PharmaCoNets of Carbocisteine (SPCN: 18.36 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Carbocisteinehsa00040Pentose and glucuronate interconversions2.33E-042P15121, P14550AKR1B1, AKR1A1More
Carbocisteinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Carbocisteinehsa00100Steroid biosynthesis4.70E-021P35610SOAT1More
Carbocisteinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Carbocisteinehsa00500Starch and sucrose metabolism1.13E-033O43451, P46976, P35557MGAM, GYG1, GCKMore
Carbocisteinehsa00512Mucin type O-glycan biosynthesis1.22E-022O95395, Q8N4A0GCNT3, GALNT4More
Carbocisteinehsa00524Neomycin, kanamycin and gentamicin biosynthesis4.70E-021P35557GCKMore
Carbocisteinehsa00561Glycerolipid metabolism2.62E-022P15121, P14550AKR1B1, AKR1A1More
Carbocisteinehsa00564Glycerophospholipid metabolism1.97E-023P48651, Q9Y6K0, P35790PTDSS1, CEPT1, CHKAMore
Carbocisteinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Carbocisteinehsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Carbocisteinehsa00770Pantothenate and CoA biosynthesis3.90E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Carbocisteinehsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Carbocisteinehsa00980Metabolism of xenobiotics by cytochrome P4504.00E-021P09211GSTP1More
Carbocisteinehsa00983Drug metabolism - other enzymes1.63E-022P20839, Q16772IMPDH1, GSTA3More
Carbocisteinehsa01100Metabolic pathways2.59E-0211P35790, Q16772, P30041, P20839, O94777, P15121, O95861, P14550, Q9UHK6, Q86VZ5, Q9NVH6CHKA, GSTA3, PRDX6, IMPDH1, DPM2, AKR1B1, BPNT1, AKR1A1, AMACR, SGMS1, TMLHEMore
Carbocisteinehsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Carbocisteinehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Carbocisteinehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Carbocisteinehsa03010Ribosome3.93E-047P40429, P46777, Q07020, P27635, P50914, P05386, P62249RPL13A, RPL5, RPL18, RPL10, RPL14, RPLP1, RPS16More
Carbocisteinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Carbocisteinehsa04080Neuroactive ligand-receptor interaction2.60E-022P00734, Q96G91F2, P2RY11More
Carbocisteinehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Carbocisteinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Carbocisteinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Carbocisteinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Carbocisteinehsa04610Complement and coagulation cascades4.11E-083P00734, P0C0L4, P05107F2, C4A, ITGB2More
Carbocisteinehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Carbocisteinehsa04622RIG-I-like receptor signaling pathway1.36E-022Q12933, P10145TRAF2, IL8More
Carbocisteinehsa04640Hematopoietic cell lineage4.13E-037P08514, P21926, P14778, P07766, P01730, P09564, P13765ITGA2B, CD9, IL1R1, CD3E, CD4, CD7, HLA-DOBMore
Carbocisteinehsa04659Th17 cell differentiation2.73E-024Q16539, P01730, P13765, P14778MAPK14, CD4, HLA-DOB, IL1R1More
Carbocisteinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Carbocisteinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Carbocisteinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Carbocisteinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Carbocisteinehsa04950Maturity onset diabetes of the young4.70E-021P35557GCKMore
Carbocisteinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Carbocisteinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Carbocisteinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Carbocisteinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Carbocisteinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Carbocisteinehsa05133Pertussis8.35E-053P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Carbocisteinehsa05143African trypanosomiasis4.74E-054P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Carbocisteinehsa05144Malaria5.01E-054P69905, P68871, P05107, P10145HBA2, HBB, ITGB2, IL8More
Carbocisteinehsa05150Staphylococcus aureus infection3.50E-022P0C0L4, P05107C4A, ITGB2More
Carbocisteinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Carbocisteinehsa05171Coronavirus disease - COVID-193.87E-045P62249, P40429, P27635, Q07020, P05386RPS16, RPL13A, RPL10, RPL18, RPLP1More
Carbocisteinehsa05204Chemical carcinogenesis4.00E-021P09211GSTP1More
Carbocisteinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Carbocisteinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Carbocisteinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Carbocisteinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Carbocisteinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Carbocisteinehsa05340Primary immunodeficiency5.76E-055P01730, P11912, Q8WV28, P07766, P06239CD4, CD79A, BLNK, CD3E, LCKMore
Carbocisteinehsa05410Hypertrophic cardiomyopathy2.60E-022P26012, P09493ITGB8, TPM1More
Carbocisteinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Carbocisteinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Carbocisteine (SDC: 3.27)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09211GSTP1Glutathione SNonetransferase PReported00.32040.35230.45661.3213
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P48058GRIA4Glutamate receptor 4Predicted00.40370.12090.37480.8184
P43003SLC1A3Excitatory amino acid transporter 1Predicted00.09730.07740.16580.3692
P43005SLC1A1Excitatory amino acid transporter 3Predicted00.08270.06630.0190.193
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q16772GSTA3Glutathione SNonetransferase A3Predicted00.46240.03360.4250.7234
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)