PharmaCoNets of Chlordiazepoxide (SPCN: 101.27 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Chlordiazepoxidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Chlordiazepoxidehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Chlordiazepoxidehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Chlordiazepoxidehsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Chlordiazepoxidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Chlordiazepoxidehsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Chlordiazepoxidehsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Chlordiazepoxidehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Chlordiazepoxidehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Chlordiazepoxidehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Chlordiazepoxidehsa01523Antifolate resistance1.01E-045P41439, P41440, Q92820, P04818, P01375FOLR3, SLC19A1, GGH, TYMS, TNFMore
Chlordiazepoxidehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Chlordiazepoxidehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Chlordiazepoxidehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Chlordiazepoxidehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Chlordiazepoxidehsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Chlordiazepoxidehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Chlordiazepoxidehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Chlordiazepoxidehsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Chlordiazepoxidehsa03050Proteasome1.40E-021P55036PSMD4More
Chlordiazepoxidehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Chlordiazepoxidehsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Chlordiazepoxidehsa04064NF-kappa B signaling pathway4.36E-0411P10415, O00463, P14778, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P24522, P09341BCL2, TRAF5, IL1R1, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, GADD45A, CXCL1More
Chlordiazepoxidehsa04071Sphingolipid signaling pathway6.65E-047P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Chlordiazepoxidehsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Chlordiazepoxidehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Chlordiazepoxidehsa04110Cell cycle1.97E-057P06493, O60566, O75293, P30304, P33981, P42773, P01106CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Chlordiazepoxidehsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Chlordiazepoxidehsa04120Ubiquitin mediated proteolysis1.44E-047Q9UBT2, Q14145, Q13042, Q13191, Q15751, Q14669, Q7Z6Z7SAE2, KEAP1, CDC16, CBLB, HERC1, TRIP12, HUWE1More
Chlordiazepoxidehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Chlordiazepoxidehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Chlordiazepoxidehsa04141Protein processing in endoplasmic reticulum3.42E-047P18848, Q15437, O60337, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, MARH6, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Chlordiazepoxidehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Chlordiazepoxidehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Chlordiazepoxidehsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Chlordiazepoxidehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Chlordiazepoxidehsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Chlordiazepoxidehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Chlordiazepoxidehsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Chlordiazepoxidehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Chlordiazepoxidehsa04261Adrenergic signaling in cardiomyocytes1.59E-037P51828, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557ADCY7, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2DMore
Chlordiazepoxidehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Chlordiazepoxidehsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Chlordiazepoxidehsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Chlordiazepoxidehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Chlordiazepoxidehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Chlordiazepoxidehsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Chlordiazepoxidehsa04613Neutrophil extracellular trap formation2.06E-0416O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Chlordiazepoxidehsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Chlordiazepoxidehsa04640Hematopoietic cell lineage4.71E-035P21926, P07766, P01730, P06127, P09564CD9, CD3E, CD4, CD5, CD7More
Chlordiazepoxidehsa04650Natural killer cell mediated cytotoxicity3.18E-038P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Chlordiazepoxidehsa04657IL-17 signaling pathway5.20E-0410P07900, O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Chlordiazepoxidehsa04658Th1 and Th2 cell differentiation1.07E-037Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOBMore
Chlordiazepoxidehsa04659Th17 cell differentiation1.90E-026Q04759, P13765, Q9UL17, P23771, P09693, P20963PRKCQ, HLA-DOB, TBX21, GATA3, CD3G, CD247More
Chlordiazepoxidehsa04660T cell receptor signaling pathway1.00E-027Q9UDY8, Q04759, P10747, Q08881, P20963, P09693, P01732MALT1, PRKCQ, CD28, ITK, CD247, CD3G, CD8AMore
Chlordiazepoxidehsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Chlordiazepoxidehsa04714Thermogenesis6.01E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Chlordiazepoxidehsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Chlordiazepoxidehsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Chlordiazepoxidehsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Chlordiazepoxidehsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Chlordiazepoxidehsa04728Dopaminergic synapse3.20E-036Q99941, P18848, Q13557, Q13362, Q14738, P0DP23CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1More
Chlordiazepoxidehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Chlordiazepoxidehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Chlordiazepoxidehsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Chlordiazepoxidehsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Chlordiazepoxidehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Chlordiazepoxidehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Chlordiazepoxidehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Chlordiazepoxidehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Chlordiazepoxidehsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Chlordiazepoxidehsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Chlordiazepoxidehsa04928Parathyroid hormone synthesis, secretion and action3.09E-037Q14643, P51828, P22694, P23771, Q99941, P18848, P10415ITPR1, ADCY7, PRKACB, GATA3, CREBL1, ATF4, BCL2More
Chlordiazepoxidehsa04932Non-alcoholic fatty liver disease9.01E-047P49841, P18848, P01584, P13073, O15239, Q16718, O14521GSK3B, ATF4, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Chlordiazepoxidehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Chlordiazepoxidehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Chlordiazepoxidehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Chlordiazepoxidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Chlordiazepoxidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Chlordiazepoxidehsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Chlordiazepoxidehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Chlordiazepoxidehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Chlordiazepoxidehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Chlordiazepoxidehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Chlordiazepoxidehsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Chlordiazepoxidehsa05022Pathways of neurodegeneration - multiple diseases1.47E-0312P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2DMore
Chlordiazepoxidehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Chlordiazepoxidehsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Chlordiazepoxidehsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Chlordiazepoxidehsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Chlordiazepoxidehsa05133Pertussis4.20E-021P0C0L4C4AMore
Chlordiazepoxidehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Chlordiazepoxidehsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Chlordiazepoxidehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Chlordiazepoxidehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Chlordiazepoxidehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Chlordiazepoxidehsa05146Amoebiasis4.55E-025P09341, P14778, P27930, O60603, P05089CXCL1, IL1R1, IL1R2, TLR2, ARG1More
Chlordiazepoxidehsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Chlordiazepoxidehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Chlordiazepoxidehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Chlordiazepoxidehsa05163Human cytomegalovirus infection4.65E-0311P62873, Q14643, P61586, P49841, P14778, P25025, Q16539, P63092, P04637, O00463, P61769GNB1, ITPR1, RHOA, GSK3B, IL1R1, CXCR2, MAPK14, GNAS, TP53, TRAF5, B2MMore
Chlordiazepoxidehsa05167Kaposi sarcoma-associated herpesvirus infection4.82E-023P23458, Q13469, P0DP23JAK1, NFATC2, CALM1More
Chlordiazepoxidehsa05171Coronavirus disease - COVID-193.15E-049P01584, P62753, P25398, Q9UHA3, P36578, P32969, P18077, P62829, O14786IL1B, RPS6, RPS12, RSL24D1, RPL4, RPL9, RPL35A, RPL23, NRP1More
Chlordiazepoxidehsa05202Transcriptional misregulation in cancer1.40E-0315Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, BCL11B, GADD45AMore
Chlordiazepoxidehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Chlordiazepoxidehsa05212Pancreatic cancer4.16E-022Q15311, P23458RALBP1, JAK1More
Chlordiazepoxidehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Chlordiazepoxidehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Chlordiazepoxidehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Chlordiazepoxidehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Chlordiazepoxidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.69E-0411O95267, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, Q9HC35, P01730RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Chlordiazepoxidehsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Chlordiazepoxidehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Chlordiazepoxidehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Chlordiazepoxidehsa05332Graft-versus-host disease3.49E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Chlordiazepoxidehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Chlordiazepoxidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Chlordiazepoxidehsa05415Diabetic cardiomyopathy1.02E-038P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2DMore
Chlordiazepoxidehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Chlordiazepoxide (SDC: 6.21)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P11766ADH5Alcohol dehydrogenase classNone3Predicted00.2650.13970.21460.6265
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)