PharmaCoNets of Cinnarizine (SPCN: 143.23 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Cinnarizinehsa00030Pentose phosphate pathway9.38E-073P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Cinnarizinehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Cinnarizinehsa00220Arginine biosynthesis1.26E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Cinnarizinehsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Cinnarizinehsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Cinnarizinehsa00310Lysine degradation3.15E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Cinnarizinehsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Cinnarizinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Cinnarizinehsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Cinnarizinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Cinnarizinehsa00562Inositol phosphate metabolism2.00E-035Q14642, P27987, P29218, P19174, P42338INPP5A, ITPKB, IMPA1, PLCG1, PIK3CBMore
Cinnarizinehsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Cinnarizinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Cinnarizinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Cinnarizinehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Cinnarizinehsa00630Glyoxylate and dicarboxylate metabolism1.13E-022P40925, P15104MDH1, GLULMore
Cinnarizinehsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Cinnarizinehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Cinnarizinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Cinnarizinehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Cinnarizinehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Cinnarizinehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Cinnarizinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Cinnarizinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Cinnarizinehsa00983Drug metabolism - other enzymes3.32E-023P04183, P32320, P05164TK1, CDA, MPOMore
Cinnarizinehsa01100Metabolic pathways4.12E-026Q14642, P29218, Q14376, P07101, Q9UHK6, P12074INPP5A, IMPA1, GALE, TH, AMACR, COX6A1More
Cinnarizinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Cinnarizinehsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Cinnarizinehsa01230Biosynthesis of amino acids2.05E-045P51854, P60891, P05089, P15104, P37837TKTL1, PRPS1, ARG1, GLUL, TALDO1More
Cinnarizinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Cinnarizinehsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Cinnarizinehsa01523Antifolate resistance3.06E-034P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Cinnarizinehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Cinnarizinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Cinnarizinehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Cinnarizinehsa03020RNA polymerase5.24E-064P24928, P62487, Q9GZM3, P52435POLR2A, POLR2G, POLR2J2, POLR2JMore
Cinnarizinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Cinnarizinehsa03040Spliceosome9.86E-0913O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Cinnarizinehsa04010MAPK signaling pathway1.23E-033P08069, Q9H2K8, Q12933IGF1R, TAOK3, TRAF2More
Cinnarizinehsa04012ErbB signaling pathway3.69E-023Q13191, P19174, P42338CBLB, PLCG1, PIK3CBMore
Cinnarizinehsa04014Ras signaling pathway1.13E-029P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Cinnarizinehsa04015Rap1 signaling pathway5.88E-0413P20827, P49767, P08069, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P17252, P19174EFNA1, VEGFC, IGF1R, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PRKCA, PLCG1More
Cinnarizinehsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Cinnarizinehsa04060Cytokine-cytokine receptor interaction1.06E-0416P14784, P27930, P14778, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, O75509, P09341, P19875, P01730, Q93038IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, TNFRSF21, CXCL1, CXCL2, CD4, TNFRSF25More
Cinnarizinehsa04061Viral protein interaction with cytokine and cytokine receptor1.32E-026P09341, P25024, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Cinnarizinehsa04062Chemokine signaling pathway2.28E-0415P25024, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, Q8WYR1CXCR1, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, PIK3R5More
Cinnarizinehsa04064NF-kappa B signaling pathway2.39E-0512O00463, P14778, P01375, P19174, Q04759, Q16548, P07948, P06239, P24522, P09341, P19875, Q06643TRAF5, IL1R1, TNF, PLCG1, PRKCQ, BCL2A1, LYN, LCK, GADD45A, CXCL1, CXCL2, LTBMore
Cinnarizinehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Cinnarizinehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Cinnarizinehsa04070Phosphatidylinositol signaling system2.65E-022P29218, Q14642IMPA1, INPP5AMore
Cinnarizinehsa04071Sphingolipid signaling pathway6.68E-046P21453, Q9H228, P01375, Q13362, Q12933, Q02156S1PR1, EDG8, TNF, PPP2R5C, TRAF2, PRKCEMore
Cinnarizinehsa04072Phospholipase D signaling pathway9.70E-032Q92529, Q14344SHC3, GNA13More
Cinnarizinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Cinnarizinehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Cinnarizinehsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Cinnarizinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Cinnarizinehsa04140Autophagy - animal1.29E-025P08069, Q9Y4H2, P42338, Q9NQL2, Q04759IGF1R, IRS2, PIK3CB, RRAGD, PRKCQMore
Cinnarizinehsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Cinnarizinehsa04144Endocytosis1.24E-029Q13191, P11142, O75351, P62491, P25024, P43250, Q14161, P14784, Q9Y5X3CBLB, HSPA8, VPS4B, RAB11A, CXCR1, GRK6, GIT2, IL2RB, SNX5More
Cinnarizinehsa04145Phagosome3.11E-022Q99437, P25774ATP6V0B, CTSSMore
Cinnarizinehsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Cinnarizinehsa04151PI3K-Akt signaling pathway1.67E-0318P62753, P42338, P43657, O43521, P27348, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P18848, O00141, Q6ZUJ8, P30281RPS6, PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, ATF4, SGK, PIK3AP1, CCND3More
Cinnarizinehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Cinnarizinehsa04210Apoptosis3.63E-023O75460, O43521, P18848ERN1, BCL2L11, ATF4More
Cinnarizinehsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Cinnarizinehsa04213Longevity regulating pathway - multiple species3.78E-035P42338, P08069, Q9Y4H2, P11142, Q13547PIK3CB, IGF1R, IRS2, HSPA8, HDAC1More
Cinnarizinehsa04217Necroptosis4.76E-0617P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q9H444, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP4B, CHMP2A, PPIDMore
Cinnarizinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Cinnarizinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Cinnarizinehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Cinnarizinehsa04370VEGF signaling pathway4.05E-022P19174, P42338PLCG1, PIK3CBMore
Cinnarizinehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Cinnarizinehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Cinnarizinehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Cinnarizinehsa04520Adherens junction8.29E-031P08069IGF1RMore
Cinnarizinehsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Cinnarizinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Cinnarizinehsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Cinnarizinehsa04612Antigen processing and presentation7.49E-0711P13765, P01730, Q14953, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375HLA-DOB, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNFMore
Cinnarizinehsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Cinnarizinehsa04621NOD-like receptor signaling pathway3.40E-028Q14643, P10599, P43490, O00463, P29728, P01375, P09341, P12838ITPR1, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Cinnarizinehsa04622RIG-I-like receptor signaling pathway2.47E-021Q12933TRAF2More
Cinnarizinehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Cinnarizinehsa04640Hematopoietic cell lineage2.00E-0713P13612, P21926, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375ITGA4, CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNFMore
Cinnarizinehsa04650Natural killer cell mediated cytotoxicity2.42E-1115P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1More
Cinnarizinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Cinnarizinehsa04658Th1 and Th2 cell differentiation4.00E-1614Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Cinnarizinehsa04659Th17 cell differentiation3.39E-1617Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Cinnarizinehsa04660T cell receptor signaling pathway3.15E-0913P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Cinnarizinehsa04662B cell receptor signaling pathway1.16E-045P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Cinnarizinehsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Cinnarizinehsa04668TNF signaling pathway2.67E-036P01375, P18848, P19875, P01584, P14780, P20333TNF, ATF4, CXCL2, IL1B, MMP9, TNFRSF1BMore
Cinnarizinehsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Cinnarizinehsa04710Circadian rhythm3.74E-032O00327, O15055ARNTL, PER2More
Cinnarizinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Cinnarizinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Cinnarizinehsa04722Neurotrophin signaling pathway1.98E-035Q05655, P49841, O43524, P48023, P52566PRKCD, GSK3B, FOXO3, FASLG, ARHGDIBMore
Cinnarizinehsa04724Glutamatergic synapse2.22E-024O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Cinnarizinehsa04727GABAergic synapse4.42E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Cinnarizinehsa04730Long-term depression1.55E-032Q14344, P08069GNA13, IGF1RMore
Cinnarizinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Cinnarizinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Cinnarizinehsa04750Inflammatory mediator regulation of TRP channels2.19E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Cinnarizinehsa04913Ovarian steroidogenesis7.72E-033P42330, P22694, P08069AKR1C3, PRKACB, IGF1RMore
Cinnarizinehsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Cinnarizinehsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Cinnarizinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Cinnarizinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Cinnarizinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Cinnarizinehsa04930Type II diabetes mellitus9.83E-042Q05655, Q02156PRKCD, PRKCEMore
Cinnarizinehsa04932Non-alcoholic fatty liver disease1.52E-0510P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, Q16718, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA5, SDHDMore
Cinnarizinehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Cinnarizinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Cinnarizinehsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Cinnarizinehsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Cinnarizinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Cinnarizinehsa04974Protein digestion and absorption2.47E-021Q7Z2H8SLC36A1More
Cinnarizinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Cinnarizinehsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Cinnarizinehsa05012Parkinson disease3.89E-025P13073, P05141, O75460, P18848, P0DP24COX4I1, SLC25A5, ERN1, ATF4, CALM2More
Cinnarizinehsa05016Huntington disease1.05E-048P13073, Q9GZM3, P24928, P62487, P52435, P05141, Q9NYC9, O75460COX4I1, POLR2J2, POLR2A, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1More
Cinnarizinehsa05017Spinocerebellar ataxia2.22E-024Q92915, O15399, P42338, P21796FGF14, GRIN2D, PIK3CB, VDAC1More
Cinnarizinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Cinnarizinehsa05022Pathways of neurodegeneration - multiple diseases6.94E-0413P49841, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, P0DP24GSK3B, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, CALM2More
Cinnarizinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Cinnarizinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Cinnarizinehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Cinnarizinehsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Cinnarizinehsa05120Epithelial cell signaling in Helicobacter pylori infection4.95E-023P09341, P19875, P19174CXCL1, CXCL2, PLCG1More
Cinnarizinehsa05131Shigellosis8.54E-044Q12933, Q05655, Q02156, P07737TRAF2, PRKCD, PRKCE, PFN1More
Cinnarizinehsa05132Salmonella infection4.88E-022P84095, P07737RHOG, PFN1More
Cinnarizinehsa05134Legionellosis4.88E-034P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Cinnarizinehsa05135Yersinia infection4.39E-024P06239, P19174, P42338, P01732LCK, PLCG1, PIK3CB, CD8AMore
Cinnarizinehsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Cinnarizinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Cinnarizinehsa05144Malaria7.09E-045P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Cinnarizinehsa05146Amoebiasis2.76E-0912P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Cinnarizinehsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Cinnarizinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Cinnarizinehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Cinnarizinehsa05169Epstein-Barr virus infection8.84E-0514P13765, P01106, Q13547, O00463, Q16539, P07948, Q13761, P24522, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, MAPK14, LYN, RUNX3, GADD45A, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Cinnarizinehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Cinnarizinehsa05202Transcriptional misregulation in cancer3.47E-0311P14780, P27930, Q15744, Q16548, P08069, P05164, P12838, P08246, Q9C0K0, Q13547, P24522MMP9, IL1R2, CEBPE, BCL2A1, IGF1R, MPO, DEFA4, ELA2, BCL11B, HDAC1, GADD45AMore
Cinnarizinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Cinnarizinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Cinnarizinehsa05205Proteoglycans in cancer1.38E-0310Q12955, Q14247, P14780, P17252, P01375, P08069, P23588, Q13635, P22694, P08962ANK3, CTTN, MMP9, PRKCA, TNF, IGF1R, EIF4B, PTCH1, PRKACB, CD63More
Cinnarizinehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Cinnarizinehsa05214Glioma9.95E-031P08069IGF1RMore
Cinnarizinehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Cinnarizinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Cinnarizinehsa05218Melanoma6.63E-031P08069IGF1RMore
Cinnarizinehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Cinnarizinehsa05221Acute myeloid leukemia4.95E-023P42338, Q15744, P11215PIK3CB, CEBPE, ITGAMMore
Cinnarizinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Cinnarizinehsa05224Breast cancer1.49E-021P08069IGF1RMore
Cinnarizinehsa05225Hepatocellular carcinoma6.30E-043Q92529, P08069, P51531SHC3, IGF1R, SMARCA2More
Cinnarizinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.09E-0812P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, EML4, CD4More
Cinnarizinehsa05310Asthma2.59E-044P13765, P29965, P12724, P01375HLA-DOB, CD40LG, RNASE3, TNFMore
Cinnarizinehsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Cinnarizinehsa05321Inflammatory bowel disease1.83E-056P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Cinnarizinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Cinnarizinehsa05323Rheumatoid arthritis4.95E-023Q06643, P09341, P19875LTB, CXCL1, CXCL2More
Cinnarizinehsa05330Allograft rejection1.76E-034P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Cinnarizinehsa05332Graft-versus-host disease2.11E-065P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Cinnarizinehsa05340Primary immunodeficiency2.02E-055P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Cinnarizinehsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Cinnarizinehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Cinnarizinehsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Cinnarizine (SDC: 7.29)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
O15164TRIM24Transcription intermediary factor 1NonealphaPredicted00.28070.105500.3514
Q09472EP300Histone acetyltransferase p300Predicted00.41820.06720.93071.2742
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)