PharmaCoNets of Chlorpromazine (SPCN: 154.67 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Chlorpromazinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Chlorpromazinehsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Chlorpromazinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Chlorpromazinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Chlorpromazinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Chlorpromazinehsa00230Purine metabolism4.60E-024Q13370, P36959, Q13956, P27707PDE3B, GMPR, PDE6H, DCKMore
Chlorpromazinehsa00240Pyrimidine metabolism4.50E-022P32320, P27707CDA, DCKMore
Chlorpromazinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Chlorpromazinehsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin4.77E-021Q7LGA3HS2ST1More
Chlorpromazinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Chlorpromazinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Chlorpromazinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Chlorpromazinehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Chlorpromazinehsa00620Pyruvate metabolism3.90E-022P07195, P11766LDHB, ADH5More
Chlorpromazinehsa00670One carbon pool by folate3.99E-022O95954, Q99707FTCD, MTRMore
Chlorpromazinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Chlorpromazinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Chlorpromazinehsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Chlorpromazinehsa00920Sulfur metabolism3.01E-021O95571ETHE1More
Chlorpromazinehsa00980Metabolism of xenobiotics by cytochrome P4506.38E-043P78417, P09211, P11712GSTO1, GSTP1, CYP2C9More
Chlorpromazinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Chlorpromazinehsa00983Drug metabolism - other enzymes1.70E-043P04183, P32320, P05164TK1, CDA, MPOMore
Chlorpromazinehsa01100Metabolic pathways3.95E-0223Q9Y234, Q99707, P29218, P11310, P27707, Q13370, P36959, Q13956, P30043, Q02252, O60701, O14772, O95954, Q02318, P04406, O15466, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809LIPT1, MTR, IMPA1, ACADM, DCK, PDE3B, GMPR, PDE6H, BLVRB, ALDH6A1, UGDH, FPGT, FTCD, CYP27A1, GAPDH, ST8SIA5, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1More
Chlorpromazinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Chlorpromazinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Chlorpromazinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Chlorpromazinehsa01522Endocrine resistance3.74E-046P14780, P22694, P04049, Q9UM47, P10415, Q13323MMP9, PRKACB, RAF1, NOTCH3, BCL2, BIKMore
Chlorpromazinehsa01524Platinum drug resistance4.45E-024P10415, Q13489, P78417, P43246BCL2, BIRC3, GSTO1, MSH2More
Chlorpromazinehsa02010ABC transporters1.99E-044P45844, P08183, Q8IZY2, Q99758ABCG1, ABCB1, ABCA7, ABCA3More
Chlorpromazinehsa03010Ribosome1.08E-0411P62753, P25398, P32969, P40429, P62829, Q07020, P18077, P36578, P27635, P05386, P62249RPS6, RPS12, RPL9, RPL13A, RPL23, RPL18, RPL35A, RPL4, RPL10, RPLP1, RPS16More
Chlorpromazinehsa03013RNA transport1.12E-0211P62826, P52298, O14893, P61326, Q7Z3B4, P35658, P63279, Q14152, O75822, P78345, Q9Y6A5RAN, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, UBE2I, EIF3A, EIF3J, RPP38, TACC3More
Chlorpromazinehsa03015mRNA surveillance pathway3.62E-023O43148, P61326, P52298RNMT, MAGOH, NCBP2More
Chlorpromazinehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Chlorpromazinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Chlorpromazinehsa03040Spliceosome1.11E-0718Q14562, O43143, O60508, P17844, O14776, P08579, O75940, P52298, P09651, Q15365, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, P61326DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, MAGOHMore
Chlorpromazinehsa03050Proteasome5.53E-032P43686, P28070PSMC4, PSMB4More
Chlorpromazinehsa03060Protein export4.46E-032Q15070, O76094OXA1L, SRP72More
Chlorpromazinehsa03320PPAR signaling pathway2.89E-034Q6PCB7, O00767, Q9UNU6, Q02318SLC27A1, SCD, CYP8B1, CYP27A1More
Chlorpromazinehsa03430Mismatch repair4.38E-021P20585MSH3More
Chlorpromazinehsa03460Fanconi anemia pathway3.70E-033Q9NPI8, O60673, Q9UNA4FANCF, REV3L, POLIMore
Chlorpromazinehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Chlorpromazinehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Chlorpromazinehsa04014Ras signaling pathway1.42E-0310P04049, P31751, P20827, P49767, Q13009, P17252, Q15311, P0DP23, P62873, P19174RAF1, AKT2, EFNA1, VEGFC, TIAM1, PRKCA, RALBP1, CALM1, GNB1, PLCG1More
Chlorpromazinehsa04015Rap1 signaling pathway3.67E-0412P04049, P20827, P49767, P06213, Q13009, O00522, Q08828, P51828, P31751, P0DP23, P17252, P19174RAF1, EFNA1, VEGFC, INSR, TIAM1, KRIT1, ADCY1, ADCY7, AKT2, CALM1, PRKCA, PLCG1More
Chlorpromazinehsa04020Calcium signaling pathway1.04E-0611P27987, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P51828, P23634, P49767ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, VEGFCMore
Chlorpromazinehsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Chlorpromazinehsa04024cAMP signaling pathway1.25E-0310Q08828, P51828, P31751, P0DP23, P23634, P04049, Q13557, Q13370, O15399, Q13009ADCY1, ADCY7, AKT2, CALM1, ATP2B4, RAF1, CAMK2D, PDE3B, GRIN2D, TIAM1More
Chlorpromazinehsa04062Chemokine signaling pathway9.36E-0311P51684, Q8NHW4, P19174, P62873, Q08828, P51828, Q13009, P14598, P42224, P31751, P04049CCR6, CCL4L2, PLCG1, GNB1, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2, RAF1More
Chlorpromazinehsa04064NF-kappa B signaling pathway2.28E-049P10415, Q13489, P51617, P01584, P29965, P19174, O75293, Q8NHW4, Q9NQC7BCL2, BIRC3, IRAK1, IL1B, CD40LG, PLCG1, GADD45B, CCL4L2, CYLDMore
Chlorpromazinehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Chlorpromazinehsa04070Phosphatidylinositol signaling system5.66E-046P19174, P0DP23, P23743, P48426, P27987, P17252PLCG1, CALM1, DGKA, PIP4K2A, ITPKB, PRKCAMore
Chlorpromazinehsa04071Sphingolipid signaling pathway3.96E-0812P04049, P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2, P01042RAF1, PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2, KNG1More
Chlorpromazinehsa04072Phospholipase D signaling pathway9.87E-039P04049, P31751, P19174, P17252, Q15438, Q08828, P51828, P23743, P00734RAF1, AKT2, PLCG1, PRKCA, PSCD1, ADCY1, ADCY7, DGKA, F2More
Chlorpromazinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Chlorpromazinehsa04114Oocyte meiosis6.23E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Chlorpromazinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Chlorpromazinehsa04137Mitophagy - animal3.55E-044Q96CV9, Q9H1Y0, P18848, O43524OPTN, ATG5, ATF4, FOXO3More
Chlorpromazinehsa04140Autophagy - animal1.61E-028P31751, P04049, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9AKT2, RAF1, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8More
Chlorpromazinehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Chlorpromazinehsa04144Endocytosis8.99E-0312P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6More
Chlorpromazinehsa04145Phagosome5.56E-038P60709, P63261, Q15075, Q15080, P14598, Q13509, Q13488, O60603ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TCIRG1, TLR2More
Chlorpromazinehsa04146Peroxisome3.03E-046O43933, O96011, P56589, Q9UKG9, O75521, P33121PEX1, PEX11B, PEX3, CROT, ECI2, ACSL1More
Chlorpromazinehsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Chlorpromazinehsa04151PI3K-Akt signaling pathway4.68E-0318O43521, P27348, P20827, P49767, Q13362, P08238, P62873, P16144, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, Q6ZUJ8BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AB1, GNB1, ITGB4, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, PIK3AP1More
Chlorpromazinehsa04210Apoptosis8.00E-058O76075, P07384, P01375, Q9NR28, Q16548, P60709, P63261, P04049DFFB, CAPN1, TNF, DIABLO, BCL2A1, ACTB, ACTG1, RAF1More
Chlorpromazinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Chlorpromazinehsa04217Necroptosis1.49E-1122P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4BMore
Chlorpromazinehsa04218Cellular senescence2.49E-021P04049RAF1More
Chlorpromazinehsa04261Adrenergic signaling in cardiomyocytes4.46E-0713P09493, P07550, Q08828, P51828, P22694, P31751, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Chlorpromazinehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Chlorpromazinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Chlorpromazinehsa04360Axon guidance3.05E-049P61073, P16333, P20827, O95631, P17252, Q13557, P23528, P04049, P19174CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, CFL1, RAF1, PLCG1More
Chlorpromazinehsa04370VEGF signaling pathway2.77E-044P16298, Q05397, Q02750, P04049PPP3CB, PTK2, MAP2K1, RAF1More
Chlorpromazinehsa04371Apelin signaling pathway1.61E-028P62873, P31751, P04049, Q08828, P51828, Q13370, Q13485, P0DP23GNB1, AKT2, RAF1, ADCY1, ADCY7, PDE3B, SMAD4, CALM1More
Chlorpromazinehsa04380Osteoclast differentiation4.18E-027Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1More
Chlorpromazinehsa04390Hippo signaling pathway2.80E-022P60709, P63261ACTB, ACTG1More
Chlorpromazinehsa04510Focal adhesion1.26E-028P16144, O75369, Q15942, P17252, Q13489, P10415, P04049, P49767ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, RAF1, VEGFCMore
Chlorpromazinehsa04520Adherens junction1.58E-022P60709, P63261ACTB, ACTG1More
Chlorpromazinehsa04530Tight junction6.83E-046P60709, P63261, P16989, P56750, Q14247, P60660ACTB, ACTG1, CSDA, CLDN17, CTTN, MYL6More
Chlorpromazinehsa04540Gap junction1.12E-026P17252, Q13509, P68371, Q08828, P51828, P04049PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7, RAF1More
Chlorpromazinehsa04550Signaling pathways regulating pluripotency of stem cells9.61E-034Q13873, P04049, Q02750, Q86SE9BMPR2, RAF1, MAP2K1, PCGF5More
Chlorpromazinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Chlorpromazinehsa04611Platelet activation2.61E-022P60709, P63261ACTB, ACTG1More
Chlorpromazinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Chlorpromazinehsa04613Neutrophil extracellular trap formation1.49E-1124P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Chlorpromazinehsa04620Toll-like receptor signaling pathway1.33E-025P51617, P01568, P31751, P42224, Q8NHW4IRAK1, IFNA21, AKT2, STAT1, CCL4L2More
Chlorpromazinehsa04621NOD-like receptor signaling pathway2.73E-0415P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Chlorpromazinehsa04623Cytosolic DNA-sensing pathway4.25E-022P01568, Q8NHW4IFNA21, CCL4L2More
Chlorpromazinehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Chlorpromazinehsa04630JAK-STAT signaling pathway1.77E-039P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P04049, P01568AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1, IFNA21More
Chlorpromazinehsa04640Hematopoietic cell lineage2.82E-034P08514, P21926, P07766, P09564ITGA2B, CD9, CD3E, CD7More
Chlorpromazinehsa04650Natural killer cell mediated cytotoxicity5.84E-0611P16298, P50591, P01375, P20963, Q02750, P04049, Q13241, P26718, P26717, Q14953, P26715PPP3CB, TNFSF10, TNF, CD247, MAP2K1, RAF1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Chlorpromazinehsa04657IL-17 signaling pathway5.66E-0510P07900, O00463, Q16539, P49841, P19875, P14780, Q9UJX4, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL2, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Chlorpromazinehsa04660T cell receptor signaling pathway1.66E-021P04049RAF1More
Chlorpromazinehsa04662B cell receptor signaling pathway2.13E-033P25963, P20023, P04049NFKBIA, CR2, RAF1More
Chlorpromazinehsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Chlorpromazinehsa04666Fc gamma R-mediated phagocytosis1.47E-027P08575, P19174, P04049, P23528, Q9UQC2, P14598, P17252PTPRC, PLCG1, RAF1, CFL1, GAB2, NCF1, PRKCAMore
Chlorpromazinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Chlorpromazinehsa04670Leukocyte transendothelial migration4.07E-022P60709, P63261ACTB, ACTG1More
Chlorpromazinehsa04713Circadian entrainment5.61E-057O15399, P0DP23, Q13557, P17252, P62873, Q08828, P51828GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, ADCY1, ADCY7More
Chlorpromazinehsa04714Thermogenesis3.66E-058Q16539, P15336, P60709, P63261, P33121, Q16718, O14521, P36542MAPK14, ATF2, ACTB, ACTG1, ACSL1, NDUFA5, SDHD, ATP5C1More
Chlorpromazinehsa04720Long-term potentiation1.22E-0410P17252, Q13557, P16298, P0DP23, P51812, P18848, O15399, Q08828, Q02750, P04049PRKCA, CAMK2D, PPP3CB, CALM1, RPS6KA3, ATF4, GRIN2D, ADCY1, MAP2K1, RAF1More
Chlorpromazinehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Chlorpromazinehsa04724Glutamatergic synapse5.91E-037P48058, O15399, Q08828, P51828, P17252, P62873, P15104GRIA4, GRIN2D, ADCY1, ADCY7, PRKCA, GNB1, GLULMore
Chlorpromazinehsa04725Cholinergic synapse4.42E-048Q08828, P51828, P17252, P62873, P18848, Q13557, P31751, P10415ADCY1, ADCY7, PRKCA, GNB1, ATF4, CAMK2D, AKT2, BCL2More
Chlorpromazinehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Chlorpromazinehsa04727GABAergic synapse4.08E-025Q08828, P51828, P62873, P46459, P17252ADCY1, ADCY7, GNB1, NSF, PRKCAMore
Chlorpromazinehsa04730Long-term depression1.16E-021P04049RAF1More
Chlorpromazinehsa04740Olfactory transduction5.88E-034P62873, Q9H255, Q13557, P0DP23GNB1, OR51E2, CAMK2D, CALM1More
Chlorpromazinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Chlorpromazinehsa04744Phototransduction1.30E-052P62873, P0DP23GNB1, CALM1More
Chlorpromazinehsa04750Inflammatory mediator regulation of TRP channels4.32E-058P01584, Q08828, P51828, Q13557, P19174, P17252, P0DP23, P01042IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PRKCA, CALM1, KNG1More
Chlorpromazinehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Chlorpromazinehsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Chlorpromazinehsa04911Insulin secretion3.47E-024Q08828, P17252, P18848, Q13557ADCY1, PRKCA, ATF4, CAMK2DMore
Chlorpromazinehsa04912GnRH signaling pathway1.35E-026P17252, Q08828, P18848, Q13557, P0DP23, P04049PRKCA, ADCY1, ATF4, CAMK2D, CALM1, RAF1More
Chlorpromazinehsa04913Ovarian steroidogenesis2.45E-033P42330, P22694, P06213AKR1C3, PRKACB, INSRMore
Chlorpromazinehsa04914Progesterone-mediated oocyte maturation6.70E-0411Q17RY0, Q08828, P51828, P31751, Q13370, Q9UJX4, Q9Y6D9, P08238, P51812, Q02750, P04049CPEB4, ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Chlorpromazinehsa04915Estrogen signaling pathway2.35E-0310P04049, P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415RAF1, ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2More
Chlorpromazinehsa04916Melanogenesis1.33E-021P04049RAF1More
Chlorpromazinehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Chlorpromazinehsa04919Thyroid hormone signaling pathway6.15E-057P49841, P04049, P22694, P60709, P63261, O60244, Q9NVC6GSK3B, RAF1, PRKACB, ACTB, ACTG1, MED14, MED17More
Chlorpromazinehsa04921Oxytocin signaling pathway1.43E-044P04049, P60660, P60709, P63261RAF1, MYL6, ACTB, ACTG1More
Chlorpromazinehsa04923Regulation of lipolysis in adipocytes4.48E-035Q08828, P51828, P06213, Q13370, P31751ADCY1, ADCY7, INSR, PDE3B, AKT2More
Chlorpromazinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Chlorpromazinehsa04925Aldosterone synthesis and secretion6.45E-047P18848, Q08828, P51828, P0DP23, P17252, Q13557, P23634ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B4More
Chlorpromazinehsa04926Relaxin signaling pathway6.24E-035P18848, P22694, P14780, P04049, P30679ATF4, PRKACB, MMP9, RAF1, GNA15More
Chlorpromazinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Chlorpromazinehsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Chlorpromazinehsa04929GnRH secretion4.98E-031P04049RAF1More
Chlorpromazinehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Chlorpromazinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Chlorpromazinehsa04932Non-alcoholic fatty liver disease6.73E-059P01375, P49841, P18848, P48023, P01584, P13073, O15239, Q16718, O14521TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Chlorpromazinehsa04933AGE-RAGE signaling pathway in diabetic complications2.04E-068Q13485, P01584, P42224, P10415, P31751, P49767, P17252, P19174SMAD4, IL1B, STAT1, BCL2, AKT2, VEGFC, PRKCA, PLCG1More
Chlorpromazinehsa04935Growth hormone synthesis, secretion and action1.77E-027P19174, Q08828, P51828, P04049, P17252, P31751, P42224PLCG1, ADCY1, ADCY7, RAF1, PRKCA, AKT2, STAT1More
Chlorpromazinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Chlorpromazinehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Chlorpromazinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Chlorpromazinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Chlorpromazinehsa04970Salivary secretion9.40E-058P07550, Q08828, P51828, P22694, P23634, P17252, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ATP2B4, PRKCA, CALM1, CAMPMore
Chlorpromazinehsa04971Gastric acid secretion1.02E-022P60709, P63261ACTB, ACTG1More
Chlorpromazinehsa04972Pancreatic secretion1.92E-035P23634, P17252, Q08828, P51828, P62491ATP2B4, PRKCA, ADCY1, ADCY7, RAB11AMore
Chlorpromazinehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Chlorpromazinehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Chlorpromazinehsa05014Amyotrophic lateral sclerosis2.98E-023P36542, P60709, P63261ATP5C1, ACTB, ACTG1More
Chlorpromazinehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Chlorpromazinehsa05017Spinocerebellar ataxia3.80E-038P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12More
Chlorpromazinehsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Chlorpromazinehsa05022Pathways of neurodegeneration - multiple diseases1.47E-0312P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2DMore
Chlorpromazinehsa05031Amphetamine addiction3.62E-037O15399, P0DP23, Q13557, P22694, P18848, P17252, Q13547GRIN2D, CALM1, CAMK2D, PRKACB, ATF4, PRKCA, HDAC1More
Chlorpromazinehsa05032Morphine addiction4.08E-025Q08828, P51828, P62873, Q13370, P17252ADCY1, ADCY7, GNB1, PDE3B, PRKCAMore
Chlorpromazinehsa05034Alcoholism1.81E-068Q13547, P04049, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, RAF1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Chlorpromazinehsa05100Bacterial invasion of epithelial cells7.49E-045Q14141, P60709, P63261, Q05397, Q96JJ3SEPT6, ACTB, ACTG1, PTK2, ELMO2More
Chlorpromazinehsa05110Vibrio cholerae infection3.95E-032P60709, P63261ACTB, ACTG1More
Chlorpromazinehsa05131Shigellosis6.67E-0412P01375, O00463, Q04759, Q9UDY8, Q9H1Y0, P60709, P63261, P20810, O43524, P07384, P10415, Q96A32TNF, TRAF5, PRKCQ, MALT1, ATG5, ACTB, ACTG1, CAST, FOXO3, CAPN1, BCL2, MYLPFMore
Chlorpromazinehsa05132Salmonella infection2.26E-0414P51617, P01584, P08238, P04049, Q96RF0, Q13489, P10415, P08575, O75369, Q13561, Q13509, P68371, P49754, Q9NP90IRAK1, IL1B, HSP90AB1, RAF1, SNAG1, BIRC3, BCL2, PTPRC, FLNB, DCTN2, TUBB3, TUBB2C, VPS41, RAB9BMore
Chlorpromazinehsa05133Pertussis6.00E-056P0DP23, P01584, P23528, P09871, P0C0L4, P51617CALM1, IL1B, CFL1, C1S, C4A, IRAK1More
Chlorpromazinehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Chlorpromazinehsa05135Yersinia infection6.16E-047P60709, P63261, Q05397, Q16513, P51812, Q02750, Q96JJ3ACTB, ACTG1, PTK2, PKN2, RPS6KA3, MAP2K1, ELMO2More
Chlorpromazinehsa05140Leishmaniasis2.58E-025P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Chlorpromazinehsa05143African trypanosomiasis1.93E-047P01375, P01584, P69905, P68871, P48023, P17252, P01042TNF, IL1B, HBA2, HBB, FASLG, PRKCA, KNG1More
Chlorpromazinehsa05144Malaria6.73E-066P69905, P68871, O60603, P01375, P35443, P26718HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Chlorpromazinehsa05145Toxoplasmosis5.28E-059P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RAMore
Chlorpromazinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Chlorpromazinehsa05150Staphylococcus aureus infection8.69E-045P21730, P21462, O75015, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA4, CAMPMore
Chlorpromazinehsa05152Tuberculosis1.17E-038P04049, O75015, P48382, O60603, P01375, P10415, P49913, Q9UDY8RAF1, FCGR3B, RFX5, TLR2, TNF, BCL2, CAMP, MALT1More
Chlorpromazinehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Chlorpromazinehsa05161Hepatitis B2.85E-0511P17252, P04049, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617PRKCA, RAF1, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1More
Chlorpromazinehsa05162Measles2.45E-0510P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2More
Chlorpromazinehsa05163Human cytomegalovirus infection2.33E-0315P31751, P04049, P62873, P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, P17252, Q13651, P18848, P61769, P01568AKT2, RAF1, GNB1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, PRKCA, IL10RA, ATF4, B2M, IFNA21More
Chlorpromazinehsa05164Influenza A8.97E-044P48551, P04049, P60709, P63261IFNAR2, RAF1, ACTB, ACTG1More
Chlorpromazinehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Chlorpromazinehsa05168Herpes simplex virus 1 infection2.45E-0518P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P61769, P31751, Q13398, Q6P280, Q03923, Q9UDV6, P10415, Q14232IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, B2M, AKT2, ZNF211, ZNF529, ZNF85, ZNF212, BCL2, EIF2B1More
Chlorpromazinehsa05170Human immunodeficiency virus 1 infection1.46E-0513P31751, P04049, P62873, P0DP23, P61073, P17252, P61769, P01568, P51617, P19174, P23528, P10415, Q9Y6Q5AKT2, RAF1, GNB1, CALM1, CXCR4, PRKCA, B2M, IFNA21, IRAK1, PLCG1, CFL1, BCL2, AP1M2More
Chlorpromazinehsa05171Coronavirus disease - COVID-196.98E-0512P01584, P62753, P25398, P62249, P40429, P36578, P32969, P27635, Q07020, P18077, P05386, P62829IL1B, RPS6, RPS12, RPS16, RPL13A, RPL4, RPL9, RPL10, RPL18, RPL35A, RPLP1, RPL23More
Chlorpromazinehsa05200Pathways in cancer4.30E-0928P23458, P08238, P42224, P19174, Q15311, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P31751, Q08828, P51828, P62873, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042JAK1, HSP90AB1, STAT1, PLCG1, RALBP1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, AKT2, ADCY1, ADCY7, GNB1, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1More
Chlorpromazinehsa05202Transcriptional misregulation in cancer1.62E-0315Q15532, P41732, P14780, P27930, P14923, Q16548, P11215, Q13077, O15550, P35226, P05164, P08246, Q13547, P12980, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, ITGAM, TRAF1, UTX, BMI1, MPO, ELA2, HDAC1, LYL1, GADD45AMore
Chlorpromazinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Chlorpromazinehsa05204Chemical carcinogenesis4.02E-055P00325, P09211, P78417, P11712, P33260ADH1B, GSTP1, GSTO1, CYP2C9, CYP2C18More
Chlorpromazinehsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Chlorpromazinehsa05206MicroRNAs in cancer4.38E-033P15311, P63279, P04049VIL2, UBE2I, RAF1More
Chlorpromazinehsa05210Colorectal cancer1.66E-021P04049RAF1More
Chlorpromazinehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Chlorpromazinehsa05212Pancreatic cancer1.15E-037P31751, P04049, Q15311, P23458, P42224, Q13485, O75293AKT2, RAF1, RALBP1, JAK1, STAT1, SMAD4, GADD45BMore
Chlorpromazinehsa05213Endometrial cancer9.95E-031P04049RAF1More
Chlorpromazinehsa05214Glioma3.96E-067P0DP23, Q13557, P17252, P04049, P31751, P19174, O75293CALM1, CAMK2D, PRKCA, RAF1, AKT2, PLCG1, GADD45BMore
Chlorpromazinehsa05215Prostate cancer1.33E-021P04049RAF1More
Chlorpromazinehsa05218Melanoma6.63E-031P04049RAF1More
Chlorpromazinehsa05219Bladder cancer4.98E-031P04049RAF1More
Chlorpromazinehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Chlorpromazinehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Chlorpromazinehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Chlorpromazinehsa05224Breast cancer1.49E-021P04049RAF1More
Chlorpromazinehsa05225Hepatocellular carcinoma2.85E-033P04049, P60709, P63261RAF1, ACTB, ACTG1More
Chlorpromazinehsa05226Gastric cancer8.29E-031P04049RAF1More
Chlorpromazinehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Chlorpromazinehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Chlorpromazinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-021P04049RAF1More
Chlorpromazinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Chlorpromazinehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Chlorpromazinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Chlorpromazinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Chlorpromazinehsa05340Primary immunodeficiency2.68E-022P11912, P07766CD79A, CD3EMore
Chlorpromazinehsa05410Hypertrophic cardiomyopathy1.02E-022P60709, P63261ACTB, ACTG1More
Chlorpromazinehsa05412Arrhythmogenic right ventricular cardiomyopathy3.44E-033P54284, P60709, P63261CACNB3, ACTB, ACTG1More
Chlorpromazinehsa05414Dilated cardiomyopathy1.73E-022P60709, P63261ACTB, ACTG1More
Chlorpromazinehsa05415Diabetic cardiomyopathy1.02E-038P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2DMore
Chlorpromazinehsa05416Viral myocarditis8.96E-032P60709, P63261ACTB, ACTG1More
Chlorpromazinehsa05418Fluid shear stress and atherosclerosis3.64E-038P14598, P78417, P60709, P63261, P10415, P0DP23, P08238, Q92974NCF1, GSTO1, ACTB, ACTG1, BCL2, CALM1, HSP90AB1, ARHGEF2More

Community members of Chlorpromazine (SDC: 5.59)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P0DP23CALM1CalmodulinNone1Reported00.45520.147911.5235
P02763ORM1AlphaNone1Noneacid glycoprotein 1Reported10.05530.057900.1435
P19652ORM2AlphaNone1Noneacid glycoprotein 2Reported10.09380.057900.1628
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P04156PRNPMajor prion proteinPredicted00.59090.173700.6429
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P37840SNCAAlphaNonesynucleinPredicted10.08530.13240.33210.6395
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P0DP25CALM3CalmodulinNone3Predicted00.56610.147900.5789
P0DP24CALM2CalmodulinNone2Predicted00.43760.147900.5147
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P60660MYL6Myosin light polypeptide 6Predicted00.55950.06870.21750.6346
P24844MYL9Myosin regulatory light polypeptide 9Predicted00.00640.0630.60260.7318
P14649MYL6BMyosin light chain 6BPredicted00.04770.06530.21750.3719
P05976MYL1Myosin light chain 1/3, skeletal muscle isoformPredicted00.25810.061900.2528
O15182CETN3CentrinNone3Predicted00.18720.059400.2123
Q96A32MYLPFMyosin regulatory light chain 2, skeletal muscle isoformPredicted00.01350.04730.54120.6425
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416IC501
DRD2P14416IC503
DRD2P14416IC5012
DRD2P14416Ki0.66
DRD2P14416Ki1.2
DRD2P14416Ki1.3