PharmaCoNets of Cilazapril (SPCN: 12.03 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Cilazaprilhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Cilazaprilhsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Cilazaprilhsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Cilazaprilhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Cilazaprilhsa04015Rap1 signaling pathway2.05E-034P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Cilazaprilhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Cilazaprilhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Cilazaprilhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Cilazaprilhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Cilazaprilhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Cilazaprilhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Cilazaprilhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Cilazaprilhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Cilazaprilhsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Cilazaprilhsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Cilazaprilhsa04611Platelet activation7.40E-065P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Cilazaprilhsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Cilazaprilhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Cilazaprilhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Cilazaprilhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Cilazaprilhsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Cilazaprilhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Cilazaprilhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Cilazaprilhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Cilazaprilhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Cilazaprilhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Cilazaprilhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Cilazaprilhsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Cilazaprilhsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Cilazaprilhsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Cilazaprilhsa05330Allograft rejection1.76E-034P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Cilazaprilhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Cilazaprilhsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Cilazaprilhsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Cilazapril (SDC: 2.45)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)