PharmaCoNets of Citric-acid (SPCN: 37.13 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Citric-acidhsa00030Pentose phosphate pathway1.77E-044P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Citric-acidhsa00040Pentose and glucuronate interconversions9.59E-032P15121, P14550AKR1B1, AKR1A1More
Citric-acidhsa00220Arginine biosynthesis6.71E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Citric-acidhsa00230Purine metabolism1.82E-021P49915GMPSMore
Citric-acidhsa00250Alanine, aspartate and glutamate metabolism2.48E-042Q96RQ9, P15104IL4I1, GLULMore
Citric-acidhsa00270Cysteine and methionine metabolism4.90E-021Q96RQ9IL4I1More
Citric-acidhsa00280Valine, leucine and isoleucine degradation3.29E-021Q96RQ9IL4I1More
Citric-acidhsa00310Lysine degradation3.15E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Citric-acidhsa00350Tyrosine metabolism3.29E-021Q96RQ9IL4I1More
Citric-acidhsa00360Phenylalanine metabolism1.66E-021Q96RQ9IL4I1More
Citric-acidhsa00380Tryptophan metabolism1.66E-021Q96RQ9IL4I1More
Citric-acidhsa00400Phenylalanine, tyrosine and tryptophan biosynthesis1.66E-021Q96RQ9IL4I1More
Citric-acidhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Citric-acidhsa00440Phosphonate and phosphinate metabolism4.98E-021Q9Y6K0CEPT1More
Citric-acidhsa00471D-Glutamine and D-glutamate metabolism9.35E-042Q7Z3D6, P49448C14orf159, GLUD2More
Citric-acidhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Citric-acidhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Citric-acidhsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate4.70E-021Q9Y2C2USTMore
Citric-acidhsa00533Glycosaminoglycan biosynthesis - keratan sulfate2.92E-021Q9NY97B3GNT2More
Citric-acidhsa00561Glycerolipid metabolism7.94E-033P15121, P14550, Q86XP1AKR1B1, AKR1A1, DGKHMore
Citric-acidhsa00620Pyruvate metabolism3.19E-022P40926, P14550MDH2, AKR1A1More
Citric-acidhsa00630Glyoxylate and dicarboxylate metabolism1.13E-022P40925, P15104MDH1, GLULMore
Citric-acidhsa00740Riboflavin metabolism4.98E-021Q969G6RFKMore
Citric-acidhsa00750Vitamin B6 metabolism4.70E-021O00764PDXKMore
Citric-acidhsa00770Pantothenate and CoA biosynthesis3.98E-021Q6ZQY3GADL1More
Citric-acidhsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Citric-acidhsa00860Porphyrin and chlorophyll metabolism3.77E-021P53004BLVRAMore
Citric-acidhsa00910Nitrogen metabolism1.66E-021P15104GLULMore
Citric-acidhsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Citric-acidhsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Citric-acidhsa00983Drug metabolism - other enzymes6.46E-067P49915, P04183, P20839, P32320, P05164, Q16772, P09211GMPS, TK1, IMPDH1, CDA, MPO, GSTA3, GSTP1More
Citric-acidhsa01040Biosynthesis of unsaturated fatty acids4.77E-021O00767SCDMore
Citric-acidhsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Citric-acidhsa012102-Oxocarboxylic acid metabolism2.92E-021P50213IDH3AMore
Citric-acidhsa01230Biosynthesis of amino acids2.19E-024P51854, P60891, P05089, P37837TKTL1, PRPS1, ARG1, TALDO1More
Citric-acidhsa01240Biosynthesis of cofactors2.95E-022P13716, P14618ALAD, PKM2More
Citric-acidhsa01521EGFR tyrosine kinase inhibitor resistance1.80E-022P17252, Q9GZP0PRKCA, PDGFDMore
Citric-acidhsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Citric-acidhsa03008Ribosome biogenesis in eukaryotes4.56E-033Q9NYH9, P78345, Q9BVP2UTP6, RPP38, GNL3More
Citric-acidhsa03010Ribosome1.60E-029P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3More
Citric-acidhsa03015mRNA surveillance pathway3.20E-035Q13362, Q14738, O43809, Q15287, Q9UBU9PPP2R5C, PPP2R5D, NUDT21, RNPS1, NXF1More
Citric-acidhsa03030DNA replication1.48E-023P49005, P33993, P15927POLD2, MCM7, RPA2More
Citric-acidhsa03040Spliceosome2.10E-0410O60508, P08579, P26368, Q13595, Q01130, P84103, Q13243, P11142, Q9Y2W2, O75643CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, ASCC3L1More
Citric-acidhsa03050Proteasome2.42E-021O43242PSMD3More
Citric-acidhsa04010MAPK signaling pathway5.69E-034P17252, O95267, P09603, Q9GZP0PRKCA, RASGRP1, CSF1, PDGFDMore
Citric-acidhsa04012ErbB signaling pathway4.91E-023P49841, Q13191, P42338GSK3B, CBLB, PIK3CBMore
Citric-acidhsa04014Ras signaling pathway2.60E-034P09603, Q9GZP0, P17252, O95267CSF1, PDGFD, PRKCA, RASGRP1More
Citric-acidhsa04015Rap1 signaling pathway1.84E-045P09603, Q9GZP0, P25116, P08514, P17252CSF1, PDGFD, F2R, ITGA2B, PRKCAMore
Citric-acidhsa04020Calcium signaling pathway3.18E-0510Q96DU7, Q13557, P17252, P21860, P25116, P05141, P12236, P26678, P63092, Q9GZP0ITPKC, CAMK2D, PRKCA, ERBB3, F2R, SLC25A5, SLC25A6, PLN, GNAS, PDGFDMore
Citric-acidhsa04022cGMP-PKG signaling pathway9.36E-036P61586, P26678, Q99941, P18848, P05141, P12236RHOA, PLN, CREBL1, ATF4, SLC25A5, SLC25A6More
Citric-acidhsa04060Cytokine-cytokine receptor interaction7.09E-0414P14784, P27930, P14778, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P01375, P09341, P01730, Q93038IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNF, CXCL1, CD4, TNFRSF25More
Citric-acidhsa04061Viral protein interaction with cytokine and cytokine receptor9.09E-047P09341, P25024, P47992, Q9UBD3, Q13651, P14784, P01375CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Citric-acidhsa04062Chemokine signaling pathway6.73E-039P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITKMore
Citric-acidhsa04064NF-kappa B signaling pathway2.56E-0914P10415, O00463, P14778, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q13315, P24522, P09341, Q06643BCL2, TRAF5, IL1R1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, ATM, GADD45A, CXCL1, LTBMore
Citric-acidhsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Citric-acidhsa04072Phospholipase D signaling pathway7.75E-033P25116, P17252, Q9GZP0F2R, PRKCA, PDGFDMore
Citric-acidhsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Citric-acidhsa04114Oocyte meiosis1.06E-025Q15418, P0DP23, Q08828, Q13362, Q14738RPS6KA1, CALM1, ADCY1, PPP2R5C, PPP2R5DMore
Citric-acidhsa04137Mitophagy - animal2.06E-023P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Citric-acidhsa04140Autophagy - animal4.72E-045P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Citric-acidhsa04141Protein processing in endoplasmic reticulum3.03E-024Q12933, P49257, P54727, Q99933TRAF2, LMAN1, RAD23B, BAG1More
Citric-acidhsa04144Endocytosis2.81E-026Q13191, P11142, P25024, P43250, P14784, Q9Y5X3CBLB, HSPA8, CXCR1, GRK6, IL2RB, SNX5More
Citric-acidhsa04145Phagosome4.71E-037O75015, Q15080, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Citric-acidhsa04150mTOR signaling pathway6.20E-032Q9NQL2, Q13322RRAGD, GRB10More
Citric-acidhsa04151PI3K-Akt signaling pathway3.68E-0414P21860, P25116, P27348, P09603, O14944, Q9GZP0, P07900, Q15831, P08514, P22105, Q99941, P18848, P17252, O95988ERBB3, F2R, YWHAQ, CSF1, EREG, PDGFD, HSP90AA1, STK11, ITGA2B, TNXB, CREBL1, ATF4, PRKCA, TCL1BMore
Citric-acidhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Citric-acidhsa04217Necroptosis4.39E-022Q12933, P15104TRAF2, GLULMore
Citric-acidhsa04260Cardiac muscle contraction3.17E-022P09493, P14927TPM1, UQCRBMore
Citric-acidhsa04261Adrenergic signaling in cardiomyocytes1.23E-039P63092, Q08828, Q99941, P18848, P26678, Q13362, Q14738, P0DP23, Q13557GNAS, ADCY1, CREBL1, ATF4, PLN, PPP2R5C, PPP2R5D, CALM1, CAMK2DMore
Citric-acidhsa04340Hedgehog signaling pathway2.66E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Citric-acidhsa04350TGF-beta signaling pathway3.68E-022Q14766, Q15583LTBP1, TGIF1More
Citric-acidhsa04360Axon guidance9.54E-033P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Citric-acidhsa04390Hippo signaling pathway4.79E-023P63261, P04628, O43623ACTG1, WNT1, SNAI2More
Citric-acidhsa04392Hippo signaling pathway - multiple species6.35E-031Q9UGP4LIMD1More
Citric-acidhsa04510Focal adhesion3.52E-036P08514, Q15942, P17252, P51636, P30281, Q9GZP0ITGA2B, ZYX, PRKCA, CAV2, CCND3, PDGFDMore
Citric-acidhsa04512ECM-receptor interaction1.90E-022P26012, P16070ITGB8, CD44More
Citric-acidhsa04540Gap junction2.22E-022P17252, Q9GZP0PRKCA, PDGFDMore
Citric-acidhsa04610Complement and coagulation cascades4.59E-033P25116, P0C0L4, Q9Y279F2R, C4A, VSIG4More
Citric-acidhsa04611Platelet activation4.53E-033P25116, O95267, P08514F2R, RASGRP1, ITGA2BMore
Citric-acidhsa04612Antigen processing and presentation3.32E-078P13765, P48382, P01730, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Citric-acidhsa04613Neutrophil extracellular trap formation4.93E-028O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P21730TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, C5AR1More
Citric-acidhsa04621NOD-like receptor signaling pathway9.20E-038Q14643, P10599, P43490, O00463, P29728, P01375, P09341, P12838ITPR1, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Citric-acidhsa04622RIG-I-like receptor signaling pathway4.90E-021Q12933TRAF2More
Citric-acidhsa04640Hematopoietic cell lineage2.44E-0815P13612, P08514, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P09603ITGA4, ITGA2B, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, CSF1More
Citric-acidhsa04650Natural killer cell mediated cytotoxicity2.86E-1212P01375, P17252, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715TNF, PRKCA, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Citric-acidhsa04657IL-17 signaling pathway2.58E-025O00463, P09341, P14780, P80188, P01375TRAF5, CXCL1, MMP9, LCN2, TNFMore
Citric-acidhsa04658Th1 and Th2 cell differentiation3.85E-2112Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Citric-acidhsa04659Th17 cell differentiation2.26E-1514Q04759, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963PRKCQ, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Citric-acidhsa04660T cell receptor signaling pathway1.29E-1315P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, GSK3BMore
Citric-acidhsa04662B cell receptor signaling pathway4.07E-024P42338, P60033, P07948, Q8N149PIK3CB, CD81, LYN, LILRA2More
Citric-acidhsa04668TNF signaling pathway3.38E-036P01375, O00463, P09341, P20749, P14780, P42338TNF, TRAF5, CXCL1, BCL3, MMP9, PIK3CBMore
Citric-acidhsa04714Thermogenesis4.22E-049P15336, Q08828, Q6STE5, Q969G3, P63261, Q15418, P13073, P12074, O95298ATF2, ADCY1, SMARCD3, SMARCE1, ACTG1, RPS6KA1, COX4I1, COX6A1, NDUFC2More
Citric-acidhsa04720Long-term potentiation5.46E-034P0DP23, Q15418, P18848, Q08828CALM1, RPS6KA1, ATF4, ADCY1More
Citric-acidhsa04724Glutamatergic synapse2.22E-024O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Citric-acidhsa04727GABAergic synapse4.42E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Citric-acidhsa04728Dopaminergic synapse3.29E-024P18848, Q13362, Q14738, P0DP23ATF4, PPP2R5C, PPP2R5D, CALM1More
Citric-acidhsa04750Inflammatory mediator regulation of TRP channels1.70E-035P22694, P42338, Q14643, P24723, Q04759PRKACB, PIK3CB, ITPR1, PRKCH, PRKCQMore
Citric-acidhsa04810Regulation of actin cytoskeleton1.21E-023P08514, Q9GZP0, P25116ITGA2B, PDGFD, F2RMore
Citric-acidhsa04910Insulin signaling pathway1.08E-025P22694, P06737, P42338, P49841, Q13191PRKACB, PYGL, PIK3CB, GSK3B, CBLBMore
Citric-acidhsa04911Insulin secretion4.47E-034P63092, Q99941, P18848, Q13557GNAS, CREBL1, ATF4, CAMK2DMore
Citric-acidhsa04912GnRH signaling pathway4.99E-021P18146EGR1More
Citric-acidhsa04920Adipocytokine signaling pathway2.06E-022Q06124, Q9Y478PTPN11, PRKAB1More
Citric-acidhsa04922Glucagon signaling pathway7.57E-035P14618, P22694, P06737, Q12778, Q14643PKM2, PRKACB, PYGL, FOXO1, ITPR1More
Citric-acidhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Citric-acidhsa04925Aldosterone synthesis and secretion1.68E-024Q99941, P18848, P63092, Q13557CREBL1, ATF4, GNAS, CAMK2DMore
Citric-acidhsa04927Cortisol synthesis and secretion2.40E-023Q99941, P18848, P63092CREBL1, ATF4, GNASMore
Citric-acidhsa04928Parathyroid hormone synthesis, secretion and action2.59E-038Q14643, P63092, P22694, P23771, P61586, Q99941, P18848, P10415ITPR1, GNAS, PRKACB, GATA3, RHOA, CREBL1, ATF4, BCL2More
Citric-acidhsa04931Insulin resistance7.80E-035P01375, P42338, P49841, Q04759, P06737TNF, PIK3CB, GSK3B, PRKCQ, PYGLMore
Citric-acidhsa04932Non-alcoholic fatty liver disease4.04E-024P18848, P13073, P12074, O95298ATF4, COX4I1, COX6A1, NDUFC2More
Citric-acidhsa04934Cushing syndrome6.95E-057Q99941, P18848, P63092, O15169, Q13557, P46527, O00170CREBL1, ATF4, GNAS, AXIN1, CAMK2D, CDKN1B, AIPMore
Citric-acidhsa05010Alzheimer disease1.68E-0416Q92542, O15239, O95298, P05496, P13073, P12074, Q00535, P0DP23, P18848, O15169, P67870, P05141, P12236, P28070, P43686, P62195NCSTN, NDUFA1, NDUFC2, ATP5G1, COX4I1, COX6A1, CDK5, CALM1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4, PSMC5More
Citric-acidhsa05012Parkinson disease1.15E-0414O15239, O95298, P13073, P12074, P05496, P05141, P12236, P63092, P18848, P28070, P43686, P62195, P0DP23, Q13557NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, GNAS, ATF4, PSMB4, PSMC4, PSMC5, CALM1, CAMK2DMore
Citric-acidhsa05014Amyotrophic lateral sclerosis4.41E-0314P20333, O15239, O95298, P13073, P12074, P05496, P18848, P28070, P43686, P62195, Q8TEV9, P51991, P35658, Q9UBU9TNFRSF1B, NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, ATF4, PSMB4, PSMC4, PSMC5, SMCR8, HNRPA3, NUP214, NXF1More
Citric-acidhsa05016Huntington disease1.67E-027O95298, P13073, P12074, P24928, P62487, P05141, P28070NDUFC2, COX4I1, COX6A1, POLR2A, POLR2G, SLC25A5, PSMB4More
Citric-acidhsa05017Spinocerebellar ataxia1.89E-025Q92915, O15399, P42338, O43242, P21796FGF14, GRIN2D, PIK3CB, PSMD3, VDAC1More
Citric-acidhsa05020Prion disease1.21E-0314P46531, O15239, O95298, P05496, P13073, P12074, P18848, P05141, P12236, P28070, P43686, P62195, P67870, Q99941NOTCH1, NDUFA1, NDUFC2, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, PSMC5, CSNK2B, CREBL1More
Citric-acidhsa05022Pathways of neurodegeneration - multiple diseases2.06E-0418P67870, O15239, O95298, P13073, P12074, P05496, Q8TEV9, P18848, P05141, P12236, P20333, Q00535, O15169, P0DP23, Q13557, P28070, P43686, P62195CSNK2B, NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, SMCR8, ATF4, SLC25A5, SLC25A6, TNFRSF1B, CDK5, AXIN1, CALM1, CAMK2D, PSMB4, PSMC4, PSMC5More
Citric-acidhsa05030Cocaine addiction2.40E-023P63092, Q99941, P18848GNAS, CREBL1, ATF4More
Citric-acidhsa05031Amphetamine addiction4.47E-034Q13557, P63092, Q99941, P18848CAMK2D, GNAS, CREBL1, ATF4More
Citric-acidhsa05120Epithelial cell signaling in Helicobacter pylori infection3.23E-042Q99437, P41240ATP6V0B, CSKMore
Citric-acidhsa05133Pertussis2.63E-022P10145, P0C0L4IL8, C4AMore
Citric-acidhsa05135Yersinia infection1.45E-025P06239, P01375, P42338, P49841, P01732LCK, TNF, PIK3CB, GSK3B, CD8AMore
Citric-acidhsa05140Leishmaniasis3.53E-026P13612, O75015, P13765, O60603, P01375, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, NCF4More
Citric-acidhsa05142Chagas disease3.97E-024P01375, P42338, P07766, P20963TNF, PIK3CB, CD3E, CD247More
Citric-acidhsa05143African trypanosomiasis1.35E-022P69905, P68871HBA2, HBBMore
Citric-acidhsa05144Malaria5.11E-078P60033, P69905, P68871, O60603, P01375, P05107, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, KLRK1More
Citric-acidhsa05146Amoebiasis1.48E-0910P09341, P14778, P27930, P01375, O60603, P42338, P05089, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ARG1, PRKACB, ACTN1, CTSGMore
Citric-acidhsa05163Human cytomegalovirus infection4.01E-026P42338, P01375, P22694, P49841, Q13651, O00463PIK3CB, TNF, PRKACB, GSK3B, IL10RA, TRAF5More
Citric-acidhsa05169Epstein-Barr virus infection4.35E-0515P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Citric-acidhsa05202Transcriptional misregulation in cancer3.81E-0415Q12778, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Citric-acidhsa05203Viral carcinogenesis9.40E-048Q12933, Q99941, P18848, P42229, P27348, Q15283, P61586, P61978TRAF2, CREBL1, ATF4, STAT5A, YWHAQ, RASA2, RHOA, HNRPKMore
Citric-acidhsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Citric-acidhsa05205Proteoglycans in cancer4.43E-023P63261, O60603, Q06124ACTG1, TLR2, PTPN11More
Citric-acidhsa05206MicroRNAs in cancer1.54E-026P21860, P61978, P46531, P63279, P22105, P61586ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RHOAMore
Citric-acidhsa05211Renal cell carcinoma1.97E-022Q06124, Q99814PTPN11, EPAS1More
Citric-acidhsa05225Hepatocellular carcinoma2.57E-024P04628, P63261, Q6STE5, Q969G3WNT1, ACTG1, SMARCD3, SMARCE1More
Citric-acidhsa05231Choline metabolism in cancer2.22E-022Q9GZP0, P17252PDGFD, PRKCAMore
Citric-acidhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.65E-0710P42338, O95267, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, P01730PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, CD4More
Citric-acidhsa05310Asthma1.20E-063P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Citric-acidhsa05321Inflammatory bowel disease1.69E-157O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Citric-acidhsa05323Rheumatoid arthritis8.71E-044P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Citric-acidhsa05332Graft-versus-host disease2.19E-105P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Citric-acidhsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Citric-acidhsa05410Hypertrophic cardiomyopathy1.35E-022P26012, P09493ITGB8, TPM1More
Citric-acidhsa05415Diabetic cardiomyopathy1.92E-026P05141, P12236, O15239, P05496, Q13557, P26678SLC25A5, SLC25A6, NDUFA1, ATP5G1, CAMK2D, PLNMore
Citric-acidhsa05416Viral myocarditis3.89E-022P10747, P63261CD28, ACTG1More
Citric-acidhsa05418Fluid shear stress and atherosclerosis3.77E-025P42338, Q14145, P10599, P01375, P27930PIK3CB, KEAP1, TXN, TNF, IL1R2More

Community members of Citric-acid (SDC: 2.35)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)