| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Celecoxib | hsa00020 | Citrate cycle (TCA cycle) | 6.05E-03 | 3 | Q9P2R7, P40925, O14521 | SUCLA2, MDH1, SDHD | More | | | Celecoxib | hsa00030 | Pentose phosphate pathway | 1.28E-03 | 3 | P60891, P51854, P37837 | PRPS1, TKTL1, TALDO1 | More | | | Celecoxib | hsa00051 | Fructose and mannose metabolism | 4.48E-02 | 1 | P19367 | HK1 | More | | | Celecoxib | hsa00052 | Galactose metabolism | 4.48E-02 | 1 | P19367 | HK1 | More | | | Celecoxib | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Celecoxib | hsa00100 | Steroid biosynthesis | 3.94E-02 | 1 | P35610 | SOAT1 | More | | | Celecoxib | hsa00190 | Oxidative phosphorylation | 2.29E-02 | 2 | Q16718, O14521 | NDUFA5, SDHD | More | | | Celecoxib | hsa00220 | Arginine biosynthesis | 4.40E-03 | 2 | P15104, P49448 | GLUL, GLUD2 | More | | | Celecoxib | hsa00250 | Alanine, aspartate and glutamate metabolism | 4.40E-03 | 2 | P49448, P15104 | GLUD2, GLUL | More | | | Celecoxib | hsa00471 | D-Glutamine and D-glutamate metabolism | 3.94E-02 | 1 | P49448 | GLUD2 | More | | | Celecoxib | hsa00500 | Starch and sucrose metabolism | 7.04E-05 | 4 | P19367, O43451, P46976, P06737 | HK1, MGAM, GYG1, PYGL | More | | | Celecoxib | hsa00510 | N-Glycan biosynthesis | 3.15E-02 | 2 | P15907, Q9NR34 | ST6GAL1, MAN1C1 | More | | | Celecoxib | hsa00512 | Mucin type O-glycan biosynthesis | 3.78E-02 | 2 | O95395, Q8N4A0 | GCNT3, GALNT4 | More | | | Celecoxib | hsa00520 | Amino sugar and nucleotide sugar metabolism | 3.76E-02 | 1 | Q13231 | CHIT1 | More | | | Celecoxib | hsa00524 | Neomycin, kanamycin and gentamicin biosynthesis | 9.10E-03 | 1 | P19367 | HK1 | More | | | Celecoxib | hsa00531 | Glycosaminoglycan degradation | 1.05E-03 | 2 | P15586, P34059 | GNS, GALNS | More | | | Celecoxib | hsa00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 3.30E-02 | 1 | Q9Y2C2 | UST | More | | | Celecoxib | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 1.91E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Celecoxib | hsa00561 | Glycerolipid metabolism | 4.48E-02 | 1 | Q16760 | DGKD | More | | | Celecoxib | hsa00562 | Inositol phosphate metabolism | 4.55E-02 | 2 | P27987, P42338 | ITPKB, PIK3CB | More | | | Celecoxib | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Celecoxib | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Celecoxib | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Celecoxib | hsa00600 | Sphingolipid metabolism | 2.77E-02 | 3 | Q9BX95, Q8TCT0, P15289 | SGPP1, CERK, ARSA | More | | | Celecoxib | hsa00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 3.78E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Celecoxib | hsa00630 | Glyoxylate and dicarboxylate metabolism | 5.34E-03 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Celecoxib | hsa00730 | Thiamine metabolism | 2.49E-03 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Celecoxib | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Celecoxib | hsa00860 | Porphyrin and chlorophyll metabolism | 1.69E-02 | 2 | P36551, P30043 | CPOX, BLVRB | More | | | Celecoxib | hsa00910 | Nitrogen metabolism | 4.40E-03 | 2 | P15104, P49448 | GLUL, GLUD2 | More | | | Celecoxib | hsa00970 | Aminoacyl-tRNA biosynthesis | 6.41E-05 | 4 | O95363, P54136, P14868, Q15046 | FARS2, RARS1, DARS, KARS | More | | | Celecoxib | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Celecoxib | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Celecoxib | hsa00983 | Drug metabolism - other enzymes | 1.13E-03 | 4 | P04183, P20839, P32320, P05164 | TK1, IMPDH1, CDA, MPO | More | | | Celecoxib | hsa01040 | Biosynthesis of unsaturated fatty acids | 2.92E-02 | 2 | P22307, Q9H5J4 | SCP2, ELOVL6 | More | | | Celecoxib | hsa01100 | Metabolic pathways | 3.02E-03 | 30 | Q9NR34, P05089, P21953, P15104, P42338, P27987, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P53004, P05186, P24666, Q9HCC0, P33121, P09917, P57054, Q9UNP4, Q9BX95, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737 | MAN1C1, ARG1, BCKDHB, GLUL, PIK3CB, ITPKB, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, BLVRA, ALPL, ACP1, MCCC2, ACSL1, ALOX5, PIGP, ST3GAL5, SGPP1, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9NR34 | MAN1C1 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC | -0.716 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P21953 | BCKDHB | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 0.765 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P15104 | GLUL | Glutamine synthetase | -0.819 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.733 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P27987 | ITPKB | Inositol-trisphosphate 3-kinase B | 0.745 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32320 | CDA | Cytidine deaminase | 0.701 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P22748 | CA4 | Carbonic anhydrase 4 | 0.767 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P55809 | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | -0.746 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06280 | GLA | Alpha-galactosidase A | 0.714 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 0.849 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43286 | B4GALT5 | Beta-1,4-galactosyltransferase 5 | 0.917 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43451 | MGAM | Maltase-glucoamylase | 0.871 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P53004 | BLVRA | Biliverdin reductase A | 0.901 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | 0.901 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24666 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | -0.832 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9HCC0 | MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial | -0.782 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P33121 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | 0.886 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | -0.705 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P57054 | PIGP | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P | -0.881 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UNP4 | ST3GAL5 | Lactosylceramide alpha-2,3-sialyltransferase | -0.819 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | Q9UNP4 | ST3GAL5 | Lactosylceramide alpha-2,3-sialyltransferase | 0.743 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.743 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32321 | DCTD | Deoxycytidylate deaminase | -0.748 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P32321 | DCTD | Deoxycytidylate deaminase | 0.79 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P49448 | GLUD2 | Glutamate dehydrogenase 2, mitochondrial | 0.74 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | 0.817 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | -0.798 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75911 | DHRS3 | Short-chain dehydrogenase/reductase 3 | -0.81 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UHY7 | ENOPH1 | Enolase-phosphatase E1 | -0.737 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.883 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P46976 | GYG1 | Glycogenin-1 | 0.817 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P46976 | GYG1 | Glycogenin-1 | -0.82 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06737 | PYGL | Glycogen phosphorylase, liver form | 0.863 |
| | Celecoxib | hsa01200 | Carbon metabolism | 8.75E-03 | 5 | P04406, P40925, O14521, Q9P2R7, Q02252 | GAPDH, MDH1, SDHD, SUCLA2, ALDH6A1 | More | | | Celecoxib | hsa01210 | 2-Oxocarboxylic acid metabolism | 1.91E-02 | 1 | P50213 | IDH3A | More | | | Celecoxib | hsa01230 | Biosynthesis of amino acids | 3.59E-02 | 3 | P60891, Q99707, P37837 | PRPS1, MTR, TALDO1 | More | | | Celecoxib | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1.82E-02 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa01522 | Endocrine resistance | 4.37E-03 | 8 | P14780, P22694, Q02750, Q9UM47, P46527, P08069, P10415, Q13323 | MMP9, PRKACB, MAP2K1, NOTCH3, CDKN1B, IGF1R, BCL2, BIK | More | | | Celecoxib | hsa01523 | Antifolate resistance | 1.95E-03 | 5 | P41439, P41440, Q92820, P04818, P01375 | FOLR3, SLC19A1, GGH, TYMS, TNF | More | | | Celecoxib | hsa01524 | Platinum drug resistance | 1.47E-03 | 3 | O15392, P11388, P31751 | BIRC5, TOP2A, AKT2 | More | | | Celecoxib | hsa02010 | ABC transporters | 2.17E-03 | 3 | P45844, P08183, Q8IZY2 | ABCG1, ABCB1, ABCA7 | More | | | Celecoxib | hsa03008 | Ribosome biogenesis in eukaryotes | 2.03E-03 | 5 | Q9NYH9, O14980, O60832, P78345, Q9BVP2 | UTP6, XPO1, DKC1, RPP38, GNL3 | More | | | Celecoxib | hsa03013 | RNA transport | 7.49E-07 | 12 | O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5 | XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3 | More | | | Celecoxib | hsa03015 | mRNA surveillance pathway | 4.42E-02 | 4 | O60942, O43148, P52298, Q53GS7 | RNGTT, RNMT, NCBP2, GLE1 | More | | | Celecoxib | hsa03018 | RNA degradation | 5.00E-02 | 1 | Q9NQT4 | EXOSC5 | More | | | Celecoxib | hsa03020 | RNA polymerase | 8.48E-06 | 5 | P30876, P24928, P62487, Q9GZM3, P52435 | POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J | More | | | Celecoxib | hsa03022 | Basal transcription factors | 3.32E-02 | 2 | O00268, Q15544 | TAF4, TAF11 | More | | | Celecoxib | hsa03040 | Spliceosome | 5.12E-07 | 18 | Q14562, O43143, O60508, P08579, P26368, O75940, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O95777, O43447, O43395, O75643 | DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, LSM8, PPIH, PRPF3, ASCC3L1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | -0.708 | | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.76 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.837 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.702 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | O75940 | SMNDC1 | Survival of motor neuron-related-splicing factor 30 | -0.812 | | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | O75494 | FUSIP1 | Serine/arginine-rich splicing factor 10 | -0.809 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.839 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.835 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.775 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | O95777 | LSM8 | U6 snRNA-associated Sm-like protein LSm8 | -0.891 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.761 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | O43395 | PRPF3 | U4/U6 small nuclear ribonucleoprotein Prp3 | -0.747 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
| | Celecoxib | hsa03060 | Protein export | 4.42E-02 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Celecoxib | hsa03450 | Non-homologous end-joining | 4.21E-02 | 1 | P13010 | XRCC5 | More | | | Celecoxib | hsa04010 | MAPK signaling pathway | 4.15E-02 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa04014 | Ras signaling pathway | 2.49E-04 | 17 | Q02750, P31751, P42338, P20827, Q15389, P49767, P08069, Q13009, P17252, Q7LDG7, P21359, P0DP23, P62879, P63218, P50151, P19174, P22694 | MAP2K1, AKT2, PIK3CB, EFNA1, ANGPT1, VEGFC, IGF1R, TIAM1, PRKCA, RASGRP2, NF1, CALM1, GNB2, GNG5, GNG10, PLCG1, PRKACB | More | | | Celecoxib | hsa04015 | Rap1 signaling pathway | 7.70E-04 | 11 | P20827, P49767, P08069, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P31751, P0DP23, P19174 | EFNA1, VEGFC, IGF1R, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, AKT2, CALM1, PLCG1 | More | | | Celecoxib | hsa04022 | cGMP-PKG signaling pathway | 5.07E-03 | 2 | P31751, P0DP23 | AKT2, CALM1 | More | | | Celecoxib | hsa04024 | cAMP signaling pathway | 3.23E-03 | 2 | P31751, P0DP23 | AKT2, CALM1 | More | | | Celecoxib | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 1.71E-03 | 10 | P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P09603, P01375 | CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, CSF1, TNF | More | | | Celecoxib | hsa04062 | Chemokine signaling pathway | 9.01E-06 | 20 | P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P22694, P49841, Q8WYR1 | CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, PRKACB, GSK3B, PIK3R5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | 0.901 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.917 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.859 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P47992 | XCL1 | Lymphotactin | -0.797 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q9UBD3 | XCL2 | Cytokine SCM-1 beta | -0.797 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.713 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.724 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.733 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.743 | | Q13547 | HDAC1 | Histone deacetylase 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.864 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.737 | | Q13547 | HDAC1 | Histone deacetylase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.716 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.81 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P49407 | ARRB1 | Beta-arrestin-1 | 0.803 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.847 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.758 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.794 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 |
| | Celecoxib | hsa04064 | NF-kappa B signaling pathway | 3.98E-12 | 25 | P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7 | BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLD | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P22894 | MMP8 | Neutrophil collagenase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.959 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.744 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.84 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.713 | | P08235 | NR3C2 | Mineralocorticoid receptor | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.868 | | P22894 | MMP8 | Neutrophil collagenase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.765 | | P22894 | MMP8 | Neutrophil collagenase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.744 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.722 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.896 | | P22894 | MMP8 | Neutrophil collagenase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.867 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.945 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.717 | | P08235 | NR3C2 | Mineralocorticoid receptor | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.749 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.868 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.823 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01375 | TNF | Tumor necrosis factor | 0.782 | | P22894 | MMP8 | Neutrophil collagenase | P01375 | TNF | Tumor necrosis factor | 0.728 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q04759 | PRKCQ | Protein kinase C theta type | -0.807 | | P22894 | MMP8 | Neutrophil collagenase | Q04759 | PRKCQ | Protein kinase C theta type | -0.756 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q04759 | PRKCQ | Protein kinase C theta type | 0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q04759 | PRKCQ | Protein kinase C theta type | 0.776 | | P08235 | NR3C2 | Mineralocorticoid receptor | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.708 | | P22894 | MMP8 | Neutrophil collagenase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.891 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.721 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.869 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.723 | | P22894 | MMP8 | Neutrophil collagenase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.806 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.73 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.83 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.768 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.889 | | P22894 | MMP8 | Neutrophil collagenase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.843 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.875 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.877 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.701 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.713 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.809 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q8WV28 | BLNK | B-cell linker protein | -0.816 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13315 | ATM | Serine-protein kinase ATM | 0.752 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q13315 | ATM | Serine-protein kinase ATM | 0.723 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.756 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.805 | | P22894 | MMP8 | Neutrophil collagenase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.766 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.75 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.712 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.734 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.859 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09341 | CXCL1 | Growth-regulated alpha protein | -0.802 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.789 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q06643 | LTB | Lymphotoxin-beta | 0.74 | | P08235 | NR3C2 | Mineralocorticoid receptor | Q9UNE0 | EDAR | Tumor necrosis factor receptor superfamily member EDAR | 0.819 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.825 |
| | Celecoxib | hsa04066 | HIF-1 signaling pathway | 1.49E-02 | 5 | P08069, P17252, Q15389, Q02750, P46527 | IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1B | More | | | Celecoxib | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa04070 | Phosphatidylinositol signaling system | 4.07E-02 | 4 | P0DP23, Q14643, O14732, P17252 | CALM1, ITPR1, IMPA2, PRKCA | More | | | Celecoxib | hsa04071 | Sphingolipid signaling pathway | 3.46E-08 | 10 | P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2 | More | | | Celecoxib | hsa04072 | Phospholipase D signaling pathway | 4.48E-02 | 5 | P42338, P43657, P25024, P25025, P19174 | PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1 | More | | | Celecoxib | hsa04080 | Neuroactive ligand-receptor interaction | 1.30E-04 | 9 | P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2 | More | | | Celecoxib | hsa04110 | Cell cycle | 6.80E-03 | 6 | P06493, O75293, P30304, P33981, P42773, P01106 | CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC | More | | | Celecoxib | hsa04114 | Oocyte meiosis | 2.99E-02 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa04120 | Ubiquitin mediated proteolysis | 3.44E-02 | 4 | Q14145, Q13042, P62837, Q15751 | KEAP1, CDC16, UBE2D2, HERC1 | More | | | Celecoxib | hsa04122 | Sulfur relay system | 9.10E-03 | 1 | O95396 | MOCS3 | More | | | Celecoxib | hsa04136 | Autophagy - other | 5.92E-03 | 2 | O94817, Q9H1Y0 | ATG12, ATG5 | More | | | Celecoxib | hsa04140 | Autophagy - animal | 9.83E-05 | 8 | P08069, Q9Y4H2, Q9NQL2, P22694, Q14643, P10415, Q9H1Y0, Q04759 | IGF1R, IRS2, RRAGD, PRKACB, ITPR1, BCL2, ATG5, PRKCQ | More | | | Celecoxib | hsa04142 | Lysosome | 8.21E-05 | 11 | P43234, P06865, P15586, P22304, P34059, P38571, Q13510, P07602, Q9NRA2, P49281, P61916 | CTSO, HEXA, GNS, IDS, GALNS, LIPA, ASAH1, PSAP, SLC17A5, SLC11A2, NPC2 | More | | | Celecoxib | hsa04144 | Endocytosis | 1.67E-02 | 8 | P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4 | HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12 | More | | | Celecoxib | hsa04145 | Phagosome | 1.29E-06 | 11 | O75015, P63261, Q15080, P14598, Q13509, P68371, P05164, P78380, O60603, P35443, P13765 | FCGR3B, ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, OLR1, TLR2, THBS4, HLA-DOB | More | | | Celecoxib | hsa04146 | Peroxisome | 2.42E-02 | 5 | O43933, P56589, Q9UKG9, O75521, P33121 | PEX1, PEX3, CROT, ECI2, ACSL1 | More | | | Celecoxib | hsa04150 | mTOR signaling pathway | 2.32E-02 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa04151 | PI3K-Akt signaling pathway | 1.14E-02 | 14 | P42338, P43657, P20827, P49767, Q14738, P08238, Q8WYR1, P62873, P63218, P50151, O15335, Q13751, P14784, P30281 | PIK3CB, P2RY5, EFNA1, VEGFC, PPP2R5D, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3 | More | | | Celecoxib | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa04210 | Apoptosis | 2.35E-03 | 9 | Q13315, P04637, P10415, O76075, P24522, Q16548, P43234, Q14643, P63261 | ATM, TP53, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1, ACTG1 | More | | | Celecoxib | hsa04211 | Longevity regulating pathway | 1.34E-03 | 4 | Q12778, P08069, Q9UEF7, Q96KQ7 | FOXO1, IGF1R, KL, EHMT2 | More | | | Celecoxib | hsa04213 | Longevity regulating pathway - multiple species | 9.82E-04 | 8 | P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547 | PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1 | More | | | Celecoxib | hsa04216 | Ferroptosis | 1.45E-02 | 2 | P04637, P49281 | TP53, SLC11A2 | More | | | Celecoxib | hsa04217 | Necroptosis | 4.38E-05 | 11 | P01375, P01568, P48023, Q13489, Q13546, Q14765, P07384, Q6FI13, Q99878, P10415, O43633 | TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, CAPN1, H2AC18; H2AC19, H2AC14, BCL2, CHMP2A | More | | | Celecoxib | hsa04218 | Cellular senescence | 2.09E-03 | 6 | P01106, P31751, O75293, P30304, P06493, P0DP23 | MYC, AKT2, GADD45B, CDC25A, CDK1, CALM1 | More | | | Celecoxib | hsa04261 | Adrenergic signaling in cardiomyocytes | 5.59E-03 | 6 | P31751, Q16537, P0DP23, P17252, P10415, P20020 | AKT2, PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1 | More | | | Celecoxib | hsa04270 | Vascular smooth muscle contraction | 9.46E-04 | 6 | P0DP23, Q08828, P51828, P35579, P35749, P35318 | CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM | More | | | Celecoxib | hsa04310 | Wnt signaling pathway | 1.79E-02 | 2 | P17612, P67870 | PRKACA, CSNK2B | More | | | Celecoxib | hsa04340 | Hedgehog signaling pathway | 1.92E-03 | 4 | P17612, P22694, Q13635, P10415 | PRKACA, PRKACB, PTCH1, BCL2 | More | | | Celecoxib | hsa04360 | Axon guidance | 3.34E-03 | 8 | P16333, P20827, O95631, P42338, P07332, P19174, O14639, P24844 | NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1, ABLIM1, MYL9 | More | | | Celecoxib | hsa04370 | VEGF signaling pathway | 3.60E-02 | 1 | P31751 | AKT2 | More | | | Celecoxib | hsa04371 | Apelin signaling pathway | 9.78E-04 | 9 | P63218, P50151, Q8WYR1, P31751, Q14814, Q14344, Q13485, P84022, P0DP23 | GNG5, GNG10, PIK3R5, AKT2, MEF2D, GNA13, SMAD4, SMAD3, CALM1 | More | | | Celecoxib | hsa04380 | Osteoclast differentiation | 2.11E-03 | 2 | Q9NQC7, P31751 | CYLD, AKT2 | More | | | Celecoxib | hsa04390 | Hippo signaling pathway | 4.35E-02 | 2 | P63261, O15105 | ACTG1, SMAD7 | More | | | Celecoxib | hsa04510 | Focal adhesion | 1.54E-02 | 7 | O75369, Q15942, Q13489, P10415, P08069, P49767, P63261 | FLNB, ZYX, BIRC3, BCL2, IGF1R, VEGFC, ACTG1 | More | | | Celecoxib | hsa04520 | Adherens junction | 8.29E-03 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa04530 | Tight junction | 3.60E-03 | 5 | P63261, P16989, P56750, Q92974, Q14247 | ACTG1, CSDA, CLDN17, ARHGEF2, CTTN | More | | | Celecoxib | hsa04540 | Gap junction | 2.03E-02 | 4 | P17252, P22694, P68371, Q02750 | PRKCA, PRKACB, TUBB2C, MAP2K1 | More | | | Celecoxib | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa04610 | Complement and coagulation cascades | 2.33E-03 | 1 | P0C0L4 | C4A | More | | | Celecoxib | hsa04611 | Platelet activation | 2.12E-02 | 2 | Q9Y490, P17612 | TLN1, PRKACA | More | | | Celecoxib | hsa04612 | Antigen processing and presentation | 1.66E-05 | 8 | P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Celecoxib | hsa04613 | Neutrophil extracellular trap formation | 1.84E-09 | 23 | P17252, O60603, P05164, P08246, Q9UM07, Q92769, P04908, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539 | PRKCA, TLR2, MPO, ELA2, PADI4, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P22894 | MMP8 | Neutrophil collagenase | P17252 | PRKCA | Protein kinase C alpha type | -0.759 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P17252 | PRKCA | Protein kinase C alpha type | 0.738 | | P22894 | MMP8 | Neutrophil collagenase | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P51684 | CCR6 | C-C chemokine receptor type 6 | O60603 | TLR2 | Toll-like receptor 2 | -0.767 | | P22748 | CA4 | Carbonic anhydrase 4 | O60603 | TLR2 | Toll-like receptor 2 | 0.919 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | O60603 | TLR2 | Toll-like receptor 2 | -0.717 | | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | | P22748 | CA4 | Carbonic anhydrase 4 | P05164 | MPO | Myeloperoxidase | 0.826 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P05164 | MPO | Myeloperoxidase | -0.866 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P05164 | MPO | Myeloperoxidase | -0.817 | | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P08246 | ELA2 | Neutrophil elastase | -0.706 | | P22748 | CA4 | Carbonic anhydrase 4 | P08246 | ELA2 | Neutrophil elastase | 0.921 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P08246 | ELA2 | Neutrophil elastase | -0.76 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P08246 | ELA2 | Neutrophil elastase | -0.772 | | P22894 | MMP8 | Neutrophil collagenase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.877 | | P22748 | CA4 | Carbonic anhydrase 4 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.856 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | -0.819 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | -0.809 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q92769 | HDAC2 | Histone deacetylase 2 | 0.702 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P04908 | H2AC4; H2AC8 | Histone H2A type 1-B/E | 0.734 | | P22894 | MMP8 | Neutrophil collagenase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.909 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | -0.86 | | P22748 | CA4 | Carbonic anhydrase 4 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.866 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.737 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P33778 | H2BC3 | Histone H2B type 1-B | 0.704 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.913 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P22894 | MMP8 | Neutrophil collagenase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.74 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.713 | | P22894 | MMP8 | Neutrophil collagenase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.963 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.803 | | P22748 | CA4 | Carbonic anhydrase 4 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.951 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.731 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.742 | | P22894 | MMP8 | Neutrophil collagenase | P20160 | AZU1 | Azurocidin | 0.824 | | P22748 | CA4 | Carbonic anhydrase 4 | P20160 | AZU1 | Azurocidin | 0.747 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20160 | AZU1 | Azurocidin | -0.799 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P20160 | AZU1 | Azurocidin | -0.771 | | P22894 | MMP8 | Neutrophil collagenase | P08311 | CTSG | Cathepsin G | 0.8 | | P22748 | CA4 | Carbonic anhydrase 4 | P08311 | CTSG | Cathepsin G | 0.717 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P08311 | CTSG | Cathepsin G | -0.811 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P08311 | CTSG | Cathepsin G | -0.847 | | P22894 | MMP8 | Neutrophil collagenase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.7 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P49913 | CAMP | Cathelicidin antimicrobial peptide | -0.722 | | P22894 | MMP8 | Neutrophil collagenase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.734 | | P22748 | CA4 | Carbonic anhydrase 4 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.81 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | -0.704 | | P22894 | MMP8 | Neutrophil collagenase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.756 | | P22748 | CA4 | Carbonic anhydrase 4 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.826 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | -0.772 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | -0.779 | | P22894 | MMP8 | Neutrophil collagenase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.88 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P21462 | FPR1 | fMet-Leu-Phe receptor | -0.7 | | P22748 | CA4 | Carbonic anhydrase 4 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.895 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P21462 | FPR1 | fMet-Leu-Phe receptor | -0.737 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O43315 | AQP9 | Aquaporin-9 | -0.764 | | P22748 | CA4 | Carbonic anhydrase 4 | O43315 | AQP9 | Aquaporin-9 | 0.771 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P22748 | CA4 | Carbonic anhydrase 4 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.767 |
| | Celecoxib | hsa04614 | Renin-angiotensin system | 2.52E-02 | 1 | P50052 | AGTR2 | More | | | Celecoxib | hsa04620 | Toll-like receptor signaling pathway | 4.81E-03 | 3 | Q13546, P01568, P31751 | RIPK1, IFNA21, AKT2 | More | | | Celecoxib | hsa04621 | NOD-like receptor signaling pathway | 3.49E-04 | 18 | Q16539, Q14643, P01568, P21796, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838 | MAPK14, ITPR1, IFNA21, VDAC1, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4 | More | | | Celecoxib | hsa04622 | RIG-I-like receptor signaling pathway | 1.02E-03 | 3 | P01568, Q9NQC7, Q13546 | IFNA21, CYLD, RIPK1 | More | | | Celecoxib | hsa04623 | Cytosolic DNA-sensing pathway | 4.94E-06 | 4 | P01584, P01568, Q13546, Q8NHW4 | IL1B, IFNA21, RIPK1, CCL4L2 | More | | | Celecoxib | hsa04625 | C-type lectin receptor signaling pathway | 1.38E-05 | 3 | Q9NQC7, P31751, P0DP23 | CYLD, AKT2, CALM1 | More | | | Celecoxib | hsa04640 | Hematopoietic cell lineage | 1.26E-06 | 16 | P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P09603 | ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, CSF1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P13612 | ITGA4 | Integrin alpha-4 | -0.88 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13612 | ITGA4 | Integrin alpha-4 | 0.774 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P21926 | CD9 | CD9 antigen | -0.787 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.823 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.906 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.727 | | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P15144 | ANPEP | Aminopeptidase N | 0.764 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P15144 | ANPEP | Aminopeptidase N | -0.757 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P11836 | MS4A1 | B-lymphocyte antigen CD20 | -0.717 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P25063 | CD24 | Signal transducer CD24 | 0.717 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P25063 | CD24 | Signal transducer CD24 | -0.839 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25063 | CD24 | Signal transducer CD24 | -0.706 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.782 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.724 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.815 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.813 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.783 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.719 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P09564 | CD7 | T-cell antigen CD7 | -0.886 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09564 | CD7 | T-cell antigen CD7 | 0.738 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.748 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01375 | TNF | Tumor necrosis factor | 0.782 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09603 | CSF1 | Macrophage colony-stimulating factor 1 | 0.713 |
| | Celecoxib | hsa04650 | Natural killer cell mediated cytotoxicity | 7.22E-12 | 13 | P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715 | PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P01375 | TNF | Tumor necrosis factor | P01375 | TNF | Tumor necrosis factor | 1 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01375 | TNF | Tumor necrosis factor | 0.782 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | P11766 | ADH5 | Alcohol dehydrogenase class-3 | P01375 | TNF | Tumor necrosis factor | -0.709 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P01375 | TNF | Tumor necrosis factor | -0.813 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.769 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.718 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.809 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | P01375 | TNF | Tumor necrosis factor | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.717 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.848 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.862 | | Q13547 | HDAC1 | Histone deacetylase 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.786 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.764 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.869 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.912 | | P01375 | TNF | Tumor necrosis factor | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.727 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.862 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.839 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.776 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P01375 | TNF | Tumor necrosis factor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.769 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.846 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.852 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.807 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.863 | | P11766 | ADH5 | Alcohol dehydrogenase class-3 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.726 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.883 | | P01375 | TNF | Tumor necrosis factor | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.754 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.931 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.922 | | Q13547 | HDAC1 | Histone deacetylase 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.772 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.803 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.762 | | P11766 | ADH5 | Alcohol dehydrogenase class-3 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.71 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.794 | | Q13547 | HDAC1 | Histone deacetylase 1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.735 | | P01375 | TNF | Tumor necrosis factor | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.838 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.855 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | -0.778 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.81 | | P11766 | ADH5 | Alcohol dehydrogenase class-3 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | -0.833 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | -0.704 | | P01375 | TNF | Tumor necrosis factor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.814 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.846 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.943 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.853 | | P11766 | ADH5 | Alcohol dehydrogenase class-3 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.737 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.972 | | P01375 | TNF | Tumor necrosis factor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.814 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.846 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.943 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.853 | | P11766 | ADH5 | Alcohol dehydrogenase class-3 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.737 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.972 |
| | Celecoxib | hsa04657 | IL-17 signaling pathway | 1.16E-04 | 13 | P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, Q9UJX4, P04141, P80188, P01375, P06702 | NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, CSF2, LCN2, TNF, S100A9 | More | | | Celecoxib | hsa04658 | Th1 and Th2 cell differentiation | 1.24E-14 | 13 | Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q04759 | PRKCQ | Protein kinase C theta type | -0.807 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q04759 | PRKCQ | Protein kinase C theta type | 0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q04759 | PRKCQ | Protein kinase C theta type | 0.776 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q04759 | PRKCQ | Protein kinase C theta type | 0.755 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.782 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.862 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.839 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.776 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.815 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.813 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.744 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.849 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.809 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.756 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.904 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.742 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.928 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.765 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.784 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.85 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.715 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.927 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.884 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.735 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.852 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.748 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.795 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.76 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.769 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 |
| | Celecoxib | hsa04659 | Th17 cell differentiation | 2.06E-10 | 16 | Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963 | PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q04759 | PRKCQ | Protein kinase C theta type | -0.807 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q04759 | PRKCQ | Protein kinase C theta type | 0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q04759 | PRKCQ | Protein kinase C theta type | 0.776 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.849 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.809 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.748 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.795 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.823 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.909 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.764 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9HBE5 | IL21R | Interleukin-21 receptor | 0.713 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.927 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.884 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.735 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.765 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.784 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.85 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.782 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.838 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.815 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.813 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.744 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.862 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.839 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 |
| | Celecoxib | hsa04660 | T cell receptor signaling pathway | 1.52E-10 | 16 | P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841 | TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01375 | TNF | Tumor necrosis factor | 0.782 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P01375 | TNF | Tumor necrosis factor | -0.813 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.721 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.723 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q04759 | PRKCQ | Protein kinase C theta type | -0.807 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q04759 | PRKCQ | Protein kinase C theta type | 0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q04759 | PRKCQ | Protein kinase C theta type | 0.776 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q04759 | PRKCQ | Protein kinase C theta type | 0.755 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.794 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.79 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.824 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.925 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.754 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.847 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 1 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.746 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.873 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.782 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.862 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.839 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.776 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.815 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.813 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.744 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.783 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.92 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.812 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.858 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.811 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.734 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.809 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.849 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.794 |
| | Celecoxib | hsa04662 | B cell receptor signaling pathway | 8.85E-07 | 6 | P31751, P42338, P60033, P07948, P21854, Q8N149 | AKT2, PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Celecoxib | hsa04664 | Fc epsilon RI signaling pathway | 4.07E-07 | 7 | P31751, P42338, Q9UQC2, P07948, P19174, P09917, P20292 | AKT2, PIK3CB, GAB2, LYN, PLCG1, ALOX5, ALOX5AP | More | | | Celecoxib | hsa04666 | Fc gamma R-mediated phagocytosis | 1.88E-03 | 6 | O75015, P49006, P06396, O14494, P14598, P17252 | FCGR3B, MARCKSL1, GSN, PLPP1, NCF1, PRKCA | More | | | Celecoxib | hsa04714 | Thermogenesis | 5.21E-03 | 4 | Q16539, P33121, Q16718, O14521 | MAPK14, ACSL1, NDUFA5, SDHD | More | | | Celecoxib | hsa04720 | Long-term potentiation | 1.43E-03 | 6 | P17252, P0DP23, P51812, P22694, Q02750, Q14643 | PRKCA, CALM1, RPS6KA3, PRKACB, MAP2K1, ITPR1 | More | | | Celecoxib | hsa04722 | Neurotrophin signaling pathway | 1.26E-03 | 5 | P31751, P49841, O43524, P48023, P0DP23 | AKT2, GSK3B, FOXO3, FASLG, CALM1 | More | | | Celecoxib | hsa04723 | Retrograde endocannabinoid signaling | 4.40E-02 | 5 | Q14643, P63218, P50151, P22694, Q16539 | ITPR1, GNG5, GNG10, PRKACB, MAPK14 | More | | | Celecoxib | hsa04724 | Glutamatergic synapse | 5.94E-03 | 4 | O15399, P63218, P50151, P15104 | GRIN2D, GNG5, GNG10, GLUL | More | | | Celecoxib | hsa04725 | Cholinergic synapse | 2.59E-03 | 7 | P22694, P17252, P62879, P63218, P50151, P42338, Q02750 | PRKACB, PRKCA, GNB2, GNG5, GNG10, PIK3CB, MAP2K1 | More | | | Celecoxib | hsa04726 | Serotonergic synapse | 2.43E-02 | 4 | P22694, P17252, P62879, Q02750 | PRKACB, PRKCA, GNB2, MAP2K1 | More | | | Celecoxib | hsa04727 | GABAergic synapse | 1.00E-04 | 7 | P62879, P63218, P50151, P15104, P22694, O60296, P17252 | GNB2, GNG5, GNG10, GLUL, PRKACB, TRAK2, PRKCA | More | | | Celecoxib | hsa04728 | Dopaminergic synapse | 5.44E-05 | 4 | P62873, P31751, Q14738, P0DP23 | GNB1, AKT2, PPP2R5D, CALM1 | More | | | Celecoxib | hsa04730 | Long-term depression | 1.16E-02 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa04740 | Olfactory transduction | 1.42E-03 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Celecoxib | hsa04742 | Taste transduction | 3.91E-02 | 1 | P17612 | PRKACA | More | | | Celecoxib | hsa04744 | Phototransduction | 7.65E-04 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Celecoxib | hsa04750 | Inflammatory mediator regulation of TRP channels | 4.47E-05 | 12 | P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP23 | IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM1 | More | | | Celecoxib | hsa04910 | Insulin signaling pathway | 9.82E-04 | 2 | P0DP23, P31751 | CALM1, AKT2 | More | | | Celecoxib | hsa04912 | GnRH signaling pathway | 4.42E-02 | 3 | P17252, Q14643, P0DP23 | PRKCA, ITPR1, CALM1 | More | | | Celecoxib | hsa04913 | Ovarian steroidogenesis | 1.16E-02 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa04914 | Progesterone-mediated oocyte maturation | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa04915 | Estrogen signaling pathway | 3.76E-03 | 6 | Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788 | ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1 | More | | | Celecoxib | hsa04916 | Melanogenesis | 4.78E-02 | 1 | P0DP23 | CALM1 | More | | | Celecoxib | hsa04917 | Prolactin signaling pathway | 2.41E-02 | 1 | P31751 | AKT2 | More | | | Celecoxib | hsa04919 | Thyroid hormone signaling pathway | 2.22E-02 | 5 | P17252, Q02750, P22694, Q12778, Q9UM47 | PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3 | More | | | Celecoxib | hsa04920 | Adipocytokine signaling pathway | 4.19E-02 | 1 | P31751 | AKT2 | More | | | Celecoxib | hsa04922 | Glucagon signaling pathway | 3.14E-03 | 6 | P22694, P06737, Q12778, P31751, P0DP23, Q14643 | PRKACB, PYGL, FOXO1, AKT2, CALM1, ITPR1 | More | | | Celecoxib | hsa04923 | Regulation of lipolysis in adipocytes | 3.88E-03 | 4 | P07550, P42338, Q9Y4H2, P31751 | ADRB2, PIK3CB, IRS2, AKT2 | More | | | Celecoxib | hsa04924 | Renin secretion | 9.33E-05 | 4 | P22694, P07550, Q14643, P0DP23 | PRKACB, ADRB2, ITPR1, CALM1 | More | | | Celecoxib | hsa04925 | Aldosterone synthesis and secretion | 1.54E-02 | 4 | Q14643, P0DP23, P17252, P20020 | ITPR1, CALM1, PRKCA, ATP2B1 | More | | | Celecoxib | hsa04926 | Relaxin signaling pathway | 4.11E-04 | 5 | P42338, P63218, P50151, P49767, P49407 | PIK3CB, GNG5, GNG10, VEGFC, ARRB1 | More | | | Celecoxib | hsa04928 | Parathyroid hormone synthesis, secretion and action | 5.42E-03 | 7 | Q14643, P22694, P23771, Q02750, P17252, P10415, Q9Y5Q3 | ITPR1, PRKACB, GATA3, MAP2K1, PRKCA, BCL2, MAFB | More | | | Celecoxib | hsa04929 | GnRH secretion | 1.11E-04 | 3 | P42338, P31751, P49407 | PIK3CB, AKT2, ARRB1 | More | | | Celecoxib | hsa04930 | Type II diabetes mellitus | 3.60E-02 | 1 | P19367 | HK1 | More | | | Celecoxib | hsa04932 | Non-alcoholic fatty liver disease | 7.01E-05 | 11 | P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521 | TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHD | More | | | Celecoxib | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 3.21E-02 | 5 | P84022, Q13485, P42338, P49767, P19174 | SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1 | More | | | Celecoxib | hsa04940 | Type I diabetes mellitus | 9.23E-05 | 4 | P10747, P48023, P13765, P01375 | CD28, FASLG, HLA-DOB, TNF | More | | | Celecoxib | hsa04962 | Vasopressin-regulated water reabsorption | 7.22E-03 | 2 | P52566, P62491 | ARHGDIB, RAB11A | More | | | Celecoxib | hsa04964 | Proximal tubule bicarbonate reclamation | 4.93E-02 | 1 | P00918 | CA2 | More | | | Celecoxib | hsa04966 | Collecting duct acid secretion | 2.32E-03 | 3 | P02730, P00918, Q9Y666 | SLC4A1, CA2, SLC12A7 | More | | | Celecoxib | hsa04970 | Salivary secretion | 1.82E-06 | 9 | P07550, Q08828, P51828, P22694, Q14643, P20020, P17252, P0DP23, P49913 | ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B1, PRKCA, CALM1, CAMP | More | | | Celecoxib | hsa04971 | Gastric acid secretion | 4.78E-02 | 1 | P0DP23 | CALM1 | More | | | Celecoxib | hsa04972 | Pancreatic secretion | 1.00E-02 | 3 | Q14643, P20020, P17252 | ITPR1, ATP2B1, PRKCA | More | | | Celecoxib | hsa04973 | Carbohydrate digestion and absorption | 8.08E-04 | 4 | O43451, P19367, P42338, P31751 | MGAM, HK1, PIK3CB, AKT2 | More | | | Celecoxib | hsa04975 | Fat digestion and absorption | 2.80E-02 | 1 | O14494 | PLPP1 | More | | | Celecoxib | hsa04976 | Bile secretion | 3.14E-03 | 5 | O43315, Q08828, P51828, P08183, Q14032 | AQP9, ADCY1, ADCY7, ABCB1, BAAT | More | | | Celecoxib | hsa05010 | Alzheimer disease | 8.59E-04 | 3 | Q00535, P0DP23, P31751 | CDK5, CALM1, AKT2 | More | | | Celecoxib | hsa05016 | Huntington disease | 1.00E-04 | 12 | O95298, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, Q9NYC9, O75460, P28070, O00232 | NDUFC2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, DNAH9, ERN1, PSMB4, PSMD12 | More | | | Celecoxib | hsa05020 | Prion disease | 3.80E-02 | 4 | Q16718, O14521, P49841, Q16539 | NDUFA5, SDHD, GSK3B, MAPK14 | More | | | Celecoxib | hsa05022 | Pathways of neurodegeneration - multiple diseases | 9.02E-04 | 14 | O15399, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, Q16539, P07384, Q00535, P04628, Q08752, P0DP23 | GRIN2D, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, MAPK14, CAPN1, CDK5, WNT1, PPID, CALM1 | More | | | Celecoxib | hsa05030 | Cocaine addiction | 4.19E-02 | 1 | Q00535 | CDK5 | More | | | Celecoxib | hsa05031 | Amphetamine addiction | 4.78E-02 | 1 | P0DP23 | CALM1 | More | | | Celecoxib | hsa05034 | Alcoholism | 1.96E-04 | 6 | Q96RR4, Q93077, P62807, O60814, P84243, P68431 | CAMKK2, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Celecoxib | hsa05100 | Bacterial invasion of epithelial cells | 4.50E-02 | 1 | Q92529 | SHC3 | More | | | Celecoxib | hsa05110 | Vibrio cholerae infection | 2.11E-03 | 2 | Q99437, P17612 | ATP6V0B, PRKACA | More | | | Celecoxib | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.00E-05 | 7 | Q16539, P09341, P19875, P19174, P25024, P25025, P07948 | MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN | More | | | Celecoxib | hsa05131 | Shigellosis | 3.15E-02 | 12 | P01375, O00463, P14778, Q16539, Q04759, P61088, Q9NQL2, Q9H1Y0, P12814, Q14643, P49841, P21796 | TNF, TRAF5, IL1R1, MAPK14, PRKCQ, UBE2N, RRAGD, ATG5, ACTN1, ITPR1, GSK3B, VDAC1 | More | | | Celecoxib | hsa05132 | Salmonella infection | 1.34E-06 | 14 | P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, O60282, Q13509, P68371 | IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, KIF5C, TUBB3, TUBB2C | More | | | Celecoxib | hsa05133 | Pertussis | 4.20E-02 | 1 | P0C0L4 | C4A | More | | | Celecoxib | hsa05134 | Legionellosis | 8.80E-04 | 7 | P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875 | IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2 | More | | | Celecoxib | hsa05140 | Leishmaniasis | 4.35E-06 | 10 | P13612, O75015, P14598, P13765, O60603, P01375, P49006, Q16539, P51617, Q15080 | ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MARCKSL1, MAPK14, IRAK1, NCF4 | More | | | Celecoxib | hsa05143 | African trypanosomiasis | 7.50E-04 | 4 | P01375, P69905, P68871, P48023 | TNF, HBA2, HBB, FASLG | More | | | Celecoxib | hsa05144 | Malaria | 5.39E-06 | 7 | P60033, P69905, P68871, O60603, P01375, P35443, P26718 | CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1 | More | | | Celecoxib | hsa05146 | Amoebiasis | 2.83E-08 | 12 | P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.859 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09341 | CXCL1 | Growth-regulated alpha protein | -0.802 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P09341 | CXCL1 | Growth-regulated alpha protein | -0.826 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.823 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.906 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.811 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.727 | | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01375 | TNF | Tumor necrosis factor | 0.782 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P01375 | TNF | Tumor necrosis factor | -0.813 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O60603 | TLR2 | Toll-like receptor 2 | -0.714 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P05089 | ARG1 | Arginase-1 | 0.89 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P05089 | ARG1 | Arginase-1 | -0.868 | | Q13547 | HDAC1 | Histone deacetylase 1 | P05089 | ARG1 | Arginase-1 | -0.769 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P05089 | ARG1 | Arginase-1 | -0.791 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.758 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | 0.873 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | 1 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P12814 | ACTN1 | Alpha-actinin-1 | 0.788 | | Q13547 | HDAC1 | Histone deacetylase 1 | P12814 | ACTN1 | Alpha-actinin-1 | -0.887 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P08311 | CTSG | Cathepsin G | 0.76 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P08311 | CTSG | Cathepsin G | -0.866 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P08311 | CTSG | Cathepsin G | -0.847 |
| | Celecoxib | hsa05150 | Staphylococcus aureus infection | 5.38E-07 | 9 | P21730, P21462, O75015, P13765, Q16581, P59665, P59666, P12838, P49913 | C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP | More | | | Celecoxib | hsa05152 | Tuberculosis | 7.94E-03 | 11 | P0DP23, O75015, P48382, O60603, P01375, P31751, P10415, P13765, P49913, Q9UDY8, P51617 | CALM1, FCGR3B, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CAMP, MALT1, IRAK1 | More | | | Celecoxib | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Celecoxib | hsa05162 | Measles | 3.18E-02 | 4 | P23458, P0DMV8, P01584, Q9NP90 | JAK1, HSPA1A, IL1B, RAB9B | More | | | Celecoxib | hsa05163 | Human cytomegalovirus infection | 9.12E-05 | 19 | P31751, P01375, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463 | AKT2, TNF, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 1 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01375 | TNF | Tumor necrosis factor | 0.782 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.743 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.737 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.763 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.728 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.761 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.758 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 1 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.794 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.823 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | -0.702 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.799 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.917 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.889 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.849 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.896 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 |
| | Celecoxib | hsa05165 | Human papillomavirus infection | 4.71E-03 | 10 | P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315 | CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATM | More | | | Celecoxib | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 5.07E-03 | 2 | P31751, P0DP23 | AKT2, CALM1 | More | | | Celecoxib | hsa05168 | Herpes simplex virus 1 infection | 1.17E-02 | 10 | Q9UKJ0, Q06124, P01568, Q01130, Q13489, Q13398, Q9NR11, Q03923, Q9UDV6, P10415 | PILRB, PTPN11, IFNA21, SFRS2, BIRC3, ZNF211, ZNF302, ZNF85, ZNF212, BCL2 | More | | | Celecoxib | hsa05169 | Epstein-Barr virus infection | 4.76E-05 | 20 | P13765, Q13547, Q92769, P04637, Q13546, O00463, P10415, Q16539, P42338, P07948, Q13761, P24522, O75293, P01375, O60603, P29728, P51617, P07766, P09693, P20963 | HLA-DOB, HDAC1, HDAC2, TP53, RIPK1, TRAF5, BCL2, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TNF, TLR2, OAS2, IRAK1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.748 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q13547 | HDAC1 | Histone deacetylase 1 | -0.774 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.795 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q13547 | HDAC1 | Histone deacetylase 1 | -0.727 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q92769 | HDAC2 | Histone deacetylase 2 | 0.702 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P04637 | TP53 | Cellular tumor antigen p53 | 0.728 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.868 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.896 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.788 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.84 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.849 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.735 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.713 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.708 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.769 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.805 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.712 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.768 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01375 | TNF | Tumor necrosis factor | 0.782 | | P51684 | CCR6 | C-C chemokine receptor type 6 | O60603 | TLR2 | Toll-like receptor 2 | -0.767 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60603 | TLR2 | Toll-like receptor 2 | 0.72 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P29728 | OAS2 | 2'-5'-oligoadenylate synthase 2 | -0.72 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.722 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.77 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.782 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.815 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.753 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.862 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 |
| | Celecoxib | hsa05170 | Human immunodeficiency virus 1 infection | 4.11E-04 | 10 | P31751, P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5 | AKT2, CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2 | More | | | Celecoxib | hsa05200 | Pathways in cancer | 1.81E-03 | 19 | Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P31751, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784 | LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, AKT2, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB | More | | | Celecoxib | hsa05202 | Transcriptional misregulation in cancer | 7.42E-10 | 20 | Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P24522 | FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P22894 | MMP8 | Neutrophil collagenase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.72 | | Q13315 | ATM | Serine-protein kinase ATM | Q12778 | FOXO1 | Forkhead box protein O1 | 0.821 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.795 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q12778 | FOXO1 | Forkhead box protein O1 | 0.716 | | P22894 | MMP8 | Neutrophil collagenase | Q15532 | SS18 | Protein SSXT | -0.867 | | P22748 | CA4 | Carbonic anhydrase 4 | Q15532 | SS18 | Protein SSXT | -0.862 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13315 | ATM | Serine-protein kinase ATM | 0.752 | | Q13315 | ATM | Serine-protein kinase ATM | Q13315 | ATM | Serine-protein kinase ATM | 1 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q13315 | ATM | Serine-protein kinase ATM | 0.723 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q13315 | ATM | Serine-protein kinase ATM | 0.858 | | P22748 | CA4 | Carbonic anhydrase 4 | P41732 | TSPAN7 | Tetraspanin-7 | 0.706 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P41732 | TSPAN7 | Tetraspanin-7 | -0.733 | | P22894 | MMP8 | Neutrophil collagenase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.882 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.855 | | P22748 | CA4 | Carbonic anhydrase 4 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.925 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.746 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.826 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.727 | | P22748 | CA4 | Carbonic anhydrase 4 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.708 | | P22894 | MMP8 | Neutrophil collagenase | P14923 | JUP | Junction plakoglobin | -0.809 | | P22748 | CA4 | Carbonic anhydrase 4 | P14923 | JUP | Junction plakoglobin | -0.772 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | -0.833 | | Q13315 | ATM | Serine-protein kinase ATM | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | -0.709 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | -0.779 | | P22894 | MMP8 | Neutrophil collagenase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.843 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.877 | | P22748 | CA4 | Carbonic anhydrase 4 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.833 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.701 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.769 | | P22894 | MMP8 | Neutrophil collagenase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.765 | | P22894 | MMP8 | Neutrophil collagenase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.806 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.83 | | P22748 | CA4 | Carbonic anhydrase 4 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.718 | | P22748 | CA4 | Carbonic anhydrase 4 | O15550 | UTX | Lysine-specific demethylase 6A | 0.714 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | O15550 | UTX | Lysine-specific demethylase 6A | -0.778 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | Q13315 | ATM | Serine-protein kinase ATM | P46527 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | 0.708 | | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.76 | | P22748 | CA4 | Carbonic anhydrase 4 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.834 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.759 | | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.76 | | P22748 | CA4 | Carbonic anhydrase 4 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.834 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.759 | | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P05164 | MPO | Myeloperoxidase | -0.811 | | P22748 | CA4 | Carbonic anhydrase 4 | P05164 | MPO | Myeloperoxidase | 0.826 | | Q13315 | ATM | Serine-protein kinase ATM | P05164 | MPO | Myeloperoxidase | -0.725 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P05164 | MPO | Myeloperoxidase | -0.866 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P05164 | MPO | Myeloperoxidase | -0.817 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P12838 | DEFA4 | Neutrophil defensin 4 | -0.86 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P12838 | DEFA4 | Neutrophil defensin 4 | -0.796 | | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P08246 | ELA2 | Neutrophil elastase | -0.782 | | P22748 | CA4 | Carbonic anhydrase 4 | P08246 | ELA2 | Neutrophil elastase | 0.921 | | Q13315 | ATM | Serine-protein kinase ATM | P08246 | ELA2 | Neutrophil elastase | -0.742 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P08246 | ELA2 | Neutrophil elastase | -0.76 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P08246 | ELA2 | Neutrophil elastase | -0.772 | | P22894 | MMP8 | Neutrophil collagenase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.778 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.9 | | Q13315 | ATM | Serine-protein kinase ATM | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.741 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.879 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.807 | | P22894 | MMP8 | Neutrophil collagenase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.766 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.75 | | P22748 | CA4 | Carbonic anhydrase 4 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.769 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.734 |
| | Celecoxib | hsa05203 | Viral carcinogenesis | 4.85E-02 | 3 | Q15283, P62807, O60814 | RASA2, HIST1H2BC, H2BC12 | More | | | Celecoxib | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Celecoxib | hsa05205 | Proteoglycans in cancer | 3.48E-02 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa05206 | MicroRNAs in cancer | 3.66E-02 | 6 | P46527, Q9UM47, P16070, Q13315, P17252, Q02750 | CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1 | More | | | Celecoxib | hsa05211 | Renal cell carcinoma | 2.01E-03 | 3 | Q06124, Q99814, P31751 | PTPN11, EPAS1, AKT2 | More | | | Celecoxib | hsa05212 | Pancreatic cancer | 1.07E-03 | 7 | P42338, P31751, P84022, Q13485, P04637, P24522, O75293 | PIK3CB, AKT2, SMAD3, SMAD4, TP53, GADD45A, GADD45B | More | | | Celecoxib | hsa05213 | Endometrial cancer | 3.10E-03 | 3 | P31751, P04637, P24522 | AKT2, TP53, GADD45A | More | | | Celecoxib | hsa05214 | Glioma | 2.06E-06 | 6 | P08069, P0DP23, P17252, P31751, P04637, P24522 | IGF1R, CALM1, PRKCA, AKT2, TP53, GADD45A | More | | | Celecoxib | hsa05215 | Prostate cancer | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Celecoxib | hsa05216 | Thyroid cancer | 7.27E-05 | 5 | P01106, Q9UJU2, P04637, P24522, O75293 | MYC, LEF1, TP53, GADD45A, GADD45B | More | | | Celecoxib | hsa05217 | Basal cell carcinoma | 3.57E-03 | 3 | Q9UJU2, P04637, P24522 | LEF1, TP53, GADD45A | More | | | Celecoxib | hsa05218 | Melanoma | 5.22E-05 | 4 | P08069, P04637, P31751, P24522 | IGF1R, TP53, AKT2, GADD45A | More | | | Celecoxib | hsa05219 | Bladder cancer | 4.07E-02 | 2 | P14780, P04637 | MMP9, TP53 | More | | | Celecoxib | hsa05220 | Chronic myeloid leukemia | 1.88E-04 | 9 | Q06124, P04637, Q13547, Q13485, P84022, P31751, P42338, P24522, O75293 | PTPN11, TP53, HDAC1, SMAD4, SMAD3, AKT2, PIK3CB, GADD45A, GADD45B | More | | | Celecoxib | hsa05221 | Acute myeloid leukemia | 4.19E-02 | 1 | P31751 | AKT2 | More | | | Celecoxib | hsa05222 | Small cell lung cancer | 4.78E-02 | 1 | P31751 | AKT2 | More | | | Celecoxib | hsa05223 | Non-small cell lung cancer | 8.38E-05 | 6 | P31751, P10826, Q9HC35, P04637, P24522, O75293 | AKT2, RARB, EML4, TP53, GADD45A, GADD45B | More | | | Celecoxib | hsa05224 | Breast cancer | 1.24E-02 | 5 | P08069, P49841, Q92837, P04637, P24522 | IGF1R, GSK3B, FRAT1, TP53, GADD45A | More | | | Celecoxib | hsa05225 | Hepatocellular carcinoma | 3.15E-03 | 4 | P08069, P04637, P24522, P63261 | IGF1R, TP53, GADD45A, ACTG1 | More | | | Celecoxib | hsa05226 | Gastric cancer | 3.60E-02 | 1 | P31751 | AKT2 | More | | | Celecoxib | hsa05230 | Central carbon metabolism in cancer | 4.78E-02 | 1 | P31751 | AKT2 | More | | | Celecoxib | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 9.65E-08 | 13 | P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, Q9HC35, P01730 | PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.824 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.782 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.724 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.862 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.815 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.744 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.744 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.809 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.721 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60603 | TLR2 | Toll-like receptor 2 | 0.72 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | O60603 | TLR2 | Toll-like receptor 2 | -0.717 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.794 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q04759 | PRKCQ | Protein kinase C theta type | -0.807 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q04759 | PRKCQ | Protein kinase C theta type | 0.776 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.849 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | P52732 | KIF11 | Kinesin-like protein KIF11 | Q9HC35 | EML4 | Echinoderm microtubule-associated protein-like 4 | 0.794 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.707 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.719 |
| | Celecoxib | hsa05310 | Asthma | 4.49E-07 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Celecoxib | hsa05321 | Inflammatory bowel disease | 1.12E-11 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P22894 | MMP8 | Neutrophil collagenase | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O60603 | TLR2 | Toll-like receptor 2 | -0.714 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | O60603 | TLR2 | Toll-like receptor 2 | -0.717 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01375 | TNF | Tumor necrosis factor | 0.782 | | P22894 | MMP8 | Neutrophil collagenase | P01375 | TNF | Tumor necrosis factor | 0.728 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P01375 | TNF | Tumor necrosis factor | -0.813 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.748 | | P22894 | MMP8 | Neutrophil collagenase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.797 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.795 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.76 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.756 | | P22894 | MMP8 | Neutrophil collagenase | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.757 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.904 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.742 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.928 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.927 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.884 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.735 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.852 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.765 | | P22894 | MMP8 | Neutrophil collagenase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.751 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.784 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.85 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.715 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9HBE5 | IL21R | Interleukin-21 receptor | 0.713 |
| | Celecoxib | hsa05322 | Systemic lupus erythematosus | 2.23E-05 | 13 | O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455 | FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB | More | | | Celecoxib | hsa05323 | Rheumatoid arthritis | 1.05E-03 | 5 | P01375, P13765, P10747, P09341, O60603 | TNF, HLA-DOB, CD28, CXCL1, TLR2 | More | | | Celecoxib | hsa05330 | Allograft rejection | 2.02E-03 | 4 | P13765, P48023, P10747, P01375 | HLA-DOB, FASLG, CD28, TNF | More | | | Celecoxib | hsa05332 | Graft-versus-host disease | 4.17E-11 | 6 | P13765, P48023, P10747, P01375, P26715, Q13241 | HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.748 | | P22894 | MMP8 | Neutrophil collagenase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.797 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.795 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.76 | | P14416 | DRD2 | D(2) dopamine receptor | P48023 | FASLG | Tumor necrosis factor ligand superfamily member 6 | 0.7 | | P22894 | MMP8 | Neutrophil collagenase | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | -0.801 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.794 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.79 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01375 | TNF | Tumor necrosis factor | 0.782 | | P22894 | MMP8 | Neutrophil collagenase | P01375 | TNF | Tumor necrosis factor | 0.728 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | P14416 | DRD2 | D(2) dopamine receptor | P01375 | TNF | Tumor necrosis factor | -0.767 | | P11766 | ADH5 | Alcohol dehydrogenase class-3 | P01375 | TNF | Tumor necrosis factor | -0.709 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P01375 | TNF | Tumor necrosis factor | -0.813 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.846 | | P22894 | MMP8 | Neutrophil collagenase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.77 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.943 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.853 | | P11766 | ADH5 | Alcohol dehydrogenase class-3 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.737 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.972 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.846 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.852 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.863 | | P11766 | ADH5 | Alcohol dehydrogenase class-3 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.726 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.883 |
| | Celecoxib | hsa05340 | Primary immunodeficiency | 1.28E-03 | 4 | P01730, P11912, P07766, P06239 | CD4, CD79A, CD3E, LCK | More | | | Celecoxib | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.93E-02 | 1 | P54284 | CACNB3 | More | | | Celecoxib | hsa05415 | Diabetic cardiomyopathy | 1.28E-02 | 4 | Q16718, O14521, Q16539, P49841 | NDUFA5, SDHD, MAPK14, GSK3B | More | | | Celecoxib | hsa05418 | Fluid shear stress and atherosclerosis | 2.84E-03 | 8 | Q16539, P31751, P10599, P14780, P04637, P14778, P27930, P0DP23 | MAPK14, AKT2, TXN, MMP9, TP53, IL1R1, IL1R2, CALM1 | More | |
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