PharmaCoNets of Carbamazepine (SPCN: 133.01 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Carbamazepinehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Carbamazepinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Carbamazepinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Carbamazepinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Carbamazepinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Carbamazepinehsa00620Pyruvate metabolism3.90E-022P07195, P11766LDHB, ADH5More
Carbamazepinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Carbamazepinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Carbamazepinehsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Carbamazepinehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Carbamazepinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Carbamazepinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Carbamazepinehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Carbamazepinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Carbamazepinehsa03013RNA transport5.92E-0314P62826, P52298, Q09161, O14893, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, P78345, Q9Y6A5, Q14232RAN, NCBP2, NCBP1, GEMIN2, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, TACC3, EIF2B1More
Carbamazepinehsa03020RNA polymerase6.21E-044P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Carbamazepinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Carbamazepinehsa03060Protein export4.46E-032Q15070, O76094OXA1L, SRP72More
Carbamazepinehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Carbamazepinehsa04020Calcium signaling pathway4.83E-024Q08828, P0DP23, P05141, P51828ADCY1, CALM1, SLC25A5, ADCY7More
Carbamazepinehsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Carbamazepinehsa04024cAMP signaling pathway3.94E-024Q08828, P51828, P31751, P0DP23ADCY1, ADCY7, AKT2, CALM1More
Carbamazepinehsa04061Viral protein interaction with cytokine and cytokine receptor4.79E-037Q8NHW4, P09341, P19875, P25024, P25025, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, IL10RA, IL2RBMore
Carbamazepinehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Carbamazepinehsa04064NF-kappa B signaling pathway1.64E-0925P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Carbamazepinehsa04070Phosphatidylinositol signaling system9.86E-034P0DP23, O14986, Q16760, P48426CALM1, PIP5K1B, DGKD, PIP4K2AMore
Carbamazepinehsa04071Sphingolipid signaling pathway9.39E-037P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Carbamazepinehsa04072Phospholipase D signaling pathway4.96E-0411P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Carbamazepinehsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Carbamazepinehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Carbamazepinehsa04114Oocyte meiosis5.20E-049P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Carbamazepinehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Carbamazepinehsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Carbamazepinehsa04140Autophagy - animal1.71E-025P31751, Q7L523, O75460, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, TMEM49, SMCR8More
Carbamazepinehsa04144Endocytosis3.78E-037P0DMV8, Q9H444, O75351, Q9NZZ3, P62491, P42566, P61073HSPA1A, CHMP4B, VPS4B, CHMP5, RAB11A, EPS15, CXCR4More
Carbamazepinehsa04145Phagosome1.98E-028Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Carbamazepinehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Carbamazepinehsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Carbamazepinehsa04211Longevity regulating pathway9.34E-047Q12778, P31751, Q08828, P51828, P18848, Q9UEF7, Q96KQ7FOXO1, AKT2, ADCY1, ADCY7, ATF4, KL, EHMT2More
Carbamazepinehsa04213Longevity regulating pathway - multiple species4.97E-048P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Carbamazepinehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Carbamazepinehsa04217Necroptosis3.47E-0513P01375, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, Q14765, P0C0S5, Q99878, Q9H444, Q9NZZ3, O75351TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT4, H2AFZ, H2AC14, CHMP4B, CHMP5, VPS4BMore
Carbamazepinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Carbamazepinehsa04261Adrenergic signaling in cardiomyocytes4.98E-047Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Carbamazepinehsa04270Vascular smooth muscle contraction2.96E-024P0DP24, P51828, P35579, P35318CALM2, ADCY7, MYH9, ADMMore
Carbamazepinehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Carbamazepinehsa04371Apelin signaling pathway3.94E-024P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Carbamazepinehsa04380Osteoclast differentiation1.11E-0413Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Carbamazepinehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Carbamazepinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Carbamazepinehsa04612Antigen processing and presentation4.78E-026P48382, P26715, P26717, Q13241, O43908, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, TNFMore
Carbamazepinehsa04613Neutrophil extracellular trap formation6.93E-0624P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Carbamazepinehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Carbamazepinehsa04620Toll-like receptor signaling pathway4.30E-045Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Carbamazepinehsa04621NOD-like receptor signaling pathway5.71E-0515Q14643, P01568, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P49913, P59665, P59666, P12838ITPR1, IFNA21, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Carbamazepinehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Carbamazepinehsa04623Cytosolic DNA-sensing pathway5.24E-075P01584, P01568, Q13546, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, POLR3H, CCL4L2More
Carbamazepinehsa04625C-type lectin receptor signaling pathway3.25E-0411Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Carbamazepinehsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Carbamazepinehsa04640Hematopoietic cell lineage4.59E-0416P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1BMore
Carbamazepinehsa04650Natural killer cell mediated cytotoxicity1.57E-0616P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Carbamazepinehsa04657IL-17 signaling pathway1.56E-028O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Carbamazepinehsa04658Th1 and Th2 cell differentiation2.95E-0514Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Carbamazepinehsa04659Th17 cell differentiation1.82E-0517P25963, Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, CD3E, CD3G, CD247, JAK1More
Carbamazepinehsa04660T cell receptor signaling pathway2.85E-0517P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Carbamazepinehsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Carbamazepinehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Carbamazepinehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Carbamazepinehsa04713Circadian entrainment4.54E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Carbamazepinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Carbamazepinehsa04720Long-term potentiation1.71E-036P16298, P0DP23, P51812, P18848, Q08828, Q02750PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1More
Carbamazepinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Carbamazepinehsa04725Cholinergic synapse1.39E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Carbamazepinehsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Carbamazepinehsa04750Inflammatory mediator regulation of TRP channels1.30E-0513P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Carbamazepinehsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Carbamazepinehsa04912GnRH signaling pathway3.22E-039Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACBMore
Carbamazepinehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Carbamazepinehsa04915Estrogen signaling pathway1.17E-038P18848, Q08828, P51828, P31751, P0DMV8, P0DP23, P0DP24, Q15788ATF4, ADCY1, ADCY7, AKT2, HSPA1A, CALM1, CALM2, NCOA1More
Carbamazepinehsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Carbamazepinehsa04920Adipocytokine signaling pathway5.84E-036P25963, P33121, Q9Y478, Q04759, Q96RR4, P01375NFKBIA, ACSL1, PRKAB1, PRKCQ, CAMKK2, TNFMore
Carbamazepinehsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Carbamazepinehsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Carbamazepinehsa04926Relaxin signaling pathway2.46E-024P31751, P18848, Q08828, P51828AKT2, ATF4, ADCY1, ADCY7More
Carbamazepinehsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Carbamazepinehsa04932Non-alcoholic fatty liver disease5.67E-0510P31751, P01375, P49841, P18848, P48023, O75460, P01584, Q16718, O95298, O14521AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFA5, NDUFC2, SDHDMore
Carbamazepinehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Carbamazepinehsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Carbamazepinehsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Carbamazepinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Carbamazepinehsa04970Salivary secretion2.40E-037Q08828, P51828, P22694, Q14643, P17252, P0DP23, P49913ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CAMPMore
Carbamazepinehsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Carbamazepinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Carbamazepinehsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Carbamazepinehsa04976Bile secretion9.77E-045O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Carbamazepinehsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Carbamazepinehsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Carbamazepinehsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Carbamazepinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Carbamazepinehsa05022Pathways of neurodegeneration - multiple diseases4.63E-0415P49841, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, P0DP23, P28070GSK3B, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4More
Carbamazepinehsa05034Alcoholism4.86E-048P0DP24, Q96RR4, P0C0S5, Q93077, P62807, O60814, P84243, P68431CALM2, CAMKK2, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Carbamazepinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Carbamazepinehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Carbamazepinehsa05132Salmonella infection1.74E-0414P51617, P25963, P01375, Q9UJU2, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Carbamazepinehsa05134Legionellosis1.58E-036Q9NR31, P11215, P0DMV8, P11142, P09341, P19875SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Carbamazepinehsa05140Leishmaniasis8.89E-0412P13612, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, MAPK14, IRAK1, NCF4More
Carbamazepinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Carbamazepinehsa05144Malaria2.04E-036P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Carbamazepinehsa05145Toxoplasmosis4.06E-037P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Carbamazepinehsa05146Amoebiasis1.54E-0413P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Carbamazepinehsa05150Staphylococcus aureus infection6.29E-058P21730, P21462, O75015, Q14532, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Carbamazepinehsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Carbamazepinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Carbamazepinehsa05161Hepatitis B1.61E-0310P17252, P14780, P25963, Q13485, P01375, P10415, P84022, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, SMAD4, TNF, BCL2, SMAD3, IRAK1, TLR2, STAT4More
Carbamazepinehsa05162Measles2.96E-023P23458, P0DMV8, Q9NP90JAK1, HSPA1A, RAB9BMore
Carbamazepinehsa05163Human cytomegalovirus infection9.70E-059P31751, P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651, P18848AKT2, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RA, ATF4More
Carbamazepinehsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Carbamazepinehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Carbamazepinehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Carbamazepinehsa05168Herpes simplex virus 1 infection4.79E-028P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189More
Carbamazepinehsa05170Human immunodeficiency virus 1 infection2.58E-0518Q02750, P62879, P16298, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333MAP2K1, GNB2, PPP3CB, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Carbamazepinehsa05202Transcriptional misregulation in cancer7.38E-0620Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Carbamazepinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Carbamazepinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Carbamazepinehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Carbamazepinehsa05212Pancreatic cancer1.98E-035P31751, Q15311, P23458, P84022, Q13485AKT2, RALBP1, JAK1, SMAD3, SMAD4More
Carbamazepinehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Carbamazepinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Carbamazepinehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Carbamazepinehsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Carbamazepinehsa05222Small cell lung cancer2.38E-036Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Carbamazepinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Carbamazepinehsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Carbamazepinehsa05231Choline metabolism in cancer3.38E-023P31751, Q16760, O14986AKT2, DGKD, PIP5K1BMore
Carbamazepinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.06E-0413P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Carbamazepinehsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Carbamazepinehsa05321Inflammatory bowel disease4.27E-047O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Carbamazepinehsa05322Systemic lupus erythematosus2.09E-0412P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Carbamazepinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Carbamazepinehsa05332Graft-versus-host disease8.44E-046P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Carbamazepinehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Carbamazepinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Carbamazepine (SDC: 6.58)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Reported10.03150.949301.9143
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P04156PRNPMajor prion proteinPredicted00.59090.173700.6429
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q13510ASAH1Acid ceramidasePredicted00.40640.04230.28020.568
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P37840SNCAAlphaNonesynucleinPredicted10.08530.13240.33210.6395
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)