PharmaCoNets of Carvedilol (SPCN: 53.68 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Carvedilolhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Carvedilolhsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Carvedilolhsa00071Fatty acid degradation2.52E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Carvedilolhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Carvedilolhsa00500Starch and sucrose metabolism7.59E-073O43451, P46976, P06737MGAM, GYG1, PYGLMore
Carvedilolhsa00630Glyoxylate and dicarboxylate metabolism4.12E-032P40925, P15104MDH1, GLULMore
Carvedilolhsa00730Thiamine metabolism5.31E-073Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Carvedilolhsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Carvedilolhsa00770Pantothenate and CoA biosynthesis5.15E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Carvedilolhsa00830Retinol metabolism3.19E-021P00325ADH1BMore
Carvedilolhsa00970Aminoacyl-tRNA biosynthesis2.77E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Carvedilolhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Carvedilolhsa01100Metabolic pathways3.52E-0223P05089, O95455, P21953, P32320, P11766, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, Q08477, P15907, Q9UNP4, P37837, P32321, Q9BPW9, Q9UHY7, P43490, P46976, P06737ARG1, TGDS, BCKDHB, CDA, ADH5, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, CYP4F3, ST6GAL1, ST3GAL5, TALDO1, DCTD, DHRS9, ENOPH1, PBEF1, GYG1, PYGLMore
Carvedilolhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Carvedilolhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Carvedilolhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Carvedilolhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Carvedilolhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Carvedilolhsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Carvedilolhsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Carvedilolhsa04072Phospholipase D signaling pathway9.70E-032Q92529, Q14344SHC3, GNA13More
Carvedilolhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Carvedilolhsa04114Oocyte meiosis6.23E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Carvedilolhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Carvedilolhsa04140Autophagy - animal1.95E-023Q96RR4, O75460, Q8TEV9CAMKK2, ERN1, SMCR8More
Carvedilolhsa04150mTOR signaling pathway2.23E-023P42338, Q13322, P49841PIK3CB, GRB10, GSK3BMore
Carvedilolhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Carvedilolhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Carvedilolhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Carvedilolhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Carvedilolhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Carvedilolhsa04370VEGF signaling pathway3.06E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Carvedilolhsa04380Osteoclast differentiation1.39E-038Q9UQC2, Q16539, P06239, P42338, P14778, O75015, P01375, Q8N149GAB2, MAPK14, LCK, PIK3CB, IL1R1, FCGR3B, TNF, LILRA2More
Carvedilolhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Carvedilolhsa04550Signaling pathways regulating pluripotency of stem cells4.73E-023Q13873, Q02750, Q86SE9BMPR2, MAP2K1, PCGF5More
Carvedilolhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Carvedilolhsa04613Neutrophil extracellular trap formation3.76E-0410P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Carvedilolhsa04621NOD-like receptor signaling pathway1.93E-028Q16539, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838MAPK14, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4More
Carvedilolhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Carvedilolhsa04650Natural killer cell mediated cytotoxicity5.56E-0510P16298, P50591, P01375, P20963, Q02750, Q13241, P26718, P26717, Q14953, P26715PPP3CB, TNFSF10, TNF, CD247, MAP2K1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Carvedilolhsa04657IL-17 signaling pathway3.50E-068O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Carvedilolhsa04659Th17 cell differentiation4.12E-024P06239, P14784, P14778, P07766LCK, IL2RB, IL1R1, CD3EMore
Carvedilolhsa04662B cell receptor signaling pathway7.25E-034P49841, P42338, P21854, Q8N149GSK3B, PIK3CB, CD72, LILRA2More
Carvedilolhsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Carvedilolhsa04668TNF signaling pathway2.12E-037P01375, O00463, Q16539, P18848, P19875, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9More
Carvedilolhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Carvedilolhsa04720Long-term potentiation2.85E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Carvedilolhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Carvedilolhsa04723Retrograde endocannabinoid signaling4.48E-022Q08828, O95298ADCY1, NDUFC2More
Carvedilolhsa04730Long-term depression3.52E-021Q14344GNA13More
Carvedilolhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Carvedilolhsa04742Taste transduction1.01E-021P30939HTR1FMore
Carvedilolhsa04750Inflammatory mediator regulation of TRP channels3.72E-023P14778, P42338, P24723IL1R1, PIK3CB, PRKCHMore
Carvedilolhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Carvedilolhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Carvedilolhsa04914Progesterone-mediated oocyte maturation1.00E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Carvedilolhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Carvedilolhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Carvedilolhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Carvedilolhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Carvedilolhsa04929GnRH secretion3.63E-022P42338, P49407PIK3CB, ARRB1More
Carvedilolhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Carvedilolhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Carvedilolhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Carvedilolhsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Carvedilolhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Carvedilolhsa04973Carbohydrate digestion and absorption4.12E-032O43451, P42338MGAM, PIK3CBMore
Carvedilolhsa04976Bile secretion8.77E-055O43315, Q08828, P22694, P08183, Q14032AQP9, ADCY1, PRKACB, ABCB1, BAATMore
Carvedilolhsa04979Cholesterol metabolism9.14E-032P38571, P61916LIPA, NPC2More
Carvedilolhsa05010Alzheimer disease3.57E-024O95298, Q00535, O75460, P28070NDUFC2, CDK5, ERN1, PSMB4More
Carvedilolhsa05014Amyotrophic lateral sclerosis3.57E-024O95298, O75460, P28070, Q8TEV9NDUFC2, ERN1, PSMB4, SMCR8More
Carvedilolhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Carvedilolhsa05022Pathways of neurodegeneration - multiple diseases2.00E-0413P49841, Q16718, O95298, O14521, Q06055, Q8TEV9, O75460, Q13561, Q16539, Q00535, Q08752, O15020, P28070GSK3B, NDUFA5, NDUFC2, SDHD, ATP5G2, SMCR8, ERN1, DCTN2, MAPK14, CDK5, PPID, SPTBN2, PSMB4More
Carvedilolhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Carvedilolhsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Carvedilolhsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Carvedilolhsa05120Epithelial cell signaling in Helicobacter pylori infection2.27E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Carvedilolhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Carvedilolhsa05140Leishmaniasis2.47E-025P13612, O75015, P01375, P49006, Q16539ITGA4, FCGR3B, TNF, MARCKSL1, MAPK14More
Carvedilolhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Carvedilolhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Carvedilolhsa05146Amoebiasis3.03E-038P09341, P19875, P14778, P27930, P01375, P05089, P30679, P22694CXCL1, CXCL2, IL1R1, IL1R2, TNF, ARG1, GNA15, PRKACBMore
Carvedilolhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Carvedilolhsa05163Human cytomegalovirus infection2.72E-037P01375, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Carvedilolhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Carvedilolhsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Carvedilolhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Carvedilolhsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Carvedilolhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Carvedilolhsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Carvedilolhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Carvedilolhsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Carvedilolhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Carvedilolhsa05418Fluid shear stress and atherosclerosis1.29E-058Q16539, P42338, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, PIK3CB, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Carvedilol (SDC: 4.82)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
O95298NDUFC2NADH dehydrogenase [ubiquinone] 1 subunit C2Reported00.28560.01330.52910.6986
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
Q99712KCNJ15ATPNonesensitive inward rectifier potassium channel 15Predicted00.15870.07790.12670.3619
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Predicted00.07310.08780.20670.4189
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
ADRB2P07550Ki1.1
ADRB2P07550Kd0.4