| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Chloroquine | hsa00040 | Pentose and glucuronate interconversions | 2.33E-04 | 2 | P15121, P14550 | AKR1B1, AKR1A1 | More | | | Chloroquine | hsa00310 | Lysine degradation | 2.59E-02 | 2 | Q96KQ7, P51648 | EHMT2, ALDH3A2 | More | | | Chloroquine | hsa00512 | Mucin type O-glycan biosynthesis | 4.86E-02 | 2 | O95395, Q9NY28 | GCNT3, GALNT8 | More | | | Chloroquine | hsa00561 | Glycerolipid metabolism | 2.62E-02 | 2 | P15121, P14550 | AKR1B1, AKR1A1 | More | | | Chloroquine | hsa00630 | Glyoxylate and dicarboxylate metabolism | 9.21E-03 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Chloroquine | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Chloroquine | hsa00790 | Folate biosynthesis | 1.36E-03 | 3 | Q92820, P15121, P42330 | GGH, AKR1B1, AKR1C3 | More | | | Chloroquine | hsa00830 | Retinol metabolism | 3.15E-02 | 1 | P00325 | ADH1B | More | | | Chloroquine | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 4.00E-02 | 1 | P09211 | GSTP1 | More | | | Chloroquine | hsa00983 | Drug metabolism - other enzymes | 1.63E-02 | 2 | P20839, Q16772 | IMPDH1, GSTA3 | More | | | Chloroquine | hsa01100 | Metabolic pathways | 2.59E-02 | 11 | P35790, Q16772, P30041, P20839, O94777, P15121, O95861, P14550, Q9UHK6, Q86VZ5, Q9NVH6 | CHKA, GSTA3, PRDX6, IMPDH1, DPM2, AKR1B1, BPNT1, AKR1A1, AMACR, SGMS1, TMLHE | More | | | Chloroquine | hsa01523 | Antifolate resistance | 1.68E-02 | 2 | Q92820, P04818 | GGH, TYMS | More | | | Chloroquine | hsa03010 | Ribosome | 2.25E-04 | 5 | P40429, Q07020, P27635, P05386, P62249 | RPL13A, RPL18, RPL10, RPLP1, RPS16 | More | | | Chloroquine | hsa03020 | RNA polymerase | 1.31E-02 | 2 | P24928, P62487 | POLR2A, POLR2G | More | | | Chloroquine | hsa03040 | Spliceosome | 1.08E-02 | 7 | Q14562, O43143, O60508, Q07955, Q01130, Q13243, P11142 | DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5, HSPA8 | More | | | Chloroquine | hsa04014 | Ras signaling pathway | 8.66E-03 | 7 | Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174 | PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1 | More | | | Chloroquine | hsa04060 | Cytokine-cytokine receptor interaction | 2.31E-02 | 7 | P08476, Q13651, Q9HBE5, Q9UBD3, P47992, P09341, Q93038 | INHBA, IL10RA, IL21R, XCL2, XCL1, CXCL1, TNFRSF25 | More | | | Chloroquine | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 3.52E-02 | 4 | P09341, P47992, Q9UBD3, Q13651 | CXCL1, XCL1, XCL2, IL10RA | More | | | Chloroquine | hsa04062 | Chemokine signaling pathway | 1.59E-03 | 9 | P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963 | LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIA | More | | | Chloroquine | hsa04070 | Phosphatidylinositol signaling system | 2.93E-02 | 4 | P19174, P0DP23, P23743, P27987 | PLCG1, CALM1, DGKA, ITPKB | More | | | Chloroquine | hsa04110 | Cell cycle | 6.63E-04 | 6 | P06493, O60566, P30304, P33981, P42773, P01106 | CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC | More | | | Chloroquine | hsa04120 | Ubiquitin mediated proteolysis | 3.44E-02 | 4 | Q14145, Q13042, P62837, Q15751 | KEAP1, CDC16, UBE2D2, HERC1 | More | | | Chloroquine | hsa04140 | Autophagy - animal | 4.96E-02 | 3 | Q9NQL2, P22694, Q04759 | RRAGD, PRKACB, PRKCQ | More | | | Chloroquine | hsa04141 | Protein processing in endoplasmic reticulum | 8.60E-03 | 6 | P30101, P60604, P11142, P08238, Q9H173, Q9UNL2 | PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3 | More | | | Chloroquine | hsa04145 | Phagosome | 1.72E-04 | 11 | P11215, P14598, Q71U36, Q13509, P68371, Q13488, P05164, Q9UEW3, P78380, P35443, P13765 | ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, MARCO, OLR1, THBS4, HLA-DOB | More | | | Chloroquine | hsa04217 | Necroptosis | 2.34E-02 | 4 | P01375, P48023, Q14765, Q99878 | TNF, FASLG, STAT4, H2AC14 | More | | | Chloroquine | hsa04371 | Apelin signaling pathway | 7.95E-04 | 7 | P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23 | GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1 | More | | | Chloroquine | hsa04392 | Hippo signaling pathway - multiple species | 6.35E-03 | 1 | Q9UGP4 | LIMD1 | More | | | Chloroquine | hsa04540 | Gap junction | 1.08E-02 | 4 | Q13509, P68371, Q71U36, Q9NRA1 | TUBB3, TUBB2C, TUBA1A, PDGFC | More | | | Chloroquine | hsa04612 | Antigen processing and presentation | 4.78E-02 | 6 | P48382, P26715, P26717, Q13241, O43908, P01375 | RFX5, KLRC1, KLRC2, KLRD1, KLRC4, TNF | More | | | Chloroquine | hsa04621 | NOD-like receptor signaling pathway | 2.27E-02 | 9 | Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838 | ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4 | More | | | Chloroquine | hsa04623 | Cytosolic DNA-sensing pathway | 2.59E-02 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Chloroquine | hsa04640 | Hematopoietic cell lineage | 4.95E-02 | 3 | P01730, P06127, P09564 | CD4, CD5, CD7 | More | | | Chloroquine | hsa04650 | Natural killer cell mediated cytotoxicity | 1.25E-02 | 8 | P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715 | TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1 | More | | | Chloroquine | hsa04658 | Th1 and Th2 cell differentiation | 5.28E-03 | 5 | Q04759, P20963, P06239, P23771, P13765 | PRKCQ, CD247, LCK, GATA3, HLA-DOB | More | | | Chloroquine | hsa04659 | Th17 cell differentiation | 9.87E-05 | 12 | P25963, Q04759, P19174, P06239, P42224, P14784, P13765, Q9HBE5, P23771, P84022, P08238, P20963 | NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL21R, GATA3, SMAD3, HSP90AB1, CD247 | More | | | Chloroquine | hsa04664 | Fc epsilon RI signaling pathway | 6.97E-03 | 4 | P04141, P07948, P19174, P09917 | CSF2, LYN, PLCG1, ALOX5 | More | | | Chloroquine | hsa04713 | Circadian entrainment | 2.18E-02 | 4 | P0DP23, P62873, P63218, P50151 | CALM1, GNB1, GNG5, GNG10 | More | | | Chloroquine | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Chloroquine | hsa04724 | Glutamatergic synapse | 1.57E-02 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Chloroquine | hsa04726 | Serotonergic synapse | 3.80E-02 | 4 | P62873, P63218, P50151, P09917 | GNB1, GNG5, GNG10, ALOX5 | More | | | Chloroquine | hsa04727 | GABAergic synapse | 4.18E-03 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Chloroquine | hsa04730 | Long-term depression | 4.86E-02 | 2 | Q14344, P07948 | GNA13, LYN | More | | | Chloroquine | hsa04744 | Phototransduction | 9.21E-03 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Chloroquine | hsa04750 | Inflammatory mediator regulation of TRP channels | 4.96E-02 | 3 | P22694, P24723, Q04759 | PRKACB, PRKCH, PRKCQ | More | | | Chloroquine | hsa04912 | GnRH signaling pathway | 4.99E-02 | 1 | P18146 | EGR1 | More | | | Chloroquine | hsa04913 | Ovarian steroidogenesis | 2.81E-02 | 2 | P42330, P22694 | AKR1C3, PRKACB | More | | | Chloroquine | hsa04932 | Non-alcoholic fatty liver disease | 2.74E-02 | 3 | P01375, P49841, P48023 | TNF, GSK3B, FASLG | More | | | Chloroquine | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Chloroquine | hsa04972 | Pancreatic secretion | 1.31E-02 | 2 | Q08828, P62491 | ADCY1, RAB11A | More | | | Chloroquine | hsa05012 | Parkinson disease | 1.77E-02 | 6 | P60604, P19174, P0DP23, Q71U36, Q13509, P68371 | UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C | More | | | Chloroquine | hsa05032 | Morphine addiction | 2.18E-02 | 4 | P62873, P63218, P50151, Q13370 | GNB1, GNG5, GNG10, PDE3B | More | | | Chloroquine | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.08E-02 | 4 | P25963, Q13488, P19174, P07948 | NFKBIA, TCIRG1, PLCG1, LYN | More | | | Chloroquine | hsa05130 | Pathogenic Escherichia coli infection | 3.19E-02 | 6 | Q71U36, P16333, Q13509, P68371, Q14344, P25963 | TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA | More | | | Chloroquine | hsa05132 | Salmonella infection | 2.75E-02 | 7 | P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754 | NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41 | More | | | Chloroquine | hsa05134 | Legionellosis | 4.75E-02 | 3 | P25963, P11215, P11142 | NFKBIA, ITGAM, HSPA8 | More | | | Chloroquine | hsa05140 | Leishmaniasis | 4.82E-02 | 4 | P14598, P11215, P42224, P25963 | NCF1, ITGAM, STAT1, NFKBIA | More | | | Chloroquine | hsa05143 | African trypanosomiasis | 2.72E-02 | 2 | P01375, P48023 | TNF, FASLG | More | | | Chloroquine | hsa05144 | Malaria | 3.12E-02 | 4 | P60033, P01375, P35443, P26718 | CD81, TNF, THBS4, KLRK1 | More | | | Chloroquine | hsa05146 | Amoebiasis | 2.89E-02 | 4 | P09341, P05089, P22694, P08311 | CXCL1, ARG1, PRKACB, CTSG | More | | | Chloroquine | hsa05150 | Staphylococcus aureus infection | 1.02E-03 | 7 | P21730, P21462, O75015, P59665, P59666, P12838, P49913 | C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP | More | | | Chloroquine | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Chloroquine | hsa05163 | Human cytomegalovirus infection | 2.56E-03 | 8 | P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568 | NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21 | More | | | Chloroquine | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 8.62E-05 | 10 | P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23 | IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1 | More | | | Chloroquine | hsa05168 | Herpes simplex virus 1 infection | 3.79E-02 | 9 | P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820 | NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189 | More | | | Chloroquine | hsa05170 | Human immunodeficiency virus 1 infection | 1.19E-02 | 8 | P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174 | GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1 | More | | | Chloroquine | hsa05171 | Coronavirus disease - COVID-19 | 3.87E-04 | 5 | P62249, P40429, P27635, Q07020, P05386 | RPS16, RPL13A, RPL10, RPL18, RPLP1 | More | | | Chloroquine | hsa05200 | Pathways in cancer | 1.99E-03 | 15 | P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784 | HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.816 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P20585 | MSH3 | DNA mismatch repair protein Msh3 | 0.825 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.756 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.742 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.816 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P20585 | MSH3 | DNA mismatch repair protein Msh3 | 0.825 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.756 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.742 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 |
| | Chloroquine | hsa05204 | Chemical carcinogenesis | 4.00E-02 | 1 | P09211 | GSTP1 | More | | | Chloroquine | hsa05212 | Pancreatic cancer | 4.75E-02 | 3 | P42224, P84022, O75293 | STAT1, SMAD3, GADD45B | More | | | Chloroquine | hsa05214 | Glioma | 4.75E-02 | 3 | P0DP23, P19174, O75293 | CALM1, PLCG1, GADD45B | More | | | Chloroquine | hsa05310 | Asthma | 2.81E-02 | 2 | P13765, P12724 | HLA-DOB, RNASE3 | More | | | Chloroquine | hsa05321 | Inflammatory bowel disease | 2.21E-02 | 3 | P13765, P23771, Q9HBE5 | HLA-DOB, GATA3, IL21R | More | | | Chloroquine | hsa05330 | Allograft rejection | 2.72E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Chloroquine | hsa05332 | Graft-versus-host disease | 3.70E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Hydroxychloroquine | hsa00310 | Lysine degradation | 2.59E-02 | 2 | Q96KQ7, P51648 | EHMT2, ALDH3A2 | More | | | Hydroxychloroquine | hsa00512 | Mucin type O-glycan biosynthesis | 4.86E-02 | 2 | O95395, Q9NY28 | GCNT3, GALNT8 | More | | | Hydroxychloroquine | hsa00600 | Sphingolipid metabolism | 4.56E-02 | 3 | Q9BX95, Q06136, P06280 | SGPP1, FVT1, GLA | More | | | Hydroxychloroquine | hsa00630 | Glyoxylate and dicarboxylate metabolism | 9.21E-03 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Hydroxychloroquine | hsa00830 | Retinol metabolism | 3.15E-02 | 1 | P00325 | ADH1B | More | | | Hydroxychloroquine | hsa01523 | Antifolate resistance | 1.68E-02 | 2 | Q92820, P04818 | GGH, TYMS | More | | | Hydroxychloroquine | hsa03013 | RNA transport | 1.91E-02 | 9 | P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5 | NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3 | More | | | Hydroxychloroquine | hsa03020 | RNA polymerase | 1.31E-02 | 2 | P24928, P62487 | POLR2A, POLR2G | More | | | Hydroxychloroquine | hsa03040 | Spliceosome | 1.08E-02 | 7 | Q14562, O43143, O60508, Q07955, Q01130, Q13243, P11142 | DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5, HSPA8 | More | | | Hydroxychloroquine | hsa04014 | Ras signaling pathway | 8.66E-03 | 7 | Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174 | PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1 | More | | | Hydroxychloroquine | hsa04062 | Chemokine signaling pathway | 1.59E-03 | 9 | P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963 | LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIA | More | | | Hydroxychloroquine | hsa04064 | NF-kappa B signaling pathway | 2.83E-02 | 8 | P10415, Q13489, O00463, Q13546, Q9UDY8, Q13077, Q16548, P24522 | BCL2, BIRC3, TRAF5, RIPK1, MALT1, TRAF1, BCL2A1, GADD45A | More | | | Hydroxychloroquine | hsa04070 | Phosphatidylinositol signaling system | 2.93E-02 | 4 | P19174, P0DP23, P23743, P27987 | PLCG1, CALM1, DGKA, ITPKB | More | | | Hydroxychloroquine | hsa04071 | Sphingolipid signaling pathway | 1.03E-02 | 6 | P21453, Q9H228, Q16537, Q9BX95, Q16539, P10415 | S1PR1, EDG8, PPP2R5E, SGPP1, MAPK14, BCL2 | More | | | Hydroxychloroquine | hsa04110 | Cell cycle | 6.63E-04 | 6 | P06493, O60566, P30304, P33981, P42773, P01106 | CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC | More | | | Hydroxychloroquine | hsa04141 | Protein processing in endoplasmic reticulum | 8.60E-03 | 6 | P30101, P60604, P11142, P08238, Q9H173, Q9UNL2 | PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3 | More | | | Hydroxychloroquine | hsa04145 | Phagosome | 6.51E-03 | 6 | P11215, P14598, Q71U36, Q13509, P68371, Q13488 | ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1 | More | | | Hydroxychloroquine | hsa04371 | Apelin signaling pathway | 7.95E-04 | 7 | P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23 | GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1 | More | | | Hydroxychloroquine | hsa04392 | Hippo signaling pathway - multiple species | 6.35E-03 | 1 | Q9UGP4 | LIMD1 | More | | | Hydroxychloroquine | hsa04540 | Gap junction | 1.08E-02 | 4 | Q13509, P68371, Q71U36, Q9NRA1 | TUBB3, TUBB2C, TUBA1A, PDGFC | More | | | Hydroxychloroquine | hsa04612 | Antigen processing and presentation | 4.78E-02 | 6 | P48382, P26715, P26717, Q13241, O43908, P01375 | RFX5, KLRC1, KLRC2, KLRD1, KLRC4, TNF | More | | | Hydroxychloroquine | hsa04613 | Neutrophil extracellular trap formation | 7.45E-03 | 12 | O60603, P05164, P08246, Q9UM07, Q92769, Q6FI13, Q15080, O75015, P21730, P21462, O43315, Q16539 | TLR2, MPO, ELA2, PADI4, HDAC2, H2AC18; H2AC19, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | | Hydroxychloroquine | hsa04621 | NOD-like receptor signaling pathway | 2.27E-02 | 9 | Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838 | ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4 | More | | | Hydroxychloroquine | hsa04623 | Cytosolic DNA-sensing pathway | 2.59E-02 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Hydroxychloroquine | hsa04640 | Hematopoietic cell lineage | 4.95E-02 | 3 | P01730, P06127, P09564 | CD4, CD5, CD7 | More | | | Hydroxychloroquine | hsa04650 | Natural killer cell mediated cytotoxicity | 1.25E-02 | 8 | P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715 | TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1 | More | | | Hydroxychloroquine | hsa04659 | Th17 cell differentiation | 1.11E-02 | 6 | P25963, P19174, P42224, P14784, P84022, P08238 | NFKBIA, PLCG1, STAT1, IL2RB, SMAD3, HSP90AB1 | More | | | Hydroxychloroquine | hsa04664 | Fc epsilon RI signaling pathway | 6.97E-03 | 4 | P04141, P07948, P19174, P09917 | CSF2, LYN, PLCG1, ALOX5 | More | | | Hydroxychloroquine | hsa04668 | TNF signaling pathway | 4.96E-02 | 6 | O00463, Q13546, Q13489, Q16539, Q13077, P14780 | TRAF5, RIPK1, BIRC3, MAPK14, TRAF1, MMP9 | More | | | Hydroxychloroquine | hsa04713 | Circadian entrainment | 2.18E-02 | 4 | P0DP23, P62873, P63218, P50151 | CALM1, GNB1, GNG5, GNG10 | More | | | Hydroxychloroquine | hsa04724 | Glutamatergic synapse | 1.57E-02 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Hydroxychloroquine | hsa04726 | Serotonergic synapse | 3.80E-02 | 4 | P62873, P63218, P50151, P09917 | GNB1, GNG5, GNG10, ALOX5 | More | | | Hydroxychloroquine | hsa04727 | GABAergic synapse | 4.18E-03 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Hydroxychloroquine | hsa04730 | Long-term depression | 4.86E-02 | 2 | Q14344, P07948 | GNA13, LYN | More | | | Hydroxychloroquine | hsa04744 | Phototransduction | 9.21E-03 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Hydroxychloroquine | hsa04912 | GnRH signaling pathway | 4.99E-02 | 1 | P18146 | EGR1 | More | | | Hydroxychloroquine | hsa04972 | Pancreatic secretion | 1.31E-02 | 2 | Q08828, P62491 | ADCY1, RAB11A | More | | | Hydroxychloroquine | hsa05012 | Parkinson disease | 1.77E-02 | 6 | P60604, P19174, P0DP23, Q71U36, Q13509, P68371 | UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C | More | | | Hydroxychloroquine | hsa05032 | Morphine addiction | 2.18E-02 | 4 | P62873, P63218, P50151, Q13370 | GNB1, GNG5, GNG10, PDE3B | More | | | Hydroxychloroquine | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.08E-02 | 4 | P25963, Q13488, P19174, P07948 | NFKBIA, TCIRG1, PLCG1, LYN | More | | | Hydroxychloroquine | hsa05130 | Pathogenic Escherichia coli infection | 3.19E-02 | 6 | Q71U36, P16333, Q13509, P68371, Q14344, P25963 | TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA | More | | | Hydroxychloroquine | hsa05132 | Salmonella infection | 2.75E-02 | 7 | P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754 | NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41 | More | | | Hydroxychloroquine | hsa05134 | Legionellosis | 4.75E-02 | 3 | P25963, P11215, P11142 | NFKBIA, ITGAM, HSPA8 | More | | | Hydroxychloroquine | hsa05140 | Leishmaniasis | 4.82E-02 | 4 | P14598, P11215, P42224, P25963 | NCF1, ITGAM, STAT1, NFKBIA | More | | | Hydroxychloroquine | hsa05144 | Malaria | 3.12E-02 | 4 | P60033, P01375, P35443, P26718 | CD81, TNF, THBS4, KLRK1 | More | | | Hydroxychloroquine | hsa05150 | Staphylococcus aureus infection | 1.02E-03 | 7 | P21730, P21462, O75015, P59665, P59666, P12838, P49913 | C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP | More | | | Hydroxychloroquine | hsa05163 | Human cytomegalovirus infection | 2.56E-03 | 8 | P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568 | NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21 | More | | | Hydroxychloroquine | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 8.62E-05 | 10 | P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23 | IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1 | More | | | Hydroxychloroquine | hsa05168 | Herpes simplex virus 1 infection | 3.79E-02 | 9 | P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820 | NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189 | More | | | Hydroxychloroquine | hsa05170 | Human immunodeficiency virus 1 infection | 1.19E-02 | 8 | P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174 | GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1 | More | | | Hydroxychloroquine | hsa05200 | Pathways in cancer | 1.99E-03 | 15 | P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784 | HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.816 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P20585 | MSH3 | DNA mismatch repair protein Msh3 | 0.825 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.756 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.742 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.816 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P20585 | MSH3 | DNA mismatch repair protein Msh3 | 0.825 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.756 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.742 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 |
| | Hydroxychloroquine | hsa05202 | Transcriptional misregulation in cancer | 1.61E-03 | 13 | Q15532, P41732, P14780, P27930, Q16548, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, Q92769, P24522 | SS18, TSPAN7, MMP9, IL1R2, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, HDAC2, GADD45A | More | | | Hydroxychloroquine | hsa05212 | Pancreatic cancer | 4.75E-02 | 3 | P42224, P84022, O75293 | STAT1, SMAD3, GADD45B | More | | | Hydroxychloroquine | hsa05214 | Glioma | 4.75E-02 | 3 | P0DP23, P19174, O75293 | CALM1, PLCG1, GADD45B | More | | | Hydroxychloroquine | hsa05217 | Basal cell carcinoma | 2.01E-02 | 4 | Q13635, P04628, Q9UJU2, P24522 | PTCH1, WNT1, LEF1, GADD45A | More | |
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