PharmaCoNets of Cimetidine (SPCN: 14.83 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Cimetidinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Cimetidinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Cimetidinehsa00500Starch and sucrose metabolism1.03E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Cimetidinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Cimetidinehsa00970Aminoacyl-tRNA biosynthesis9.57E-033O95363, P54136, P14868FARS2, RARS1, DARSMore
Cimetidinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Cimetidinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Cimetidinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Cimetidinehsa04061Viral protein interaction with cytokine and cytokine receptor2.91E-026P09341, P25024, P25025, P47992, Q9UBD3, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNFMore
Cimetidinehsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Cimetidinehsa04080Neuroactive ligand-receptor interaction7.88E-0411P08311, P28472, Q15722, P21453, Q9H228, P43657, P21462, P21730, P14416, P07550, P35318CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, DRD2, ADRB2, ADMMore
Cimetidinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Cimetidinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Cimetidinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Cimetidinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Cimetidinehsa04612Antigen processing and presentation5.66E-058P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Cimetidinehsa04613Neutrophil extracellular trap formation3.18E-0415P11215, O60603, P05164, Q9UM07, Q13547, P58876, Q16778, O60814, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539ITGAM, TLR2, MPO, PADI4, HDAC1, H2BC5, HIST2H2BE, H2BC12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Cimetidinehsa04650Natural killer cell mediated cytotoxicity2.83E-059P01375, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Cimetidinehsa04657IL-17 signaling pathway1.87E-048O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Cimetidinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Cimetidinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Cimetidinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Cimetidinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Cimetidinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Cimetidinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Cimetidinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Cimetidinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Cimetidinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Cimetidinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Cimetidinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Cimetidinehsa04976Bile secretion2.79E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Cimetidinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Cimetidinehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Cimetidinehsa05120Epithelial cell signaling in Helicobacter pylori infection3.87E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Cimetidinehsa05140Leishmaniasis4.59E-025O75015, O60603, P01375, Q16539, Q15080FCGR3B, TLR2, TNF, MAPK14, NCF4More
Cimetidinehsa05144Malaria1.38E-034O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Cimetidinehsa05146Amoebiasis7.83E-0510P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, CTSGMore
Cimetidinehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Cimetidinehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Cimetidinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Cimetidinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Cimetidinehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Cimetidinehsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More
Cimetidinehsa05418Fluid shear stress and atherosclerosis4.81E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Cimetidine (SDC: 2.50)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)