PharmaCoNets of Cholesterol (SPCN: 66.19 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Cholesterolhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Cholesterolhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Cholesterolhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Cholesterolhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Cholesterolhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Cholesterolhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Cholesterolhsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Cholesterolhsa00561Glycerolipid metabolism2.51E-022P51648, P23743ALDH3A2, DGKAMore
Cholesterolhsa00562Inositol phosphate metabolism7.30E-044P27987, Q96PE3, P19174, P42338ITPKB, INPP4A, PLCG1, PIK3CBMore
Cholesterolhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Cholesterolhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Cholesterolhsa00620Pyruvate metabolism2.51E-022P40925, P51648MDH1, ALDH3A2More
Cholesterolhsa00630Glyoxylate and dicarboxylate metabolism3.80E-052P40925, P15104MDH1, GLULMore
Cholesterolhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Cholesterolhsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Cholesterolhsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Cholesterolhsa00983Drug metabolism - other enzymes8.59E-044P32320, P05164, Q16772, P09211CDA, MPO, GSTA3, GSTP1More
Cholesterolhsa01100Metabolic pathways1.17E-0430P35790, Q9Y259, Q16772, P09211, Q9UJ14, P30041, P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, Q13956, P40925, P40926, Q7KZN9, P15121, P23743, P49619, O95954, Q02318, Q9UHK6, P43034, Q86VZ5, P09917, Q9UBX8, Q53FZ2, P35573, Q9BQB6CHKA, CHKB, GSTA3, GSTP1, GGTL3, PRDX6, GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, PDE6H, MDH1, MDH2, COX15, AKR1B1, DGKA, DGKG, FTCD, CYP27A1, AMACR, PAFAH1B1, SGMS1, ALOX5, B4GALT6, ACSM3, AGL, VKORC1More
Cholesterolhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Cholesterolhsa01521EGFR tyrosine kinase inhibitor resistance7.30E-044Q92529, P19174, P42338, Q9NRA1SHC3, PLCG1, PIK3CB, PDGFCMore
Cholesterolhsa01524Platinum drug resistance3.80E-034O15392, Q16772, P09211, P11388BIRC5, GSTA3, GSTP1, TOP2AMore
Cholesterolhsa03013RNA transport8.19E-047Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Cholesterolhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Cholesterolhsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Cholesterolhsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Cholesterolhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Cholesterolhsa04012ErbB signaling pathway8.47E-058P21860, P16333, Q92529, Q13557, P19174, O14944, P42338, P01106ERBB3, NCK1, SHC3, CAMK2D, PLCG1, EREG, PIK3CB, MYCMore
Cholesterolhsa04014Ras signaling pathway2.29E-047P42338, Q92529, Q9NRA1, P49767, P63218, P50151, P19174PIK3CB, SHC3, PDGFC, VEGFC, GNG5, GNG10, PLCG1More
Cholesterolhsa04015Rap1 signaling pathway3.91E-024Q9NRA1, P49767, P42338, P19174PDGFC, VEGFC, PIK3CB, PLCG1More
Cholesterolhsa04020Calcium signaling pathway7.29E-0611P27987, Q96DU7, P45880, Q13557, P21860, P19174, P0DP24, P51828, P23634, Q9NRA1, P49767ITPKB, ITPKC, VDAC2, CAMK2D, ERBB3, PLCG1, CALM2, ADCY7, ATP2B4, PDGFC, VEGFCMore
Cholesterolhsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Cholesterolhsa04024cAMP signaling pathway3.79E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Cholesterolhsa04062Chemokine signaling pathway2.08E-0410P25024, P25025, P07948, P42338, P19174, Q92529, P63218, P50151, P49407, P49841CXCR1, CXCR2, LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10, ARRB1, GSK3BMore
Cholesterolhsa04070Phosphatidylinositol signaling system3.19E-045P19174, P42338, P23743, Q96PE3, P27987PLCG1, PIK3CB, DGKA, INPP4A, ITPKBMore
Cholesterolhsa04071Sphingolipid signaling pathway9.99E-045Q9H228, P01375, Q13510, Q13362, Q9UQC2EDG8, TNF, ASAH1, PPP2R5C, GAB2More
Cholesterolhsa04072Phospholipase D signaling pathway1.85E-046P42338, Q92529, P19174, Q14344, P23743, Q9NRA1PIK3CB, SHC3, PLCG1, GNA13, DGKA, PDGFCMore
Cholesterolhsa04110Cell cycle1.79E-038Q9UBD5, P06493, O75293, P30304, P33981, P42773, P01106, Q13547ORC3, CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Cholesterolhsa04114Oocyte meiosis3.15E-048P51812, Q02750, P0DP24, P16298, Q17RY0, P51828, P27348, Q13362RPS6KA3, MAP2K1, CALM2, PPP3CB, CPEB4, ADCY7, YWHAQ, PPP2R5CMore
Cholesterolhsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Cholesterolhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Cholesterolhsa04150mTOR signaling pathway2.28E-036P42338, Q02750, Q9NQL2, P51812, Q13322, P49841PIK3CB, MAP2K1, RRAGD, RPS6KA3, GRB10, GSK3BMore
Cholesterolhsa04151PI3K-Akt signaling pathway2.55E-038P42338, Q9NRA1, P49767, P08238, P63218, P50151, O15335, P14784PIK3CB, PDGFC, VEGFC, HSP90AB1, GNG5, GNG10, CHAD, IL2RBMore
Cholesterolhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Cholesterolhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Cholesterolhsa04261Adrenergic signaling in cardiomyocytes1.31E-036P51828, Q99941, Q13362, P0DP24, Q13557, P23634ADCY7, CREBL1, PPP2R5C, CALM2, CAMK2D, ATP2B4More
Cholesterolhsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Cholesterolhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Cholesterolhsa04370VEGF signaling pathway8.20E-055P19174, P16298, P42338, Q05397, Q02750PLCG1, PPP3CB, PIK3CB, PTK2, MAP2K1More
Cholesterolhsa04371Apelin signaling pathway1.24E-024P63218, P50151, Q13370, Q14344GNG5, GNG10, PDE3B, GNA13More
Cholesterolhsa04390Hippo signaling pathway2.17E-035P63261, P84022, Q13485, O15105, Q13489ACTG1, SMAD3, SMAD4, SMAD7, BIRC3More
Cholesterolhsa04510Focal adhesion1.55E-025P42338, O15335, Q9NRA1, P49767, Q92529PIK3CB, CHAD, PDGFC, VEGFC, SHC3More
Cholesterolhsa04530Tight junction4.35E-022P63261, Q92974ACTG1, ARHGEF2More
Cholesterolhsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Cholesterolhsa04611Platelet activation4.11E-023P42338, Q14344, P07948PIK3CB, GNA13, LYNMore
Cholesterolhsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Cholesterolhsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Cholesterolhsa04658Th1 and Th2 cell differentiation1.59E-078P07766, P20963, P19174, P01730, P06239, P42224, P14784, Q13761CD3E, CD247, PLCG1, CD4, LCK, STAT1, IL2RB, RUNX3More
Cholesterolhsa04659Th17 cell differentiation2.31E-0612P25963, P19174, P01730, P06239, P42224, P14784, P14778, P84022, Q13485, P08238, P07766, P20963NFKBIA, PLCG1, CD4, LCK, STAT1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3E, CD247More
Cholesterolhsa04660T cell receptor signaling pathway3.69E-038P42338, P19174, P16333, P07766, P20963, P01730, P06239, P49841PIK3CB, PLCG1, NCK1, CD3E, CD247, CD4, LCK, GSK3BMore
Cholesterolhsa04662B cell receptor signaling pathway9.27E-056P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Cholesterolhsa04664Fc epsilon RI signaling pathway7.30E-044P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Cholesterolhsa04666Fc gamma R-mediated phagocytosis1.73E-023P07948, P42338, P19174LYN, PIK3CB, PLCG1More
Cholesterolhsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Cholesterolhsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Cholesterolhsa04722Neurotrophin signaling pathway4.87E-023P42338, P19174, Q92529PIK3CB, PLCG1, SHC3More
Cholesterolhsa04724Glutamatergic synapse1.05E-034P43003, P63218, P50151, P15104SLC1A3, GNG5, GNG10, GLULMore
Cholesterolhsa04725Cholinergic synapse1.73E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Cholesterolhsa04726Serotonergic synapse3.41E-023P63218, P50151, P09917GNG5, GNG10, ALOX5More
Cholesterolhsa04727GABAergic synapse9.19E-043P63218, P50151, P15104GNG5, GNG10, GLULMore
Cholesterolhsa04730Long-term depression1.56E-022Q14344, P07948GNA13, LYNMore
Cholesterolhsa04750Inflammatory mediator regulation of TRP channels3.74E-023P01584, P51828, Q13557IL1B, ADCY7, CAMK2DMore
Cholesterolhsa04910Insulin signaling pathway2.44E-036P22694, P06737, Q92529, Q13370, P42338, P49841PRKACB, PYGL, SHC3, PDE3B, PIK3CB, GSK3BMore
Cholesterolhsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Cholesterolhsa04914Progesterone-mediated oocyte maturation1.58E-036Q17RY0, P42338, Q13370, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1More
Cholesterolhsa04915Estrogen signaling pathway7.27E-047Q99941, P51828, P42338, Q92529, P07900, P08238, P11142CREBL1, ADCY7, PIK3CB, SHC3, HSP90AA1, HSP90AB1, HSPA8More
Cholesterolhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Cholesterolhsa04923Regulation of lipolysis in adipocytes3.64E-022Q13370, P42338PDE3B, PIK3CBMore
Cholesterolhsa04925Aldosterone synthesis and secretion1.75E-045Q99941, P51828, P0DP24, Q13557, P23634CREBL1, ADCY7, CALM2, CAMK2D, ATP2B4More
Cholesterolhsa04926Relaxin signaling pathway1.31E-035P42338, P63218, P50151, P49767, Q92529PIK3CB, GNG5, GNG10, VEGFC, SHC3More
Cholesterolhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Cholesterolhsa04933AGE-RAGE signaling pathway in diabetic complications1.47E-036P84022, Q13485, P10415, P42338, P49767, P19174SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1More
Cholesterolhsa04934Cushing syndrome3.48E-034Q99941, P51828, O15169, Q13557CREBL1, ADCY7, AXIN1, CAMK2DMore
Cholesterolhsa04935Growth hormone synthesis, secretion and action2.78E-023P19174, P42338, Q92529PLCG1, PIK3CB, SHC3More
Cholesterolhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Cholesterolhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Cholesterolhsa04970Salivary secretion3.20E-033P51828, P23634, P0DP24ADCY7, ATP2B4, CALM2More
Cholesterolhsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Cholesterolhsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Cholesterolhsa04973Carbohydrate digestion and absorption1.10E-022O43451, P42338MGAM, PIK3CBMore
Cholesterolhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Cholesterolhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Cholesterolhsa05010Alzheimer disease2.07E-027Q92542, P05496, P12074, O75460, P01584, O15169, P45880NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2More
Cholesterolhsa05020Prion disease1.81E-027P01584, P46531, P11142, P05496, P12074, P45880, Q99941IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1More
Cholesterolhsa05032Morphine addiction2.22E-023P63218, P50151, Q13370GNG5, GNG10, PDE3BMore
Cholesterolhsa05100Bacterial invasion of epithelial cells3.64E-022P42338, Q92529PIK3CB, SHC3More
Cholesterolhsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Cholesterolhsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Cholesterolhsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Cholesterolhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Cholesterolhsa05146Amoebiasis2.58E-025P14778, P27930, P42338, P11215, P12814IL1R1, IL1R2, PIK3CB, ITGAM, ACTN1More
Cholesterolhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Cholesterolhsa05162Measles3.91E-024P14784, P07766, P42338, P11142IL2RB, CD3E, PIK3CB, HSPA8More
Cholesterolhsa05163Human cytomegalovirus infection1.14E-025P42338, P63218, P50151, Q14344, P30101PIK3CB, GNG5, GNG10, GNA13, PDIA3More
Cholesterolhsa05167Kaposi sarcoma-associated herpesvirus infection6.22E-049P42338, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P0CG47PIK3CB, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, UBBMore
Cholesterolhsa05169Epstein-Barr virus infection3.34E-025P42338, P07948, P30101, Q13761, P07766PIK3CB, LYN, PDIA3, RUNX3, CD3EMore
Cholesterolhsa05170Human immunodeficiency virus 1 infection1.36E-0411P42338, Q02750, P62879, P63218, P50151, P16298, Q05397, P30101, P19174, P07766, P20333PIK3CB, MAP2K1, GNB2, GNG5, GNG10, PPP3CB, PTK2, PDIA3, PLCG1, CD3E, TNFRSF1BMore
Cholesterolhsa05200Pathways in cancer3.05E-028P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RBMore
Cholesterolhsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Cholesterolhsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Cholesterolhsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Cholesterolhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Cholesterolhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Cholesterolhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Cholesterolhsa05214Glioma9.49E-033Q92529, P42338, P19174SHC3, PIK3CB, PLCG1More
Cholesterolhsa05215Prostate cancer4.87E-023Q9NRA1, P08238, P42338PDGFC, HSP90AB1, PIK3CBMore
Cholesterolhsa05218Melanoma3.64E-022Q9NRA1, P42338PDGFC, PIK3CBMore
Cholesterolhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Cholesterolhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Cholesterolhsa05223Non-small cell lung cancer4.24E-023P19174, Q9HC35, O75293PLCG1, EML4, GADD45BMore
Cholesterolhsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Cholesterolhsa05231Choline metabolism in cancer1.36E-056P42338, Q9NRA1, Q9Y259, P19174, P23743, P49619PIK3CB, PDGFC, CHKB, PLCG1, DGKA, DGKGMore
Cholesterolhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.50E-048P42338, P19174, P07766, P20963, P06239, P42224, Q9HC35, P01730PIK3CB, PLCG1, CD3E, CD247, LCK, STAT1, EML4, CD4More
Cholesterolhsa05340Primary immunodeficiency4.24E-023P01730, P07766, P06239CD4, CD3E, LCKMore

Community members of Cholesterol (SDC: 4.41)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9ULY5CLEC4ECNonetype lectin domain family 4 member EReported00.08290.00670.25410.3088
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P06746POLBDNA polymerase betaPredicted00.45730.18680.48561.0878
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)