 | 0.785 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | O14732 | IMPA2 | Inositol monophosphatase 2 | 0.738 | | P31350 | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 | P21589 | NT5E | 5'-nucleotidase | -0.732 | | P31350 | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 | P04183 | TK1 | Thymidine kinase, cytosolic | 0.784 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q02153 | GUCY1B3 | Guanylate cyclase soluble subunit beta-1 | -0.774 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q16774 | GUK1 | Guanylate kinase | 0.757 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | 1 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P00918 | CA2 | Carbonic anhydrase 2 | 0.772 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P10768 | ESD | S-formylglutathione hydrolase | -0.701 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P55809 | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | -0.744 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P06280 | GLA | Alpha-galactosidase A | 0.728 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9Y6K0 | CEPT1 | Choline/ethanolaminephosphotransferase 1 | 0.771 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P08237 | PFKM | ATP-dependent 6-phosphofructokinase, muscle type | 0.868 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P21399 | ACO1 | Cytoplasmic aconitate hydratase | -0.739 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9UHK6 | AMACR | Alpha-methylacyl-CoA racemase | -0.784 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P51854 | TKTL1 | Transketolase-like protein 1 | -0.753 | | P31350 | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 | P04818 | TYMS | Thymidylate synthase | 0.797 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q86VZ5 | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | -0.81 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9BVK2 | ALG8 | Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase | -0.726 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P15907 | ST6GAL1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | -0.827 | | P31350 | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 | Q9UBX8 | B4GALT6 | Beta-1,4-galactosyltransferase 6 | 0.74 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | O96024 | B3GALT4 | Beta-1,3-galactosyltransferase 4 | 0.797 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P37837 | TALDO1 | Transaldolase | 0.732 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P50213 | IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | -0.732 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.702 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q969G6 | RFK | Riboflavin kinase | 0.705 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q13029 | PRDM2 | PR domain zinc finger protein 2 | 0.744 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9NVH6 | TMLHE | Trimethyllysine dioxygenase, mitochondrial | -0.721 |
| | Cladribine | hsa01200 | Carbon metabolism | 3.30E-04 | 13 | P04075, P51854, P04406, P08237, P60174, P37837, P06733, O14521, Q9P2R7, P50213, P21399, P10768, Q02252 | ALDOA, TKTL1, GAPDH, PFKM, TPI1, TALDO1, ENO1, SDHD, SUCLA2, IDH3A, ACO1, ESD, ALDH6A1 | More | | | Cladribine | hsa01210 | 2-Oxocarboxylic acid metabolism | 1.73E-02 | 2 | P21399, P50213 | ACO1, IDH3A | More | | | Cladribine | hsa01230 | Biosynthesis of amino acids | 2.08E-04 | 10 | P60174, P04406, P06733, P04075, P08237, P51854, Q99707, P21399, P50213, P37837 | TPI1, GAPDH, ENO1, ALDOA, PFKM, TKTL1, MTR, ACO1, IDH3A, TALDO1 | More | | | Cladribine | hsa01522 | Endocrine resistance | 2.84E-02 | 3 | P22694, Q9UM47, P46527 | PRKACB, NOTCH3, CDKN1B | More | | | Cladribine | hsa01524 | Platinum drug resistance | 4.94E-02 | 2 | P78417, P52701 | GSTO1, MSH6 | More | | | Cladribine | hsa02010 | ABC transporters | 4.93E-02 | 1 | Q8IZY2 | ABCA7 | More | | | Cladribine | hsa03013 | RNA transport | 5.90E-03 | 10 | P52298, O14893, P61326, Q7Z3B4, P35658, O14602, Q14152, O75822, P78345, Q9Y6A5 | NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF1AY, EIF3A, EIF3J, RPP38, TACC3 | More | | | Cladribine | hsa03040 | Spliceosome | 8.05E-04 | 9 | Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447 | DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIH | More | | | Cladribine | hsa04020 | Calcium signaling pathway | 5.11E-04 | 9 | P27987, P21796, P45880, Q13557, P30679, P19174, P0DP23, P05141, P23634 | ITPKB, VDAC1, VDAC2, CAMK2D, GNA15, PLCG1, CALM1, SLC25A5, ATP2B4 | More | | | Cladribine | hsa04022 | cGMP-PKG signaling pathway | 2.26E-03 | 8 | Q14814, Q99941, P18848, P05141, P21796, P45880, P0DP23, P01042 | MEF2D, CREBL1, ATF4, SLC25A5, VDAC1, VDAC2, CALM1, KNG1 | More | | | Cladribine | hsa04064 | NF-kappa B signaling pathway | 3.05E-06 | 10 | P10415, Q13489, P51617, Q13546, Q04759, Q9UDY8, Q13315, P24522, P09341, Q9UNE0 | BCL2, BIRC3, IRAK1, RIPK1, PRKCQ, MALT1, ATM, GADD45A, CXCL1, EDAR | More | | | Cladribine | hsa04070 | Phosphatidylinositol signaling system | 1.32E-02 | 5 | P19174, P0DP23, O14986, P23743, P27987 | PLCG1, CALM1, PIP5K1B, DGKA, ITPKB | More | | | Cladribine | hsa04071 | Sphingolipid signaling pathway | 2.52E-03 | 6 | Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415 | EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2 | More | | | Cladribine | hsa04110 | Cell cycle | 4.76E-03 | 3 | O95997, Q12834, O95067 | PTTG1, CDC20, CCNB2 | More | | | Cladribine | hsa04114 | Oocyte meiosis | 5.39E-04 | 3 | O95067, Q12834, O95997 | CCNB2, CDC20, PTTG1 | More | | | Cladribine | hsa04115 | p53 signaling pathway | 1.43E-05 | 6 | P24522, O15151, Q13315, P31350, O95067, P10415 | GADD45A, MDM4, ATM, RRM2, CCNB2, BCL2 | More | | | Cladribine | hsa04120 | Ubiquitin mediated proteolysis | 3.44E-02 | 4 | Q14145, Q13042, P62837, Q15751 | KEAP1, CDC16, UBE2D2, HERC1 | More | | | Cladribine | hsa04141 | Protein processing in endoplasmic reticulum | 6.42E-03 | 8 | P18848, P30101, Q15437, Q15436, Q99941, P11142, P07900, P08238 | ATF4, PDIA3, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, HSP90AB1 | More | | | Cladribine | hsa04142 | Lysosome | 2.71E-02 | 4 | Q13510, P13473, Q04900, Q9Y227 | ASAH1, LAMP2, CD164, ENTPD4 | More | | | Cladribine | hsa04145 | Phagosome | 2.54E-04 | 8 | Q15080, P14598, Q13509, P68371, P05164, P78380, P35443, P13765 | NCF4, NCF1, TUBB3, TUBB2C, MPO, OLR1, THBS4, HLA-DOB | More | | | Cladribine | hsa04146 | Peroxisome | 2.42E-02 | 5 | O43933, P56589, Q9UKG9, O75521, P33121 | PEX1, PEX3, CROT, ECI2, ACSL1 | More | | | Cladribine | hsa04151 | PI3K-Akt signaling pathway | 1.24E-02 | 12 | P62753, P27348, P07900, P08238, P62873, P63218, Q16363, P22105, P14784, Q99941, P18848, P30279 | RPS6, YWHAQ, HSP90AA1, HSP90AB1, GNB1, GNG5, LAMA4, TNXB, IL2RB, CREBL1, ATF4, CCND2 | More | | | Cladribine | hsa04211 | Longevity regulating pathway | 1.18E-02 | 3 | Q12778, Q9UEF7, Q96KQ7 | FOXO1, KL, EHMT2 | More | | | Cladribine | hsa04217 | Necroptosis | 8.20E-05 | 15 | P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P07900, P08238, P15104, P05141, Q99878, Q13557, P21796, P45880 | TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, H2AC14, CAMK2D, VDAC1, VDAC2 | More | | | Cladribine | hsa04261 | Adrenergic signaling in cardiomyocytes | 1.71E-02 | 4 | P07550, P22694, P18848, Q13362 | ADRB2, PRKACB, ATF4, PPP2R5C | More | | | Cladribine | hsa04310 | Wnt signaling pathway | 5.60E-03 | 3 | P30279, Q13485, O43318 | CCND2, SMAD4, MAP3K7 | More | | | Cladribine | hsa04330 | Notch signaling pathway | 3.28E-03 | 4 | Q92542, P49768, Q92830, P78504 | NCSTN, PSEN1, KAT2A, JAG1 | More | | | Cladribine | hsa04380 | Osteoclast differentiation | 1.02E-02 | 6 | Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149 | GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2 | More | | | Cladribine | hsa04520 | Adherens junction | 3.91E-02 | 2 | Q13485, O43318 | SMAD4, MAP3K7 | More | | | Cladribine | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | | Cladribine | hsa04540 | Gap junction | 7.81E-03 | 3 | Q13509, P68371, Q9NRA1 | TUBB3, TUBB2C, PDGFC | More | | | Cladribine | hsa04610 | Complement and coagulation cascades | 7.40E-04 | 3 | P00734, P0C0L4, P21730 | F2, C4A, C5AR1 | More | | | Cladribine | hsa04612 | Antigen processing and presentation | 4.72E-02 | 4 | P13765, P48382, P26715, P26717 | HLA-DOB, RFX5, KLRC1, KLRC2 | More | | | Cladribine | hsa04613 | Neutrophil extracellular trap formation | 6.68E-04 | 17 | O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539 | TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | | Cladribine | hsa04620 | Toll-like receptor signaling pathway | 4.16E-02 | 2 | Q13546, P01568 | RIPK1, IFNA21 | More | | | Cladribine | hsa04621 | NOD-like receptor signaling pathway | 3.39E-03 | 8 | P01568, P25963, Q13489, Q13546, Q05823, P01375, P49913, P12838 | IFNA21, NFKBIA, BIRC3, RIPK1, RNASEL, TNF, CAMP, DEFA4 | More | | | Cladribine | hsa04622 | RIG-I-like receptor signaling pathway | 2.39E-02 | 2 | P01568, Q13546 | IFNA21, RIPK1 | More | | | Cladribine | hsa04623 | Cytosolic DNA-sensing pathway | 2.20E-03 | 2 | P01568, Q13546 | IFNA21, RIPK1 | More | | | Cladribine | hsa04625 | C-type lectin receptor signaling pathway | 3.87E-02 | 4 | Q9ULY5, P20749, P01375, Q16539 | CLEC4E, BCL3, TNF, MAPK14 | More | | | Cladribine | hsa04657 | IL-17 signaling pathway | 2.40E-03 | 7 | O00463, Q16539, P49841, P14780, Q9UJX4, P80188, P01375 | TRAF5, MAPK14, GSK3B, MMP9, ANAPC5, LCN2, TNF | More | | | Cladribine | hsa04659 | Th17 cell differentiation | 3.71E-02 | 6 | P19174, P42224, P14784, P07900, P08238, P07766 | PLCG1, STAT1, IL2RB, HSP90AA1, HSP90AB1, CD3E | More | | | Cladribine | hsa04662 | B cell receptor signaling pathway | 1.49E-03 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Cladribine | hsa04664 | Fc epsilon RI signaling pathway | 2.20E-03 | 6 | P01375, Q16539, P42338, Q9UQC2, P07948, P09917 | TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5 | More | | | Cladribine | hsa04668 | TNF signaling pathway | 2.21E-02 | 5 | P01375, O00463, Q16539, P20749, P14780 | TNF, TRAF5, MAPK14, BCL3, MMP9 | More | | | Cladribine | hsa04713 | Circadian entrainment | 4.76E-02 | 4 | P0DP23, Q13557, P62873, P63218 | CALM1, CAMK2D, GNB1, GNG5 | More | | | Cladribine | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Cladribine | hsa04724 | Glutamatergic synapse | 5.94E-03 | 4 | O15399, P63218, P50151, P15104 | GRIN2D, GNG5, GNG10, GLUL | More | | | Cladribine | hsa04725 | Cholinergic synapse | 5.23E-03 | 6 | P62873, P63218, P50151, P18848, Q13557, P42338 | GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB | More | | | Cladribine | hsa04727 | GABAergic synapse | 2.26E-03 | 5 | P62873, P63218, P50151, P15104, P46459 | GNB1, GNG5, GNG10, GLUL, NSF | More | | | Cladribine | hsa04728 | Dopaminergic synapse | 1.87E-02 | 6 | P62873, P63218, Q99941, P18848, Q13557, P0DP23 | GNB1, GNG5, CREBL1, ATF4, CAMK2D, CALM1 | More | | | Cladribine | hsa04740 | Olfactory transduction | 9.79E-03 | 3 | P62873, Q13557, P0DP23 | GNB1, CAMK2D, CALM1 | More | | | Cladribine | hsa04744 | Phototransduction | 1.42E-02 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Cladribine | hsa04750 | Inflammatory mediator regulation of TRP channels | 1.61E-02 | 5 | Q13557, P19174, P24723, P0DP23, P01042 | CAMK2D, PLCG1, PRKCH, CALM1, KNG1 | More | | | Cladribine | hsa04911 | Insulin secretion | 4.31E-02 | 2 | P22694, P18848 | PRKACB, ATF4 | More | | | Cladribine | hsa04915 | Estrogen signaling pathway | 1.87E-02 | 6 | Q99941, P18848, P07900, P08238, P11142, P0DP23 | CREBL1, ATF4, HSP90AA1, HSP90AB1, HSPA8, CALM1 | More | | | Cladribine | hsa04918 | Thyroid hormone synthesis | 4.31E-02 | 2 | P22694, P18848 | PRKACB, ATF4 | More | | | Cladribine | hsa04923 | Regulation of lipolysis in adipocytes | 4.31E-02 | 2 | P22694, P07550 | PRKACB, ADRB2 | More | | | Cladribine | hsa04924 | Renin secretion | 2.99E-02 | 2 | P22694, P07550 | PRKACB, ADRB2 | More | | | Cladribine | hsa04925 | Aldosterone synthesis and secretion | 3.35E-02 | 4 | Q99941, P18848, P0DP23, Q13557 | CREBL1, ATF4, CALM1, CAMK2D | More | | | Cladribine | hsa04926 | Relaxin signaling pathway | 8.02E-04 | 6 | P42338, P63218, P50151, P49767, P30679, P49407 | PIK3CB, GNG5, GNG10, VEGFC, GNA15, ARRB1 | More | | | Cladribine | hsa04927 | Cortisol synthesis and secretion | 1.86E-02 | 2 | P18848, P22694 | ATF4, PRKACB | More | | | Cladribine | hsa04929 | GnRH secretion | 4.62E-02 | 2 | P42338, P49407 | PIK3CB, ARRB1 | More | | | Cladribine | hsa04932 | Non-alcoholic fatty liver disease | 2.74E-02 | 3 | P01375, P49841, P48023 | TNF, GSK3B, FASLG | More | | | Cladribine | hsa04934 | Cushing syndrome | 2.84E-02 | 3 | P18848, P22694, P46527 | ATF4, PRKACB, CDKN1B | More | | | Cladribine | hsa04940 | Type I diabetes mellitus | 1.13E-03 | 3 | P10747, P48023, P01375 | CD28, FASLG, TNF | More | | | Cladribine | hsa04964 | Proximal tubule bicarbonate reclamation | 4.93E-02 | 1 | P00918 | CA2 | More | | | Cladribine | hsa04966 | Collecting duct acid secretion | 4.93E-02 | 1 | P00918 | CA2 | More | | | Cladribine | hsa04970 | Salivary secretion | 1.23E-02 | 3 | P07550, P22694, P49913 | ADRB2, PRKACB, CAMP | More | | | Cladribine | hsa04974 | Protein digestion and absorption | 2.78E-02 | 1 | Q03692 | COL10A1 | More | | | Cladribine | hsa04975 | Fat digestion and absorption | 2.80E-02 | 1 | O14494 | PLPP1 | More | | | Cladribine | hsa05010 | Alzheimer disease | 4.56E-02 | 9 | P19404, P13073, P0DP23, P18848, Q71U36, Q13509, P05141, P21796, P45880 | NDUFV2, COX4I1, CALM1, ATF4, TUBA1A, TUBB3, SLC25A5, VDAC1, VDAC2 | More | | | Cladribine | hsa05012 | Parkinson disease | 6.70E-04 | 11 | P19404, P13073, P05141, P21796, P45880, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509 | NDUFV2, COX4I1, SLC25A5, VDAC1, VDAC2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3 | More | | | Cladribine | hsa05016 | Huntington disease | 9.64E-03 | 10 | P19404, P13073, Q13547, P30876, P62487, P05141, P21796, P45880, Q71U36, Q13509 | NDUFV2, COX4I1, HDAC1, POLR2B, POLR2G, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3 | More | | | Cladribine | hsa05017 | Spinocerebellar ataxia | 2.16E-02 | 2 | Q8TB72, P21796 | PUM2, VDAC1 | More | | | Cladribine | hsa05020 | Prion disease | 9.64E-03 | 10 | P11142, P19404, P13073, P18848, P05141, P21796, P45880, Q71U36, Q13509, Q99941 | HSPA8, NDUFV2, COX4I1, ATF4, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3, CREBL1 | More | | | Cladribine | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.36E-02 | 12 | Q71U36, Q13509, P19404, P13073, P21796, P18848, P19174, P05141, P45880, P20333, P0DP23, Q13557 | TUBA1A, TUBB3, NDUFV2, COX4I1, VDAC1, ATF4, PLCG1, SLC25A5, VDAC2, TNFRSF1B, CALM1, CAMK2D | More | | | Cladribine | hsa05030 | Cocaine addiction | 4.31E-02 | 2 | P22694, P18848 | PRKACB, ATF4 | More | | | Cladribine | hsa05031 | Amphetamine addiction | 6.57E-03 | 5 | P0DP23, Q13557, Q99941, P18848, Q13547 | CALM1, CAMK2D, CREBL1, ATF4, HDAC1 | More | | | Cladribine | hsa05034 | Alcoholism | 2.40E-04 | 10 | Q99941, P18848, Q13547, P0DP23, P62873, P63218, Q93077, P62807, O60814, P68431 | CREBL1, ATF4, HDAC1, CALM1, GNB1, GNG5, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Cladribine | hsa05131 | Shigellosis | 1.80E-02 | 5 | Q13546, Q9UDY8, Q12778, Q13315, P10415 | RIPK1, MALT1, FOXO1, ATM, BCL2 | More | | | Cladribine | hsa05132 | Salmonella infection | 1.63E-03 | 6 | Q13546, Q13489, P10415, O60282, Q13509, P68371 | RIPK1, BIRC3, BCL2, KIF5C, TUBB3, TUBB2C | More | | | Cladribine | hsa05133 | Pertussis | 4.20E-02 | 1 | P0C0L4 | C4A | More | | | Cladribine | hsa05134 | Legionellosis | 3.35E-02 | 4 | P11215, P68104, P11142, P19875 | ITGAM, EEF1A1, HSPA8, CXCL2 | More | | | Cladribine | hsa05143 | African trypanosomiasis | 7.50E-04 | 4 | P01375, P69905, P68871, P48023 | TNF, HBA2, HBB, FASLG | More | | | Cladribine | hsa05144 | Malaria | 3.32E-03 | 4 | P69905, P68871, O60603, P10145 | HBA2, HBB, TLR2, IL8 | More | | | Cladribine | hsa05150 | Staphylococcus aureus infection | 4.66E-02 | 4 | P0C0L4, P21730, P21462, P13646 | C4A, C5AR1, FPR1, KRT13 | More | | | Cladribine | hsa05152 | Tuberculosis | 1.95E-02 | 5 | P48382, P10415, P13765, Q9UDY8, P51617 | RFX5, BCL2, HLA-DOB, MALT1, IRAK1 | More | | | Cladribine | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Cladribine | hsa05163 | Human cytomegalovirus infection | 2.80E-02 | 6 | P01375, P49841, P14778, P25025, Q16539, O00463 | TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5 | More | | | Cladribine | hsa05165 | Human papillomavirus infection | 9.48E-04 | 8 | P46527, P35443, P01375, Q08999, Q9UM47, P22694, Q13362, Q13315 | CDKN1B, THBS4, TNF, RBL2, NOTCH3, PRKACB, PPP2R5C, ATM | More | | | Cladribine | hsa05166 | Human T-cell leukemia virus 1 infection | 4.23E-03 | 9 | P22694, P18848, Q12834, O95067, O95997, P25963, P25208, Q13315, P01375 | PRKACB, ATF4, CDC20, CCNB2, PTTG1, NFKBIA, NFYB, ATM, TNF | More | | | Cladribine | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 3.15E-02 | 7 | P42224, P62873, P63218, P19875, P19174, P07948, P0DP23 | STAT1, GNB1, GNG5, CXCL2, PLCG1, LYN, CALM1 | More | | | Cladribine | hsa05169 | Epstein-Barr virus infection | 4.48E-03 | 9 | Q13547, P42338, P07948, P30101, Q13761, O75293, P30279, P42224, P07766 | HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CCND2, STAT1, CD3E | More | | | Cladribine | hsa05200 | Pathways in cancer | 1.83E-04 | 19 | Q16363, P07900, P08238, P42224, P19174, P43246, Q13485, P20585, P52701, Q13547, P30279, P62873, P63218, P78417, O75293, P0DP23, Q13557, P14784, P01042 | LAMA4, HSP90AA1, HSP90AB1, STAT1, PLCG1, MSH2, SMAD4, MSH3, MSH6, HDAC1, CCND2, GNB1, GNG5, GSTO1, GADD45B, CALM1, CAMK2D, IL2RB, KNG1 | More | | | Cladribine | hsa05202 | Transcriptional misregulation in cancer | 1.91E-04 | 17 | Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P24522 | SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A | More | | | Cladribine | hsa05203 | Viral carcinogenesis | 1.86E-05 | 17 | Q08999, Q99941, P18848, P06746, P07948, P30279, P27348, P29083, Q7KZF4, P46527, Q13547, Q15283, P06396, P25963, P22694, P62807, O60814 | RBL2, CREBL1, ATF4, POLB, LYN, CCND2, YWHAQ, GTF2E1, SND1, CDKN1B, HDAC1, RASA2, GSN, NFKBIA, PRKACB, HIST1H2BC, H2BC12 | More | | | Cladribine | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Cladribine | hsa05206 | MicroRNAs in cancer | 1.67E-02 | 4 | P46527, Q9UM47, P35226, Q13315 | CDKN1B, NOTCH3, BMI1, ATM | More | | | Cladribine | hsa05210 | Colorectal cancer | 4.94E-02 | 2 | Q13485, P52701 | SMAD4, MSH6 | More | | | Cladribine | hsa05214 | Glioma | 1.76E-02 | 4 | P0DP23, Q13557, P19174, O75293 | CALM1, CAMK2D, PLCG1, GADD45B | More | | | Cladribine | hsa05215 | Prostate cancer | 3.03E-02 | 3 | P10415, Q12778, Q9NRA1 | BCL2, FOXO1, PDGFC | More | | | Cladribine | hsa05221 | Acute myeloid leukemia | 3.29E-02 | 3 | P14923, Q15744, P05164 | JUP, CEBPE, MPO | More | | | Cladribine | hsa05310 | Asthma | 3.01E-02 | 2 | P13765, P12724 | HLA-DOB, RNASE3 | More | | | Cladribine | hsa05322 | Systemic lupus erythematosus | 1.31E-04 | 5 | P09871, Q93077, P62807, O60814, P68431 | C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Cladribine | hsa05330 | Allograft rejection | 2.46E-03 | 3 | P48023, P10747, P01375 | FASLG, CD28, TNF | More | | | Cladribine | hsa05332 | Graft-versus-host disease | 3.70E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Cladribine | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.93E-02 | 1 | P54284 | CACNB3 | More | | | Cladribine | hsa05418 | Fluid shear stress and atherosclerosis | 1.08E-03 | 7 | Q16539, Q14145, P10599, P14780, P01375, P14778, P27930 | MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2 | More | |
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