PharmaCoNets of Cinacalcet (SPCN: 5.77 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Cinacalcethsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Cinacalcethsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Cinacalcethsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Cinacalcethsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Cinacalcethsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Cinacalcethsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Cinacalcethsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Cinacalcethsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Cinacalcethsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Cinacalcethsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Cinacalcethsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Cinacalcethsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Cinacalcethsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Cinacalcethsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Cinacalcethsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Cinacalcethsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Cinacalcethsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Cinacalcethsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Cinacalcethsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Cinacalcet (SDC: 2.61)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)