PharmaCoNets of Cetrorelix (SPCN: 9.34 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Cetrorelixhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Cetrorelixhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Cetrorelixhsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Cetrorelixhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Cetrorelixhsa00280Valine, leucine and isoleucine degradation4.31E-022P26440, Q02252IVD, ALDH6A1More
Cetrorelixhsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Cetrorelixhsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Cetrorelixhsa00860Porphyrin and chlorophyll metabolism5.29E-032P53004, P30043BLVRA, BLVRBMore
Cetrorelixhsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Cetrorelixhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Cetrorelixhsa01100Metabolic pathways4.11E-027P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHEMore
Cetrorelixhsa01200Carbon metabolism4.06E-025P37837, O14521, P50213, P60891, Q02252TALDO1, SDHD, IDH3A, PRPS1, ALDH6A1More
Cetrorelixhsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Cetrorelixhsa01521EGFR tyrosine kinase inhibitor resistance2.18E-022P49841, Q9NRA1GSK3B, PDGFCMore
Cetrorelixhsa03013RNA transport4.73E-029P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q9Y6A5NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, TACC3More
Cetrorelixhsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Cetrorelixhsa04080Neuroactive ligand-receptor interaction4.15E-022Q01726, P41968MC1R, MC3RMore
Cetrorelixhsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Cetrorelixhsa04145Phagosome3.11E-022Q99437, P25774ATP6V0B, CTSSMore
Cetrorelixhsa04330Notch signaling pathway7.49E-032Q92542, P49768NCSTN, PSEN1More
Cetrorelixhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Cetrorelixhsa04613Neutrophil extracellular trap formation9.53E-0313P17252, O60603, P08246, Q9UM07, Q92769, Q6FI13, P14598, Q15080, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, ELA2, PADI4, HDAC2, H2AC18; H2AC19, NCF1, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Cetrorelixhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Cetrorelixhsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Cetrorelixhsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Cetrorelixhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Cetrorelixhsa04912GnRH signaling pathway3.39E-024P17252, Q16539, Q9Y6R4, Q14643PRKCA, MAPK14, MAP3K4, ITPR1More
Cetrorelixhsa04916Melanogenesis2.18E-022P49841, Q01726GSK3B, MC1RMore
Cetrorelixhsa04919Thyroid hormone signaling pathway3.71E-022P26678, P08237PLN, PFKMMore
Cetrorelixhsa04972Pancreatic secretion3.86E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Cetrorelixhsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Cetrorelixhsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Cetrorelixhsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Cetrorelixhsa05222Small cell lung cancer4.26E-026P10826, Q13489, P10415, Q13077, O00463, P24522RARB, BIRC3, BCL2, TRAF1, TRAF5, GADD45AMore
Cetrorelixhsa05415Diabetic cardiomyopathy3.19E-027P17252, P14598, Q15080, Q16718, O14521, Q16539, P14780PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9More
Cetrorelixhsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Cetrorelix (SDC: 2.56)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
O60603TLR2TollNonelike receptor 2Predicted10.21260.080511.2673
O15151MDM4Protein Mdm4Predicted00.10140.08980.24890.4791
O95931CBX7Chromobox protein homolog 7Predicted00.41860.181600.5726
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)