PharmaCoNets of Chlorzoxazone (SPCN: 24.91 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Chlorzoxazonehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Chlorzoxazonehsa00190Oxidative phosphorylation1.00E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Chlorzoxazonehsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Chlorzoxazonehsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Chlorzoxazonehsa00380Tryptophan metabolism1.33E-022P46952, P51648HAAO, ALDH3A2More
Chlorzoxazonehsa00562Inositol phosphate metabolism1.91E-023P27987, Q13572, Q96PE3ITPKB, ITPK1, INPP4AMore
Chlorzoxazonehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Chlorzoxazonehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Chlorzoxazonehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Chlorzoxazonehsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Chlorzoxazonehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Chlorzoxazonehsa03013RNA transport4.09E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Chlorzoxazonehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Chlorzoxazonehsa04020Calcium signaling pathway1.92E-036P27987, Q16566, P30679, O15399, P23634, P49767ITPKB, CAMK4, GNA15, GRIN2D, ATP2B4, VEGFCMore
Chlorzoxazonehsa04064NF-kappa B signaling pathway1.91E-0412P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45AMore
Chlorzoxazonehsa04071Sphingolipid signaling pathway9.39E-037P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Chlorzoxazonehsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Chlorzoxazonehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Chlorzoxazonehsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Chlorzoxazonehsa04145Phagosome7.50E-0310Q15080, P14598, Q13509, Q13488, Q99437, P05164, O60603, P35443, P13765, P25774NCF4, NCF1, TUBB3, TCIRG1, ATP6V0B, MPO, TLR2, THBS4, HLA-DOB, CTSSMore
Chlorzoxazonehsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Chlorzoxazonehsa04217Necroptosis2.87E-038P01568, Q13489, P42224, P08238, Q6FI13, Q93077, O43633, Q08752IFNA21, BIRC3, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, CHMP2A, PPIDMore
Chlorzoxazonehsa04371Apelin signaling pathway2.95E-024P63218, Q14344, Q13485, Q16566GNG5, GNA13, SMAD4, CAMK4More
Chlorzoxazonehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Chlorzoxazonehsa04613Neutrophil extracellular trap formation1.30E-0313P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, P21730, P21462PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1More
Chlorzoxazonehsa04621NOD-like receptor signaling pathway3.10E-0311Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Chlorzoxazonehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Chlorzoxazonehsa04660T cell receptor signaling pathway4.20E-027P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITKMore
Chlorzoxazonehsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Chlorzoxazonehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Chlorzoxazonehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Chlorzoxazonehsa04724Glutamatergic synapse3.40E-023O15399, P63218, Q9NSB8GRIN2D, GNG5, HOMER2More
Chlorzoxazonehsa04730Long-term depression2.54E-022Q14344, P07948GNA13, LYNMore
Chlorzoxazonehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Chlorzoxazonehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Chlorzoxazonehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Chlorzoxazonehsa04970Salivary secretion4.49E-024P22694, Q14643, P17252, P49913PRKACB, ITPR1, PRKCA, CAMPMore
Chlorzoxazonehsa05033Nicotine addiction2.54E-022P28472, O15399GABRB3, GRIN2DMore
Chlorzoxazonehsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Chlorzoxazonehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Chlorzoxazonehsa05132Salmonella infection2.98E-0211P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3More
Chlorzoxazonehsa05133Pertussis4.20E-021P0C0L4C4AMore
Chlorzoxazonehsa05140Leishmaniasis5.67E-049P14598, P42224, P13765, O60603, P25963, P01375, P29350, P51617, Q15080NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, IRAK1, NCF4More
Chlorzoxazonehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Chlorzoxazonehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Chlorzoxazonehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Chlorzoxazonehsa05152Tuberculosis9.13E-0311Q13488, Q99437, P48382, O60603, P01375, P10415, P13765, P25774, P49913, Q9UDY8, P51617TCIRG1, ATP6V0B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CTSS, CAMP, MALT1, IRAK1More
Chlorzoxazonehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Chlorzoxazonehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Chlorzoxazonehsa05170Human immunodeficiency virus 1 infection1.06E-0313P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2More
Chlorzoxazonehsa05202Transcriptional misregulation in cancer1.51E-0414Q12778, Q15532, Q13315, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Chlorzoxazonehsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Chlorzoxazonehsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Chlorzoxazonehsa05321Inflammatory bowel disease1.28E-025O60603, P01375, P13765, Q14765, P23771TLR2, TNF, HLA-DOB, STAT4, GATA3More
Chlorzoxazonehsa05322Systemic lupus erythematosus4.20E-027P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Chlorzoxazonehsa05332Graft-versus-host disease9.30E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Chlorzoxazonehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Chlorzoxazonehsa05415Diabetic cardiomyopathy1.07E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore

Community members of Chlorzoxazone (SDC: 3.95)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
O15294OGTUDPNoneNNoneacetylglucosamineNoneNonepeptide NNoneacetylglucosaminyltransferase 110 kDa subunitPredicted00.27390.06020.10210.3594
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)