PharmaCoNets of Carfilzomib (SPCN: 21.82 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Carfilzomibhsa00220Arginine biosynthesis1.54E-022P05089, P49448ARG1, GLUD2More
Carfilzomibhsa00240Pyrimidine metabolism6.59E-034P21589, P32320, P27707, P04183NT5E, CDA, DCK, TK1More
Carfilzomibhsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Carfilzomibhsa00910Nitrogen metabolism2.93E-022P22748, P49448CA4, GLUD2More
Carfilzomibhsa00920Sulfur metabolism1.78E-021Q16762TSTMore
Carfilzomibhsa00980Metabolism of xenobiotics by cytochrome P4503.10E-022P78417, P11712GSTO1, CYP2C9More
Carfilzomibhsa00982Drug metabolism - cytochrome P4503.10E-022P11712, P78417CYP2C9, GSTO1More
Carfilzomibhsa00983Drug metabolism - other enzymes2.27E-033P04183, P32320, P05164TK1, CDA, MPOMore
Carfilzomibhsa01100Metabolic pathways2.44E-0225Q9Y234, O00764, Q99707, O14732, P27707, P21589, P04183, P32320, P36959, P22748, P06280, P33260, Q02252, O14772, Q9HCC0, P33121, P42330, Q13093, Q9NY28, Q9BX95, Q9P2R7, Q9UHY7, P06737, Q16718, Q02809LIPT1, PDXK, MTR, IMPA2, DCK, NT5E, TK1, CDA, GMPR, CA4, GLA, CYP2C18, ALDH6A1, FPGT, MCCC2, ACSL1, AKR1C3, PLA2G7, GALNT8, SGPP1, SUCLA2, ENOPH1, PYGL, NDUFA5, PLOD1More
Carfilzomibhsa03013RNA transport2.37E-028P52298, O14893, P61326, Q7Z3B4, P35658, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3J, RPP38, TACC3More
Carfilzomibhsa03040Spliceosome5.25E-049O43143, P17844, P08579, P51991, P61978, Q13595, Q07955, P84103, P11142DHX15, DDX5, SNRPB2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS3, HSPA8More
Carfilzomibhsa03050Proteasome1.35E-032P28074, P40306PSMB5, PSMB10More
Carfilzomibhsa04014Ras signaling pathway4.12E-025P20827, P49767, Q14644, P0DP23, P63218EFNA1, VEGFC, RASA3, CALM1, GNG5More
Carfilzomibhsa04020Calcium signaling pathway3.36E-036Q16566, P30679, O15399, P0DP23, P23634, P49767CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Carfilzomibhsa04060Cytokine-cytokine receptor interaction5.39E-0310P27930, P08476, Q13651, Q9HBE5, Q9UBD3, P47992, P01375, P09341, P18510, Q93038IL1R2, INHBA, IL10RA, IL21R, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25More
Carfilzomibhsa04061Viral protein interaction with cytokine and cytokine receptor4.34E-025P09341, P47992, Q9UBD3, Q13651, P01375CXCL1, XCL1, XCL2, IL10RA, TNFMore
Carfilzomibhsa04064NF-kappa B signaling pathway6.00E-038O00463, P01375, Q04759, Q16548, P06239, Q13315, P24522, P09341TRAF5, TNF, PRKCQ, BCL2A1, LCK, ATM, GADD45A, CXCL1More
Carfilzomibhsa04122Sulfur relay system1.78E-021Q16762TSTMore
Carfilzomibhsa04136Autophagy - other3.53E-021O94817ATG12More
Carfilzomibhsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Carfilzomibhsa04145Phagosome6.34E-037Q15080, P14598, Q13509, P68371, P05164, O60603, P35443NCF4, NCF1, TUBB3, TUBB2C, MPO, TLR2, THBS4More
Carfilzomibhsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Carfilzomibhsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Carfilzomibhsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Carfilzomibhsa04371Apelin signaling pathway4.16E-024P63218, Q13485, Q16566, P0DP23GNG5, SMAD4, CAMK4, CALM1More
Carfilzomibhsa04512ECM-receptor interaction4.78E-021Q16787LAMA3More
Carfilzomibhsa04514Cell adhesion molecules2.37E-022P16109, O00501SELP, CLDN5More
Carfilzomibhsa04530Tight junction3.82E-022O00501, P24844CLDN5, MYL9More
Carfilzomibhsa04610Complement and coagulation cascades4.48E-023P01042, P09871, P11215KNG1, C1S, ITGAMMore
Carfilzomibhsa04612Antigen processing and presentation9.89E-037P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Carfilzomibhsa04640Hematopoietic cell lineage4.96E-026P27930, P25063, P09693, P01732, P13765, P01375IL1R2, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Carfilzomibhsa04650Natural killer cell mediated cytotoxicity2.94E-038P01375, P06239, O60880, P20963, Q13241, P26718, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KLRC1More
Carfilzomibhsa04657IL-17 signaling pathway2.29E-025O00463, P09341, P14780, P80188, P01375TRAF5, CXCL1, MMP9, LCN2, TNFMore
Carfilzomibhsa04658Th1 and Th2 cell differentiation1.26E-038Q04759, P20963, P09693, P06239, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, LCK, STAT4, GATA3, TBX21, HLA-DOBMore
Carfilzomibhsa04659Th17 cell differentiation3.55E-038Q04759, P06239, P13765, Q9HBE5, Q9UL17, P23771, P09693, P20963PRKCQ, LCK, HLA-DOB, IL21R, TBX21, GATA3, CD3G, CD247More
Carfilzomibhsa04660T cell receptor signaling pathway2.94E-038P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, P06239TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, LCKMore
Carfilzomibhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Carfilzomibhsa04720Long-term potentiation1.79E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Carfilzomibhsa04724Glutamatergic synapse4.48E-023O15399, P63218, Q9NSB8GRIN2D, GNG5, HOMER2More
Carfilzomibhsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Carfilzomibhsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Carfilzomibhsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Carfilzomibhsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Carfilzomibhsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Carfilzomibhsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Carfilzomibhsa04925Aldosterone synthesis and secretion2.31E-047Q99941, P18848, P51828, P0DP23, Q16566, Q13557, P23634CREBL1, ATF4, ADCY7, CALM1, CAMK4, CAMK2D, ATP2B4More
Carfilzomibhsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Carfilzomibhsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Carfilzomibhsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Carfilzomibhsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Carfilzomibhsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Carfilzomibhsa04964Proximal tubule bicarbonate reclamation2.93E-022P22748, P49448CA4, GLUD2More
Carfilzomibhsa04973Carbohydrate digestion and absorption2.41E-021P13866SLC5A1More
Carfilzomibhsa04976Bile secretion4.19E-021P13866SLC5A1More
Carfilzomibhsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Carfilzomibhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Carfilzomibhsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Carfilzomibhsa05034Alcoholism1.05E-026O15399, Q16566, P0DP23, P63218, O60814, P68431GRIN2D, CAMK4, CALM1, GNG5, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Carfilzomibhsa05132Salmonella infection1.46E-029Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Carfilzomibhsa05133Pertussis1.70E-034P11215, P0DP23, P23528, P09871ITGAM, CALM1, CFL1, C1SMore
Carfilzomibhsa05146Amoebiasis7.00E-037P09341, P27930, P01375, P05089, P22694, P12814, P08311CXCL1, IL1R2, TNF, ARG1, PRKACB, ACTN1, CTSGMore
Carfilzomibhsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Carfilzomibhsa05202Transcriptional misregulation in cancer5.05E-0416Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Carfilzomibhsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Carfilzomibhsa05204Chemical carcinogenesis4.92E-022P78417, P11712GSTO1, CYP2C9More
Carfilzomibhsa05222Small cell lung cancer4.78E-021Q16787LAMA3More
Carfilzomibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.34E-025O95267, P20963, P09693, P06239, Q04759RASGRP1, CD247, CD3G, LCK, PRKCQMore
Carfilzomibhsa05310Asthma3.20E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Carfilzomibhsa05321Inflammatory bowel disease1.25E-036P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Carfilzomibhsa05322Systemic lupus erythematosus3.90E-026P08246, P08311, P01375, P13765, Q16778, P12814ELA2, CTSG, TNF, HLA-DOB, HIST2H2BE, ACTN1More
Carfilzomibhsa05332Graft-versus-host disease2.55E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More

Community members of Carfilzomib (SDC: 2.45)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P28074PSMB5Proteasome subunit beta typeNone5Reported10.28390.47230.54391.6305
P40306PSMB10Proteasome subunit beta typeNone10Reported00.26880.0510.01830.2548
P10619CTSALysosomal protective proteinPredicted00.12260.15310.19010.5575
P08311CTSGCathepsin GPredicted00.49490.18740.64781.2701
P78417GSTO1Glutathione SNonetransferase omegaNone1Predicted00.41090.13990.4250.9103
O43148RNMTmRNA cap guanineNoneN7 methyltransferasePredicted10.32110.00670.2040.3779
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
PSMB5P28074IC508.4
PSMB5P28074IC508.6
PSMB5P28074IC509.6