PharmaCoNets

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Chenodeoxycholic-acid

Oxidative phosphorylation

2.21E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P15954	COX7C	Cytochrome c oxidase subunit 7C, mitochondrial	P15954	COX7C	Cytochrome c oxidase subunit 7C, mitochondrial	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.734
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.726
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.793
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931

Chenodeoxycholic-acid

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Chenodeoxycholic-acid

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Chenodeoxycholic-acid

Valine, leucine and isoleucine degradation

1.67E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	0.704
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	0.728
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878

Chenodeoxycholic-acid

Arginine and proline metabolism

4.86E-02

P17707

AMD1

Chenodeoxycholic-acid

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Chenodeoxycholic-acid

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Chenodeoxycholic-acid

Glycerolipid metabolism

1.37E-03

O14494, P51648, P06280, P23743

PLPP1, ALDH3A2, GLA, DGKA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
Q16772	GSTA3	Glutathione S-transferase A3	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	-0.793
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
Q16772	GSTA3	Glutathione S-transferase A3	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	-0.706
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814

Chenodeoxycholic-acid

Inositol phosphate metabolism

7.30E-04

P27987, Q96PE3, P19174, P42338

ITPKB, INPP4A, PLCG1, PIK3CB

Chenodeoxycholic-acid

Sphingolipid metabolism

3.96E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Chenodeoxycholic-acid

Pyruvate metabolism

1.58E-03

P40925, P40926, P51648, P14550

MDH1, MDH2, ALDH3A2, AKR1A1

Chenodeoxycholic-acid

Glyoxylate and dicarboxylate metabolism

2.78E-03

P40925, P15104

MDH1, GLUL

Chenodeoxycholic-acid

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Chenodeoxycholic-acid

Metabolism of xenobiotics by cytochrome P450

4.08E-04

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P09211	GSTP1	Glutathione S-transferase P	P09211	GSTP1	Glutathione S-transferase P	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806

Chenodeoxycholic-acid

Drug metabolism - cytochrome P450

7.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Chenodeoxycholic-acid

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Chenodeoxycholic-acid

Metabolic pathways

1.44E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P40926, Q7KZN9, P15121, P23743, Q9UHK6, P43034, Q86VZ5, P09917, Q53FZ2, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, MDH2, COX15, AKR1B1, DGKA, AMACR, PAFAH1B1, SGMS1, ALOX5, ACSM3, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16772	GSTA3	Glutathione S-transferase A3	P35790	CHKA	Choline kinase alpha	0.74
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
Q16772	GSTA3	Glutathione S-transferase A3	Q16772	GSTA3	Glutathione S-transferase A3	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16772	GSTA3	Glutathione S-transferase A3	P30041	PRDX6	Peroxiredoxin-6	-0.788
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
Q16772	GSTA3	Glutathione S-transferase A3	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	-0.768
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16772	GSTA3	Glutathione S-transferase A3	O94777	DPM2	Dolichol phosphate-mannose biosynthesis regulatory protein	-0.723
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16772	GSTA3	Glutathione S-transferase A3	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	-0.793
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
Q16772	GSTA3	Glutathione S-transferase A3	O95861	BPNT1	3'(2'),5'-bisphosphate nucleotidase 1	0.7
Q16772	GSTA3	Glutathione S-transferase A3	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	-0.706
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
Q16772	GSTA3	Glutathione S-transferase A3	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	0.787
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16772	GSTA3	Glutathione S-transferase A3	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.907
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
Q16772	GSTA3	Glutathione S-transferase A3	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Chenodeoxycholic-acid

hsa01200

Carbon metabolism

2.91E-02

P11413

G6PD

Chenodeoxycholic-acid

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Chenodeoxycholic-acid

EGFR tyrosine kinase inhibitor resistance

7.30E-04

Q92529, P19174, P42338, Q9NRA1

SHC3, PLCG1, PIK3CB, PDGFC

Chenodeoxycholic-acid

Platinum drug resistance

3.80E-03

O15392, Q16772, P09211, P11388

BIRC5, GSTA3, GSTP1, TOP2A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816

Chenodeoxycholic-acid

RNA transport

2.99E-02

P38919, P37198, P35658, P55884

EIF4A3, NUP62, NUP214, EIF3B

Chenodeoxycholic-acid

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Chenodeoxycholic-acid

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Chenodeoxycholic-acid

Spliceosome

1.27E-02

O43143, P08579, Q13595, Q07955, P84103, P11142

DHX15, SNRPB2, TRA2A, SFRS1, SFRS3, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715

Chenodeoxycholic-acid

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Chenodeoxycholic-acid

ErbB signaling pathway

9.49E-03

Q92529, P19174, P42338

SHC3, PLCG1, PIK3CB

Chenodeoxycholic-acid

Ras signaling pathway

6.70E-05

P42338, Q92529, P20827, Q9NRA1, P49767, Q14644, P0DP23, P63218, P50151, P19174

PIK3CB, SHC3, EFNA1, PDGFC, VEGFC, RASA3, CALM1, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
Q8NFZ4	NLGN2	Neuroligin-2	Q15311	RALBP1	RalA-binding protein 1	0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787

Chenodeoxycholic-acid

Rap1 signaling pathway

3.91E-02

Q9NRA1, P49767, P42338, P19174

PDGFC, VEGFC, PIK3CB, PLCG1

Chenodeoxycholic-acid

Calcium signaling pathway

2.74E-05

P27987, Q16566, P30679, O15399, P19174, P0DP24, P0DP23, P51828, P23634, Q9NRA1, P49767

ITPKB, CAMK4, GNA15, GRIN2D, PLCG1, CALM2, CALM1, ADCY7, ATP2B4, PDGFC, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821

Chenodeoxycholic-acid

cAMP signaling pathway

3.79E-02

P51828, P0DP24, P23634

ADCY7, CALM2, ATP2B4

Chenodeoxycholic-acid

Chemokine signaling pathway

2.13E-04

P25024, P25025, P07948, P42338, P19174, Q92529, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10, ARRB1, ITK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Chenodeoxycholic-acid

NF-kappa B signaling pathway

3.38E-04

P10415, O00463, P01584, Q04759, Q9UDY8, Q16548, Q13315, P63279, P24522, Q8NHW4, P09341, Q9NQC7

BCL2, TRAF5, IL1B, PRKCQ, MALT1, BCL2A1, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Chenodeoxycholic-acid

Phosphatidylinositol signaling system

3.19E-04

P19174, P42338, P23743, Q96PE3, P27987

PLCG1, PIK3CB, DGKA, INPP4A, ITPKB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835

Chenodeoxycholic-acid

Sphingolipid signaling pathway

8.69E-04

P21453, Q9H228, Q13510, Q13362, Q9BX95, P10415, Q9UQC2

S1PR1, EDG8, ASAH1, PPP2R5C, SGPP1, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707

Chenodeoxycholic-acid

Phospholipase D signaling pathway

3.21E-05

P42338, Q92529, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1, Q9GZP0

PIK3CB, SHC3, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFC, PDGFD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713

Chenodeoxycholic-acid

hsa04080

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Chenodeoxycholic-acid

Oocyte meiosis

8.69E-03

P0DP24, P51828, P27348, Q13362

CALM2, ADCY7, YWHAQ, PPP2R5C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
Q8NFZ4	NLGN2	Neuroligin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723

Chenodeoxycholic-acid

Ubiquitin mediated proteolysis

2.57E-02

Q14145, Q13042, Q93034, Q15751

KEAP1, CDC16, CUL5, HERC1

Chenodeoxycholic-acid

hsa04140

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Chenodeoxycholic-acid

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Chenodeoxycholic-acid

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.833
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.786
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q13510	ASAH1	Acid ceramidase	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P07602	PSAP	Prosaposin	0.757
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.705
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q04900	CD164	Sialomucin core protein 24	0.718
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9Y227	ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813

Chenodeoxycholic-acid

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
Q8NFZ4	NLGN2	Neuroligin-2	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.773
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.792
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
Q8NFZ4	NLGN2	Neuroligin-2	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.713
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.783
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P62491	RAB11A	Ras-related protein Rab-11A	0.816
Q8NFZ4	NLGN2	Neuroligin-2	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.711
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
Q8NFZ4	NLGN2	Neuroligin-2	Q15438	PSCD1	Cytohesin-1	0.782
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q15438	PSCD1	Cytohesin-1	0.794
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
Q8NFZ4	NLGN2	Neuroligin-2	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.715
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.833
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q96QK1	VPS35	Vacuolar protein sorting-associated protein 35	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9UMY4	SNX12	Sorting nexin-12	0.764
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9UNH7	SNX6	Sorting nexin-6	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835

Chenodeoxycholic-acid

Phagosome

4.79E-03

P60709, Q15075, Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765

ACTB, EEA1, NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Chenodeoxycholic-acid

PI3K-Akt signaling pathway

2.55E-03

P42338, Q9NRA1, P49767, P08238, P63218, P50151, O15335, P14784

PIK3CB, PDGFC, VEGFC, HSP90AB1, GNG5, GNG10, CHAD, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766

Chenodeoxycholic-acid

hsa04210

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Chenodeoxycholic-acid

Longevity regulating pathway - multiple species

2.82E-02

Q08828, P51828, P0DMV8

ADCY1, ADCY7, HSPA1A

Chenodeoxycholic-acid

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Chenodeoxycholic-acid

Adrenergic signaling in cardiomyocytes

1.06E-02

P51828, Q13362, P0DP24, P23634

ADCY7, PPP2R5C, CALM2, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
Q8NFZ4	NLGN2	Neuroligin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723

Chenodeoxycholic-acid

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705

Chenodeoxycholic-acid

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Chenodeoxycholic-acid

hsa04340

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Chenodeoxycholic-acid

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Chenodeoxycholic-acid

VEGF signaling pathway

1.56E-02

P19174, P42338

PLCG1, PIK3CB

Chenodeoxycholic-acid

Apelin signaling pathway

1.56E-03

P63218, P50151, Q13370, Q14344, Q13485, Q16566, P0DP23

GNG5, GNG10, PDE3B, GNA13, SMAD4, CAMK4, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804

Chenodeoxycholic-acid

Osteoclast differentiation

3.37E-03

P09603, P06239, P42338, P14778, O75015, P01375, Q8N149, P78324

CSF1, LCK, PIK3CB, IL1R1, FCGR3B, TNF, LILRA2, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737

Chenodeoxycholic-acid

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Chenodeoxycholic-acid

Focal adhesion

1.55E-02

P42338, O15335, Q9NRA1, P49767, Q92529

PIK3CB, CHAD, PDGFC, VEGFC, SHC3

Chenodeoxycholic-acid

Tight junction

2.08E-02

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Chenodeoxycholic-acid

Complement and coagulation cascades

3.92E-03

P01042, P09871, P0C0L4, P11215

KNG1, C1S, C4A, ITGAM

Chenodeoxycholic-acid

Platelet activation

4.11E-02

P42338, Q14344, P07948

PIK3CB, GNA13, LYN

Chenodeoxycholic-acid

Antigen processing and presentation

5.69E-03

P13765, P26715, P26717, Q13241, O43908, P01732, P30511, P01375

HLA-DOB, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HLA-F, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844

Chenodeoxycholic-acid

hsa04613

Neutrophil extracellular trap formation

4.93E-02

O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P21730

TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, C5AR1

Chenodeoxycholic-acid

NOD-like receptor signaling pathway

3.24E-02

P52630, P10599, P01375, P12838

STAT2, TXN, TNF, DEFA4

Chenodeoxycholic-acid

Cytosolic DNA-sensing pathway

1.65E-02

P01584, Q8NHW4

IL1B, CCL4L2

Chenodeoxycholic-acid

C-type lectin receptor signaling pathway

2.38E-03

Q9ULY5, P52630, P20749, P01375, Q13191, P42338

CLEC4E, STAT2, BCL3, TNF, CBLB, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714

Chenodeoxycholic-acid

Natural killer cell mediated cytotoxicity

1.54E-03

P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O75015, P26717, P26715

TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
P11766	ADH5	Alcohol dehydrogenase class-3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.71
P11766	ADH5	Alcohol dehydrogenase class-3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.833
P11766	ADH5	Alcohol dehydrogenase class-3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.737
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.767
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.818
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.724
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Chenodeoxycholic-acid

IL-17 signaling pathway

3.06E-02

P49841, P80188, P01375

GSK3B, LCN2, TNF

Chenodeoxycholic-acid

Th1 and Th2 cell differentiation

3.54E-05

Q04759, P07766, P20963, P09693, P19174, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13761	RUNX3	Runt-related transcription factor 3	0.73
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738

Chenodeoxycholic-acid

Th17 cell differentiation

1.41E-04

P25963, Q04759, P19174, P14784, P13765, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, IL2RB, HLA-DOB, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Chenodeoxycholic-acid

T cell receptor signaling pathway

1.96E-04

P01375, Q9UDY8, Q04759, P42338, P10747, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.752
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Chenodeoxycholic-acid

B cell receptor signaling pathway

1.32E-03

P49841, P42338, P60033, P07948, Q8N149

GSK3B, PIK3CB, CD81, LYN, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78

Chenodeoxycholic-acid

Fc epsilon RI signaling pathway

6.90E-05

P01375, P42338, P07948, P19174, P09917

TNF, PIK3CB, LYN, PLCG1, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83

Chenodeoxycholic-acid

Fc gamma R-mediated phagocytosis

1.73E-02

P07948, P42338, P19174

LYN, PIK3CB, PLCG1

Chenodeoxycholic-acid

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Chenodeoxycholic-acid

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Chenodeoxycholic-acid

Long-term potentiation

1.79E-02

Q16566, P0DP23, O15399

CAMK4, CALM1, GRIN2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745

Chenodeoxycholic-acid

Neurotrophin signaling pathway

4.87E-02

P42338, P19174, Q92529

PIK3CB, PLCG1, SHC3

Chenodeoxycholic-acid

Glutamatergic synapse

2.04E-03

O15399, P63218, P50151, P15104, Q9NSB8

GRIN2D, GNG5, GNG10, GLUL, HOMER2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808

Chenodeoxycholic-acid

Cholinergic synapse

1.73E-02

P63218, P50151, P42338

GNG5, GNG10, PIK3CB

Chenodeoxycholic-acid

Serotonergic synapse

3.41E-02

P63218, P50151, P09917

GNG5, GNG10, ALOX5

Chenodeoxycholic-acid

GABAergic synapse

6.57E-03

P63218, P50151, P15104

GNG5, GNG10, GLUL

Chenodeoxycholic-acid

Long-term depression

1.56E-02

Q14344, P07948

GNA13, LYN

Chenodeoxycholic-acid

Inflammatory mediator regulation of TRP channels

4.01E-02

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Chenodeoxycholic-acid

Insulin signaling pathway

4.11E-02

Q92529, Q13370, P42338

SHC3, PDE3B, PIK3CB

Chenodeoxycholic-acid

Progesterone-mediated oocyte maturation

2.22E-02

P42338, Q13370, P08238

PIK3CB, PDE3B, HSP90AB1

Chenodeoxycholic-acid

Estrogen signaling pathway

3.80E-04

Q08828, P51828, P42338, Q92529, P08238, P0DMV8, P11142, P0DP23, Q15788

ADCY1, ADCY7, PIK3CB, SHC3, HSP90AB1, HSPA1A, HSPA8, CALM1, NCOA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86

Chenodeoxycholic-acid

Adipocytokine signaling pathway

2.62E-03

Q06124, Q9Y478, Q96RR4

PTPN11, PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737

Chenodeoxycholic-acid

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Chenodeoxycholic-acid

Regulation of lipolysis in adipocytes

3.64E-02

Q13370, P42338

PDE3B, PIK3CB

Chenodeoxycholic-acid

hsa04924

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Chenodeoxycholic-acid

Aldosterone synthesis and secretion

1.40E-03

P51828, P0DP24, P0DP23, Q16566, P23634

ADCY7, CALM2, CALM1, CAMK4, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862

Chenodeoxycholic-acid

Relaxin signaling pathway

1.31E-03

P42338, P63218, P50151, P49767, Q92529

PIK3CB, GNG5, GNG10, VEGFC, SHC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785

Chenodeoxycholic-acid

hsa04928

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Chenodeoxycholic-acid

Non-alcoholic fatty liver disease

1.39E-02

O43521, O75460, P01584, P13073, P12074, O95298

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83

Chenodeoxycholic-acid

AGE-RAGE signaling pathway in diabetic complications

1.47E-03

P84022, Q13485, P10415, P42338, P49767, P19174

SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1

Chenodeoxycholic-acid

Growth hormone synthesis, secretion and action

2.78E-02

P19174, P42338, Q92529

PLCG1, PIK3CB, SHC3

Chenodeoxycholic-acid

Type I diabetes mellitus

1.58E-02

P30511, P01375

HLA-F, TNF

Chenodeoxycholic-acid

Endocrine and other factor-regulated calcium reabsorption

2.09E-02

P23634, P62491

ATP2B4, RAB11A

Chenodeoxycholic-acid

Salivary secretion

6.83E-04

Q08828, P51828, P23634, P0DP24, P0DP23

ADCY1, ADCY7, ATP2B4, CALM2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822

Chenodeoxycholic-acid

Pancreatic secretion

4.94E-03

P23634, P51828, P62491

ATP2B4, ADCY7, RAB11A

Chenodeoxycholic-acid

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Chenodeoxycholic-acid

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Chenodeoxycholic-acid

Bile secretion

4.78E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Chenodeoxycholic-acid

Alzheimer disease

3.75E-02

P01375, Q9NZJ5, Q13564, P49841, Q92837, P09603, P42338, P21796

TNF, EIF2AK3, APPBP1, GSK3B, FRAT1, CSF1, PIK3CB, VDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.797
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15169	AXIN1	Axin-1	0.737
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P67870	CSNK2B	Casein kinase II subunit beta	0.784
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P28070	PSMB4	Proteasome subunit beta type-4	0.814
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78

Chenodeoxycholic-acid

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.714
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.777
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.705
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.714
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.721
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.786
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.805
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.77
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P28070	PSMB4	Proteasome subunit beta type-4	0.814
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P28070	PSMB4	Proteasome subunit beta type-4	0.841
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.773
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703

Chenodeoxycholic-acid

Morphine addiction

2.22E-02

P63218, P50151, Q13370

GNG5, GNG10, PDE3B

Chenodeoxycholic-acid

Alcoholism

1.05E-02

O15399, Q16566, P0DP23, P63218, O60814, P68431

GRIN2D, CAMK4, CALM1, GNG5, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
Q8NFZ4	NLGN2	Neuroligin-2	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736

Chenodeoxycholic-acid

Bacterial invasion of epithelial cells

3.64E-02

P42338, Q92529

PIK3CB, SHC3

Chenodeoxycholic-acid

Vibrio cholerae infection

4.50E-03

Q13488, P17252, P19174, P60709

TCIRG1, PRKCA, PLCG1, ACTB

Chenodeoxycholic-acid

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Chenodeoxycholic-acid

hsa05132

Salmonella infection

2.04E-02

P25963, Q13489, P10415, Q9BQS8

NFKBIA, BIRC3, BCL2, FYCO1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.77
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.837
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.711
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O75369	FLNB	Filamin-B	-0.863
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P51808	DYNLT3	Dynein light chain Tctex-type 3	0.705
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13561	DCTN2	Dynactin subunit 2	-0.818
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13509	TUBB3	Tubulin beta-3 chain	-0.815
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	-0.744

Chenodeoxycholic-acid

Pertussis

1.33E-04

P11215, P0DP23, P10145, P23528, P09871, P0C0L4

ITGAM, CALM1, IL8, CFL1, C1S, C4A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P10145	IL8	Interleukin-8	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P00918	CA2	Carbonic anhydrase 2	P0C0L4	C4A	Complement C4-A	0.774
P00918	CA2	Carbonic anhydrase 2	P0C0L4	C4A	Complement C4-A	0.774
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P10145	IL8	Interleukin-8	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703

Chenodeoxycholic-acid

Legionellosis

2.82E-02

P01584, Q9NR31, P0DMV8

IL1B, SAR1A, HSPA1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P01584	IL1B	Interleukin-1 beta	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753

Chenodeoxycholic-acid

Yersinia infection

4.00E-02

P13612, P06239, P01375, P42338, P49841

ITGA4, LCK, TNF, PIK3CB, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Chenodeoxycholic-acid

Leishmaniasis

4.75E-02

P14598, P42224, P25963, P29350, Q15080

NCF1, STAT1, NFKBIA, PTPN6, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752

Chenodeoxycholic-acid

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Chenodeoxycholic-acid

Hepatitis C

9.27E-03

P52630, P60033, P49841, P01375

STAT2, CD81, GSK3B, TNF

Chenodeoxycholic-acid

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Chenodeoxycholic-acid

Measles

5.79E-03

P23458, P14784, P07766, P42338, P0DMV8, P11142, P01584, Q9NP90

JAK1, IL2RB, CD3E, PIK3CB, HSPA1A, HSPA8, IL1B, RAB9B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759

Chenodeoxycholic-acid

Human cytomegalovirus infection

1.23E-06

P42338, P01375, P30511, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, O00463, P30101

PIK3CB, TNF, HLA-F, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, TRAF5, PDIA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708

Chenodeoxycholic-acid

Human papillomavirus infection

1.76E-02

P49841, P24821, P01375, P52630, P30511

GSK3B, TNC, TNF, STAT2, HLA-F

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836

Chenodeoxycholic-acid

Kaposi sarcoma-associated herpesvirus infection

1.14E-02

P42338, P63218, P50151, P19174, P07948

PIK3CB, GNG5, GNG10, PLCG1, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804

Chenodeoxycholic-acid

Epstein-Barr virus infection

8.75E-04

Q13547, O00463, P42338, P07948, P30511, P30101, Q13761, P01375, P07766, P20963

HDAC1, TRAF5, PIK3CB, LYN, HLA-F, PDIA3, RUNX3, TNF, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77

Chenodeoxycholic-acid

Human immunodeficiency virus 1 infection

6.31E-04

P42338, P30511, P63218, P50151, P01375, O00463, P30101, P19174, P07766, P20963

PIK3CB, HLA-F, GNG5, GNG10, TNF, TRAF5, PDIA3, PLCG1, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.767
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P0DP23	CALM1	Calmodulin-1	-0.816
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P17252	PRKCA	Protein kinase C alpha type	0.74
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P01568	IFNA21	Interferon alpha-21	0.828
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13619	CUL4A	Cullin-4A	0.706
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.889
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77

Chenodeoxycholic-acid

Pathways in cancer

3.05E-02

P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784

PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766

Chenodeoxycholic-acid

hsa05202

Transcriptional misregulation in cancer

2.90E-02

Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522

FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45A

Chenodeoxycholic-acid

Viral carcinogenesis

4.62E-02

Q12933, P42229, Q15283

TRAF2, STAT5A, RASA2

Chenodeoxycholic-acid

Chemical carcinogenesis

7.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P09211	GSTP1	Glutathione S-transferase P	P09211	GSTP1	Glutathione S-transferase P	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806

Chenodeoxycholic-acid

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Chenodeoxycholic-acid

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Chenodeoxycholic-acid

hsa05212

Pancreatic cancer

3.52E-02

P84022, Q13485

SMAD3, SMAD4

Chenodeoxycholic-acid

Glioma

9.49E-03

Q92529, P42338, P19174

SHC3, PIK3CB, PLCG1

Chenodeoxycholic-acid

Prostate cancer

4.87E-02

Q9NRA1, P08238, P42338

PDGFC, HSP90AB1, PIK3CB

Chenodeoxycholic-acid

Melanoma

3.64E-02

Q9NRA1, P42338

PDGFC, PIK3CB

Chenodeoxycholic-acid

hsa05220

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Chenodeoxycholic-acid

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Chenodeoxycholic-acid

Non-small cell lung cancer

3.99E-02

P17252, O43524, P19174, O75293

PRKCA, FOXO3, PLCG1, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717

Chenodeoxycholic-acid

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Chenodeoxycholic-acid

hsa05230

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Chenodeoxycholic-acid

Choline metabolism in cancer

3.04E-04

P42338, Q9NRA1, P19174, P23743, O14494, P17252

PIK3CB, PDGFC, PLCG1, DGKA, PLPP1, PRKCA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754

Chenodeoxycholic-acid

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.84E-02

P20963, P09693, O60603, P10747, Q04759

CD247, CD3G, TLR2, CD28, PRKCQ

Chenodeoxycholic-acid

Asthma

9.71E-03

P12724, P01375

RNASE3, TNF

Chenodeoxycholic-acid

hsa05321

Inflammatory bowel disease

1.17E-03

O60603, P13765, Q14765, Q9UL17, P23771

TLR2, HLA-DOB, STAT4, TBX21, GATA3

Chenodeoxycholic-acid

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Chenodeoxycholic-acid

Allograft rejection

2.30E-02

P30511, P01375

HLA-F, TNF

Chenodeoxycholic-acid

Graft-versus-host disease

2.86E-04

P13765, P30511, P10747, P01375, P26715, Q13241

HLA-DOB, HLA-F, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Chenodeoxycholic-acid

Diabetic cardiomyopathy

3.33E-02

P17252, P14598, Q15080, Q16718, O14521, P04406, P11413

PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH, G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.712
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Chenodeoxycholic-acid

Fluid shear stress and atherosclerosis

4.52E-03

P42338, Q14145, P10599, P01375, P14778, P27930

PIK3CB, KEAP1, TXN, TNF, IL1R1, IL1R2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q14145	KEAP1	Kelch-like ECH-associated protein 1	Q14145	KEAP1	Kelch-like ECH-associated protein 1	1
P60033	CD81	CD81 antigen	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.8
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P60033	CD81	CD81 antigen	P10599	TXN	Thioredoxin	-0.87
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q14145	KEAP1	Kelch-like ECH-associated protein 1	Q14145	KEAP1	Kelch-like ECH-associated protein 1	1
P60033	CD81	CD81 antigen	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.8
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P60033	CD81	CD81 antigen	P10599	TXN	Thioredoxin	-0.87
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q14145	KEAP1	Kelch-like ECH-associated protein 1	Q14145	KEAP1	Kelch-like ECH-associated protein 1	1
P60033	CD81	CD81 antigen	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.8
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P60033	CD81	CD81 antigen	P10599	TXN	Thioredoxin	-0.87
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q14145	KEAP1	Kelch-like ECH-associated protein 1	Q14145	KEAP1	Kelch-like ECH-associated protein 1	1
P60033	CD81	CD81 antigen	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.8
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P60033	CD81	CD81 antigen	P10599	TXN	Thioredoxin	-0.87
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779

Cholic-Acid

hsa00071

Fatty acid degradation

4.87E-03

P11310, P28332

ACADM, ADH6

Cholic-Acid

Oxidative phosphorylation

4.59E-02

P15954

COX7C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P15954	COX7C	Cytochrome c oxidase subunit 7C, mitochondrial	P15954	COX7C	Cytochrome c oxidase subunit 7C, mitochondrial	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.734
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.726
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.793
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931

Cholic-Acid

Arginine and proline metabolism

4.86E-02

P17707

AMD1

Cholic-Acid

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Cholic-Acid

hsa00520

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Cholic-Acid

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Cholic-Acid

hsa00830

Retinol metabolism

3.49E-02

P00325

ADH1B

Cholic-Acid

Metabolism of xenobiotics by cytochrome P450

4.08E-04

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P09211	GSTP1	Glutathione S-transferase P	P09211	GSTP1	Glutathione S-transferase P	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806

Cholic-Acid

Drug metabolism - cytochrome P450

7.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Cholic-Acid

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Cholic-Acid

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16772	GSTA3	Glutathione S-transferase A3	P35790	CHKA	Choline kinase alpha	0.74
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
Q16772	GSTA3	Glutathione S-transferase A3	Q16772	GSTA3	Glutathione S-transferase A3	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16772	GSTA3	Glutathione S-transferase A3	P30041	PRDX6	Peroxiredoxin-6	-0.788
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
Q16772	GSTA3	Glutathione S-transferase A3	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	-0.768
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16772	GSTA3	Glutathione S-transferase A3	O94777	DPM2	Dolichol phosphate-mannose biosynthesis regulatory protein	-0.723
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16772	GSTA3	Glutathione S-transferase A3	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	-0.793
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
Q16772	GSTA3	Glutathione S-transferase A3	O95861	BPNT1	3'(2'),5'-bisphosphate nucleotidase 1	0.7
Q16772	GSTA3	Glutathione S-transferase A3	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	-0.706
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
Q16772	GSTA3	Glutathione S-transferase A3	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	0.787
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16772	GSTA3	Glutathione S-transferase A3	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.907
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
Q16772	GSTA3	Glutathione S-transferase A3	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Cholic-Acid

hsa01523

Antifolate resistance

2.24E-02

P41439, P41440, P01375

FOLR3, SLC19A1, TNF

Cholic-Acid

Platinum drug resistance

3.80E-03

O15392, Q16772, P09211, P11388

BIRC5, GSTA3, GSTP1, TOP2A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816

Cholic-Acid

hsa03010

Ribosome

2.19E-05

P62753, P42677, P32969, P62829, P46776, Q9H0U6, P62910, P61927, P61513, P36578, P05386, P62249, P23396

RPS6, RPS27, RPL9, RPL23, RPL27A, MRPL18, RPL32, RPL37, RPL37A, RPL4, RPLP1, RPS16, RPS3

Cholic-Acid

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Cholic-Acid

RNA polymerase

1.88E-03

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Cholic-Acid

Spliceosome

1.27E-02

O43143, P08579, Q13595, Q07955, P84103, P11142

DHX15, SNRPB2, TRA2A, SFRS1, SFRS3, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715

Cholic-Acid

Protein export

3.11E-03

P37108, Q15005

SRP14, SPCS2

Cholic-Acid

hsa03320

PPAR signaling pathway

3.78E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Cholic-Acid

Ras signaling pathway

6.22E-03

P20827, P49767, Q15311, Q14644, P0DP23, P63218, P17612

EFNA1, VEGFC, RALBP1, RASA3, CALM1, GNG5, PRKACA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
Q8NFZ4	NLGN2	Neuroligin-2	Q15311	RALBP1	RalA-binding protein 1	0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787

Cholic-Acid

Calcium signaling pathway

4.05E-04

Q16566, P30679, O15399, P0DP24, P0DP23, P51828, P23634, P49767

CAMK4, GNA15, GRIN2D, CALM2, CALM1, ADCY7, ATP2B4, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821

Cholic-Acid

cAMP signaling pathway

3.79E-02

P51828, P0DP24, P23634

ADCY7, CALM2, ATP2B4

Cholic-Acid

NF-kappa B signaling pathway

2.35E-02

P01584, P63279, Q8NHW4, Q9NQC7

IL1B, UBE2I, CCL4L2, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Cholic-Acid

Sphingolipid signaling pathway

2.14E-02

Q13510, Q13362, Q9UQC2

ASAH1, PPP2R5C, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707

Cholic-Acid

Oocyte meiosis

6.54E-06

Q9Y6D9, P51812, Q02750, P0DP24, P0DP23, P16298, Q17RY0, P17612, P51828, P27348, Q13362

MAD1L1, RPS6KA3, MAP2K1, CALM2, CALM1, PPP3CB, CPEB4, PRKACA, ADCY7, YWHAQ, PPP2R5C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
Q8NFZ4	NLGN2	Neuroligin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723

Cholic-Acid

hsa04137

Mitophagy - animal

2.76E-02

P67870, P19532, P18848

CSNK2B, TFE3, ATF4

Cholic-Acid

Lysosome

6.33E-04

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916, Q04900, Q9Y227

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2, CD164, ENTPD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.833
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.786
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q13510	ASAH1	Acid ceramidase	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P07602	PSAP	Prosaposin	0.757
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.705
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q04900	CD164	Sialomucin core protein 24	0.718
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9Y227	ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813

Cholic-Acid

Endocytosis

2.89E-06

P0DMV8, Q9H444, O75351, P62491, P42566, Q96B97, Q15438, Q14161, Q96QK1, Q9UMY4, Q9UNH7

HSPA1A, CHMP4B, VPS4B, RAB11A, EPS15, SH3KBP1, PSCD1, GIT2, VPS35, SNX12, SNX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
Q8NFZ4	NLGN2	Neuroligin-2	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.773
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.792
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
Q8NFZ4	NLGN2	Neuroligin-2	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.713
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.783
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P62491	RAB11A	Ras-related protein Rab-11A	0.816
Q8NFZ4	NLGN2	Neuroligin-2	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.711
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
Q8NFZ4	NLGN2	Neuroligin-2	Q15438	PSCD1	Cytohesin-1	0.782
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q15438	PSCD1	Cytohesin-1	0.794
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
Q8NFZ4	NLGN2	Neuroligin-2	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.715
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.833
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q96QK1	VPS35	Vacuolar protein sorting-associated protein 35	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9UMY4	SNX12	Sorting nexin-12	0.764
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9UNH7	SNX6	Sorting nexin-6	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835

Cholic-Acid

Longevity regulating pathway - multiple species

2.82E-02

Q08828, P51828, P0DMV8

ADCY1, ADCY7, HSPA1A

Cholic-Acid

hsa04217

Necroptosis

1.31E-03

P23458, Q9NQC7, P01584, Q9BTM1, Q9H444, O75351

JAK1, CYLD, IL1B, H2AFJ, CHMP4B, VPS4B

Cholic-Acid

hsa04260

Cardiac muscle contraction

8.94E-03

P67936, P13073, P12074, P15954

TPM4, COX4I1, COX6A1, COX7C

Cholic-Acid

Adrenergic signaling in cardiomyocytes

6.91E-04

P51828, P17612, Q13362, P0DP24, P0DP23, P23634

ADCY7, PRKACA, PPP2R5C, CALM2, CALM1, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
Q8NFZ4	NLGN2	Neuroligin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723

Cholic-Acid

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705

Cholic-Acid

VEGF signaling pathway

2.47E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Cholic-Acid

Apelin signaling pathway

4.16E-02

P63218, Q13485, Q16566, P0DP23

GNG5, SMAD4, CAMK4, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804

Cholic-Acid

Complement and coagulation cascades

4.48E-02

P01042, P09871, P11215

KNG1, C1S, ITGAM

Cholic-Acid

Cytosolic DNA-sensing pathway

1.65E-02

P01584, Q8NHW4

IL1B, CCL4L2

Cholic-Acid

Natural killer cell mediated cytotoxicity

2.87E-03

P16298, P50591, P01375, Q02750, Q13241, P26718, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
P11766	ADH5	Alcohol dehydrogenase class-3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.71
P11766	ADH5	Alcohol dehydrogenase class-3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.833
P11766	ADH5	Alcohol dehydrogenase class-3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.737
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.767
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.818
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.724
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Cholic-Acid

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Cholic-Acid

hsa04713

Circadian entrainment

4.42E-02

P0DP23, P17612

CALM1, PRKACA

Cholic-Acid

Long-term potentiation

1.51E-04

Q16566, P16298, P0DP23, P51812, O15399, P17612, Q02750

CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, PRKACA, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745

Cholic-Acid

Glutamatergic synapse

4.48E-02

O15399, P63218, Q9NSB8

GRIN2D, GNG5, HOMER2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808

Cholic-Acid

hsa04728

Dopaminergic synapse

1.55E-02

P17612, Q13362, P0DP23

PRKACA, PPP2R5C, CALM1

Cholic-Acid

hsa04740

Olfactory transduction

6.71E-03

P0DP23, P17612

CALM1, PRKACA

Cholic-Acid

Inflammatory mediator regulation of TRP channels

4.01E-02

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Cholic-Acid

Insulin signaling pathway

3.62E-02

P0DP23, P17612

CALM1, PRKACA

Cholic-Acid

Progesterone-mediated oocyte maturation

7.70E-03

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Cholic-Acid

Estrogen signaling pathway

3.17E-02

Q08828, P51828, P0DMV8, P0DP23, Q15788

ADCY1, ADCY7, HSPA1A, CALM1, NCOA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86

Cholic-Acid

hsa04916

Melanogenesis

2.87E-02

P17612, P0DP23

PRKACA, CALM1

Cholic-Acid

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737

Cholic-Acid

hsa04921

Oxytocin signaling pathway

1.84E-02

P0DP23, P17612, Q96RR4

CALM1, PRKACA, CAMKK2

Cholic-Acid

hsa04924

Renin secretion

1.09E-02

P17612, P0DP23

PRKACA, CALM1

Cholic-Acid

Aldosterone synthesis and secretion

1.40E-03

P51828, P0DP24, P0DP23, Q16566, P23634

ADCY7, CALM2, CALM1, CAMK4, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862

Cholic-Acid

Non-alcoholic fatty liver disease

1.39E-02

O43521, O75460, P01584, P13073, P12074, O95298

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83

Cholic-Acid

Endocrine and other factor-regulated calcium reabsorption

2.09E-02

P23634, P62491

ATP2B4, RAB11A

Cholic-Acid

Salivary secretion

4.55E-05

Q08828, P51828, P17612, P23634, P0DP24, P0DP23

ADCY1, ADCY7, PRKACA, ATP2B4, CALM2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822

Cholic-Acid

hsa04971

Gastric acid secretion

2.87E-02

P17612, P0DP23

PRKACA, CALM1

Cholic-Acid

Pancreatic secretion

4.94E-03

P23634, P51828, P62491

ATP2B4, ADCY7, RAB11A

Cholic-Acid

Bile secretion

3.56E-03

Q08828, P51828, P17612, Q14032

ADCY1, ADCY7, PRKACA, BAAT

Cholic-Acid

Alzheimer disease

2.29E-02

O15239, P13073, P12074, P18848, O15169, P67870, P05141, P28070

NDUFA1, COX4I1, COX6A1, ATF4, AXIN1, CSNK2B, SLC25A5, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.797
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15169	AXIN1	Axin-1	0.737
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P67870	CSNK2B	Casein kinase II subunit beta	0.784
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P28070	PSMB4	Proteasome subunit beta type-4	0.814
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78

Cholic-Acid

hsa05012

Parkinson disease

2.14E-02

O15239, P13073, P12074, P05141, P18848, P28070, Q13557

NDUFA1, COX4I1, COX6A1, SLC25A5, ATF4, PSMB4, CAMK2D

Cholic-Acid

Huntington disease

1.88E-04

O15239, O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232

NDUFA1, NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.714
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.777
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.705
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.714
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.721
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.786
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.805
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.77
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P28070	PSMB4	Proteasome subunit beta type-4	0.814
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P28070	PSMB4	Proteasome subunit beta type-4	0.841
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.773
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703

Cholic-Acid

hsa05020

Prion disease

5.97E-03

P46531, P11142, O15239, P13073, P12074, P18848, P05141, P28070, P67870

NOTCH1, HSPA8, NDUFA1, COX4I1, COX6A1, ATF4, SLC25A5, PSMB4, CSNK2B

Cholic-Acid

hsa05022

Pathways of neurodegeneration - multiple diseases

7.82E-03

P67870, O15239, P13073, P12074, P18848, P05141, P20333, O15169, Q13557, P28070

CSNK2B, NDUFA1, COX4I1, COX6A1, ATF4, SLC25A5, TNFRSF1B, AXIN1, CAMK2D, PSMB4

Cholic-Acid

hsa05031

Amphetamine addiction

2.87E-02

P0DP23, P17612

CALM1, PRKACA

Cholic-Acid

Alcoholism

3.39E-04

O15399, P17612, Q16566, P0DP23, Q96RR4, P63218, O60814, P68431

GRIN2D, PRKACA, CAMK4, CALM1, CAMKK2, GNG5, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
Q8NFZ4	NLGN2	Neuroligin-2	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736

Cholic-Acid

Pertussis

1.70E-03

P11215, P0DP23, P23528, P09871

ITGAM, CALM1, CFL1, C1S

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P10145	IL8	Interleukin-8	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P00918	CA2	Carbonic anhydrase 2	P0C0L4	C4A	Complement C4-A	0.774
P00918	CA2	Carbonic anhydrase 2	P0C0L4	C4A	Complement C4-A	0.774
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P10145	IL8	Interleukin-8	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703

Cholic-Acid

Legionellosis

1.92E-03

P01584, Q9NR31, P0DMV8

IL1B, SAR1A, HSPA1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P01584	IL1B	Interleukin-1 beta	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753

Cholic-Acid

Yersinia infection

2.58E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Cholic-Acid

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759

Cholic-Acid

Human cytomegalovirus infection

3.31E-02

P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651

CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708

Cholic-Acid

Human immunodeficiency virus 1 infection

4.37E-02

Q02750, P62879, P16298, Q05397

MAP2K1, GNB2, PPP3CB, PTK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.767
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P0DP23	CALM1	Calmodulin-1	-0.816
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P17252	PRKCA	Protein kinase C alpha type	0.74
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P01568	IFNA21	Interferon alpha-21	0.828
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13619	CUL4A	Cullin-4A	0.706
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.889
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77

Cholic-Acid

hsa05171

Coronavirus disease - COVID-19

1.08E-04

P23458, P23396, P62753, P62249, P42677, P36578, P32969, P46776, P62910, P61927, P61513, P05386, P62829

JAK1, RPS3, RPS6, RPS16, RPS27, RPL4, RPL9, RPL27A, RPL32, RPL37, RPL37A, RPLP1, RPL23

Cholic-Acid

Viral carcinogenesis

4.62E-02

Q12933, P42229, Q15283

TRAF2, STAT5A, RASA2

Cholic-Acid

Chemical carcinogenesis

7.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P09211	GSTP1	Glutathione S-transferase P	P09211	GSTP1	Glutathione S-transferase P	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806

Cholic-Acid

hsa05212

Pancreatic cancer

2.87E-02

Q15311, P23458

RALBP1, JAK1

Cholic-Acid

Graft-versus-host disease

3.60E-02

P01375, P26715, Q13241

TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Cholic-Acid

Diabetic cardiomyopathy

4.63E-02

P05141, O15239, P13073, P12074, Q13557

SLC25A5, NDUFA1, COX4I1, COX6A1, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.712
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Deoxycholic-acid

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Deoxycholic-acid

hsa00040

Pentose and glucuronate interconversions

2.81E-05

Q9UEF7, P15121, O60701, P14550

KL, AKR1B1, UGDH, AKR1A1

Deoxycholic-acid

Oxidative phosphorylation

1.18E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P15954	COX7C	Cytochrome c oxidase subunit 7C, mitochondrial	P15954	COX7C	Cytochrome c oxidase subunit 7C, mitochondrial	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.734
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.726
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.793
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931

Deoxycholic-acid

Arginine biosynthesis

4.82E-05

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Deoxycholic-acid

Alanine, aspartate and glutamate metabolism

5.84E-03

P51649, P49448, P15104

ALDH5A1, GLUD2, GLUL

Deoxycholic-acid

Valine, leucine and isoleucine degradation

8.49E-04

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	0.704
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	0.728
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878

Deoxycholic-acid

Arginine and proline metabolism

4.86E-02

P17707

AMD1

Deoxycholic-acid

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Deoxycholic-acid

hsa00531

Glycosaminoglycan degradation

3.03E-02

P15586

GNS

Deoxycholic-acid

Glycerolipid metabolism

1.06E-04

O14494, P15121, P51648, P14550, P06280, P23743

PLPP1, AKR1B1, ALDH3A2, AKR1A1, GLA, DGKA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
Q16772	GSTA3	Glutathione S-transferase A3	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	-0.793
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
Q16772	GSTA3	Glutathione S-transferase A3	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	-0.706
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814

Deoxycholic-acid

Inositol phosphate metabolism

7.30E-04

P27987, Q96PE3, P19174, P42338

ITPKB, INPP4A, PLCG1, PIK3CB

Deoxycholic-acid

Sphingolipid metabolism

3.96E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Deoxycholic-acid

Pyruvate metabolism

2.51E-02

P40925, P51648

MDH1, ALDH3A2

Deoxycholic-acid

Glyoxylate and dicarboxylate metabolism

2.78E-03

P40925, P15104

MDH1, GLUL

Deoxycholic-acid

hsa00790

Folate biosynthesis

2.02E-02

P15121

AKR1B1

Deoxycholic-acid

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Deoxycholic-acid

Metabolism of xenobiotics by cytochrome P450

3.60E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P09211	GSTP1	Glutathione S-transferase P	P09211	GSTP1	Glutathione S-transferase P	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806

Deoxycholic-acid

Drug metabolism - cytochrome P450

7.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Deoxycholic-acid

Drug metabolism - other enzymes

5.54E-04

P20839, Q16772, P09211

IMPDH1, GSTA3, GSTP1

Deoxycholic-acid

Metabolic pathways

1.28E-04

P35790, Q16772, P09211, Q9UJ14, P30041, P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P20839, P40925, P40926, O94777, Q7KZN9, P15121, P23743, O95861, P14550, Q9UHK6, P43034, Q86VZ5, P09917, Q53FZ2, Q9BQB6, Q9NVH6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, IMPDH1, MDH1, MDH2, DPM2, COX15, AKR1B1, DGKA, BPNT1, AKR1A1, AMACR, PAFAH1B1, SGMS1, ALOX5, ACSM3, VKORC1, TMLHE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16772	GSTA3	Glutathione S-transferase A3	P35790	CHKA	Choline kinase alpha	0.74
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
Q16772	GSTA3	Glutathione S-transferase A3	Q16772	GSTA3	Glutathione S-transferase A3	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16772	GSTA3	Glutathione S-transferase A3	P30041	PRDX6	Peroxiredoxin-6	-0.788
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
Q16772	GSTA3	Glutathione S-transferase A3	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	-0.768
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16772	GSTA3	Glutathione S-transferase A3	O94777	DPM2	Dolichol phosphate-mannose biosynthesis regulatory protein	-0.723
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16772	GSTA3	Glutathione S-transferase A3	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	-0.793
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
Q16772	GSTA3	Glutathione S-transferase A3	O95861	BPNT1	3'(2'),5'-bisphosphate nucleotidase 1	0.7
Q16772	GSTA3	Glutathione S-transferase A3	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	-0.706
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
Q16772	GSTA3	Glutathione S-transferase A3	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	0.787
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16772	GSTA3	Glutathione S-transferase A3	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.907
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
Q16772	GSTA3	Glutathione S-transferase A3	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Deoxycholic-acid

hsa01200

Carbon metabolism

2.91E-02

P11413

G6PD

Deoxycholic-acid

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Deoxycholic-acid

EGFR tyrosine kinase inhibitor resistance

7.30E-04

Q92529, P19174, P42338, Q9NRA1

SHC3, PLCG1, PIK3CB, PDGFC

Deoxycholic-acid

Platinum drug resistance

2.94E-04

P04637, O15392, P48023, Q16772, P09211, P11388

TP53, BIRC5, FASLG, GSTA3, GSTP1, TOP2A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816

Deoxycholic-acid

hsa03010

Ribosome

2.25E-04

P40429, Q07020, P27635, P05386, P62249

RPL13A, RPL18, RPL10, RPLP1, RPS16

Deoxycholic-acid

RNA transport

2.99E-02

P38919, P37198, P35658, P55884

EIF4A3, NUP62, NUP214, EIF3B

Deoxycholic-acid

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Deoxycholic-acid

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Deoxycholic-acid

Spliceosome

1.27E-02

O43143, P08579, Q13595, Q07955, P84103, P11142

DHX15, SNRPB2, TRA2A, SFRS1, SFRS3, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715

Deoxycholic-acid

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Deoxycholic-acid

ErbB signaling pathway

9.49E-03

Q92529, P19174, P42338

SHC3, PLCG1, PIK3CB

Deoxycholic-acid

Ras signaling pathway

6.70E-05

P42338, Q92529, P20827, Q9NRA1, P49767, Q14644, P0DP23, P63218, P50151, P19174

PIK3CB, SHC3, EFNA1, PDGFC, VEGFC, RASA3, CALM1, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
Q8NFZ4	NLGN2	Neuroligin-2	Q15311	RALBP1	RalA-binding protein 1	0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787

Deoxycholic-acid

Rap1 signaling pathway

3.91E-02

Q9NRA1, P49767, P42338, P19174

PDGFC, VEGFC, PIK3CB, PLCG1

Deoxycholic-acid

Calcium signaling pathway

2.74E-05

P27987, Q16566, P30679, O15399, P19174, P0DP24, P0DP23, P51828, P23634, Q9NRA1, P49767

ITPKB, CAMK4, GNA15, GRIN2D, PLCG1, CALM2, CALM1, ADCY7, ATP2B4, PDGFC, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821

Deoxycholic-acid

cAMP signaling pathway

3.79E-02

P51828, P0DP24, P23634

ADCY7, CALM2, ATP2B4

Deoxycholic-acid

Chemokine signaling pathway

2.13E-04

P25024, P25025, P07948, P42338, P19174, Q92529, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10, ARRB1, ITK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Deoxycholic-acid

NF-kappa B signaling pathway

2.35E-02

P01584, P63279, Q8NHW4, Q9NQC7

IL1B, UBE2I, CCL4L2, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Deoxycholic-acid

hsa04068

FoxO signaling pathway

6.45E-03

P48023, Q96BR1

FASLG, SGK3

Deoxycholic-acid

Phosphatidylinositol signaling system

3.19E-04

P19174, P42338, P23743, Q96PE3, P27987

PLCG1, PIK3CB, DGKA, INPP4A, ITPKB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835

Deoxycholic-acid

Sphingolipid signaling pathway

2.14E-02

Q13510, Q13362, Q9UQC2

ASAH1, PPP2R5C, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707

Deoxycholic-acid

Phospholipase D signaling pathway

3.21E-05

P42338, Q92529, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1, Q9GZP0

PIK3CB, SHC3, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFC, PDGFD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713

Deoxycholic-acid

Oocyte meiosis

8.69E-03

P0DP24, P51828, P27348, Q13362

CALM2, ADCY7, YWHAQ, PPP2R5C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
Q8NFZ4	NLGN2	Neuroligin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723

Deoxycholic-acid

Ubiquitin mediated proteolysis

2.57E-02

Q14145, Q13042, Q93034, Q15751

KEAP1, CDC16, CUL5, HERC1

Deoxycholic-acid

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Deoxycholic-acid

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.833
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.786
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q13510	ASAH1	Acid ceramidase	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P07602	PSAP	Prosaposin	0.757
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.705
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q04900	CD164	Sialomucin core protein 24	0.718
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9Y227	ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813

Deoxycholic-acid

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
Q8NFZ4	NLGN2	Neuroligin-2	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.773
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.792
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
Q8NFZ4	NLGN2	Neuroligin-2	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.713
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.783
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P62491	RAB11A	Ras-related protein Rab-11A	0.816
Q8NFZ4	NLGN2	Neuroligin-2	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.711
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
Q8NFZ4	NLGN2	Neuroligin-2	Q15438	PSCD1	Cytohesin-1	0.782
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q15438	PSCD1	Cytohesin-1	0.794
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
Q8NFZ4	NLGN2	Neuroligin-2	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.715
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.833
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q96QK1	VPS35	Vacuolar protein sorting-associated protein 35	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9UMY4	SNX12	Sorting nexin-12	0.764
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9UNH7	SNX6	Sorting nexin-6	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835

Deoxycholic-acid

Phagosome

3.94E-02

P60709, Q15075, Q15080, P14598, Q13509, Q13488

ACTB, EEA1, NCF4, NCF1, TUBB3, TCIRG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Deoxycholic-acid

PI3K-Akt signaling pathway

5.39E-05

P42338, P48023, P04637, Q9NRA1, P49767, P08238, P63218, P50151, O15335, P14784, Q96BR1

PIK3CB, FASLG, TP53, PDGFC, VEGFC, HSP90AB1, GNG5, GNG10, CHAD, IL2RB, SGK3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766

Deoxycholic-acid

Longevity regulating pathway - multiple species

2.82E-02

Q08828, P51828, P0DMV8

ADCY1, ADCY7, HSPA1A

Deoxycholic-acid

Adrenergic signaling in cardiomyocytes

1.06E-02

P51828, Q13362, P0DP24, P23634

ADCY7, PPP2R5C, CALM2, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
Q8NFZ4	NLGN2	Neuroligin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723

Deoxycholic-acid

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705

Deoxycholic-acid

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Deoxycholic-acid

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Deoxycholic-acid

VEGF signaling pathway

1.56E-02

P19174, P42338

PLCG1, PIK3CB

Deoxycholic-acid

Apelin signaling pathway

1.56E-03

P63218, P50151, Q13370, Q14344, Q13485, Q16566, P0DP23

GNG5, GNG10, PDE3B, GNA13, SMAD4, CAMK4, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804

Deoxycholic-acid

Osteoclast differentiation

3.37E-03

P09603, P06239, P42338, P14778, O75015, P01375, Q8N149, P78324

CSF1, LCK, PIK3CB, IL1R1, FCGR3B, TNF, LILRA2, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737

Deoxycholic-acid

Focal adhesion

1.55E-02

P42338, O15335, Q9NRA1, P49767, Q92529

PIK3CB, CHAD, PDGFC, VEGFC, SHC3

Deoxycholic-acid

Tight junction

2.08E-02

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Deoxycholic-acid

Complement and coagulation cascades

4.48E-02

P01042, P09871, P11215

KNG1, C1S, ITGAM

Deoxycholic-acid

Platelet activation

4.11E-02

P42338, Q14344, P07948

PIK3CB, GNA13, LYN

Deoxycholic-acid

Antigen processing and presentation

9.19E-04

P26715, P26717, Q07444, Q13241, O43908, P01732, P30511, P01375

KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, HLA-F, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844

Deoxycholic-acid

NOD-like receptor signaling pathway

3.24E-02

P52630, P10599, P01375, P12838

STAT2, TXN, TNF, DEFA4

Deoxycholic-acid

hsa04622

RIG-I-like receptor signaling pathway

3.49E-02

P01568, P25963, Q9H1Y0, Q13546

IFNA21, NFKBIA, ATG5, RIPK1

Deoxycholic-acid

Cytosolic DNA-sensing pathway

1.61E-04

P01584, P01568, Q13546, P25963, Q8NHW4

IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2

Deoxycholic-acid

C-type lectin receptor signaling pathway

2.38E-03

Q9ULY5, P52630, P20749, P01375, Q13191, P42338

CLEC4E, STAT2, BCL3, TNF, CBLB, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714

Deoxycholic-acid

Natural killer cell mediated cytotoxicity

2.91E-06

P01375, P06239, O60880, P20963, P42338, P48023, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715

TNF, LCK, SH2D1A, CD247, PIK3CB, FASLG, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
P11766	ADH5	Alcohol dehydrogenase class-3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.71
P11766	ADH5	Alcohol dehydrogenase class-3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.833
P11766	ADH5	Alcohol dehydrogenase class-3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.737
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.767
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.818
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.724
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Deoxycholic-acid

IL-17 signaling pathway

3.06E-02

P49841, P80188, P01375

GSK3B, LCN2, TNF

Deoxycholic-acid

Th1 and Th2 cell differentiation

2.70E-06

Q04759, P07766, P20963, P09693, P19174, P06239, P23771, Q9UL17, P14784, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, GATA3, TBX21, IL2RB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13761	RUNX3	Runt-related transcription factor 3	0.73
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738

Deoxycholic-acid

Th17 cell differentiation

1.53E-04

Q04759, P19174, P06239, P14784, Q9UL17, P23771, P08238, P07766, P09693, P20963

PRKCQ, PLCG1, LCK, IL2RB, TBX21, GATA3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Deoxycholic-acid

T cell receptor signaling pathway

2.51E-05

P01375, Q04759, P42338, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.752
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Deoxycholic-acid

B cell receptor signaling pathway

1.32E-03

P49841, P42338, P60033, P07948, Q8N149

GSK3B, PIK3CB, CD81, LYN, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78

Deoxycholic-acid

Fc epsilon RI signaling pathway

6.90E-05

P01375, P42338, P07948, P19174, P09917

TNF, PIK3CB, LYN, PLCG1, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83

Deoxycholic-acid

Fc gamma R-mediated phagocytosis

1.73E-02

P07948, P42338, P19174

LYN, PIK3CB, PLCG1

Deoxycholic-acid

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Deoxycholic-acid

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Deoxycholic-acid

Long-term potentiation

1.79E-02

Q16566, P0DP23, O15399

CAMK4, CALM1, GRIN2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745

Deoxycholic-acid

Neurotrophin signaling pathway

3.92E-03

P42338, P19174, Q92529, P48023, P04637

PIK3CB, PLCG1, SHC3, FASLG, TP53

Deoxycholic-acid

Glutamatergic synapse

2.04E-03

O15399, P63218, P50151, P15104, Q9NSB8

GRIN2D, GNG5, GNG10, GLUL, HOMER2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808

Deoxycholic-acid

Cholinergic synapse

1.73E-02

P63218, P50151, P42338

GNG5, GNG10, PIK3CB

Deoxycholic-acid

Serotonergic synapse

3.41E-02

P63218, P50151, P09917

GNG5, GNG10, ALOX5

Deoxycholic-acid

GABAergic synapse

6.57E-03

P63218, P50151, P15104

GNG5, GNG10, GLUL

Deoxycholic-acid

Long-term depression

1.56E-02

Q14344, P07948

GNA13, LYN

Deoxycholic-acid

hsa04744

Phototransduction

2.31E-02

P62873, P0DP23

GNB1, CALM1

Deoxycholic-acid

Inflammatory mediator regulation of TRP channels

4.01E-02

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Deoxycholic-acid

Insulin signaling pathway

4.11E-02

Q92529, Q13370, P42338

SHC3, PDE3B, PIK3CB

Deoxycholic-acid

Progesterone-mediated oocyte maturation

2.22E-02

P42338, Q13370, P08238

PIK3CB, PDE3B, HSP90AB1

Deoxycholic-acid

Estrogen signaling pathway

3.80E-04

Q08828, P51828, P42338, Q92529, P08238, P0DMV8, P11142, P0DP23, Q15788

ADCY1, ADCY7, PIK3CB, SHC3, HSP90AB1, HSPA1A, HSPA8, CALM1, NCOA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86

Deoxycholic-acid

hsa04916

Melanogenesis

3.49E-02

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Deoxycholic-acid

Adipocytokine signaling pathway

2.62E-03

Q06124, Q9Y478, Q96RR4

PTPN11, PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737

Deoxycholic-acid

Regulation of lipolysis in adipocytes

3.64E-02

Q13370, P42338

PDE3B, PIK3CB

Deoxycholic-acid

Aldosterone synthesis and secretion

1.40E-03

P51828, P0DP24, P0DP23, Q16566, P23634

ADCY7, CALM2, CALM1, CAMK4, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862

Deoxycholic-acid

Relaxin signaling pathway

1.31E-03

P42338, P63218, P50151, P49767, Q92529

PIK3CB, GNG5, GNG10, VEGFC, SHC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785

Deoxycholic-acid

Non-alcoholic fatty liver disease

1.39E-02

O43521, O75460, P01584, P13073, P12074, O95298

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83

Deoxycholic-acid

AGE-RAGE signaling pathway in diabetic complications

4.11E-02

P42338, P49767, P19174

PIK3CB, VEGFC, PLCG1

Deoxycholic-acid

Growth hormone synthesis, secretion and action

2.78E-02

P19174, P42338, Q92529

PLCG1, PIK3CB, SHC3

Deoxycholic-acid

Type I diabetes mellitus

1.58E-02

P30511, P01375

HLA-F, TNF

Deoxycholic-acid

Endocrine and other factor-regulated calcium reabsorption

2.09E-02

P23634, P62491

ATP2B4, RAB11A

Deoxycholic-acid

Salivary secretion

6.83E-04

Q08828, P51828, P23634, P0DP24, P0DP23

ADCY1, ADCY7, ATP2B4, CALM2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822

Deoxycholic-acid

Pancreatic secretion

4.94E-03

P23634, P51828, P62491

ATP2B4, ADCY7, RAB11A

Deoxycholic-acid

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Deoxycholic-acid

Bile secretion

4.78E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Deoxycholic-acid

Alzheimer disease

3.75E-02

P01375, Q9NZJ5, Q13564, P49841, Q92837, P09603, P42338, P21796

TNF, EIF2AK3, APPBP1, GSK3B, FRAT1, CSF1, PIK3CB, VDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.797
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15169	AXIN1	Axin-1	0.737
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P67870	CSNK2B	Casein kinase II subunit beta	0.784
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P28070	PSMB4	Proteasome subunit beta type-4	0.814
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78

Deoxycholic-acid

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.714
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.777
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.705
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.714
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.721
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.786
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.805
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.77
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P28070	PSMB4	Proteasome subunit beta type-4	0.814
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P28070	PSMB4	Proteasome subunit beta type-4	0.841
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.773
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703

Deoxycholic-acid

Morphine addiction

2.22E-02

P63218, P50151, Q13370

GNG5, GNG10, PDE3B

Deoxycholic-acid

Alcoholism

1.05E-02

O15399, Q16566, P0DP23, P63218, O60814, P68431

GRIN2D, CAMK4, CALM1, GNG5, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
Q8NFZ4	NLGN2	Neuroligin-2	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736

Deoxycholic-acid

Bacterial invasion of epithelial cells

3.64E-02

P42338, Q92529

PIK3CB, SHC3

Deoxycholic-acid

Vibrio cholerae infection

4.50E-03

Q13488, P17252, P19174, P60709

TCIRG1, PRKCA, PLCG1, ACTB

Deoxycholic-acid

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Deoxycholic-acid

hsa05132

Salmonella infection

3.43E-04

P25963, Q9UJU2, Q13546, Q13489, P10415, P04406, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P49754

NFKBIA, LEF1, RIPK1, BIRC3, BCL2, GAPDH, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, VPS41

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.77
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.837
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.711
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O75369	FLNB	Filamin-B	-0.863
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P51808	DYNLT3	Dynein light chain Tctex-type 3	0.705
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13561	DCTN2	Dynactin subunit 2	-0.818
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13509	TUBB3	Tubulin beta-3 chain	-0.815
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	-0.744

Deoxycholic-acid

Pertussis

1.70E-03

P11215, P0DP23, P23528, P09871

ITGAM, CALM1, CFL1, C1S

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P10145	IL8	Interleukin-8	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P00918	CA2	Carbonic anhydrase 2	P0C0L4	C4A	Complement C4-A	0.774
P00918	CA2	Carbonic anhydrase 2	P0C0L4	C4A	Complement C4-A	0.774
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P10145	IL8	Interleukin-8	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703

Deoxycholic-acid

Legionellosis

2.82E-02

P01584, Q9NR31, P0DMV8

IL1B, SAR1A, HSPA1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P01584	IL1B	Interleukin-1 beta	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753

Deoxycholic-acid

Yersinia infection

4.00E-02

P13612, P06239, P01375, P42338, P49841

ITGA4, LCK, TNF, PIK3CB, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Deoxycholic-acid

Leishmaniasis

4.75E-02

P14598, P42224, P25963, P29350, Q15080

NCF1, STAT1, NFKBIA, PTPN6, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752

Deoxycholic-acid

hsa05146

Amoebiasis

2.73E-02

P09341, P05089, P12814, P08311

CXCL1, ARG1, ACTN1, CTSG

Deoxycholic-acid

hsa05152

Tuberculosis

1.14E-02

Q13488, Q15075, P0DP23, P48382, O60603, P10415, P01568, Q9UDY8

TCIRG1, EEA1, CALM1, RFX5, TLR2, BCL2, IFNA21, MALT1

Deoxycholic-acid

Hepatitis C

9.39E-04

P52630, P60033, P49841, P04637, P01375, P48023

STAT2, CD81, GSK3B, TP53, TNF, FASLG

Deoxycholic-acid

Measles

5.79E-03

P23458, P14784, P07766, P42338, P0DMV8, P11142, P01584, Q9NP90

JAK1, IL2RB, CD3E, PIK3CB, HSPA1A, HSPA8, IL1B, RAB9B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759

Deoxycholic-acid

Human cytomegalovirus infection

1.23E-06

P42338, P01375, P30511, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, O00463, P30101

PIK3CB, TNF, HLA-F, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, TRAF5, PDIA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708

Deoxycholic-acid

hsa05164

Influenza A

3.48E-02

Q9GZY0, P48023

NXF2; NXF2B, FASLG

Deoxycholic-acid

Human papillomavirus infection

1.76E-02

P49841, P24821, P01375, P52630, P30511

GSK3B, TNC, TNF, STAT2, HLA-F

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836

Deoxycholic-acid

Kaposi sarcoma-associated herpesvirus infection

1.14E-02

P42338, P63218, P50151, P19174, P07948

PIK3CB, GNG5, GNG10, PLCG1, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804

Deoxycholic-acid

hsa05168

Herpes simplex virus 1 infection

2.26E-03

O60603, P25963, P01568, P04637, Q9GZY0, Q07955, P48023, Q13489, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, O75820, P98182, P10415

TLR2, NFKBIA, IFNA21, TP53, NXF2; NXF2B, SFRS1, FASLG, BIRC3, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF189, ZNF200, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P01568	IFNA21	Interferon alpha-21	0.828
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	-0.759
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.82
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.837
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13398	ZNF211	Zinc finger protein 211	-0.711
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P51522	ZNF83	Zinc finger protein 83	0.737
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9NR11	ZNF302	Zinc finger protein 302	0.808
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9HCX3	ZNF304	Zinc finger protein 304	0.701
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P17097	ZNF7	Zinc finger protein 7	0.744
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q03923	ZNF85	Zinc finger protein 85	0.705
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O75820	ZNF189	Zinc finger protein 189	0.753
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P98182	ZNF200	Zinc finger protein 200	0.747
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849

Deoxycholic-acid

Epstein-Barr virus infection

8.75E-04

Q13547, O00463, P42338, P07948, P30511, P30101, Q13761, P01375, P07766, P20963

HDAC1, TRAF5, PIK3CB, LYN, HLA-F, PDIA3, RUNX3, TNF, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77

Deoxycholic-acid

Human immunodeficiency virus 1 infection

6.50E-05

P42338, P30511, P62873, P63218, P50151, P0DP23, P01375, P17252, Q13546, O00463, P30101, P01568, P25963, O60603, P19174, P07766, P20963, P10415, Q13619, Q9Y6Q5

PIK3CB, HLA-F, GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, RIPK1, TRAF5, PDIA3, IFNA21, NFKBIA, TLR2, PLCG1, CD3E, CD247, BCL2, CUL4A, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.767
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P0DP23	CALM1	Calmodulin-1	-0.816
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P17252	PRKCA	Protein kinase C alpha type	0.74
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P01568	IFNA21	Interferon alpha-21	0.828
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13619	CUL4A	Cullin-4A	0.706
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.889
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77

Deoxycholic-acid

hsa05171

Coronavirus disease - COVID-19

3.87E-04

P62249, P40429, P27635, Q07020, P05386

RPS16, RPL13A, RPL10, RPL18, RPLP1

Deoxycholic-acid

Pathways in cancer

3.05E-02

P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784

PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766

Deoxycholic-acid

Viral carcinogenesis

4.62E-02

Q12933, P42229, Q15283

TRAF2, STAT5A, RASA2

Deoxycholic-acid

Chemical carcinogenesis

6.91E-05

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P09211	GSTP1	Glutathione S-transferase P	P09211	GSTP1	Glutathione S-transferase P	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806

Deoxycholic-acid

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Deoxycholic-acid

Glioma

9.49E-03

Q92529, P42338, P19174

SHC3, PIK3CB, PLCG1

Deoxycholic-acid

Prostate cancer

4.87E-02

Q9NRA1, P08238, P42338

PDGFC, HSP90AB1, PIK3CB

Deoxycholic-acid

Melanoma

3.64E-02

Q9NRA1, P42338

PDGFC, PIK3CB

Deoxycholic-acid

hsa05219

Bladder cancer

4.51E-02

P04637

TP53

Deoxycholic-acid

hsa05222

Small cell lung cancer

2.41E-02

P10826, Q13489, P10415, P25963, Q13077, O75293

RARB, BIRC3, BCL2, NFKBIA, TRAF1, GADD45B

Deoxycholic-acid

Non-small cell lung cancer

3.99E-02

P17252, O43524, P19174, O75293

PRKCA, FOXO3, PLCG1, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717

Deoxycholic-acid

hsa05230

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Deoxycholic-acid

Choline metabolism in cancer

3.04E-04

P42338, Q9NRA1, P19174, P23743, O14494, P17252

PIK3CB, PDGFC, PLCG1, DGKA, PLPP1, PRKCA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754

Deoxycholic-acid

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.88E-03

O95267, P20963, P09693, P06239, Q04759

RASGRP1, CD247, CD3G, LCK, PRKCQ

Deoxycholic-acid

Asthma

9.71E-03

P12724, P01375

RNASE3, TNF

Deoxycholic-acid

hsa05322

Systemic lupus erythematosus

1.57E-02

P08311, P62807, Q16778, P12814

CTSG, HIST1H2BC, HIST2H2BE, ACTN1

Deoxycholic-acid

Allograft rejection

2.30E-02

P30511, P01375

HLA-F, TNF

Deoxycholic-acid

Graft-versus-host disease

3.14E-02

P30511, P01375

HLA-F, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Deoxycholic-acid

Diabetic cardiomyopathy

3.33E-02

P17252, P14598, Q15080, Q16718, O14521, P04406, P11413

PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH, G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.712
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Deoxycholic-acid

Fluid shear stress and atherosclerosis

4.52E-03

P42338, Q14145, P10599, P01375, P14778, P27930

PIK3CB, KEAP1, TXN, TNF, IL1R1, IL1R2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q14145	KEAP1	Kelch-like ECH-associated protein 1	Q14145	KEAP1	Kelch-like ECH-associated protein 1	1
P60033	CD81	CD81 antigen	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.8
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P60033	CD81	CD81 antigen	P10599	TXN	Thioredoxin	-0.87
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q14145	KEAP1	Kelch-like ECH-associated protein 1	Q14145	KEAP1	Kelch-like ECH-associated protein 1	1
P60033	CD81	CD81 antigen	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.8
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P60033	CD81	CD81 antigen	P10599	TXN	Thioredoxin	-0.87
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q14145	KEAP1	Kelch-like ECH-associated protein 1	Q14145	KEAP1	Kelch-like ECH-associated protein 1	1
P60033	CD81	CD81 antigen	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.8
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P60033	CD81	CD81 antigen	P10599	TXN	Thioredoxin	-0.87
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q14145	KEAP1	Kelch-like ECH-associated protein 1	Q14145	KEAP1	Kelch-like ECH-associated protein 1	1
P60033	CD81	CD81 antigen	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.8
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P60033	CD81	CD81 antigen	P10599	TXN	Thioredoxin	-0.87
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779

Obeticholic-acid

Pentose phosphate pathway

1.69E-02

P60891, P37837

PRPS1, TALDO1

Obeticholic-acid

Oxidative phosphorylation

2.21E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P15954	COX7C	Cytochrome c oxidase subunit 7C, mitochondrial	P15954	COX7C	Cytochrome c oxidase subunit 7C, mitochondrial	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.734
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.726
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.793
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931

Obeticholic-acid

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Obeticholic-acid

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Obeticholic-acid

Valine, leucine and isoleucine degradation

1.67E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	0.704
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	0.728
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878

Obeticholic-acid

Arginine and proline metabolism

4.86E-02

P17707

AMD1

Obeticholic-acid

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Obeticholic-acid

Glycerolipid metabolism

1.37E-03

O14494, P51648, P06280, P23743

PLPP1, ALDH3A2, GLA, DGKA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
Q16772	GSTA3	Glutathione S-transferase A3	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	-0.793
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
Q16772	GSTA3	Glutathione S-transferase A3	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	-0.706
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814

Obeticholic-acid

Inositol phosphate metabolism

7.30E-04

P27987, Q96PE3, P19174, P42338

ITPKB, INPP4A, PLCG1, PIK3CB

Obeticholic-acid

Sphingolipid metabolism

3.96E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Obeticholic-acid

Pyruvate metabolism

2.51E-02

P40925, P51648

MDH1, ALDH3A2

Obeticholic-acid

Glyoxylate and dicarboxylate metabolism

2.78E-03

P40925, P15104

MDH1, GLUL

Obeticholic-acid

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Obeticholic-acid

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Obeticholic-acid

Metabolism of xenobiotics by cytochrome P450

4.08E-04

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P09211	GSTP1	Glutathione S-transferase P	P09211	GSTP1	Glutathione S-transferase P	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806

Obeticholic-acid

Drug metabolism - cytochrome P450

7.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Obeticholic-acid

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Obeticholic-acid

Metabolic pathways

1.44E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P40926, Q7KZN9, P15121, P23743, Q9UHK6, P43034, Q86VZ5, P09917, Q53FZ2, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, MDH2, COX15, AKR1B1, DGKA, AMACR, PAFAH1B1, SGMS1, ALOX5, ACSM3, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16772	GSTA3	Glutathione S-transferase A3	P35790	CHKA	Choline kinase alpha	0.74
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
Q16772	GSTA3	Glutathione S-transferase A3	Q16772	GSTA3	Glutathione S-transferase A3	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16772	GSTA3	Glutathione S-transferase A3	P30041	PRDX6	Peroxiredoxin-6	-0.788
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
Q16772	GSTA3	Glutathione S-transferase A3	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	-0.768
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16772	GSTA3	Glutathione S-transferase A3	O94777	DPM2	Dolichol phosphate-mannose biosynthesis regulatory protein	-0.723
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16772	GSTA3	Glutathione S-transferase A3	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	-0.793
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
Q16772	GSTA3	Glutathione S-transferase A3	O95861	BPNT1	3'(2'),5'-bisphosphate nucleotidase 1	0.7
Q16772	GSTA3	Glutathione S-transferase A3	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	-0.706
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
Q16772	GSTA3	Glutathione S-transferase A3	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	0.787
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16772	GSTA3	Glutathione S-transferase A3	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.907
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
Q16772	GSTA3	Glutathione S-transferase A3	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Obeticholic-acid

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Obeticholic-acid

hsa01230

Biosynthesis of amino acids

3.59E-02

P60891, Q99707, P37837

PRPS1, MTR, TALDO1

Obeticholic-acid

EGFR tyrosine kinase inhibitor resistance

7.30E-04

Q92529, P19174, P42338, Q9NRA1

SHC3, PLCG1, PIK3CB, PDGFC

Obeticholic-acid

Platinum drug resistance

3.80E-03

O15392, Q16772, P09211, P11388

BIRC5, GSTA3, GSTP1, TOP2A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816

Obeticholic-acid

hsa03008

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Obeticholic-acid

RNA transport

2.35E-05

O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5

XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3

Obeticholic-acid

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Obeticholic-acid

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Obeticholic-acid

Spliceosome

1.27E-02

O43143, P08579, Q13595, Q07955, P84103, P11142

DHX15, SNRPB2, TRA2A, SFRS1, SFRS3, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715

Obeticholic-acid

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Obeticholic-acid

ErbB signaling pathway

9.49E-03

Q92529, P19174, P42338

SHC3, PLCG1, PIK3CB

Obeticholic-acid

Ras signaling pathway

6.70E-05

P42338, Q92529, P20827, Q9NRA1, P49767, Q14644, P0DP23, P63218, P50151, P19174

PIK3CB, SHC3, EFNA1, PDGFC, VEGFC, RASA3, CALM1, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
Q8NFZ4	NLGN2	Neuroligin-2	Q15311	RALBP1	RalA-binding protein 1	0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787

Obeticholic-acid

Rap1 signaling pathway

3.91E-02

Q9NRA1, P49767, P42338, P19174

PDGFC, VEGFC, PIK3CB, PLCG1

Obeticholic-acid

Calcium signaling pathway

2.74E-05

P27987, Q16566, P30679, O15399, P19174, P0DP24, P0DP23, P51828, P23634, Q9NRA1, P49767

ITPKB, CAMK4, GNA15, GRIN2D, PLCG1, CALM2, CALM1, ADCY7, ATP2B4, PDGFC, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821

Obeticholic-acid

cAMP signaling pathway

3.79E-02

P51828, P0DP24, P23634

ADCY7, CALM2, ATP2B4

Obeticholic-acid

Chemokine signaling pathway

2.13E-04

P25024, P25025, P07948, P42338, P19174, Q92529, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10, ARRB1, ITK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Obeticholic-acid

NF-kappa B signaling pathway

2.35E-02

P01584, P63279, Q8NHW4, Q9NQC7

IL1B, UBE2I, CCL4L2, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Obeticholic-acid

Phosphatidylinositol signaling system

3.19E-04

P19174, P42338, P23743, Q96PE3, P27987

PLCG1, PIK3CB, DGKA, INPP4A, ITPKB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835

Obeticholic-acid

Sphingolipid signaling pathway

2.14E-02

Q13510, Q13362, Q9UQC2

ASAH1, PPP2R5C, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707

Obeticholic-acid

Phospholipase D signaling pathway

3.21E-05

P42338, Q92529, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1, Q9GZP0

PIK3CB, SHC3, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFC, PDGFD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713

Obeticholic-acid

Oocyte meiosis

8.69E-03

P0DP24, P51828, P27348, Q13362

CALM2, ADCY7, YWHAQ, PPP2R5C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
Q8NFZ4	NLGN2	Neuroligin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723

Obeticholic-acid

Ubiquitin mediated proteolysis

2.57E-02

Q14145, Q13042, Q93034, Q15751

KEAP1, CDC16, CUL5, HERC1

Obeticholic-acid

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Obeticholic-acid

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Obeticholic-acid

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.833
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.786
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q13510	ASAH1	Acid ceramidase	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P07602	PSAP	Prosaposin	0.757
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.705
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q04900	CD164	Sialomucin core protein 24	0.718
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9Y227	ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813

Obeticholic-acid

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
Q8NFZ4	NLGN2	Neuroligin-2	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.773
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.792
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
Q8NFZ4	NLGN2	Neuroligin-2	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.713
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.783
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P62491	RAB11A	Ras-related protein Rab-11A	0.816
Q8NFZ4	NLGN2	Neuroligin-2	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.711
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
Q8NFZ4	NLGN2	Neuroligin-2	Q15438	PSCD1	Cytohesin-1	0.782
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q15438	PSCD1	Cytohesin-1	0.794
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
Q8NFZ4	NLGN2	Neuroligin-2	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.715
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.833
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q96QK1	VPS35	Vacuolar protein sorting-associated protein 35	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9UMY4	SNX12	Sorting nexin-12	0.764
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9UNH7	SNX6	Sorting nexin-6	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835

Obeticholic-acid

Phagosome

3.94E-02

P60709, Q15075, Q15080, P14598, Q13509, Q13488

ACTB, EEA1, NCF4, NCF1, TUBB3, TCIRG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Obeticholic-acid

PI3K-Akt signaling pathway

2.55E-03

P42338, Q9NRA1, P49767, P08238, P63218, P50151, O15335, P14784

PIK3CB, PDGFC, VEGFC, HSP90AB1, GNG5, GNG10, CHAD, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766

Obeticholic-acid

Longevity regulating pathway - multiple species

2.82E-02

Q08828, P51828, P0DMV8

ADCY1, ADCY7, HSPA1A

Obeticholic-acid

Adrenergic signaling in cardiomyocytes

1.06E-02

P51828, Q13362, P0DP24, P23634

ADCY7, PPP2R5C, CALM2, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
Q8NFZ4	NLGN2	Neuroligin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723

Obeticholic-acid

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705

Obeticholic-acid

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Obeticholic-acid

VEGF signaling pathway

1.56E-02

P19174, P42338

PLCG1, PIK3CB

Obeticholic-acid

Apelin signaling pathway

1.56E-03

P63218, P50151, Q13370, Q14344, Q13485, Q16566, P0DP23

GNG5, GNG10, PDE3B, GNA13, SMAD4, CAMK4, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804

Obeticholic-acid

Osteoclast differentiation

3.37E-03

P09603, P06239, P42338, P14778, O75015, P01375, Q8N149, P78324

CSF1, LCK, PIK3CB, IL1R1, FCGR3B, TNF, LILRA2, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737

Obeticholic-acid

Focal adhesion

1.55E-02

P42338, O15335, Q9NRA1, P49767, Q92529

PIK3CB, CHAD, PDGFC, VEGFC, SHC3

Obeticholic-acid

Tight junction

2.08E-02

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Obeticholic-acid

Complement and coagulation cascades

4.48E-02

P01042, P09871, P11215

KNG1, C1S, ITGAM

Obeticholic-acid

Platelet activation

4.11E-02

P42338, Q14344, P07948

PIK3CB, GNA13, LYN

Obeticholic-acid

Antigen processing and presentation

4.12E-02

O43908, P30511, P01375

KLRC4, HLA-F, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844

Obeticholic-acid

NOD-like receptor signaling pathway

3.24E-02

P52630, P10599, P01375, P12838

STAT2, TXN, TNF, DEFA4

Obeticholic-acid

Cytosolic DNA-sensing pathway

1.65E-02

P01584, Q8NHW4

IL1B, CCL4L2

Obeticholic-acid

C-type lectin receptor signaling pathway

2.38E-03

Q9ULY5, P52630, P20749, P01375, Q13191, P42338

CLEC4E, STAT2, BCL3, TNF, CBLB, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714

Obeticholic-acid

Natural killer cell mediated cytotoxicity

1.79E-02

P01375, P06239, O60880, P20963, P42338, P26718, O75015

TNF, LCK, SH2D1A, CD247, PIK3CB, KLRK1, FCGR3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
P11766	ADH5	Alcohol dehydrogenase class-3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.71
P11766	ADH5	Alcohol dehydrogenase class-3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.833
P11766	ADH5	Alcohol dehydrogenase class-3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.737
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.767
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.818
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.724
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Obeticholic-acid

IL-17 signaling pathway

3.06E-02

P49841, P80188, P01375

GSK3B, LCN2, TNF

Obeticholic-acid

Th1 and Th2 cell differentiation

1.01E-02

P07766, P19174, P14784, Q13761

CD3E, PLCG1, IL2RB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13761	RUNX3	Runt-related transcription factor 3	0.73
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738

Obeticholic-acid

Th17 cell differentiation

2.16E-02

P19174, P14784, P08238, P07766

PLCG1, IL2RB, HSP90AB1, CD3E

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Obeticholic-acid

T cell receptor signaling pathway

6.23E-03

P01375, P42338, Q08881, P07766, P20963, Q13191, P06239, P49841

TNF, PIK3CB, ITK, CD3E, CD247, CBLB, LCK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.752
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Obeticholic-acid

B cell receptor signaling pathway

1.32E-03

P49841, P42338, P60033, P07948, Q8N149

GSK3B, PIK3CB, CD81, LYN, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78

Obeticholic-acid

Fc epsilon RI signaling pathway

6.90E-05

P01375, P42338, P07948, P19174, P09917

TNF, PIK3CB, LYN, PLCG1, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83

Obeticholic-acid

Fc gamma R-mediated phagocytosis

1.73E-02

P07948, P42338, P19174

LYN, PIK3CB, PLCG1

Obeticholic-acid

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Obeticholic-acid

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Obeticholic-acid

Long-term potentiation

1.79E-02

Q16566, P0DP23, O15399

CAMK4, CALM1, GRIN2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745

Obeticholic-acid

Neurotrophin signaling pathway

4.87E-02

P42338, P19174, Q92529

PIK3CB, PLCG1, SHC3

Obeticholic-acid

Glutamatergic synapse

2.04E-03

O15399, P63218, P50151, P15104, Q9NSB8

GRIN2D, GNG5, GNG10, GLUL, HOMER2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808

Obeticholic-acid

Cholinergic synapse

1.73E-02

P63218, P50151, P42338

GNG5, GNG10, PIK3CB

Obeticholic-acid

Serotonergic synapse

3.41E-02

P63218, P50151, P09917

GNG5, GNG10, ALOX5

Obeticholic-acid

GABAergic synapse

6.57E-03

P63218, P50151, P15104

GNG5, GNG10, GLUL

Obeticholic-acid

Long-term depression

1.56E-02

Q14344, P07948

GNA13, LYN

Obeticholic-acid

Inflammatory mediator regulation of TRP channels

4.01E-02

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Obeticholic-acid

Insulin signaling pathway

4.11E-02

Q92529, Q13370, P42338

SHC3, PDE3B, PIK3CB

Obeticholic-acid

Progesterone-mediated oocyte maturation

2.22E-02

P42338, Q13370, P08238

PIK3CB, PDE3B, HSP90AB1

Obeticholic-acid

Estrogen signaling pathway

3.80E-04

Q08828, P51828, P42338, Q92529, P08238, P0DMV8, P11142, P0DP23, Q15788

ADCY1, ADCY7, PIK3CB, SHC3, HSP90AB1, HSPA1A, HSPA8, CALM1, NCOA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86

Obeticholic-acid

Adipocytokine signaling pathway

2.62E-03

Q06124, Q9Y478, Q96RR4

PTPN11, PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737

Obeticholic-acid

Regulation of lipolysis in adipocytes

3.64E-02

Q13370, P42338

PDE3B, PIK3CB

Obeticholic-acid

Aldosterone synthesis and secretion

1.40E-03

P51828, P0DP24, P0DP23, Q16566, P23634

ADCY7, CALM2, CALM1, CAMK4, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862

Obeticholic-acid

Relaxin signaling pathway

1.31E-03

P42338, P63218, P50151, P49767, Q92529

PIK3CB, GNG5, GNG10, VEGFC, SHC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785

Obeticholic-acid

Non-alcoholic fatty liver disease

1.39E-02

O43521, O75460, P01584, P13073, P12074, O95298

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83

Obeticholic-acid

AGE-RAGE signaling pathway in diabetic complications

4.11E-02

P42338, P49767, P19174

PIK3CB, VEGFC, PLCG1

Obeticholic-acid

Growth hormone synthesis, secretion and action

2.78E-02

P19174, P42338, Q92529

PLCG1, PIK3CB, SHC3

Obeticholic-acid

Type I diabetes mellitus

1.58E-02

P30511, P01375

HLA-F, TNF

Obeticholic-acid

Endocrine and other factor-regulated calcium reabsorption

2.09E-02

P23634, P62491

ATP2B4, RAB11A

Obeticholic-acid

Salivary secretion

6.83E-04

Q08828, P51828, P23634, P0DP24, P0DP23

ADCY1, ADCY7, ATP2B4, CALM2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822

Obeticholic-acid

Pancreatic secretion

4.94E-03

P23634, P51828, P62491

ATP2B4, ADCY7, RAB11A

Obeticholic-acid

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Obeticholic-acid

Bile secretion

4.78E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Obeticholic-acid

Alzheimer disease

3.75E-02

P01375, Q9NZJ5, Q13564, P49841, Q92837, P09603, P42338, P21796

TNF, EIF2AK3, APPBP1, GSK3B, FRAT1, CSF1, PIK3CB, VDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.797
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15169	AXIN1	Axin-1	0.737
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P67870	CSNK2B	Casein kinase II subunit beta	0.784
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P28070	PSMB4	Proteasome subunit beta type-4	0.814
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78

Obeticholic-acid

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.714
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.777
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.705
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.714
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.721
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.786
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.805
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.77
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P28070	PSMB4	Proteasome subunit beta type-4	0.814
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P28070	PSMB4	Proteasome subunit beta type-4	0.841
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.773
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703

Obeticholic-acid

Morphine addiction

2.22E-02

P63218, P50151, Q13370

GNG5, GNG10, PDE3B

Obeticholic-acid

Alcoholism

1.05E-02

O15399, Q16566, P0DP23, P63218, O60814, P68431

GRIN2D, CAMK4, CALM1, GNG5, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
Q8NFZ4	NLGN2	Neuroligin-2	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736

Obeticholic-acid

Bacterial invasion of epithelial cells

3.64E-02

P42338, Q92529

PIK3CB, SHC3

Obeticholic-acid

Vibrio cholerae infection

4.50E-03

Q13488, P17252, P19174, P60709

TCIRG1, PRKCA, PLCG1, ACTB

Obeticholic-acid

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Obeticholic-acid

Pertussis

1.70E-03

P11215, P0DP23, P23528, P09871

ITGAM, CALM1, CFL1, C1S

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P10145	IL8	Interleukin-8	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P00918	CA2	Carbonic anhydrase 2	P0C0L4	C4A	Complement C4-A	0.774
P00918	CA2	Carbonic anhydrase 2	P0C0L4	C4A	Complement C4-A	0.774
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P10145	IL8	Interleukin-8	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703

Obeticholic-acid

Legionellosis

2.82E-02

P01584, Q9NR31, P0DMV8

IL1B, SAR1A, HSPA1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P01584	IL1B	Interleukin-1 beta	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753

Obeticholic-acid

Yersinia infection

4.00E-02

P13612, P06239, P01375, P42338, P49841

ITGA4, LCK, TNF, PIK3CB, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Obeticholic-acid

Leishmaniasis

4.75E-02

P14598, P42224, P25963, P29350, Q15080

NCF1, STAT1, NFKBIA, PTPN6, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752

Obeticholic-acid

Hepatitis C

9.27E-03

P52630, P60033, P49841, P01375

STAT2, CD81, GSK3B, TNF

Obeticholic-acid

Measles

5.79E-03

P23458, P14784, P07766, P42338, P0DMV8, P11142, P01584, Q9NP90

JAK1, IL2RB, CD3E, PIK3CB, HSPA1A, HSPA8, IL1B, RAB9B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759

Obeticholic-acid

Human cytomegalovirus infection

1.23E-06

P42338, P01375, P30511, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, O00463, P30101

PIK3CB, TNF, HLA-F, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, TRAF5, PDIA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708

Obeticholic-acid

Human papillomavirus infection

1.76E-02

P49841, P24821, P01375, P52630, P30511

GSK3B, TNC, TNF, STAT2, HLA-F

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836

Obeticholic-acid

Kaposi sarcoma-associated herpesvirus infection

1.14E-02

P42338, P63218, P50151, P19174, P07948

PIK3CB, GNG5, GNG10, PLCG1, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804

Obeticholic-acid

Epstein-Barr virus infection

8.75E-04

Q13547, O00463, P42338, P07948, P30511, P30101, Q13761, P01375, P07766, P20963

HDAC1, TRAF5, PIK3CB, LYN, HLA-F, PDIA3, RUNX3, TNF, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77

Obeticholic-acid

Human immunodeficiency virus 1 infection

6.31E-04

P42338, P30511, P63218, P50151, P01375, O00463, P30101, P19174, P07766, P20963

PIK3CB, HLA-F, GNG5, GNG10, TNF, TRAF5, PDIA3, PLCG1, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.767
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P0DP23	CALM1	Calmodulin-1	-0.816
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P17252	PRKCA	Protein kinase C alpha type	0.74
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P01568	IFNA21	Interferon alpha-21	0.828
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13619	CUL4A	Cullin-4A	0.706
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.889
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77

Obeticholic-acid

Pathways in cancer

3.05E-02

P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784

PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766

Obeticholic-acid

Viral carcinogenesis

4.62E-02

Q12933, P42229, Q15283

TRAF2, STAT5A, RASA2

Obeticholic-acid

Chemical carcinogenesis

7.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P09211	GSTP1	Glutathione S-transferase P	P09211	GSTP1	Glutathione S-transferase P	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806

Obeticholic-acid

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Obeticholic-acid

Glioma

9.49E-03

Q92529, P42338, P19174

SHC3, PIK3CB, PLCG1

Obeticholic-acid

Prostate cancer

4.87E-02

Q9NRA1, P08238, P42338

PDGFC, HSP90AB1, PIK3CB

Obeticholic-acid

Melanoma

3.64E-02

Q9NRA1, P42338

PDGFC, PIK3CB

Obeticholic-acid

Non-small cell lung cancer

3.99E-02

P17252, O43524, P19174, O75293

PRKCA, FOXO3, PLCG1, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717

Obeticholic-acid

Choline metabolism in cancer

3.04E-04

P42338, Q9NRA1, P19174, P23743, O14494, P17252

PIK3CB, PDGFC, PLCG1, DGKA, PLPP1, PRKCA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754

Obeticholic-acid

Asthma

9.71E-03

P12724, P01375

RNASE3, TNF

Obeticholic-acid

Allograft rejection

2.30E-02

P30511, P01375

HLA-F, TNF

Obeticholic-acid

Graft-versus-host disease

3.14E-02

P30511, P01375

HLA-F, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Obeticholic-acid

Diabetic cardiomyopathy

3.94E-02

P17252, P14598, Q15080, Q16718, O14521, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.712
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Obeticholic-acid

Fluid shear stress and atherosclerosis

4.52E-03

P42338, Q14145, P10599, P01375, P14778, P27930

PIK3CB, KEAP1, TXN, TNF, IL1R1, IL1R2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q14145	KEAP1	Kelch-like ECH-associated protein 1	Q14145	KEAP1	Kelch-like ECH-associated protein 1	1
P60033	CD81	CD81 antigen	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.8
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P60033	CD81	CD81 antigen	P10599	TXN	Thioredoxin	-0.87
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q14145	KEAP1	Kelch-like ECH-associated protein 1	Q14145	KEAP1	Kelch-like ECH-associated protein 1	1
P60033	CD81	CD81 antigen	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.8
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P60033	CD81	CD81 antigen	P10599	TXN	Thioredoxin	-0.87
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q14145	KEAP1	Kelch-like ECH-associated protein 1	Q14145	KEAP1	Kelch-like ECH-associated protein 1	1
P60033	CD81	CD81 antigen	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.8
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P60033	CD81	CD81 antigen	P10599	TXN	Thioredoxin	-0.87
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q14145	KEAP1	Kelch-like ECH-associated protein 1	Q14145	KEAP1	Kelch-like ECH-associated protein 1	1
P60033	CD81	CD81 antigen	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.8
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P60033	CD81	CD81 antigen	P10599	TXN	Thioredoxin	-0.87
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779

Taurocholic-acid

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Taurocholic-acid

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Taurocholic-acid

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816

Taurocholic-acid

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Taurocholic-acid

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Taurocholic-acid

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Taurocholic-acid

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Taurocholic-acid

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737

Taurocholic-acid

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Taurocholic-acid

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Taurocholic-acid

Pertussis

4.20E-02

P0C0L4

C4A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P10145	IL8	Interleukin-8	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P00918	CA2	Carbonic anhydrase 2	P0C0L4	C4A	Complement C4-A	0.774
P00918	CA2	Carbonic anhydrase 2	P0C0L4	C4A	Complement C4-A	0.774
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P10145	IL8	Interleukin-8	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703

Taurocholic-acid

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Taurocholic-acid

hsa05144

Malaria

3.09E-02

P69905, P68871

HBA2, HBB

Taurocholic-acid

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Ursodeoxycholic-acid

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Ursodeoxycholic-acid

Oxidative phosphorylation

2.21E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P15954	COX7C	Cytochrome c oxidase subunit 7C, mitochondrial	P15954	COX7C	Cytochrome c oxidase subunit 7C, mitochondrial	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.734
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.726
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.793
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931

Ursodeoxycholic-acid

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Ursodeoxycholic-acid

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Ursodeoxycholic-acid

Valine, leucine and isoleucine degradation

1.67E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	0.704
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	0.728
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.729
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	-0.792
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	-0.878

Ursodeoxycholic-acid

Arginine and proline metabolism

4.86E-02

P17707

AMD1

Ursodeoxycholic-acid

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Ursodeoxycholic-acid

Glycerolipid metabolism

1.37E-03

O14494, P51648, P06280, P23743

PLPP1, ALDH3A2, GLA, DGKA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
Q16772	GSTA3	Glutathione S-transferase A3	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	-0.793
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
Q16772	GSTA3	Glutathione S-transferase A3	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	-0.706
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P06280	GLA	Alpha-galactosidase A	0.748
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814

Ursodeoxycholic-acid

Inositol phosphate metabolism

7.30E-04

P27987, Q96PE3, P19174, P42338

ITPKB, INPP4A, PLCG1, PIK3CB

Ursodeoxycholic-acid

Sphingolipid metabolism

3.96E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Ursodeoxycholic-acid

Pyruvate metabolism

1.58E-03

P40925, P40926, P51648, P14550

MDH1, MDH2, ALDH3A2, AKR1A1

Ursodeoxycholic-acid

Glyoxylate and dicarboxylate metabolism

2.78E-03

P40925, P15104

MDH1, GLUL

Ursodeoxycholic-acid

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Ursodeoxycholic-acid

Metabolism of xenobiotics by cytochrome P450

4.08E-04

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P09211	GSTP1	Glutathione S-transferase P	P09211	GSTP1	Glutathione S-transferase P	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806

Ursodeoxycholic-acid

Drug metabolism - cytochrome P450

7.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Ursodeoxycholic-acid

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Ursodeoxycholic-acid

Metabolic pathways

1.44E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P40926, Q7KZN9, P15121, P23743, Q9UHK6, P43034, Q86VZ5, P09917, Q53FZ2, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, MDH2, COX15, AKR1B1, DGKA, AMACR, PAFAH1B1, SGMS1, ALOX5, ACSM3, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16772	GSTA3	Glutathione S-transferase A3	P35790	CHKA	Choline kinase alpha	0.74
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
Q16772	GSTA3	Glutathione S-transferase A3	Q16772	GSTA3	Glutathione S-transferase A3	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16772	GSTA3	Glutathione S-transferase A3	P30041	PRDX6	Peroxiredoxin-6	-0.788
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
Q16772	GSTA3	Glutathione S-transferase A3	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	-0.768
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16772	GSTA3	Glutathione S-transferase A3	O94777	DPM2	Dolichol phosphate-mannose biosynthesis regulatory protein	-0.723
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16772	GSTA3	Glutathione S-transferase A3	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	-0.793
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
Q16772	GSTA3	Glutathione S-transferase A3	O95861	BPNT1	3'(2'),5'-bisphosphate nucleotidase 1	0.7
Q16772	GSTA3	Glutathione S-transferase A3	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	-0.706
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
Q16772	GSTA3	Glutathione S-transferase A3	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	0.787
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16772	GSTA3	Glutathione S-transferase A3	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.907
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
Q16772	GSTA3	Glutathione S-transferase A3	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Ursodeoxycholic-acid

hsa01200

Carbon metabolism

2.91E-02

P11413

G6PD

Ursodeoxycholic-acid

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Ursodeoxycholic-acid

EGFR tyrosine kinase inhibitor resistance

7.30E-04

Q92529, P19174, P42338, Q9NRA1

SHC3, PLCG1, PIK3CB, PDGFC

Ursodeoxycholic-acid

Platinum drug resistance

3.80E-03

O15392, Q16772, P09211, P11388

BIRC5, GSTA3, GSTP1, TOP2A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816
Q13133	NR1H3	Oxysterols receptor LXR-alpha	O15392	BIRC5	Baculoviral IAP repeat-containing protein 5	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
Q13133	NR1H3	Oxysterols receptor LXR-alpha	P11388	TOP2A	DNA topoisomerase 2-alpha	-0.816

Ursodeoxycholic-acid

RNA transport

2.99E-02

P38919, P37198, P35658, P55884

EIF4A3, NUP62, NUP214, EIF3B

Ursodeoxycholic-acid

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Ursodeoxycholic-acid

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Ursodeoxycholic-acid

Spliceosome

1.27E-02

O43143, P08579, Q13595, Q07955, P84103, P11142

DHX15, SNRPB2, TRA2A, SFRS1, SFRS3, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715

Ursodeoxycholic-acid

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Ursodeoxycholic-acid

ErbB signaling pathway

9.49E-03

Q92529, P19174, P42338

SHC3, PLCG1, PIK3CB

Ursodeoxycholic-acid

Ras signaling pathway

6.70E-05

P42338, Q92529, P20827, Q9NRA1, P49767, Q14644, P0DP23, P63218, P50151, P19174

PIK3CB, SHC3, EFNA1, PDGFC, VEGFC, RASA3, CALM1, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
Q8NFZ4	NLGN2	Neuroligin-2	Q15311	RALBP1	RalA-binding protein 1	0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P78417	GSTO1	Glutathione S-transferase omega-1	P20827	EFNA1	Ephrin-A1	0.727
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q14644	RASA3	Ras GTPase-activating protein 3	0.741
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787

Ursodeoxycholic-acid

Rap1 signaling pathway

3.91E-02

Q9NRA1, P49767, P42338, P19174

PDGFC, VEGFC, PIK3CB, PLCG1

Ursodeoxycholic-acid

Calcium signaling pathway

2.74E-05

P27987, Q16566, P30679, O15399, P19174, P0DP24, P0DP23, P51828, P23634, Q9NRA1, P49767

ITPKB, CAMK4, GNA15, GRIN2D, PLCG1, CALM2, CALM1, ADCY7, ATP2B4, PDGFC, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	0.768
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P78417	GSTO1	Glutathione S-transferase omega-1	P49767	VEGFC	Vascular endothelial growth factor C	0.821

Ursodeoxycholic-acid

cAMP signaling pathway

3.79E-02

P51828, P0DP24, P23634

ADCY7, CALM2, ATP2B4

Ursodeoxycholic-acid

Chemokine signaling pathway

2.13E-04

P25024, P25025, P07948, P42338, P19174, Q92529, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10, ARRB1, ITK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Ursodeoxycholic-acid

NF-kappa B signaling pathway

3.38E-04

P10415, O00463, P01584, Q04759, Q9UDY8, Q16548, Q13315, P63279, P24522, Q8NHW4, P09341, Q9NQC7

BCL2, TRAF5, IL1B, PRKCQ, MALT1, BCL2A1, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Ursodeoxycholic-acid

Phosphatidylinositol signaling system

3.19E-04

P19174, P42338, P23743, Q96PE3, P27987

PLCG1, PIK3CB, DGKA, INPP4A, ITPKB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835

Ursodeoxycholic-acid

Sphingolipid signaling pathway

8.69E-04

P21453, Q9H228, Q13510, Q13362, Q9BX95, P10415, Q9UQC2

S1PR1, EDG8, ASAH1, PPP2R5C, SGPP1, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707

Ursodeoxycholic-acid

Phospholipase D signaling pathway

3.21E-05

P42338, Q92529, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1, Q9GZP0

PIK3CB, SHC3, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFC, PDGFD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P60033	CD81	CD81 antigen	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.798
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P60033	CD81	CD81 antigen	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.713

Ursodeoxycholic-acid

hsa04080

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Ursodeoxycholic-acid

Oocyte meiosis

8.69E-03

P0DP24, P51828, P27348, Q13362

CALM2, ADCY7, YWHAQ, PPP2R5C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
Q8NFZ4	NLGN2	Neuroligin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P27348	YWHAQ	14-3-3 protein theta	0.729
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723

Ursodeoxycholic-acid

Ubiquitin mediated proteolysis

2.57E-02

Q14145, Q13042, Q93034, Q15751

KEAP1, CDC16, CUL5, HERC1

Ursodeoxycholic-acid

hsa04140

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Ursodeoxycholic-acid

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Ursodeoxycholic-acid

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.833
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.786
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q13510	ASAH1	Acid ceramidase	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P07602	PSAP	Prosaposin	0.757
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.705
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q04900	CD164	Sialomucin core protein 24	0.718
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9Y227	ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	P06865	HEXA	Beta-hexosaminidase subunit alpha	-0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	P22304	IDS	Iduronate 2-sulfatase	0.818
P23458	JAK1	Tyrosine-protein kinase JAK1	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.879
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13510	ASAH1	Acid ceramidase	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P07602	PSAP	Prosaposin	0.762
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NRA2	SLC17A5	Sialin	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	P61916	NPC2	NPC intracellular cholesterol transporter 2	0.813

Ursodeoxycholic-acid

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
Q8NFZ4	NLGN2	Neuroligin-2	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.773
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.792
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
Q8NFZ4	NLGN2	Neuroligin-2	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.713
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.783
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P62491	RAB11A	Ras-related protein Rab-11A	0.816
Q8NFZ4	NLGN2	Neuroligin-2	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.711
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.711
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
Q8NFZ4	NLGN2	Neuroligin-2	Q15438	PSCD1	Cytohesin-1	0.782
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q15438	PSCD1	Cytohesin-1	0.794
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
Q8NFZ4	NLGN2	Neuroligin-2	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.715
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.833
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q96QK1	VPS35	Vacuolar protein sorting-associated protein 35	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9UMY4	SNX12	Sorting nexin-12	0.764
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9UNH7	SNX6	Sorting nexin-6	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835

Ursodeoxycholic-acid

Phagosome

4.79E-03

P60709, Q15075, Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765

ACTB, EEA1, NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Ursodeoxycholic-acid

PI3K-Akt signaling pathway

2.55E-03

P42338, Q9NRA1, P49767, P08238, P63218, P50151, O15335, P14784

PIK3CB, PDGFC, VEGFC, HSP90AB1, GNG5, GNG10, CHAD, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766

Ursodeoxycholic-acid

hsa04210

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Ursodeoxycholic-acid

Longevity regulating pathway - multiple species

2.82E-02

Q08828, P51828, P0DMV8

ADCY1, ADCY7, HSPA1A

Ursodeoxycholic-acid

Adrenergic signaling in cardiomyocytes

1.06E-02

P51828, Q13362, P0DP24, P23634

ADCY7, PPP2R5C, CALM2, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
Q8NFZ4	NLGN2	Neuroligin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.707
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723

Ursodeoxycholic-acid

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P35579	MYH9	Myosin-9	0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	P35749	MYH11	Myosin-11	0.706
P23458	JAK1	Tyrosine-protein kinase JAK1	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.705

Ursodeoxycholic-acid

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Ursodeoxycholic-acid

hsa04340

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Ursodeoxycholic-acid

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Ursodeoxycholic-acid

VEGF signaling pathway

1.56E-02

P19174, P42338

PLCG1, PIK3CB

Ursodeoxycholic-acid

Apelin signaling pathway

1.56E-03

P63218, P50151, Q13370, Q14344, Q13485, Q16566, P0DP23

GNG5, GNG10, PDE3B, GNA13, SMAD4, CAMK4, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P78417	GSTO1	Glutathione S-transferase omega-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.824
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804

Ursodeoxycholic-acid

Osteoclast differentiation

3.37E-03

P09603, P06239, P42338, P14778, O75015, P01375, Q8N149, P78324

CSF1, LCK, PIK3CB, IL1R1, FCGR3B, TNF, LILRA2, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737

Ursodeoxycholic-acid

Focal adhesion

1.55E-02

P42338, O15335, Q9NRA1, P49767, Q92529

PIK3CB, CHAD, PDGFC, VEGFC, SHC3

Ursodeoxycholic-acid

Tight junction

2.08E-02

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Ursodeoxycholic-acid

Complement and coagulation cascades

3.92E-03

P01042, P09871, P0C0L4, P11215

KNG1, C1S, C4A, ITGAM

Ursodeoxycholic-acid

Platelet activation

4.11E-02

P42338, Q14344, P07948

PIK3CB, GNA13, LYN

Ursodeoxycholic-acid

Antigen processing and presentation

5.69E-03

P13765, P26715, P26717, Q13241, O43908, P01732, P30511, P01375

HLA-DOB, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HLA-F, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844

Ursodeoxycholic-acid

hsa04613

Neutrophil extracellular trap formation

4.93E-02

O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P21730

TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, C5AR1

Ursodeoxycholic-acid

NOD-like receptor signaling pathway

3.24E-02

P52630, P10599, P01375, P12838

STAT2, TXN, TNF, DEFA4

Ursodeoxycholic-acid

Cytosolic DNA-sensing pathway

1.65E-02

P01584, Q8NHW4

IL1B, CCL4L2

Ursodeoxycholic-acid

C-type lectin receptor signaling pathway

2.38E-03

Q9ULY5, P52630, P20749, P01375, Q13191, P42338

CLEC4E, STAT2, BCL3, TNF, CBLB, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.703
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P20749	BCL3	B-cell lymphoma 3 protein	-0.852
P60033	CD81	CD81 antigen	P20749	BCL3	B-cell lymphoma 3 protein	-0.718
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714

Ursodeoxycholic-acid

Natural killer cell mediated cytotoxicity

1.54E-03

P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O75015, P26717, P26715

TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
P11766	ADH5	Alcohol dehydrogenase class-3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.71
P11766	ADH5	Alcohol dehydrogenase class-3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.833
P11766	ADH5	Alcohol dehydrogenase class-3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.737
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.767
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.818
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.724
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Ursodeoxycholic-acid

IL-17 signaling pathway

3.06E-02

P49841, P80188, P01375

GSK3B, LCN2, TNF

Ursodeoxycholic-acid

Th1 and Th2 cell differentiation

3.54E-05

Q04759, P07766, P20963, P09693, P19174, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13761	RUNX3	Runt-related transcription factor 3	0.73
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738

Ursodeoxycholic-acid

Th17 cell differentiation

1.30E-03

Q04759, P19174, P14784, P13765, Q9UL17, P23771, P08238, P07766, P09693, P20963

PRKCQ, PLCG1, IL2RB, HLA-DOB, TBX21, GATA3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Ursodeoxycholic-acid

T cell receptor signaling pathway

1.96E-04

P01375, Q9UDY8, Q04759, P42338, P10747, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.752
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Ursodeoxycholic-acid

B cell receptor signaling pathway

1.32E-03

P49841, P42338, P60033, P07948, Q8N149

GSK3B, PIK3CB, CD81, LYN, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.725
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78

Ursodeoxycholic-acid

Fc epsilon RI signaling pathway

6.90E-05

P01375, P42338, P07948, P19174, P09917

TNF, PIK3CB, LYN, PLCG1, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83

Ursodeoxycholic-acid

Fc gamma R-mediated phagocytosis

1.73E-02

P07948, P42338, P19174

LYN, PIK3CB, PLCG1

Ursodeoxycholic-acid

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Ursodeoxycholic-acid

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Ursodeoxycholic-acid

Long-term potentiation

1.79E-02

Q16566, P0DP23, O15399

CAMK4, CALM1, GRIN2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745

Ursodeoxycholic-acid

Neurotrophin signaling pathway

4.87E-02

P42338, P19174, Q92529

PIK3CB, PLCG1, SHC3

Ursodeoxycholic-acid

Glutamatergic synapse

2.04E-03

O15399, P63218, P50151, P15104, Q9NSB8

GRIN2D, GNG5, GNG10, GLUL, HOMER2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P78417	GSTO1	Glutathione S-transferase omega-1	Q9NSB8	HOMER2	Homer protein homolog 2	0.808

Ursodeoxycholic-acid

Cholinergic synapse

1.73E-02

P63218, P50151, P42338

GNG5, GNG10, PIK3CB

Ursodeoxycholic-acid

Serotonergic synapse

3.41E-02

P63218, P50151, P09917

GNG5, GNG10, ALOX5

Ursodeoxycholic-acid

GABAergic synapse

6.57E-03

P63218, P50151, P15104

GNG5, GNG10, GLUL

Ursodeoxycholic-acid

Long-term depression

1.56E-02

Q14344, P07948

GNA13, LYN

Ursodeoxycholic-acid

Inflammatory mediator regulation of TRP channels

4.01E-02

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Ursodeoxycholic-acid

Insulin signaling pathway

4.11E-02

Q92529, Q13370, P42338

SHC3, PDE3B, PIK3CB

Ursodeoxycholic-acid

Progesterone-mediated oocyte maturation

2.22E-02

P42338, Q13370, P08238

PIK3CB, PDE3B, HSP90AB1

Ursodeoxycholic-acid

Estrogen signaling pathway

3.80E-04

Q08828, P51828, P42338, Q92529, P08238, P0DMV8, P11142, P0DP23, Q15788

ADCY1, ADCY7, PIK3CB, SHC3, HSP90AB1, HSPA1A, HSPA8, CALM1, NCOA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86

Ursodeoxycholic-acid

Adipocytokine signaling pathway

2.62E-03

Q06124, Q9Y478, Q96RR4

PTPN11, PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737

Ursodeoxycholic-acid

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Ursodeoxycholic-acid

Regulation of lipolysis in adipocytes

3.64E-02

Q13370, P42338

PDE3B, PIK3CB

Ursodeoxycholic-acid

hsa04924

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Ursodeoxycholic-acid

Aldosterone synthesis and secretion

1.40E-03

P51828, P0DP24, P0DP23, Q16566, P23634

ADCY7, CALM2, CALM1, CAMK4, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.862

Ursodeoxycholic-acid

Relaxin signaling pathway

1.31E-03

P42338, P63218, P50151, P49767, Q92529

PIK3CB, GNG5, GNG10, VEGFC, SHC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785

Ursodeoxycholic-acid

hsa04928

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Ursodeoxycholic-acid

Non-alcoholic fatty liver disease

1.39E-02

O43521, O75460, P01584, P13073, P12074, O95298

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83

Ursodeoxycholic-acid

AGE-RAGE signaling pathway in diabetic complications

4.11E-02

P42338, P49767, P19174

PIK3CB, VEGFC, PLCG1

Ursodeoxycholic-acid

Growth hormone synthesis, secretion and action

2.78E-02

P19174, P42338, Q92529

PLCG1, PIK3CB, SHC3

Ursodeoxycholic-acid

Type I diabetes mellitus

1.58E-02

P30511, P01375

HLA-F, TNF

Ursodeoxycholic-acid

Endocrine and other factor-regulated calcium reabsorption

2.09E-02

P23634, P62491

ATP2B4, RAB11A

Ursodeoxycholic-acid

Salivary secretion

6.83E-04

Q08828, P51828, P23634, P0DP24, P0DP23

ADCY1, ADCY7, ATP2B4, CALM2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P51828	ADCY7	Adenylate cyclase type 7	0.731
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.723
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	P0DP24	CALM2	Calmodulin-2	0.73
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822

Ursodeoxycholic-acid

Pancreatic secretion

4.94E-03

P23634, P51828, P62491

ATP2B4, ADCY7, RAB11A

Ursodeoxycholic-acid

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Ursodeoxycholic-acid

Bile secretion

4.78E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Ursodeoxycholic-acid

Alzheimer disease

3.75E-02

P01375, Q9NZJ5, Q13564, P49841, Q92837, P09603, P42338, P21796

TNF, EIF2AK3, APPBP1, GSK3B, FRAT1, CSF1, PIK3CB, VDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.797
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15169	AXIN1	Axin-1	0.737
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P67870	CSNK2B	Casein kinase II subunit beta	0.784
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P28070	PSMB4	Proteasome subunit beta type-4	0.814
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78

Ursodeoxycholic-acid

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.714
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.777
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.705
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.714
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.721
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.786
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.805
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.77
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P28070	PSMB4	Proteasome subunit beta type-4	0.814
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P28070	PSMB4	Proteasome subunit beta type-4	0.841
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.773
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703

Ursodeoxycholic-acid

Morphine addiction

2.22E-02

P63218, P50151, Q13370

GNG5, GNG10, PDE3B

Ursodeoxycholic-acid

Alcoholism

1.05E-02

O15399, Q16566, P0DP23, P63218, O60814, P68431

GRIN2D, CAMK4, CALM1, GNG5, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
Q8NFZ4	NLGN2	Neuroligin-2	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736
P78417	GSTO1	Glutathione S-transferase omega-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.745
P78417	GSTO1	Glutathione S-transferase omega-1	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.809
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.762
P78417	GSTO1	Glutathione S-transferase omega-1	O60814	H2BC12	Histone H2B type 1-K	0.823
P78417	GSTO1	Glutathione S-transferase omega-1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.736

Ursodeoxycholic-acid

Bacterial invasion of epithelial cells

3.64E-02

P42338, Q92529

PIK3CB, SHC3

Ursodeoxycholic-acid

Vibrio cholerae infection

4.50E-03

Q13488, P17252, P19174, P60709

TCIRG1, PRKCA, PLCG1, ACTB

Ursodeoxycholic-acid

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Ursodeoxycholic-acid

Pertussis

1.33E-04

P11215, P0DP23, P10145, P23528, P09871, P0C0L4

ITGAM, CALM1, IL8, CFL1, C1S, C4A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P10145	IL8	Interleukin-8	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P00918	CA2	Carbonic anhydrase 2	P0C0L4	C4A	Complement C4-A	0.774
P00918	CA2	Carbonic anhydrase 2	P0C0L4	C4A	Complement C4-A	0.774
P78417	GSTO1	Glutathione S-transferase omega-1	P11215	ITGAM	Integrin alpha-M	0.728
P78417	GSTO1	Glutathione S-transferase omega-1	P0DP23	CALM1	Calmodulin-1	-0.804
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P10145	IL8	Interleukin-8	0.723
P78417	GSTO1	Glutathione S-transferase omega-1	P23528	CFL1	Cofilin-1	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P09871	C1S	Complement C1s subcomponent	0.764
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703
P14550	AKR1A1	Aldo-keto reductase family 1 member A1	P0C0L4	C4A	Complement C4-A	0.703

Ursodeoxycholic-acid

Legionellosis

2.82E-02

P01584, Q9NR31, P0DMV8

IL1B, SAR1A, HSPA1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P01584	IL1B	Interleukin-1 beta	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753

Ursodeoxycholic-acid

Yersinia infection

4.00E-02

P13612, P06239, P01375, P42338, P49841

ITGA4, LCK, TNF, PIK3CB, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808

Ursodeoxycholic-acid

Leishmaniasis

4.75E-02

P14598, P42224, P25963, P29350, Q15080

NCF1, STAT1, NFKBIA, PTPN6, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752

Ursodeoxycholic-acid

Hepatitis C

9.27E-03

P52630, P60033, P49841, P01375

STAT2, CD81, GSK3B, TNF

Ursodeoxycholic-acid

Measles

5.79E-03

P23458, P14784, P07766, P42338, P0DMV8, P11142, P01584, Q9NP90

JAK1, IL2RB, CD3E, PIK3CB, HSPA1A, HSPA8, IL1B, RAB9B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P06746	POLB	DNA polymerase beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759

Ursodeoxycholic-acid

Human cytomegalovirus infection

1.23E-06

P42338, P01375, P30511, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, O00463, P30101

PIK3CB, TNF, HLA-F, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, TRAF5, PDIA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708

Ursodeoxycholic-acid

Human papillomavirus infection

1.76E-02

P49841, P24821, P01375, P52630, P30511

GSK3B, TNC, TNF, STAT2, HLA-F

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836

Ursodeoxycholic-acid

Kaposi sarcoma-associated herpesvirus infection

1.14E-02

P42338, P63218, P50151, P19174, P07948

PIK3CB, GNG5, GNG10, PLCG1, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804

Ursodeoxycholic-acid

Epstein-Barr virus infection

8.75E-04

Q13547, O00463, P42338, P07948, P30511, P30101, Q13761, P01375, P07766, P20963

HDAC1, TRAF5, PIK3CB, LYN, HLA-F, PDIA3, RUNX3, TNF, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77

Ursodeoxycholic-acid

Human immunodeficiency virus 1 infection

6.31E-04

P42338, P30511, P63218, P50151, P01375, O00463, P30101, P19174, P07766, P20963

PIK3CB, HLA-F, GNG5, GNG10, TNF, TRAF5, PDIA3, PLCG1, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.767
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P0DP23	CALM1	Calmodulin-1	-0.816
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P17252	PRKCA	Protein kinase C alpha type	0.74
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P01568	IFNA21	Interferon alpha-21	0.828
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13619	CUL4A	Cullin-4A	0.706
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.889
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77

Ursodeoxycholic-acid

Pathways in cancer

3.05E-02

P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784

PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766

Ursodeoxycholic-acid

hsa05202

Transcriptional misregulation in cancer

2.90E-02

Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522

FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45A

Ursodeoxycholic-acid

Viral carcinogenesis

4.62E-02

Q12933, P42229, Q15283

TRAF2, STAT5A, RASA2

Ursodeoxycholic-acid

Chemical carcinogenesis

7.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P09211	GSTP1	Glutathione S-transferase P	P09211	GSTP1	Glutathione S-transferase P	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P78417	GSTO1	Glutathione S-transferase omega-1	P78417	GSTO1	Glutathione S-transferase omega-1	1
P78417	GSTO1	Glutathione S-transferase omega-1	P11712	CYP2C9	Cytochrome P450 2C9	0.806

Ursodeoxycholic-acid

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Ursodeoxycholic-acid

Glioma

9.49E-03

Q92529, P42338, P19174

SHC3, PIK3CB, PLCG1

Ursodeoxycholic-acid

Prostate cancer

4.87E-02

Q9NRA1, P08238, P42338

PDGFC, HSP90AB1, PIK3CB

Ursodeoxycholic-acid

Melanoma

3.64E-02

Q9NRA1, P42338

PDGFC, PIK3CB

Ursodeoxycholic-acid

Non-small cell lung cancer

3.99E-02

P17252, O43524, P19174, O75293

PRKCA, FOXO3, PLCG1, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O43524	FOXO3	Forkhead box protein O3	0.828
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.717

Ursodeoxycholic-acid

hsa05230

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Ursodeoxycholic-acid

Choline metabolism in cancer

3.04E-04

P42338, Q9NRA1, P19174, P23743, O14494, P17252

PIK3CB, PDGFC, PLCG1, DGKA, PLPP1, PRKCA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754

Ursodeoxycholic-acid

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.84E-02

P20963, P09693, O60603, P10747, Q04759

CD247, CD3G, TLR2, CD28, PRKCQ

Ursodeoxycholic-acid

Asthma

9.71E-03

P12724, P01375

RNASE3, TNF

Ursodeoxycholic-acid

hsa05321

Inflammatory bowel disease

1.17E-03

O60603, P13765, Q14765, Q9UL17, P23771

TLR2, HLA-DOB, STAT4, TBX21, GATA3

Ursodeoxycholic-acid

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Ursodeoxycholic-acid

Allograft rejection

2.30E-02

P30511, P01375

HLA-F, TNF

Ursodeoxycholic-acid

Graft-versus-host disease

2.86E-04

P13765, P30511, P10747, P01375, P26715, Q13241

HLA-DOB, HLA-F, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Ursodeoxycholic-acid

Diabetic cardiomyopathy

3.33E-02

P17252, P14598, Q15080, Q16718, O14521, P04406, P11413

PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH, G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.807
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.719
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	1
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.76
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.712
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Ursodeoxycholic-acid