PharmaCoNets of Cinchocaine (SPCN: 92.45 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Cinchocainehsa00030Pentose phosphate pathway1.95E-023P51854, P08237, P37837TKTL1, PFKM, TALDO1More
Cinchocainehsa00230Purine metabolism4.60E-024Q13370, P36959, Q13956, P27707PDE3B, GMPR, PDE6H, DCKMore
Cinchocainehsa00240Pyrimidine metabolism4.50E-022P32320, P27707CDA, DCKMore
Cinchocainehsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Cinchocainehsa00512Mucin type O-glycan biosynthesis3.19E-033O95395, Q8N4A0, Q9NY28GCNT3, GALNT4, GALNT8More
Cinchocainehsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin4.77E-021Q7LGA3HS2ST1More
Cinchocainehsa00630Glyoxylate and dicarboxylate metabolism9.21E-032P40925, P15104MDH1, GLULMore
Cinchocainehsa00670One carbon pool by folate3.99E-022O95954, Q99707FTCD, MTRMore
Cinchocainehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Cinchocainehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Cinchocainehsa00920Sulfur metabolism3.01E-021O95571ETHE1More
Cinchocainehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Cinchocainehsa00983Drug metabolism - other enzymes3.59E-023P04183, P32320, P05164TK1, CDA, MPOMore
Cinchocainehsa01100Metabolic pathways1.58E-0350Q9Y234, P35790, Q16772, P15144, P30041, Q99707, P29218, O14732, P11310, P27707, Q13370, P36959, Q13956, Q02153, Q16774, P20839, P00918, P10768, P55809, P06280, P30043, Q9Y6K0, P08237, Q02252, P21399, O60701, O14772, O95954, Q02318, Q9UHK6, P51854, P04406, Q86VZ5, Q9BVK2, P15907, O96024, O15466, P09960, P37837, P50213, Q9P2R7, Q9UHY7, P43490, P35573, Q969G6, Q13488, Q16718, Q13029, Q9NVH6, Q02809LIPT1, CHKA, GSTA3, ANPEP, PRDX6, MTR, IMPA1, IMPA2, ACADM, DCK, PDE3B, GMPR, PDE6H, GUCY1B3, GUK1, IMPDH1, CA2, ESD, OXCT1, GLA, BLVRB, CEPT1, PFKM, ALDH6A1, ACO1, UGDH, FPGT, FTCD, CYP27A1, AMACR, TKTL1, GAPDH, SGMS1, ALG8, ST6GAL1, B3GALT4, ST8SIA5, LTA4H, TALDO1, IDH3A, SUCLA2, ENOPH1, PBEF1, AGL, RFK, TCIRG1, NDUFA5, PRDM2, TMLHE, PLOD1More
Cinchocainehsa01200Carbon metabolism1.81E-026P51854, P08237, P37837, P50213, P21399, P10768TKTL1, PFKM, TALDO1, IDH3A, ACO1, ESDMore
Cinchocainehsa012102-Oxocarboxylic acid metabolism1.73E-022P21399, P50213ACO1, IDH3AMore
Cinchocainehsa01230Biosynthesis of amino acids7.71E-035P08237, P51854, P21399, P50213, P37837PFKM, TKTL1, ACO1, IDH3A, TALDO1More
Cinchocainehsa01524Platinum drug resistance4.45E-024P10415, Q13489, P78417, P43246BCL2, BIRC3, GSTO1, MSH2More
Cinchocainehsa02010ABC transporters4.89E-021Q99758ABCA3More
Cinchocainehsa03008Ribosome biogenesis in eukaryotes1.46E-024Q9NYH9, P78345, Q9BVP2, Q9GZY0UTP6, RPP38, GNL3, NXF2; NXF2BMore
Cinchocainehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Cinchocainehsa03013RNA transport8.03E-0310P62826, P52298, P61326, Q9GZY0, P63279, Q14152, O75822, P78345, Q9Y6A5, Q53GS7RAN, NCBP2, MAGOH, NXF2; NXF2B, UBE2I, EIF3A, EIF3J, RPP38, TACC3, GLE1More
Cinchocainehsa03015mRNA surveillance pathway1.09E-036O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Cinchocainehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Cinchocainehsa03040Spliceosome7.93E-1323Q14562, O43143, O60508, P17844, O14776, P08579, P26368, O75940, P52298, P09651, Q15365, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O95777, O43447, O75643, P61326DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, U2AF2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, LSM8, PPIH, ASCC3L1, MAGOHMore
Cinchocainehsa03050Proteasome5.53E-032P43686, P28070PSMC4, PSMB4More
Cinchocainehsa03320PPAR signaling pathway2.18E-022O00767, Q02318SCD, CYP27A1More
Cinchocainehsa03460Fanconi anemia pathway3.70E-033Q9NPI8, O60673, Q9UNA4FANCF, REV3L, POLIMore
Cinchocainehsa04014Ras signaling pathway9.15E-0614P31751, P42338, P20827, Q9NRA1, P49767, Q13009, P17252, Q15311, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, PRKCA, RALBP1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Cinchocainehsa04015Rap1 signaling pathway3.54E-0413P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, Q08828, P51828, P42338, P31751, P0DP23, P17252, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PRKCA, PLCG1More
Cinchocainehsa04020Calcium signaling pathway1.04E-0611P27987, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P51828, P23634, P49767ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, VEGFCMore
Cinchocainehsa04024cAMP signaling pathway3.01E-039Q08828, P51828, P31751, P0DP23, P23634, Q13557, Q13370, O15399, Q13009ADCY1, ADCY7, AKT2, CALM1, ATP2B4, CAMK2D, PDE3B, GRIN2D, TIAM1More
Cinchocainehsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Cinchocainehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Cinchocainehsa04062Chemokine signaling pathway5.18E-0723P51684, P25024, P25025, P09341, P19875, Q8NHW4, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08828, P51828, Q7LDG7, Q13009, P14598, P42224, P31751, P25963, Q8WYR1CCR6, CXCR1, CXCR2, CXCL1, CXCL2, CCL4L2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ADCY1, ADCY7, RASGRP2, TIAM1, NCF1, STAT1, AKT2, NFKBIA, PIK3R5More
Cinchocainehsa04064NF-kappa B signaling pathway1.67E-0515P10415, Q13489, P51617, P14778, P01584, P29965, P19174, Q04759, P06239, O75293, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, IL1R1, IL1B, CD40LG, PLCG1, PRKCQ, LCK, GADD45B, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Cinchocainehsa04070Phosphatidylinositol signaling system4.94E-056P19174, P0DP23, P23743, P48426, P27987, P17252PLCG1, CALM1, DGKA, PIP4K2A, ITPKB, PRKCAMore
Cinchocainehsa04071Sphingolipid signaling pathway3.04E-039P17252, Q13510, Q13362, Q16537, Q9BX95, P04637, P10415, Q9UQC2, P01042PRKCA, ASAH1, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2, GAB2, KNG1More
Cinchocainehsa04072Phospholipase D signaling pathway3.71E-0414P31751, P42338, Q92529, P43657, P25024, P25025, P19174, P17252, Q14344, Q15438, Q08828, P51828, P23743, P00734AKT2, PIK3CB, SHC3, P2RY5, CXCR1, CXCR2, PLCG1, PRKCA, GNA13, PSCD1, ADCY1, ADCY7, DGKA, F2More
Cinchocainehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Cinchocainehsa04140Autophagy - animal2.58E-027P31751, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9AKT2, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8More
Cinchocainehsa04141Protein processing in endoplasmic reticulum2.17E-039P18848, P30101, O60337, P60604, P11142, P07900, P08238, Q9H173, Q9UNL2ATF4, PDIA3, MARH6, UBE2G2, HSPA8, HSP90AA1, HSP90AB1, SIL1, SSR3More
Cinchocainehsa04144Endocytosis8.99E-0312P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6More
Cinchocainehsa04145Phagosome3.87E-0714P11215, P60709, P63261, Q15075, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765ITGAM, ACTB, ACTG1, EEA1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Cinchocainehsa04151PI3K-Akt signaling pathway6.34E-0426P42338, P43657, O43521, P27348, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, Q6ZUJ8, P30281PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, PIK3AP1, CCND3More
Cinchocainehsa04210Apoptosis6.18E-033P07384, P60709, P63261CAPN1, ACTB, ACTG1More
Cinchocainehsa04213Longevity regulating pathway - multiple species4.41E-034P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Cinchocainehsa04217Necroptosis1.49E-1122P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4BMore
Cinchocainehsa04261Adrenergic signaling in cardiomyocytes4.43E-0611P09493, Q08828, P51828, P31751, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Cinchocainehsa04330Notch signaling pathway3.28E-034Q92542, P49768, Q92830, P78504NCSTN, PSEN1, KAT2A, JAG1More
Cinchocainehsa04360Axon guidance1.15E-0410P61073, P16333, P20827, O95631, P17252, Q13557, P42338, P07332, P23528, P19174CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, PIK3CB, FES, CFL1, PLCG1More
Cinchocainehsa04371Apelin signaling pathway6.50E-0613P62873, P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23GNB1, GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1More
Cinchocainehsa04380Osteoclast differentiation4.18E-027Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1More
Cinchocainehsa04390Hippo signaling pathway2.80E-022P60709, P63261ACTB, ACTG1More
Cinchocainehsa04510Focal adhesion3.76E-027P16144, O75369, Q15942, P17252, Q13489, P10415, P49767ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, VEGFCMore
Cinchocainehsa04520Adherens junction1.58E-022P60709, P63261ACTB, ACTG1More
Cinchocainehsa04530Tight junction3.88E-033P60709, P63261, P60660ACTB, ACTG1, MYL6More
Cinchocainehsa04540Gap junction1.68E-048P17252, Q13509, P68371, Q08828, P51828, Q71U36, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7, TUBA1A, PDGFC, ITPR1More
Cinchocainehsa04610Complement and coagulation cascades2.46E-023P00734, P0C0L4, P21730F2, C4A, C5AR1More
Cinchocainehsa04611Platelet activation2.61E-022P60709, P63261ACTB, ACTG1More
Cinchocainehsa04612Antigen processing and presentation1.64E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Cinchocainehsa04613Neutrophil extracellular trap formation9.76E-0521P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, Q6FI13, P58876, Q16778, O60814, P14598, Q15080, P08311, O75015, P21730, P21462, P63261, O43315, Q16539PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC18; H2AC19, H2BC5, HIST2H2BE, H2BC12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, ACTG1, AQP9, MAPK14More
Cinchocainehsa04620Toll-like receptor signaling pathway1.33E-025P51617, P01568, P31751, P42224, Q8NHW4IRAK1, IFNA21, AKT2, STAT1, CCL4L2More
Cinchocainehsa04621NOD-like receptor signaling pathway3.16E-029P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, P43490, P10415IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, PBEF1, BCL2More
Cinchocainehsa04623Cytosolic DNA-sensing pathway2.89E-033P01568, P25963, Q8NHW4IFNA21, NFKBIA, CCL4L2More
Cinchocainehsa04625C-type lectin receptor signaling pathway4.80E-026Q9ULY5, P20749, Q14643, P01375, Q13191, Q16539CLEC4E, BCL3, ITPR1, TNF, CBLB, MAPK14More
Cinchocainehsa04630JAK-STAT signaling pathway1.16E-028P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21More
Cinchocainehsa04640Hematopoietic cell lineage5.48E-0515P13612, P08514, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375ITGA4, ITGA2B, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNFMore
Cinchocainehsa04650Natural killer cell mediated cytotoxicity2.05E-0413P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Cinchocainehsa04657IL-17 signaling pathway1.77E-039P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Cinchocainehsa04658Th1 and Th2 cell differentiation8.90E-0613Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Cinchocainehsa04659Th17 cell differentiation5.62E-0717P25963, Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Cinchocainehsa04660T cell receptor signaling pathway1.06E-0414P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Cinchocainehsa04662B cell receptor signaling pathway5.02E-048P25963, P42338, P20023, P60033, P13164, P07948, P21854, Q8N149NFKBIA, PIK3CB, CR2, CD81, IFITM1, LYN, CD72, LILRA2More
Cinchocainehsa04664Fc epsilon RI signaling pathway5.14E-045P04141, P42338, P07948, P19174, P09917CSF2, PIK3CB, LYN, PLCG1, ALOX5More
Cinchocainehsa04666Fc gamma R-mediated phagocytosis1.15E-038P08575, P19174, P23528, P49006, P06396, Q9UQC2, P14598, P17252PTPRC, PLCG1, CFL1, MARCKSL1, GSN, GAB2, NCF1, PRKCAMore
Cinchocainehsa04670Leukocyte transendothelial migration4.07E-022P60709, P63261ACTB, ACTG1More
Cinchocainehsa04713Circadian entrainment4.05E-069O15399, P0DP23, Q13557, P17252, P62873, P63218, P50151, Q08828, P51828GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, GNG5, GNG10, ADCY1, ADCY7More
Cinchocainehsa04714Thermogenesis3.64E-044P15336, P60709, P63261, P36542ATF2, ACTB, ACTG1, ATP5C1More
Cinchocainehsa04720Long-term potentiation3.26E-036P17252, Q13557, P0DP23, P18848, O15399, Q08828PRKCA, CAMK2D, CALM1, ATF4, GRIN2D, ADCY1More
Cinchocainehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Cinchocainehsa04724Glutamatergic synapse2.96E-049P48058, O15399, Q08828, P51828, P17252, P62873, P63218, P50151, P15104GRIA4, GRIN2D, ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, GLULMore
Cinchocainehsa04725Cholinergic synapse4.42E-048Q08828, P51828, P17252, P62873, P18848, Q13557, P31751, P10415ADCY1, ADCY7, PRKCA, GNB1, ATF4, CAMK2D, AKT2, BCL2More
Cinchocainehsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Cinchocainehsa04727GABAergic synapse9.05E-048Q08828, P51828, P62873, P63218, P50151, P15104, P46459, P17252ADCY1, ADCY7, GNB1, GNG5, GNG10, GLUL, NSF, PRKCAMore
Cinchocainehsa04730Long-term depression6.53E-032Q14344, P07948GNA13, LYNMore
Cinchocainehsa04740Olfactory transduction2.61E-023P62873, Q13557, P0DP23GNB1, CAMK2D, CALM1More
Cinchocainehsa04744Phototransduction1.82E-072P62873, P0DP23GNB1, CALM1More
Cinchocainehsa04750Inflammatory mediator regulation of TRP channels1.34E-0612P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P17252, P24723, Q04759, P0DP23, P01042IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCA, PRKCH, PRKCQ, CALM1, KNG1More
Cinchocainehsa04911Insulin secretion3.47E-024Q08828, P17252, P18848, Q13557ADCY1, PRKCA, ATF4, CAMK2DMore
Cinchocainehsa04912GnRH signaling pathway4.76E-039P17252, Q08828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P22694PRKCA, ADCY1, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, PRKACBMore
Cinchocainehsa04914Progesterone-mediated oocyte maturation3.26E-026Q08828, P51828, P31751, Q13370, Q9UJX4, P08238ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, HSP90AB1More
Cinchocainehsa04915Estrogen signaling pathway3.28E-039P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2More
Cinchocainehsa04919Thyroid hormone signaling pathway3.20E-022P60709, P63261ACTB, ACTG1More
Cinchocainehsa04920Adipocytokine signaling pathway4.72E-024P33121, Q04759, Q9Y4H2, P01375ACSL1, PRKCQ, IRS2, TNFMore
Cinchocainehsa04921Oxytocin signaling pathway1.77E-033P60660, P60709, P63261MYL6, ACTB, ACTG1More
Cinchocainehsa04923Regulation of lipolysis in adipocytes1.20E-037Q08828, P51828, P07550, Q13370, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PDE3B, PIK3CB, IRS2, AKT2More
Cinchocainehsa04925Aldosterone synthesis and secretion6.45E-047P18848, Q08828, P51828, P0DP23, P17252, Q13557, P23634ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B4More
Cinchocainehsa04932Non-alcoholic fatty liver disease6.43E-047P01375, P49841, P18848, P48023, P01584, P13073, O15239TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1More
Cinchocainehsa04933AGE-RAGE signaling pathway in diabetic complications2.38E-0710P84022, Q13485, P01584, P42224, P10415, P31751, P42338, P49767, P17252, P19174SMAD3, SMAD4, IL1B, STAT1, BCL2, AKT2, PIK3CB, VEGFC, PRKCA, PLCG1More
Cinchocainehsa04935Growth hormone synthesis, secretion and action3.93E-026P19174, Q08828, P51828, P17252, P31751, P42224PLCG1, ADCY1, ADCY7, PRKCA, AKT2, STAT1More
Cinchocainehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Cinchocainehsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Cinchocainehsa04970Salivary secretion1.35E-035Q08828, P51828, P23634, P17252, P0DP23ADCY1, ADCY7, ATP2B4, PRKCA, CALM1More
Cinchocainehsa04971Gastric acid secretion1.02E-022P60709, P63261ACTB, ACTG1More
Cinchocainehsa04972Pancreatic secretion1.41E-047Q14643, P20020, P23634, P17252, Q08828, P51828, P62491ITPR1, ATP2B1, ATP2B4, PRKCA, ADCY1, ADCY7, RAB11AMore
Cinchocainehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Cinchocainehsa05012Parkinson disease2.58E-0311O15239, P13073, P05141, P60604, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509, P68371NDUFA1, COX4I1, SLC25A5, UBE2G2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Cinchocainehsa05014Amyotrophic lateral sclerosis2.98E-023P36542, P60709, P63261ATP5C1, ACTB, ACTG1More
Cinchocainehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Cinchocainehsa05017Spinocerebellar ataxia3.80E-038P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12More
Cinchocainehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Cinchocainehsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Cinchocainehsa05031Amphetamine addiction2.85E-025O15399, P0DP23, Q13557, P18848, P17252GRIN2D, CALM1, CAMK2D, ATF4, PRKCAMore
Cinchocainehsa05032Morphine addiction2.71E-037Q08828, P51828, P62873, P63218, P50151, Q13370, P17252ADCY1, ADCY7, GNB1, GNG5, GNG10, PDE3B, PRKCAMore
Cinchocainehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Cinchocainehsa05100Bacterial invasion of epithelial cells1.02E-022P60709, P63261ACTB, ACTG1More
Cinchocainehsa05110Vibrio cholerae infection3.95E-032P60709, P63261ACTB, ACTG1More
Cinchocainehsa05120Epithelial cell signaling in Helicobacter pylori infection7.88E-058P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Cinchocainehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Cinchocainehsa05131Shigellosis1.91E-023P60709, P63261, P07384ACTB, ACTG1, CAPN1More
Cinchocainehsa05132Salmonella infection4.12E-0619P51617, P01584, P25963, P08238, Q9UJU2, P63261, Q96RF0, Q13489, P10415, P08575, O75369, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754, Q9NP90IRAK1, IL1B, NFKBIA, HSP90AB1, LEF1, ACTG1, SNAG1, BIRC3, BCL2, PTPRC, FLNB, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41, RAB9BMore
Cinchocainehsa05133Pertussis3.94E-045P0DP23, P01584, P23528, P09871, P51617CALM1, IL1B, CFL1, C1S, IRAK1More
Cinchocainehsa05134Legionellosis8.66E-057P01584, P25963, P11215, P68104, P11142, P09341, P19875IL1B, NFKBIA, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Cinchocainehsa05135Yersinia infection3.88E-033P60709, P63261, Q16513ACTB, ACTG1, PKN2More
Cinchocainehsa05140Leishmaniasis1.87E-0513P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Cinchocainehsa05143African trypanosomiasis3.56E-035P01375, P01584, P48023, P17252, P01042TNF, IL1B, FASLG, PRKCA, KNG1More
Cinchocainehsa05144Malaria1.56E-038P60033, P69905, P68871, O60603, P01375, P35443, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL8, KLRK1More
Cinchocainehsa05145Toxoplasmosis5.28E-059P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RAMore
Cinchocainehsa05146Amoebiasis8.90E-0612P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Cinchocainehsa05150Staphylococcus aureus infection4.66E-024P0C0L4, P21730, P21462, P13646C4A, C5AR1, FPR1, KRT13More
Cinchocainehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Cinchocainehsa05161Hepatitis B1.31E-0410P17252, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617PRKCA, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1More
Cinchocainehsa05162Measles2.45E-0510P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2More
Cinchocainehsa05163Human cytomegalovirus infection5.44E-0519P31751, P25963, P62873, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, P17252, Q13651, P18848, P30101, P61769, P01568AKT2, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, PRKCA, IL10RA, ATF4, PDIA3, B2M, IFNA21More
Cinchocainehsa05164Influenza A7.10E-033P48551, P60709, P63261IFNAR2, ACTB, ACTG1More
Cinchocainehsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Cinchocainehsa05168Herpes simplex virus 1 infection3.41E-0621P25963, P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P30101, P61769, P31751, Q13398, Q6P280, Q03923, O75820, Q9UDV6, P10415, Q14232NFKBIA, IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, PDIA3, B2M, AKT2, ZNF211, ZNF529, ZNF85, ZNF189, ZNF212, BCL2, EIF2B1More
Cinchocainehsa05170Human immunodeficiency virus 1 infection2.01E-0616P31751, P62873, P63218, P50151, P0DP23, P61073, P17252, P30101, P61769, P01568, P51617, P25963, P19174, P23528, P10415, Q9Y6Q5AKT2, GNB1, GNG5, GNG10, CALM1, CXCR4, PRKCA, PDIA3, B2M, IFNA21, IRAK1, NFKBIA, PLCG1, CFL1, BCL2, AP1M2More
Cinchocainehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Cinchocainehsa05200Pathways in cancer2.33E-1240Q13751, P42338, P23458, P08238, P42224, P25963, P19174, Q15311, P17252, P43246, P84022, Q13485, P20585, Q13547, P14923, P30281, P10415, Q13489, P49767, P31751, P43657, Q08828, P51828, P62873, P63218, P50151, Q14344, Q7LDG7, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042LAMB3, PIK3CB, JAK1, HSP90AB1, STAT1, NFKBIA, PLCG1, RALBP1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, AKT2, P2RY5, ADCY1, ADCY7, GNB1, GNG5, GNG10, GNA13, RASGRP2, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1More
Cinchocainehsa05202Transcriptional misregulation in cancer7.93E-0622Q12778, Q15532, P41732, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Cinchocainehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Cinchocainehsa05204Chemical carcinogenesis3.70E-033P00325, P78417, P33260ADH1B, GSTO1, CYP2C18More
Cinchocainehsa05205Proteoglycans in cancer2.66E-028Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63More
Cinchocainehsa05206MicroRNAs in cancer4.07E-022P15311, P63279VIL2, UBE2IMore
Cinchocainehsa05212Pancreatic cancer8.24E-058P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Cinchocainehsa05214Glioma2.48E-066P0DP23, Q13557, P17252, P31751, P19174, O75293CALM1, CAMK2D, PRKCA, AKT2, PLCG1, GADD45BMore
Cinchocainehsa05216Thyroid cancer3.59E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Cinchocainehsa05217Basal cell carcinoma1.46E-024Q13635, Q9UJU2, P04637, P24522PTCH1, LEF1, TP53, GADD45AMore
Cinchocainehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Cinchocainehsa05225Hepatocellular carcinoma1.85E-034Q92529, P51531, P60709, P63261SHC3, SMARCA2, ACTB, ACTG1More
Cinchocainehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Cinchocainehsa05321Inflammatory bowel disease2.22E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Cinchocainehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Cinchocainehsa05323Rheumatoid arthritis3.53E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Cinchocainehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Cinchocainehsa05332Graft-versus-host disease3.34E-035P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Cinchocainehsa05340Primary immunodeficiency2.68E-022P11912, P07766CD79A, CD3EMore
Cinchocainehsa05410Hypertrophic cardiomyopathy1.02E-022P60709, P63261ACTB, ACTG1More
Cinchocainehsa05412Arrhythmogenic right ventricular cardiomyopathy8.96E-032P60709, P63261ACTB, ACTG1More
Cinchocainehsa05414Dilated cardiomyopathy1.73E-022P60709, P63261ACTB, ACTG1More
Cinchocainehsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore
Cinchocainehsa05416Viral myocarditis8.96E-032P60709, P63261ACTB, ACTG1More
Cinchocainehsa05418Fluid shear stress and atherosclerosis6.88E-0410P14598, P78417, P14780, P60709, P63261, P04637, P10415, P0DP23, P08238, Q92974NCF1, GSTO1, MMP9, ACTB, ACTG1, TP53, BCL2, CALM1, HSP90AB1, ARHGEF2More

Community members of Cinchocaine (SDC: 3.94)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P0DP23CALM1CalmodulinNone1Reported00.45520.147911.5235
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P20839IMPDH1InosineNone5'Nonemonophosphate dehydrogenase 1Predicted00.19280.13070.16530.5231
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
P0DP25CALM3CalmodulinNone3Predicted00.56610.147900.5789
P0DP24CALM2CalmodulinNone2Predicted00.43760.147900.5147
P60660MYL6Myosin light polypeptide 6Predicted00.55950.06870.21750.6346
P24844MYL9Myosin regulatory light polypeptide 9Predicted00.00640.0630.60260.7318
P14649MYL6BMyosin light chain 6BPredicted00.04770.06530.21750.3719
P05976MYL1Myosin light chain 1/3, skeletal muscle isoformPredicted00.25810.061900.2528
O15182CETN3CentrinNone3Predicted00.18720.059400.2123
Q96A32MYLPFMyosin regulatory light chain 2, skeletal muscle isoformPredicted00.01350.04730.54120.6425
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)