PharmaCoNets of Capmatinib (SPCN: 286.92 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Capmatinibhsa00020Citrate cycle (TCA cycle)1.71E-034P50213, O75390, P40926, O14521IDH3A, CS, MDH2, SDHDMore
Capmatinibhsa00030Pentose phosphate pathway1.68E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Capmatinibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Capmatinibhsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Capmatinibhsa00071Fatty acid degradation3.65E-034O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Capmatinibhsa00190Oxidative phosphorylation1.80E-063Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Capmatinibhsa00220Arginine biosynthesis1.74E-063P15104, P05089, P49448GLUL, ARG1, GLUD2More
Capmatinibhsa00230Purine metabolism4.93E-021P21589NT5EMore
Capmatinibhsa00240Pyrimidine metabolism1.81E-021P21589NT5EMore
Capmatinibhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Capmatinibhsa00310Lysine degradation1.31E-032Q96KQ7, P51648EHMT2, ALDH3A2More
Capmatinibhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Capmatinibhsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Capmatinibhsa00380Tryptophan metabolism1.33E-022P46952, P51648HAAO, ALDH3A2More
Capmatinibhsa00500Starch and sucrose metabolism5.07E-104O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Capmatinibhsa00510N-Glycan biosynthesis1.13E-032P15907, Q9NR34ST6GAL1, MAN1C1More
Capmatinibhsa00512Mucin type O-glycan biosynthesis9.97E-053O95395, Q8N4A0, Q9NY28GCNT3, GALNT4, GALNT8More
Capmatinibhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Capmatinibhsa00514Other types of O-glycan biosynthesis7.01E-032P15907, Q8N4A0ST6GAL1, GALNT4More
Capmatinibhsa00520Amino sugar and nucleotide sugar metabolism4.15E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Capmatinibhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Capmatinibhsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Capmatinibhsa00562Inositol phosphate metabolism1.01E-047Q14642, P27987, Q13572, Q96PE3, P29218, P19174, P42338INPP5A, ITPKB, ITPK1, INPP4A, IMPA1, PLCG1, PIK3CBMore
Capmatinibhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Capmatinibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Capmatinibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Capmatinibhsa00600Sphingolipid metabolism1.78E-056P07602, Q9BX95, Q13510, Q8TCT0, Q06136, P15289PSAP, SGPP1, ASAH1, CERK, FVT1, ARSAMore
Capmatinibhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Capmatinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series6.13E-052P06865, O75752HEXA, B3GALNT1More
Capmatinibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Capmatinibhsa00630Glyoxylate and dicarboxylate metabolism7.36E-114P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Capmatinibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Capmatinibhsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Capmatinibhsa00730Thiamine metabolism2.88E-083Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Capmatinibhsa00740Riboflavin metabolism2.80E-032P30043, P24666BLVRB, ACP1More
Capmatinibhsa00760Nicotinate and nicotinamide metabolism9.09E-031P21589NT5EMore
Capmatinibhsa00770Pantothenate and CoA biosynthesis4.29E-042O95498, Q9NRN7VNN2, AASDHPPTMore
Capmatinibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Capmatinibhsa00830Retinol metabolism1.83E-045P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Capmatinibhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Capmatinibhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Capmatinibhsa00970Aminoacyl-tRNA biosynthesis1.18E-064O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Capmatinibhsa00980Metabolism of xenobiotics by cytochrome P4508.40E-043P78417, P28332, P11712GSTO1, ADH6, CYP2C9More
Capmatinibhsa00982Drug metabolism - cytochrome P4508.40E-043P11712, P78417, P28332CYP2C9, GSTO1, ADH6More
Capmatinibhsa00983Drug metabolism - other enzymes5.35E-075P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Capmatinibhsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Capmatinibhsa01100Metabolic pathways5.68E-0556Q9NR34, Q9Y259, P05089, O14521, O95455, P21953, P15144, Q13572, Q14642, P29218, O14732, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, Q14376, P05186, P24666, P49619, O60701, P07101, O95954, Q9HCC0, P33121, Q02318, Q9UHK6, P42330, P51854, P43034, Q08477, Q96EB6, Q13423, P15907, Q8N4A0, P57054, Q9UBX8, Q9UNP4, O96024, Q9BX95, P37837, P32321, P60891, Q9BPW9, O75911, Q9UHY7, P43490, O95395, P46976, P35573, P06737, P12074, Q16718MAN1C1, CHKB, ARG1, SDHD, TGDS, BCKDHB, ANPEP, ITPK1, INPP5A, IMPA1, IMPA2, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, GALE, ALPL, ACP1, DGKG, UGDH, TH, FTCD, MCCC2, ACSL1, CYP27A1, AMACR, AKR1C3, TKTL1, PAFAH1B1, CYP4F3, SIRT1, NNT, ST6GAL1, GALNT4, PIGP, B4GALT6, ST3GAL5, B3GALT4, SGPP1, TALDO1, DCTD, PRPS1, DHRS9, DHRS3, ENOPH1, PBEF1, GCNT3, GYG1, AGL, PYGL, COX6A1, NDUFA5More
Capmatinibhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Capmatinibhsa01230Biosynthesis of amino acids3.07E-047P51854, P60891, Q99707, P50213, P05089, P15104, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, GLUL, TALDO1More
Capmatinibhsa01240Biosynthesis of cofactors1.34E-034P13716, P36551, O60701, P14618ALAD, CPOX, UGDH, PKM2More
Capmatinibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Capmatinibhsa01522Endocrine resistance2.18E-059P14780, P22694, P04049, Q02750, Q9UM47, P46527, P08069, P10415, Q13323MMP9, PRKACB, RAF1, MAP2K1, NOTCH3, CDKN1B, IGF1R, BCL2, BIKMore
Capmatinibhsa01523Antifolate resistance1.02E-055P41440, Q92820, P04818, P01375, P18054SLC19A1, GGH, TYMS, TNF, ALOX12More
Capmatinibhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Capmatinibhsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Capmatinibhsa03013RNA transport7.28E-0917P62826, O14893, P38919, Q15287, Q9UBU9, P37198, P35658, P63279, P68104, P55884, O15371, Q9H777, Q13310, P20042, Q14240, Q9BZI7, Q06787RAN, GEMIN2, EIF4A3, RNPS1, NXF1, NUP62, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, ELAC1, PABPC4, EIF2S2, EIF4A2, UPF3B, FMR1More
Capmatinibhsa03015mRNA surveillance pathway5.50E-036Q9BZI7, Q13310, Q13362, O94913, Q15287, Q9UBU9UPF3B, PABPC4, PPP2R5C, PCF11, RNPS1, NXF1More
Capmatinibhsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Capmatinibhsa03022Basal transcription factors3.52E-033O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Capmatinibhsa03040Spliceosome1.33E-1519Q14562, O43143, O60508, P17844, P08579, Q15427, P26368, P51991, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, SF3B4, U2AF2, HNRPA3, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Capmatinibhsa03050Proteasome4.83E-021P55036PSMD4More
Capmatinibhsa03060Protein export1.20E-032P37108, Q15005SRP14, SPCS2More
Capmatinibhsa03320PPAR signaling pathway1.84E-033O00767, Q13133, Q02318SCD, NR1H3, CYP27A1More
Capmatinibhsa03430Mismatch repair4.38E-021P20585MSH3More
Capmatinibhsa03450Non-homologous end-joining1.58E-043Q9NP87, P78527, P13010POLM, PRKDC, XRCC5More
Capmatinibhsa03460Fanconi anemia pathway2.71E-021O94782USP1More
Capmatinibhsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Capmatinibhsa04012ErbB signaling pathway8.52E-059P21860, P16333, Q13191, Q13557, P19174, O14944, P42338, P01106, P04049ERBB3, NCK1, CBLB, CAMK2D, PLCG1, EREG, PIK3CB, MYC, RAF1More
Capmatinibhsa04014Ras signaling pathway4.07E-0620Q02750, P04049, P31751, P42338, P20827, Q15389, Q9NRA1, P49767, P08069, Q13009, P17252, Q7LDG7, P21359, P0DP23, P62873, P62879, P63218, P50151, P19174, P22694MAP2K1, RAF1, AKT2, PIK3CB, EFNA1, ANGPT1, PDGFC, VEGFC, IGF1R, TIAM1, PRKCA, RASGRP2, NF1, CALM1, GNB1, GNB2, GNG5, GNG10, PLCG1, PRKACBMore
Capmatinibhsa04015Rap1 signaling pathway1.87E-0514P04049, P20827, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P31751, P0DP23, P19174RAF1, EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, AKT2, CALM1, PLCG1More
Capmatinibhsa04020Calcium signaling pathway4.35E-0915P27987, Q96DU7, Q08828, P45880, Q16566, Q13557, P21860, P30679, O15399, P61073, P0DP24, P05141, P51828, P23634, P49767ITPKB, ITPKC, ADCY1, VDAC2, CAMK4, CAMK2D, ERBB3, GNA15, GRIN2D, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Capmatinibhsa04022cGMP-PKG signaling pathway1.54E-0412Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Capmatinibhsa04024cAMP signaling pathway4.48E-046P42338, P31751, P0DP23, P04049, Q13370, Q13009PIK3CB, AKT2, CALM1, RAF1, PDE3B, TIAM1More
Capmatinibhsa04060Cytokine-cytokine receptor interaction6.46E-0517P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Capmatinibhsa04061Viral protein interaction with cytokine and cytokine receptor7.64E-0510P09341, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784, P09603, P01375CXCL1, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB, CSF1, TNFMore
Capmatinibhsa04062Chemokine signaling pathway1.46E-0723P25024, P25025, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P14598, P22694, P42224, P04049, P25963, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, NCF1, PRKACB, STAT1, RAF1, NFKBIA, GSK3B, PIK3R5More
Capmatinibhsa04064NF-kappa B signaling pathway6.65E-2024P10415, Q13489, P51617, O00463, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Capmatinibhsa04066HIF-1 signaling pathway1.49E-025P08069, P17252, Q15389, Q02750, P46527IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Capmatinibhsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Capmatinibhsa04070Phosphatidylinositol signaling system4.12E-0611P19174, P0DP23, Q14643, P42338, P23743, Q86XP1, P29218, Q14642, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIK3CB, DGKA, DGKH, IMPA1, INPP5A, ITPKB, ITPKC, PRKCAMore
Capmatinibhsa04071Sphingolipid signaling pathway1.00E-1211P04049, P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2RAF1, PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Capmatinibhsa04072Phospholipase D signaling pathway9.16E-034P04049, Q9UQC2, Q8WYR1, Q08828RAF1, GAB2, PIK3R5, ADCY1More
Capmatinibhsa04080Neuroactive ligand-receptor interaction4.87E-0710P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2, ADMMore
Capmatinibhsa04110Cell cycle1.32E-0810Q9UBD5, P06493, O60566, P78527, Q14683, O75293, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, PRKDC, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Capmatinibhsa04114Oocyte meiosis1.43E-0611Q9Y6D9, P51812, Q02750, Q13557, P16298, Q17RY0, Q08828, P51828, P27348, Q13362, P08069MAD1L1, RPS6KA3, MAP2K1, CAMK2D, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQ, PPP2R5C, IGF1RMore
Capmatinibhsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Capmatinibhsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Capmatinibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Capmatinibhsa04140Autophagy - animal2.46E-0710P08069, Q9Y4H2, P42338, P04049, Q9NQL2, P22694, Q14643, P10415, Q9H1Y0, Q04759IGF1R, IRS2, PIK3CB, RAF1, RRAGD, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Capmatinibhsa04141Protein processing in endoplasmic reticulum2.65E-0614P18848, P30101, Q15437, Q15436, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9H173, Q9UNL2ATF4, PDIA3, SEC23B, SEC23A, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3More
Capmatinibhsa04142Lysosome2.45E-039Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Capmatinibhsa04144Endocytosis4.54E-0414Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5More
Capmatinibhsa04145Phagosome6.82E-0815O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Capmatinibhsa04150mTOR signaling pathway1.32E-035P08069, P04049, Q02750, Q9NQL2, P51812IGF1R, RAF1, MAP2K1, RRAGD, RPS6KA3More
Capmatinibhsa04151PI3K-Akt signaling pathway2.39E-0633P62753, P42338, P21860, P43657, P25116, O43521, P27348, P20827, P49767, Q13362, P07900, P08238, Q8WYR1, P62873, P63218, P50151, P61952, P16144, O15335, Q16363, Q13751, P22105, O60603, P14784, P23458, P01568, Q99941, P18848, P10415, P17252, O00141, Q6ZUJ8, P30281RPS6, PIK3CB, ERBB3, P2RY5, F2R, BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, GNG11, ITGB4, CHAD, LAMA4, LAMB3, TNXB, TLR2, IL2RB, JAK1, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK, PIK3AP1, CCND3More
Capmatinibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Capmatinibhsa04210Apoptosis6.47E-0511Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, P18848, Q14643, P04049ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ATF4, ITPR1, RAF1More
Capmatinibhsa04211Longevity regulating pathway5.33E-034P08069, P51828, Q99941, P18848IGF1R, ADCY7, CREBL1, ATF4More
Capmatinibhsa04213Longevity regulating pathway - multiple species1.23E-058P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Capmatinibhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Capmatinibhsa04217Necroptosis2.71E-0921P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P07384, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q13557, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, CAPN1, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CAMK2D, CHMP2A, PPIDMore
Capmatinibhsa04218Cellular senescence3.00E-047P01106, P31751, P04049, O75293, P30304, P06493, P0DP23MYC, AKT2, RAF1, GADD45B, CDC25A, CDK1, CALM1More
Capmatinibhsa04260Cardiac muscle contraction4.02E-022P09493, P14927TPM1, UQCRBMore
Capmatinibhsa04261Adrenergic signaling in cardiomyocytes2.73E-0612P09493, Q08828, P51828, P31751, Q99941, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634TPM1, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Capmatinibhsa04270Vascular smooth muscle contraction1.93E-057P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Capmatinibhsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Capmatinibhsa04330Notch signaling pathway2.46E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Capmatinibhsa04340Hedgehog signaling pathway2.79E-095P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Capmatinibhsa04360Axon guidance9.70E-048P16333, P20827, O95631, P42338, P07332, P23528, P04049, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, RAF1, PLCG1More
Capmatinibhsa04370VEGF signaling pathway9.16E-097P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Capmatinibhsa04371Apelin signaling pathway2.40E-0817P62873, P63218, P50151, P61952, Q8WYR1, P31751, P04049, Q08828, Q13370, Q14814, Q14344, Q13485, P84022, P62753, Q16566, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, PIK3R5, AKT2, RAF1, ADCY1, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, RPS6, CAMK4, CALM1, CALM2More
Capmatinibhsa04380Osteoclast differentiation5.19E-0614Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Capmatinibhsa04390Hippo signaling pathway3.80E-058P63261, P84022, Q13485, O15105, P04628, Q9UJU2, O43623, Q13489ACTG1, SMAD3, SMAD4, SMAD7, WNT1, LEF1, SNAI2, BIRC3More
Capmatinibhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Capmatinibhsa04510Focal adhesion1.18E-032P04049, P08069RAF1, IGF1RMore
Capmatinibhsa04512ECM-receptor interaction1.22E-034P07359, P26012, P08514, P16070GP1BA, ITGB8, ITGA2B, CD44More
Capmatinibhsa04520Adherens junction8.29E-031P08069IGF1RMore
Capmatinibhsa04530Tight junction3.00E-048Q8TEU7, P63261, P16989, P56750, O00501, Q92974, Q14247, P24844RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN, MYL9More
Capmatinibhsa04540Gap junction5.55E-079P17252, P22694, Q13509, P68371, Q71U36, Q02750, P04049, Q9NRA1, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, TUBA1A, MAP2K1, RAF1, PDGFC, ITPR1More
Capmatinibhsa04550Signaling pathways regulating pluripotency of stem cells3.80E-042P04049, P08069RAF1, IGF1RMore
Capmatinibhsa04610Complement and coagulation cascades5.86E-074P09871, P00734, P0C0L4, P20023C1S, F2, C4A, CR2More
Capmatinibhsa04611Platelet activation1.48E-067Q9Y490, P08514, Q15746, Q08828, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, ADCY1, PIK3R5, PRKACA, GP1BAMore
Capmatinibhsa04612Antigen processing and presentation7.06E-1412P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, PDIA3, HSPA8, TNFMore
Capmatinibhsa04613Neutrophil extracellular trap formation5.12E-1128P17252, P04049, P16109, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q99878, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PRKCA, RAF1, SELP, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Capmatinibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Capmatinibhsa04620Toll-like receptor signaling pathway4.78E-021P31751AKT2More
Capmatinibhsa04621NOD-like receptor signaling pathway1.51E-0818Q16539, Q14643, P23458, P21796, Q9H3M7, P10599, Q9H1Y0, P43490, O00463, P10415, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838MAPK14, ITPR1, JAK1, VDAC1, TXNIP, TXN, ATG5, PBEF1, TRAF5, BCL2, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Capmatinibhsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Capmatinibhsa04623Cytosolic DNA-sensing pathway9.49E-095P01584, P01568, Q13546, P25963, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2More
Capmatinibhsa04625C-type lectin receptor signaling pathway3.70E-0612Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Capmatinibhsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Capmatinibhsa04640Hematopoietic cell lineage6.10E-1321P13612, P07359, P08514, P21926, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603, P01584ITGA4, GP1BA, ITGA2B, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1, IL1BMore
Capmatinibhsa04650Natural killer cell mediated cytotoxicity8.00E-2018P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Capmatinibhsa04657IL-17 signaling pathway1.36E-088O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Capmatinibhsa04658Th1 and Th2 cell differentiation1.99E-3216Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P42226, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Capmatinibhsa04659Th17 cell differentiation4.01E-2623P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P42226, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, STAT6, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Capmatinibhsa04660T cell receptor signaling pathway3.60E-2718P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Capmatinibhsa04662B cell receptor signaling pathway2.30E-1111P49841, P31751, P42338, P20023, P60033, Q8WV28, P07948, P11912, P21854, Q8N149, P04049GSK3B, AKT2, PIK3CB, CR2, CD81, BLNK, LYN, CD79A, CD72, LILRA2, RAF1More
Capmatinibhsa04664Fc epsilon RI signaling pathway1.88E-0911P01375, P31751, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917, P20292TNF, AKT2, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5APMore
Capmatinibhsa04666Fc gamma R-mediated phagocytosis3.18E-038O75015, P42338, P04049, P23528, P06396, O14494, P14598, P17252FCGR3B, PIK3CB, RAF1, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Capmatinibhsa04668TNF signaling pathway9.77E-0510P01375, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429TNF, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Capmatinibhsa04672Intestinal immune network for IgA production1.27E-044P29965, P10747, P13765, P13612CD40LG, CD28, HLA-DOB, ITGA4More
Capmatinibhsa04710Circadian rhythm3.74E-032O00327, O15055ARNTL, PER2More
Capmatinibhsa04713Circadian entrainment3.32E-0611P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P63218, P50151, P61952, Q14643, Q08828CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG5, GNG10, GNG11, ITPR1, ADCY1More
Capmatinibhsa04714Thermogenesis2.06E-0210P22694, Q16539, P51828, Q969G3, P62753, P33121, P12074, O15239, Q16718, O14521PRKACB, MAPK14, ADCY7, SMARCE1, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Capmatinibhsa04720Long-term potentiation2.99E-0813P17252, Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, P22694, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, PRKACB, ADCY1, MAP2K1, RAF1, ITPR1More
Capmatinibhsa04721Synaptic vesicle cycle9.45E-042Q13488, P31645TCIRG1, SLC6A4More
Capmatinibhsa04722Neurotrophin signaling pathway1.76E-0610Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, IRAK1, BCL2, CALM1More
Capmatinibhsa04723Retrograde endocannabinoid signaling2.75E-0411Q14643, P17252, P62873, P63218, P50151, P61952, Q08828, P22694, Q16539, O15239, Q16718ITPR1, PRKCA, GNB1, GNG5, GNG10, GNG11, ADCY1, PRKACB, MAPK14, NDUFA1, NDUFA5More
Capmatinibhsa04724Glutamatergic synapse1.37E-078O15399, Q08828, P62873, P63218, P50151, P61952, P15104, Q9NSB8GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLUL, HOMER2More
Capmatinibhsa04725Cholinergic synapse5.59E-1015Q08828, P51828, P22694, Q14643, P17252, P62873, P62879, P63218, P50151, P61952, P18848, Q13557, P42338, P10415, Q02750ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNB2, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, BCL2, MAP2K1More
Capmatinibhsa04726Serotonergic synapse4.13E-049P22694, P17252, P62873, P62879, P63218, P50151, P09917, P04049, Q02750PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, ALOX5, RAF1, MAP2K1More
Capmatinibhsa04727GABAergic synapse8.50E-0811Q08828, P62873, P62879, P63218, P50151, P61952, P15104, P22694, O60296, Q15111, P17252ADCY1, GNB1, GNB2, GNG5, GNG10, GNG11, GLUL, PRKACB, TRAK2, PLCL1, PRKCAMore
Capmatinibhsa04728Dopaminergic synapse1.04E-0820Q14643, P17252, P14416, P62873, P63218, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, P0DP23, P0DP24, O15516, O00327, P48058ITPR1, PRKCA, DRD2, GNB1, GNG5, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, CALM1, CALM2, CLOCK, ARNTL, GRIA4More
Capmatinibhsa04730Long-term depression4.07E-044Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Capmatinibhsa04740Olfactory transduction5.99E-065P62873, Q9H255, Q13557, P0DP23, P0DP24GNB1, OR51E2, CAMK2D, CALM1, CALM2More
Capmatinibhsa04742Taste transduction7.70E-042P30939, P17612HTR1F, PRKACAMore
Capmatinibhsa04744Phototransduction1.36E-083P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Capmatinibhsa04750Inflammatory mediator regulation of TRP channels1.03E-0914P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Capmatinibhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Capmatinibhsa04910Insulin signaling pathway2.43E-056P0DP23, P22694, P06737, P04049, P31751, P49841CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3BMore
Capmatinibhsa04911Insulin secretion1.23E-085Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Capmatinibhsa04912GnRH signaling pathway9.58E-0612P17252, Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1More
Capmatinibhsa04913Ovarian steroidogenesis6.44E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Capmatinibhsa04914Progesterone-mediated oocyte maturation1.44E-069P08069, Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750, P04049IGF1R, CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Capmatinibhsa04915Estrogen signaling pathway6.57E-0916P14780, P22694, P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, Q14643, P0DP23, P0DP24, Q15788, P10415MMP9, PRKACB, RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, ITPR1, CALM1, CALM2, NCOA1, BCL2More
Capmatinibhsa04916Melanogenesis1.47E-035Q13557, P0DP23, Q08828, P51828, P04049CAMK2D, CALM1, ADCY1, ADCY7, RAF1More
Capmatinibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Capmatinibhsa04918Thyroid hormone synthesis1.45E-058P22694, Q08828, P51828, Q99941, P18848, Q14643, P02768, P05543PRKACB, ADCY1, ADCY7, CREBL1, ATF4, ITPR1, ALB, SERPINA7More
Capmatinibhsa04919Thyroid hormone signaling pathway1.07E-049P17252, P49841, P04049, Q02750, P22694, O60244, Q9NVC6, Q12778, Q9UM47PRKCA, GSK3B, RAF1, MAP2K1, PRKACB, MED14, MED17, FOXO1, NOTCH3More
Capmatinibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Capmatinibhsa04921Oxytocin signaling pathway5.90E-034Q08828, P04049, Q96RR4, Q8WYR1ADCY1, RAF1, CAMKK2, PIK3R5More
Capmatinibhsa04922Glucagon signaling pathway5.94E-058P14618, P22694, P06737, Q12778, P31751, Q13370, P0DP23, Q14643PKM2, PRKACB, PYGL, FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Capmatinibhsa04923Regulation of lipolysis in adipocytes1.84E-032P06213, P31751INSR, AKT2More
Capmatinibhsa04924Renin secretion6.28E-095P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Capmatinibhsa04925Aldosterone synthesis and secretion4.48E-087Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4More
Capmatinibhsa04926Relaxin signaling pathway1.44E-0512P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P49407PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, ARRB1More
Capmatinibhsa04927Cortisol synthesis and secretion8.61E-096Q14643, Q99941, P18848, Q08828, P51828, P22694ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Capmatinibhsa04928Parathyroid hormone synthesis, secretion and action5.85E-0711Q14643, P51828, P22694, P23771, P04049, Q02750, P17252, Q99941, P18848, P10415, Q9Y5Q3ITPR1, ADCY7, PRKACB, GATA3, RAF1, MAP2K1, PRKCA, CREBL1, ATF4, BCL2, MAFBMore
Capmatinibhsa04929GnRH secretion2.28E-044P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Capmatinibhsa04930Type II diabetes mellitus1.48E-032P06213, Q05655INSR, PRKCDMore
Capmatinibhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Capmatinibhsa04932Non-alcoholic fatty liver disease7.66E-0611P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2More
Capmatinibhsa04933AGE-RAGE signaling pathway in diabetic complications8.03E-059P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Capmatinibhsa04934Cushing syndrome1.11E-089Q14643, Q99941, P18848, Q08828, P51828, P22694, O15169, Q13557, P04628ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1More
Capmatinibhsa04935Growth hormone synthesis, secretion and action5.33E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Capmatinibhsa04940Type I diabetes mellitus2.21E-044P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Capmatinibhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Capmatinibhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Capmatinibhsa04962Vasopressin-regulated water reabsorption2.95E-043P52566, P62491, P46459ARHGDIB, RAB11A, NSFMore
Capmatinibhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Capmatinibhsa04966Collecting duct acid secretion1.95E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Capmatinibhsa04970Salivary secretion1.62E-0610P07550, Q08828, P51828, P22694, Q14643, P17252, P0DP23, P0DP24, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CALM2, GUCY1B3, CAMPMore
Capmatinibhsa04971Gastric acid secretion3.93E-055Q08828, P51828, P15311, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM1, CAMK2DMore
Capmatinibhsa04972Pancreatic secretion4.73E-022Q08828, P62491ADCY1, RAB11AMore
Capmatinibhsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Capmatinibhsa04975Fat digestion and absorption1.68E-031O14494PLPP1More
Capmatinibhsa04976Bile secretion2.51E-035Q08828, P51828, P22694, P08183, Q14032ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Capmatinibhsa05010Alzheimer disease2.10E-0726Q92542, O15239, Q16718, O14521, P05496, P13073, P12074, Q14643, O15399, Q00535, Q9NZJ5, O75460, P0DP23, P49841, P01584, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, P21796, P45880, Q08752, P28070NCSTN, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, GRIN2D, CDK5, EIF2AK3, ERN1, CALM1, GSK3B, IL1B, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, VDAC1, VDAC2, PPID, PSMB4More
Capmatinibhsa05012Parkinson disease5.64E-0722O15239, Q16718, O14521, P13073, P12074, P05496, P05141, P21796, P60604, P14416, Q9NZJ5, O75460, P18848, P28070, Q14643, P19174, P0DP23, P0DP24, Q13557, Q71U36, Q13509, P68371NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, VDAC1, UBE2G2, DRD2, EIF2AK3, ERN1, ATF4, PSMB4, ITPR1, PLCG1, CALM1, CALM2, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Capmatinibhsa05014Amyotrophic lateral sclerosis9.75E-035O15399, Q9NZJ5, Q13148, P21796, P20073GRIN2D, EIF2AK3, TARDBP, VDAC1, ANXA7More
Capmatinibhsa05016Huntington disease1.35E-0312O15239, O95298, P13073, P12074, P05496, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Capmatinibhsa05017Spinocerebellar ataxia2.22E-024Q92915, O15399, P42338, P21796FGF14, GRIN2D, PIK3CB, VDAC1More
Capmatinibhsa05020Prion disease2.44E-0926P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P13073, P12074, Q92736, Q14643, O15399, Q9NZJ5, P18848, P05141, P21796, P45880, P28070, O60282, Q13509, P68371, P49841, P67870, Q99941, P14598, Q15080IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, RYR2, ITPR1, GRIN2D, EIF2AK3, ATF4, SLC25A5, VDAC1, VDAC2, PSMB4, KIF5C, TUBB3, TUBB2C, GSK3B, CSNK2B, CREBL1, NCF1, NCF4More
Capmatinibhsa05022Pathways of neurodegeneration - multiple diseases2.54E-0627Q14643, O15399, Q13509, P68371, P49841, P10415, O15239, Q16718, O14521, P12074, P05496, Q06055, P21796, Q13148, Q9NZJ5, O75460, P18848, Q13561, P05141, P17252, Q00535, P01584, Q08752, O15020, P0DP23, Q13557, P28070ITPR1, GRIN2D, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G1, ATP5G2, VDAC1, TARDBP, EIF2AK3, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, CDK5, IL1B, PPID, SPTBN2, CALM1, CAMK2D, PSMB4More
Capmatinibhsa05030Cocaine addiction3.01E-045P14416, Q00535, Q99941, P18848, O15399DRD2, CDK5, CREBL1, ATF4, GRIN2DMore
Capmatinibhsa05031Amphetamine addiction5.03E-055P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Capmatinibhsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Capmatinibhsa05033Nicotine addiction2.54E-022P28472, O15399GABRB3, GRIN2DMore
Capmatinibhsa05034Alcoholism3.82E-0613Q99941, P18848, P0DP24, Q96RR4, P62873, P61952, P04049, P0C0S5, Q93077, P62807, O60814, P84243, P68431CREBL1, ATF4, CALM2, CAMKK2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Capmatinibhsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Capmatinibhsa05110Vibrio cholerae infection1.86E-042Q99437, P17612ATP6V0B, PRKACAMore
Capmatinibhsa05120Epithelial cell signaling in Helicobacter pylori infection4.38E-079Q16539, P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Capmatinibhsa05130Pathogenic Escherichia coli infection5.43E-039Q71U36, P16333, Q13509, P68371, Q14344, P25963, Q15438, P35579, P55061TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA, PSCD1, MYH9, TEGTMore
Capmatinibhsa05131Shigellosis7.05E-0525P01375, O00463, P14778, Q16539, P68431, Q05655, Q04759, Q9UDY8, P61088, Q9NQL2, Q9H1Y0, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, P12814, Q14643, Q12778, P49841, Q13315, P10415, P21796, Q08752, P07737TNF, TRAF5, IL1R1, MAPK14, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCQ, MALT1, UBE2N, RRAGD, ATG5, UBB, SEPT6, CTTN, ELMO2, PTK2, ACTN1, ITPR1, FOXO1, GSK3B, ATM, BCL2, VDAC1, PPID, PFN1More
Capmatinibhsa05132Salmonella infection8.72E-1020P51617, P25963, P08238, P04049, Q9UJU2, P84095, O00471, Q13546, Q13489, P10415, O75369, P07737, O60603, Q9BQS8, Q13561, O60282, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, RHOG, EXOC5, RIPK1, BIRC3, BCL2, FLNB, PFN1, TLR2, FYCO1, DCTN2, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41More
Capmatinibhsa05133Pertussis2.35E-032P0DP23, P0C0L4CALM1, C4AMore
Capmatinibhsa05134Legionellosis3.30E-069P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Capmatinibhsa05135Yersinia infection4.39E-024P06239, P19174, P42338, P01732LCK, PLCG1, PIK3CB, CD8AMore
Capmatinibhsa05140Leishmaniasis4.03E-1316P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Capmatinibhsa05143African trypanosomiasis3.01E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Capmatinibhsa05144Malaria4.92E-086P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Capmatinibhsa05145Toxoplasmosis2.87E-0510P25963, P10415, Q13489, P23458, P42224, P13765, Q8WYR1, P0DMV8, O60603, P29965NFKBIA, BCL2, BIRC3, JAK1, STAT1, HLA-DOB, PIK3R5, HSPA1A, TLR2, CD40LGMore
Capmatinibhsa05146Amoebiasis4.27E-1713P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Capmatinibhsa05150Staphylococcus aureus infection3.19E-0914P09871, P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, Q14532, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, KRT32, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Capmatinibhsa05152Tuberculosis2.58E-0717P04049, Q13488, Q99437, P0DP23, O75015, P42224, P48382, O60603, P01375, P31751, P10415, P13765, P25774, P01568, P49913, Q9UDY8, P51617RAF1, TCIRG1, ATP6V0B, CALM1, FCGR3B, STAT1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CTSS, IFNA21, CAMP, MALT1, IRAK1More
Capmatinibhsa05160Hepatitis C2.31E-0610P52630, P60033, O00501, P29728, Q9NZJ5, P04049, P49841, P01375, P48023, P01106STAT2, CD81, CLDN5, OAS2, EIF2AK3, RAF1, GSK3B, TNF, FASLG, MYCMore
Capmatinibhsa05161Hepatitis B1.14E-048P04049, Q99941, P18848, P25963, Q13485, P10415, P27348, P84022RAF1, CREBL1, ATF4, NFKBIA, SMAD4, BCL2, YWHAQ, SMAD3More
Capmatinibhsa05162Measles2.84E-034P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Capmatinibhsa05163Human cytomegalovirus infection1.21E-1031P31751, P04049, P01375, P25963, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769, P01568AKT2, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2M, IFNA21More
Capmatinibhsa05164Influenza A3.65E-021P04049RAF1More
Capmatinibhsa05165Human papillomavirus infection5.80E-0414P46527, Q02750, P16144, P35443, Q92796, Q05086, Q9UM47, P01568, P42224, Q13488, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, ITGB4, THBS4, DLG3, UBE3A, NOTCH3, IFNA21, STAT1, TCIRG1, PRKACB, PPP2R5C, FOXO1, ATMMore
Capmatinibhsa05167Kaposi sarcoma-associated herpesvirus infection3.54E-0818P01568, P31751, P42224, P25963, P62873, P62879, P63218, P50151, P19174, P16298, Q14643, P04049, Q02750, P07948, P04141, P0DP23, P0CG47, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, ITPR1, RAF1, MAP2K1, LYN, CSF2, CALM1, UBB, LEF1More
Capmatinibhsa05168Herpes simplex virus 1 infection4.15E-0619P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Capmatinibhsa05169Epstein-Barr virus infection1.66E-0619P13765, P01106, Q13547, O00463, P16070, P10415, Q16539, P42338, P07948, Q13761, P24522, O75293, Q8WV28, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, CD44, BCL2, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, BLNK, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Capmatinibhsa05170Human immunodeficiency virus 1 infection8.99E-1022P31751, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P17252, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, P19174, P10415, Q9Y6Q5, P20333AKT2, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PRKCA, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, PLCG1, BCL2, AP1M2, TNFRSF1BMore
Capmatinibhsa05200Pathways in cancer8.74E-0834Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, Q13547, P14923, P30281, P10415, Q13489, Q13077, P49767, Q12778, P31751, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, Q9UM47, O75293, P0DP23, P01568, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND3, BCL2, BIRC3, TRAF1, VEGFC, FOXO1, AKT2, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, NOTCH3, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Capmatinibhsa05202Transcriptional misregulation in cancer3.10E-1425Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, Q15652, O15550, P08069, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, JMJD1C, UTX, IGF1R, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Capmatinibhsa05203Viral carcinogenesis4.63E-049Q99941, P18848, P23458, P27348, Q7KZF4, Q15283, P61978, P62807, O60814CREBL1, ATF4, JAK1, YWHAQ, SND1, RASA2, HNRPK, HIST1H2BC, H2BC12More
Capmatinibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Capmatinibhsa05205Proteoglycans in cancer2.26E-036Q13009, Q12955, O75369, P04049, P08069, P08962TIAM1, ANK3, FLNB, RAF1, IGF1R, CD63More
Capmatinibhsa05206MicroRNAs in cancer1.53E-0413P46527, P15311, P21860, P61978, P46531, Q9UM47, P16070, P63279, Q13315, P22105, P17252, P04049, Q02750CDKN1B, VIL2, ERBB3, HNRPK, NOTCH1, NOTCH3, CD44, UBE2I, ATM, TNXB, PRKCA, RAF1, MAP2K1More
Capmatinibhsa05210Colorectal cancer1.46E-046Q9UKG1, P84022, Q13485, P04049, P10415, P37173APPL1, SMAD3, SMAD4, RAF1, BCL2, TGFBR2More
Capmatinibhsa05211Renal cell carcinoma1.29E-032P31751, P04049AKT2, RAF1More
Capmatinibhsa05212Pancreatic cancer1.81E-067P42338, P31751, P04049, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, STAT1, SMAD3, SMAD4, GADD45BMore
Capmatinibhsa05213Endometrial cancer4.41E-044O15169, P31751, Q02750, P04049AXIN1, AKT2, MAP2K1, RAF1More
Capmatinibhsa05214Glioma8.19E-077P08069, P0DP23, P04049, P42338, P31751, P19174, O75293IGF1R, CALM1, RAF1, PIK3CB, AKT2, PLCG1, GADD45BMore
Capmatinibhsa05215Prostate cancer1.65E-042P08069, P04049IGF1R, RAF1More
Capmatinibhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Capmatinibhsa05217Basal cell carcinoma3.29E-055Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Capmatinibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Capmatinibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Capmatinibhsa05220Chronic myeloid leukemia2.22E-058Q13547, Q13485, P25963, P84022, P31751, P42338, P04049, O75293HDAC1, SMAD4, NFKBIA, SMAD3, AKT2, PIK3CB, RAF1, GADD45BMore
Capmatinibhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Capmatinibhsa05222Small cell lung cancer1.36E-034P31751, Q13489, P10415, P25963AKT2, BIRC3, BCL2, NFKBIAMore
Capmatinibhsa05223Non-small cell lung cancer3.89E-055P31751, P10826, P04049, Q9HC35, O75293AKT2, RARB, RAF1, EML4, GADD45BMore
Capmatinibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Capmatinibhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Capmatinibhsa05226Gastric cancer2.61E-057P04049, Q02750, P31751, O15169, P84022, Q13485, P10415RAF1, MAP2K1, AKT2, AXIN1, SMAD3, SMAD4, BCL2More
Capmatinibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Capmatinibhsa05231Choline metabolism in cancer2.42E-044P04049, Q9Y259, P19174, P49619RAF1, CHKB, PLCG1, DGKGMore
Capmatinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.36E-1415P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, P10747, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Capmatinibhsa05310Asthma4.96E-113P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Capmatinibhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Capmatinibhsa05321Inflammatory bowel disease2.31E-239O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3, IL1B, IL21RMore
Capmatinibhsa05322Systemic lupus erythematosus1.07E-0716O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Capmatinibhsa05323Rheumatoid arthritis3.78E-068P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Capmatinibhsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Capmatinibhsa05332Graft-versus-host disease6.75E-166P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Capmatinibhsa05340Primary immunodeficiency2.12E-066P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Capmatinibhsa05410Hypertrophic cardiomyopathy1.73E-022P26012, P09493ITGB8, TPM1More
Capmatinibhsa05412Arrhythmogenic right ventricular cardiomyopathy4.98E-043P54284, P15924, P26012CACNB3, DSP, ITGB8More
Capmatinibhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Capmatinibhsa05415Diabetic cardiomyopathy2.11E-048P17252, P30405, P14598, Q15080, Q16718, O14521, P37173, P04406PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, TGFBR2, GAPDHMore
Capmatinibhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Capmatinibhsa05418Fluid shear stress and atherosclerosis1.58E-0613Q16539, P31751, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, AKT2, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Capmatinib (SDC: 12.57)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
O94782USP1Ubiquitin carboxylNoneterminal hydrolase 1Predicted00.4410.08980.02130.4215
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P04628WNT1ProtoNoneoncogene WntNone1Predicted00.02820.02250.45140.5105
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P63279UBE2ISUMONoneconjugating enzyme UBC9Predicted00.23320.05120.49830.7173
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
P42892ECE1EndothelinNoneconverting enzyme 1Predicted00.48530.092200.4269
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O15294OGTUDPNoneNNoneacetylglucosamineNoneNonepeptide NNoneacetylglucosaminyltransferase 110 kDa subunitPredicted00.27390.06020.10210.3594
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
Q09472EP300Histone acetyltransferase p300Predicted00.41820.06720.93071.2742
Q16548BCL2A1BclNone2Nonerelated protein A1Predicted00.03060.03360.46870.5512
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q9UM07PADI4ProteinNonearginine deiminase typeNone4Predicted10.14880.27780.42671.0567
Q16875PFKFB36NonephosphofructoNone2Nonekinase/fructoseNone2,6Nonebisphosphatase 3Predicted10.04620.08860.23420.4345
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
Q92499DDX1ATPNonedependent RNA helicase DDX1Predicted00.05070.010700.0467
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
O75381PEX14Peroxisomal membrane protein PEX14Predicted00.19070.09950.10970.4039
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)