PharmaCoNets of Carindacillin (SPCN: 23.90 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Carindacillinhsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Carindacillinhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Carindacillinhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Carindacillinhsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Carindacillinhsa03013RNA transport4.09E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Carindacillinhsa03060Protein export1.90E-022Q15070, O76094OXA1L, SRP72More
Carindacillinhsa04015Rap1 signaling pathway2.26E-023P25116, Q8TEU7, P08514F2R, RAPGEF6, ITGA2BMore
Carindacillinhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Carindacillinhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Carindacillinhsa04064NF-kappa B signaling pathway1.91E-0412P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45AMore
Carindacillinhsa04071Sphingolipid signaling pathway9.39E-037P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Carindacillinhsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Carindacillinhsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Carindacillinhsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Carindacillinhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Carindacillinhsa04145Phagosome7.50E-0310Q15080, P14598, Q13509, Q13488, Q99437, P05164, O60603, P35443, P13765, P25774NCF4, NCF1, TUBB3, TCIRG1, ATP6V0B, MPO, TLR2, THBS4, HLA-DOB, CTSSMore
Carindacillinhsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Carindacillinhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Carindacillinhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Carindacillinhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Carindacillinhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Carindacillinhsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Carindacillinhsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Carindacillinhsa04611Platelet activation1.59E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Carindacillinhsa04613Neutrophil extracellular trap formation1.30E-0313P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, P21730, P21462PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1More
Carindacillinhsa04621NOD-like receptor signaling pathway3.10E-0311Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Carindacillinhsa04650Natural killer cell mediated cytotoxicity2.95E-027P06239, P20963, Q13241, P26718, O14931, P26717, P26715LCK, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Carindacillinhsa04658Th1 and Th2 cell differentiation4.79E-037P07766, P20963, P09693, P06239, P23771, Q9UL17, Q13761CD3E, CD247, CD3G, LCK, GATA3, TBX21, RUNX3More
Carindacillinhsa04660T cell receptor signaling pathway1.37E-0313P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Carindacillinhsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Carindacillinhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Carindacillinhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Carindacillinhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Carindacillinhsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Carindacillinhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Carindacillinhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Carindacillinhsa04970Salivary secretion4.49E-024P22694, Q14643, P17252, P49913PRKACB, ITPR1, PRKCA, CAMPMore
Carindacillinhsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Carindacillinhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Carindacillinhsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Carindacillinhsa05132Salmonella infection2.98E-0211P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3More
Carindacillinhsa05140Leishmaniasis1.18E-027P14598, P13765, O60603, P25963, P01375, P51617, Q15080NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4More
Carindacillinhsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Carindacillinhsa05152Tuberculosis9.13E-0311Q13488, Q99437, P48382, O60603, P01375, P10415, P13765, P25774, P49913, Q9UDY8, P51617TCIRG1, ATP6V0B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CTSS, CAMP, MALT1, IRAK1More
Carindacillinhsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Carindacillinhsa05170Human immunodeficiency virus 1 infection1.06E-0313P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2More
Carindacillinhsa05202Transcriptional misregulation in cancer1.51E-0414Q12778, Q15532, Q13315, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Carindacillinhsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Carindacillinhsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Carindacillinhsa05321Inflammatory bowel disease1.28E-025O60603, P01375, P13765, Q14765, P23771TLR2, TNF, HLA-DOB, STAT4, GATA3More
Carindacillinhsa05322Systemic lupus erythematosus4.20E-027P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Carindacillinhsa05332Graft-versus-host disease9.30E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More

Community members of Carindacillin (SDC: 3.09)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P13612ITGA4Integrin alphaNone4Predicted00.11650.23860.68621.2217
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)