PharmaCoNets of Cholecalciferol (SPCN: 82.56 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Cholecalciferolhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Cholecalciferolhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Cholecalciferolhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Cholecalciferolhsa00520Amino sugar and nucleotide sugar metabolism1.04E-033Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Cholecalciferolhsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Cholecalciferolhsa00561Glycerolipid metabolism2.51E-022P51648, P23743ALDH3A2, DGKAMore
Cholecalciferolhsa00562Inositol phosphate metabolism7.30E-044P27987, Q96PE3, P19174, P42338ITPKB, INPP4A, PLCG1, PIK3CBMore
Cholecalciferolhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Cholecalciferolhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Cholecalciferolhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Cholecalciferolhsa00620Pyruvate metabolism2.51E-022P40925, P51648MDH1, ALDH3A2More
Cholecalciferolhsa00630Glyoxylate and dicarboxylate metabolism2.78E-032P40925, P15104MDH1, GLULMore
Cholecalciferolhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Cholecalciferolhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Cholecalciferolhsa01100Metabolic pathways4.12E-0212P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P23743, P43034, P09917, Q53FZ2GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, DGKA, PAFAH1B1, ALOX5, ACSM3More
Cholecalciferolhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Cholecalciferolhsa01521EGFR tyrosine kinase inhibitor resistance2.46E-045Q92529, P19174, P42338, P08069, Q9NRA1SHC3, PLCG1, PIK3CB, IGF1R, PDGFCMore
Cholecalciferolhsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Cholecalciferolhsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Cholecalciferolhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Cholecalciferolhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Cholecalciferolhsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Cholecalciferolhsa04012ErbB signaling pathway8.14E-045P16333, Q92529, P19174, P42338, P01106NCK1, SHC3, PLCG1, PIK3CB, MYCMore
Cholecalciferolhsa04014Ras signaling pathway6.46E-058P42338, Q92529, Q9NRA1, P49767, P08069, P63218, P50151, P19174PIK3CB, SHC3, PDGFC, VEGFC, IGF1R, GNG5, GNG10, PLCG1More
Cholecalciferolhsa04015Rap1 signaling pathway8.98E-035Q9NRA1, P49767, P08069, P42338, P19174PDGFC, VEGFC, IGF1R, PIK3CB, PLCG1More
Cholecalciferolhsa04020Calcium signaling pathway2.43E-037P27987, P19174, P0DP24, P51828, P23634, Q9NRA1, P49767ITPKB, PLCG1, CALM2, ADCY7, ATP2B4, PDGFC, VEGFCMore
Cholecalciferolhsa04024cAMP signaling pathway3.79E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Cholecalciferolhsa04062Chemokine signaling pathway4.35E-036P07948, P42338, P19174, Q92529, P63218, P50151LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10More
Cholecalciferolhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Cholecalciferolhsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Cholecalciferolhsa04070Phosphatidylinositol signaling system3.67E-056P19174, P42338, P23743, P49619, Q96PE3, P27987PLCG1, PIK3CB, DGKA, DGKG, INPP4A, ITPKBMore
Cholecalciferolhsa04071Sphingolipid signaling pathway9.99E-045Q9H228, P01375, Q13510, Q13362, Q9UQC2EDG8, TNF, ASAH1, PPP2R5C, GAB2More
Cholecalciferolhsa04072Phospholipase D signaling pathway1.85E-046P42338, Q92529, P19174, Q14344, P23743, Q9NRA1PIK3CB, SHC3, PLCG1, GNA13, DGKA, PDGFCMore
Cholecalciferolhsa04110Cell cycle1.25E-037P06493, O75293, P30304, P33981, P42773, P01106, Q13547CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Cholecalciferolhsa04114Oocyte meiosis1.89E-0710Q9Y6D9, P51812, Q02750, P0DP24, P16298, Q17RY0, P51828, P27348, Q13362, P08069MAD1L1, RPS6KA3, MAP2K1, CALM2, PPP3CB, CPEB4, ADCY7, YWHAQ, PPP2R5C, IGF1RMore
Cholecalciferolhsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Cholecalciferolhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Cholecalciferolhsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Cholecalciferolhsa04151PI3K-Akt signaling pathway2.55E-038P42338, Q9NRA1, P49767, P08238, P63218, P50151, O15335, P14784PIK3CB, PDGFC, VEGFC, HSP90AB1, GNG5, GNG10, CHAD, IL2RBMore
Cholecalciferolhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Cholecalciferolhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Cholecalciferolhsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Cholecalciferolhsa04213Longevity regulating pathway - multiple species1.66E-021P08069IGF1RMore
Cholecalciferolhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Cholecalciferolhsa04261Adrenergic signaling in cardiomyocytes1.06E-024P51828, Q13362, P0DP24, P23634ADCY7, PPP2R5C, CALM2, ATP2B4More
Cholecalciferolhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Cholecalciferolhsa04370VEGF signaling pathway1.95E-085P19174, P16298, P42338, Q05397, Q02750PLCG1, PPP3CB, PIK3CB, PTK2, MAP2K1More
Cholecalciferolhsa04371Apelin signaling pathway1.24E-024P63218, P50151, Q13370, Q14344GNG5, GNG10, PDE3B, GNA13More
Cholecalciferolhsa04390Hippo signaling pathway2.17E-035P63261, P84022, Q13485, O15105, Q13489ACTG1, SMAD3, SMAD4, SMAD7, BIRC3More
Cholecalciferolhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Cholecalciferolhsa04510Focal adhesion3.52E-036P42338, O15335, P08069, Q9NRA1, P49767, Q92529PIK3CB, CHAD, IGF1R, PDGFC, VEGFC, SHC3More
Cholecalciferolhsa04520Adherens junction8.29E-031P08069IGF1RMore
Cholecalciferolhsa04530Tight junction4.35E-022P63261, Q92974ACTG1, ARHGEF2More
Cholecalciferolhsa04550Signaling pathways regulating pluripotency of stem cells9.61E-034Q13873, Q02750, P08069, Q86SE9BMPR2, MAP2K1, IGF1R, PCGF5More
Cholecalciferolhsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Cholecalciferolhsa04611Platelet activation4.11E-023P42338, Q14344, P07948PIK3CB, GNA13, LYNMore
Cholecalciferolhsa04613Neutrophil extracellular trap formation1.56E-025P19174, P11215, Q13547, P62807, Q16778PLCG1, ITGAM, HDAC1, HIST1H2BC, HIST2H2BEMore
Cholecalciferolhsa04630JAK-STAT signaling pathway3.20E-024P01106, P42224, P14784, Q13651MYC, STAT1, IL2RB, IL10RAMore
Cholecalciferolhsa04650Natural killer cell mediated cytotoxicity2.70E-033P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Cholecalciferolhsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Cholecalciferolhsa04658Th1 and Th2 cell differentiation4.17E-097P07766, P19174, P01730, P06239, P42224, P14784, Q13761CD3E, PLCG1, CD4, LCK, STAT1, IL2RB, RUNX3More
Cholecalciferolhsa04659Th17 cell differentiation4.89E-0710P25963, P19174, P01730, P06239, P42224, P14784, P84022, Q13485, P08238, P07766NFKBIA, PLCG1, CD4, LCK, STAT1, IL2RB, SMAD3, SMAD4, HSP90AB1, CD3EMore
Cholecalciferolhsa04660T cell receptor signaling pathway4.08E-025P19174, P16333, P07766, P01730, P06239PLCG1, NCK1, CD3E, CD4, LCKMore
Cholecalciferolhsa04662B cell receptor signaling pathway2.78E-023P42338, P07948, Q8N149PIK3CB, LYN, LILRA2More
Cholecalciferolhsa04664Fc epsilon RI signaling pathway7.30E-044P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Cholecalciferolhsa04666Fc gamma R-mediated phagocytosis1.73E-023P07948, P42338, P19174LYN, PIK3CB, PLCG1More
Cholecalciferolhsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Cholecalciferolhsa04720Long-term potentiation9.52E-043P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Cholecalciferolhsa04722Neurotrophin signaling pathway4.87E-023P42338, P19174, Q92529PIK3CB, PLCG1, SHC3More
Cholecalciferolhsa04724Glutamatergic synapse1.73E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Cholecalciferolhsa04725Cholinergic synapse1.73E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Cholecalciferolhsa04726Serotonergic synapse3.41E-023P63218, P50151, P09917GNG5, GNG10, ALOX5More
Cholecalciferolhsa04727GABAergic synapse6.57E-033P63218, P50151, P15104GNG5, GNG10, GLULMore
Cholecalciferolhsa04730Long-term depression3.83E-033Q14344, P08069, P07948GNA13, IGF1R, LYNMore
Cholecalciferolhsa04910Insulin signaling pathway2.44E-036P22694, P06737, Q92529, Q13370, P42338, P49841PRKACB, PYGL, SHC3, PDE3B, PIK3CB, GSK3BMore
Cholecalciferolhsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Cholecalciferolhsa04914Progesterone-mediated oocyte maturation1.22E-068P08069, Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750IGF1R, CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1More
Cholecalciferolhsa04915Estrogen signaling pathway4.76E-034P42338, Q92529, P08238, P11142PIK3CB, SHC3, HSP90AB1, HSPA8More
Cholecalciferolhsa04919Thyroid hormone signaling pathway3.38E-048P49841, P19174, P42224, P22694, Q13547, O60244, Q9NVC6, P01106GSK3B, PLCG1, STAT1, PRKACB, HDAC1, MED14, MED17, MYCMore
Cholecalciferolhsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Cholecalciferolhsa04923Regulation of lipolysis in adipocytes3.64E-022Q13370, P42338PDE3B, PIK3CBMore
Cholecalciferolhsa04925Aldosterone synthesis and secretion1.32E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Cholecalciferolhsa04926Relaxin signaling pathway1.31E-035P42338, P63218, P50151, P49767, Q92529PIK3CB, GNG5, GNG10, VEGFC, SHC3More
Cholecalciferolhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Cholecalciferolhsa04933AGE-RAGE signaling pathway in diabetic complications1.47E-036P84022, Q13485, P10415, P42338, P49767, P19174SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1More
Cholecalciferolhsa04935Growth hormone synthesis, secretion and action2.78E-023P19174, P42338, Q92529PLCG1, PIK3CB, SHC3More
Cholecalciferolhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Cholecalciferolhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Cholecalciferolhsa04970Salivary secretion3.20E-033P51828, P23634, P0DP24ADCY7, ATP2B4, CALM2More
Cholecalciferolhsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Cholecalciferolhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Cholecalciferolhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Cholecalciferolhsa05022Pathways of neurodegeneration - multiple diseases2.95E-022Q06055, O15020ATP5G2, SPTBN2More
Cholecalciferolhsa05032Morphine addiction2.22E-023P63218, P50151, Q13370GNG5, GNG10, PDE3BMore
Cholecalciferolhsa05034Alcoholism4.79E-023Q13547, P62807, Q16778HDAC1, HIST1H2BC, HIST2H2BEMore
Cholecalciferolhsa05100Bacterial invasion of epithelial cells1.94E-035Q14141, Q05397, P42338, Q92529, Q96JJ3SEPT6, PTK2, PIK3CB, SHC3, ELMO2More
Cholecalciferolhsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Cholecalciferolhsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Cholecalciferolhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Cholecalciferolhsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Cholecalciferolhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Cholecalciferolhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Cholecalciferolhsa05162Measles3.91E-024P14784, P07766, P42338, P11142IL2RB, CD3E, PIK3CB, HSPA8More
Cholecalciferolhsa05163Human cytomegalovirus infection1.14E-025P42338, P63218, P50151, Q14344, P30101PIK3CB, GNG5, GNG10, GNA13, PDIA3More
Cholecalciferolhsa05167Kaposi sarcoma-associated herpesvirus infection6.22E-049P42338, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P0CG47PIK3CB, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, UBBMore
Cholecalciferolhsa05169Epstein-Barr virus infection3.39E-038P01106, Q13547, P42338, P07948, P30101, Q13761, P42224, P07766MYC, HDAC1, PIK3CB, LYN, PDIA3, RUNX3, STAT1, CD3EMore
Cholecalciferolhsa05170Human immunodeficiency virus 1 infection1.36E-0411P42338, Q02750, P62879, P63218, P50151, P16298, Q05397, P30101, P19174, P07766, P20333PIK3CB, MAP2K1, GNB2, GNG5, GNG10, PPP3CB, PTK2, PDIA3, PLCG1, CD3E, TNFRSF1BMore
Cholecalciferolhsa05200Pathways in cancer3.05E-028P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RBMore
Cholecalciferolhsa05202Transcriptional misregulation in cancer2.82E-021P08069IGF1RMore
Cholecalciferolhsa05203Viral carcinogenesis9.16E-035Q13547, P12814, P06493, P62807, Q16778HDAC1, ACTN1, CDK1, HIST1H2BC, HIST2H2BEMore
Cholecalciferolhsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Cholecalciferolhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Cholecalciferolhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Cholecalciferolhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Cholecalciferolhsa05214Glioma8.47E-044P08069, Q92529, P42338, P19174IGF1R, SHC3, PIK3CB, PLCG1More
Cholecalciferolhsa05215Prostate cancer5.38E-034P08069, Q9NRA1, P08238, P42338IGF1R, PDGFC, HSP90AB1, PIK3CBMore
Cholecalciferolhsa05218Melanoma2.85E-033P08069, Q9NRA1, P42338IGF1R, PDGFC, PIK3CBMore
Cholecalciferolhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Cholecalciferolhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Cholecalciferolhsa05223Non-small cell lung cancer4.24E-023P19174, Q9HC35, O75293PLCG1, EML4, GADD45BMore
Cholecalciferolhsa05224Breast cancer1.49E-021P08069IGF1RMore
Cholecalciferolhsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Cholecalciferolhsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Cholecalciferolhsa05231Choline metabolism in cancer7.94E-066P42338, Q9NRA1, Q9Y259, P19174, P23743, P49619PIK3CB, PDGFC, CHKB, PLCG1, DGKA, DGKGMore
Cholecalciferolhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer7.21E-066P19174, P07766, P06239, P42224, Q9HC35, P01730PLCG1, CD3E, LCK, STAT1, EML4, CD4More
Cholecalciferolhsa05322Systemic lupus erythematosus2.75E-023P62807, Q16778, P12814HIST1H2BC, HIST2H2BE, ACTN1More
Cholecalciferolhsa05340Primary immunodeficiency4.24E-023P01730, P07766, P06239CD4, CD3E, LCKMore

Community members of Cholecalciferol (SDC: 5.30)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
P06746POLBDNA polymerase betaPredicted00.45730.18680.48561.0878
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)