PharmaCoNets of Captopril (SPCN: 29.73 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Captoprilhsa00190Oxidative phosphorylation1.00E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Captoprilhsa00500Starch and sucrose metabolism1.79E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Captoprilhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Captoprilhsa00600Sphingolipid metabolism2.68E-022P07602, Q13510PSAP, ASAH1More
Captoprilhsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Captoprilhsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Captoprilhsa00830Retinol metabolism4.55E-021P00325ADH1BMore
Captoprilhsa00970Aminoacyl-tRNA biosynthesis7.90E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Captoprilhsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Captoprilhsa04071Sphingolipid signaling pathway5.39E-038Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Captoprilhsa04072Phospholipase D signaling pathway4.37E-023Q9UQC2, Q8WYR1, Q08828GAB2, PIK3R5, ADCY1More
Captoprilhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Captoprilhsa04151PI3K-Akt signaling pathway3.25E-025O43521, Q13362, Q8WYR1, P23458, Q6ZUJ8BCL2L11, PPP2R5C, PIK3R5, JAK1, PIK3AP1More
Captoprilhsa04213Longevity regulating pathway - multiple species8.24E-032Q08828, P0DMV8ADCY1, HSPA1AMore
Captoprilhsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Captoprilhsa04270Vascular smooth muscle contraction2.68E-023Q08828, P35579, P35318ADCY1, MYH9, ADMMore
Captoprilhsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Captoprilhsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Captoprilhsa04611Platelet activation1.42E-023Q9Y490, Q08828, Q8WYR1TLN1, ADCY1, PIK3R5More
Captoprilhsa04612Antigen processing and presentation2.40E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Captoprilhsa04613Neutrophil extracellular trap formation3.61E-0213O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Captoprilhsa04621NOD-like receptor signaling pathway1.45E-0313Q16539, Q14643, P23458, Q9H3M7, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, JAK1, TXNIP, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Captoprilhsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Captoprilhsa04650Natural killer cell mediated cytotoxicity1.35E-039P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Captoprilhsa04657IL-17 signaling pathway3.91E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Captoprilhsa04658Th1 and Th2 cell differentiation1.12E-028Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Captoprilhsa04660T cell receptor signaling pathway3.59E-0412P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Captoprilhsa04664Fc epsilon RI signaling pathway4.73E-022Q9UQC2, P20292GAB2, ALOX5APMore
Captoprilhsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Captoprilhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Captoprilhsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Captoprilhsa04915Estrogen signaling pathway1.02E-023Q08828, P0DMV8, Q15788ADCY1, HSPA1A, NCOA1More
Captoprilhsa04921Oxytocin signaling pathway3.76E-023Q08828, Q96RR4, Q8WYR1ADCY1, CAMKK2, PIK3R5More
Captoprilhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Captoprilhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Captoprilhsa04972Pancreatic secretion4.73E-022Q08828, P62491ADCY1, RAB11AMore
Captoprilhsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Captoprilhsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Captoprilhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Captoprilhsa05140Leishmaniasis9.39E-0411P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, NCF4More
Captoprilhsa05143African trypanosomiasis3.01E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Captoprilhsa05144Malaria2.07E-024P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Captoprilhsa05145Toxoplasmosis6.86E-033P23458, Q8WYR1, P0DMV8JAK1, PIK3R5, HSPA1AMore
Captoprilhsa05146Amoebiasis3.91E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Captoprilhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Captoprilhsa05162Measles2.68E-022P23458, P0DMV8JAK1, HSPA1AMore
Captoprilhsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Captoprilhsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Captoprilhsa05202Transcriptional misregulation in cancer3.00E-0213P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Captoprilhsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Captoprilhsa05321Inflammatory bowel disease3.16E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Captoprilhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Captoprilhsa05332Graft-versus-host disease4.38E-035P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Captoprilhsa05415Diabetic cardiomyopathy1.07E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore
Captoprilhsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Captopril (SDC: 3.71)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14780MMP9Matrix metalloproteinaseNone9Reported10.16960.84240.73152.5012
P09960LTA4HLeukotriene ANone4 hydrolaseReported00.2770.95190.15652.1988
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P42892ECE1EndothelinNoneconverting enzyme 1Predicted00.48530.092200.4269
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
LTA4HP09960IC5070
LTA4HP09960IC503600
LTA4HP09960IC5010000
LTA4HP09960Ki3700
LTA4HP09960Kd6250
LTA4HP09960Kd6370
LTA4HP09960Kd8470