PharmaCoNets

PharmaCoNets of Cannabidiol (S_PCN: 120.88 )

Cannabidiol regulated-network (S_DN: 26.57)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Cannabidiol

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Cannabidiol

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Cannabidiol

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Cannabidiol

hsa00072

Synthesis and degradation of ketone bodies

2.78E-02

Q01581

HMGCS1

Cannabidiol

hsa00190

Oxidative phosphorylation

3.74E-02

Q16718, P19404, P12074, Q13488, O14521

NDUFA5, NDUFV2, COX6A1, TCIRG1, SDHD

Cannabidiol

hsa00220

Arginine biosynthesis

1.77E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Cannabidiol

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Cannabidiol

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Cannabidiol

hsa00380

Tryptophan metabolism

4.14E-02

Q16613

AANAT

Cannabidiol

hsa00480

Glutathione metabolism

2.31E-02

P22352

GPX3

Cannabidiol

hsa00500

Starch and sucrose metabolism

9.22E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Cannabidiol

hsa00510

N-Glycan biosynthesis

3.01E-02

O94777

DPM2

Cannabidiol

hsa00512

Mucin type O-glycan biosynthesis

2.28E-03

O95395, Q8N4A0

GCNT3, GALNT4

Cannabidiol

hsa00514

Other types of O-glycan biosynthesis

1.83E-03

P15907, O15294, Q8N4A0, Q9NY28

ST6GAL1, OGT, GALNT4, GALNT8

Cannabidiol

hsa00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

3.56E-02

Q9Y2C2

UST

Cannabidiol

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Cannabidiol

hsa00563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

7.16E-04

O94777, Q14442

DPM2, PIGH

Cannabidiol

hsa00565

Ether lipid metabolism

3.00E-03

Q8N661

TMEM86B

Cannabidiol

hsa00590

Arachidonic acid metabolism

1.43E-03

P11712, P22352, P09960

CYP2C9, GPX3, LTA4H

Cannabidiol

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Cannabidiol

hsa00630

Glyoxylate and dicarboxylate metabolism

5.72E-03

P40925, P15104

MDH1, GLUL

Cannabidiol

hsa00730

Thiamine metabolism

4.66E-02

P05186, P24666

ALPL, ACP1

Cannabidiol

hsa00770

Pantothenate and CoA biosynthesis

2.26E-04

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Cannabidiol

hsa00830

Retinol metabolism

2.17E-03

P00325, P00352, Q9BPW9, O75911

ADH1B, ALDH1A1, DHRS9, DHRS3

Cannabidiol

hsa00900

Terpenoid backbone biosynthesis

1.40E-02

Q01581

HMGCS1

Cannabidiol

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Cannabidiol

hsa00970

Aminoacyl-tRNA biosynthesis

9.22E-06

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Cannabidiol

hsa00980

Metabolism of xenobiotics by cytochrome P450

6.67E-04

P78417, P11712

GSTO1, CYP2C9

Cannabidiol

hsa00982

Drug metabolism - cytochrome P450

6.67E-04

P11712, P78417

CYP2C9, GSTO1

Cannabidiol

hsa00983

Drug metabolism - other enzymes

2.99E-02

P04183, P32320, P05164

TK1, CDA, MPO

Cannabidiol

hsa01100

Metabolic pathways

4.53E-03

P36969, O94777, P04406, Q06055

GPX4, DPM2, GAPDH, ATP5G2

Cannabidiol

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Cannabidiol

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Cannabidiol

hsa01521

EGFR tyrosine kinase inhibitor resistance

2.18E-02

P49841, Q9NRA1

GSK3B, PDGFC

Cannabidiol

hsa01522

Endocrine resistance

4.74E-02

P22694, P10415, Q13323

PRKACB, BCL2, BIK

Cannabidiol

hsa01524

Platinum drug resistance

1.13E-03

P10415, Q13489, P98170, P78417, P23025, P43246

BCL2, BIRC3, BIRC4, GSTO1, XPA, MSH2

Cannabidiol

hsa02010

ABC transporters

2.40E-03

P45844, Q8IZY2

ABCG1, ABCA7

Cannabidiol

hsa03008

Ribosome biogenesis in eukaryotes

4.44E-04

Q9NYH9, P19784, P67870, P78345, Q9BVP2, O15381, Q9GZY0

UTP6, CSNK2A2, CSNK2B, RPP38, GNL3, NVL, NXF2; NXF2B

Cannabidiol

hsa03010

Ribosome

3.22E-03

Q9UHA3, P50914

RSL24D1, RPL14

Cannabidiol

hsa03013

RNA transport

5.13E-08

O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, Q9Y6A5, Q14232, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, TACC3, EIF2B1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21462	FPR1	fMet-Leu-Phe receptor	O14980	XPO1	Exportin-1	-0.742
P10415	BCL2	Apoptosis regulator Bcl-2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.888
P21462	FPR1	fMet-Leu-Phe receptor	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.874
P51684	CCR6	C-C chemokine receptor type 6	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.924
P10415	BCL2	Apoptosis regulator Bcl-2	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
P21462	FPR1	fMet-Leu-Phe receptor	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.78
P10415	BCL2	Apoptosis regulator Bcl-2	O14893	GEMIN2	Gem-associated protein 2	0.853
P21462	FPR1	fMet-Leu-Phe receptor	O14893	GEMIN2	Gem-associated protein 2	-0.87
P51684	CCR6	C-C chemokine receptor type 6	O14893	GEMIN2	Gem-associated protein 2	0.771
P21462	FPR1	fMet-Leu-Phe receptor	P61326	MAGOH	Protein mago nashi homolog	-0.835
P51684	CCR6	C-C chemokine receptor type 6	P61326	MAGOH	Protein mago nashi homolog	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.701
P10415	BCL2	Apoptosis regulator Bcl-2	Q7Z3B4	NUP54	Nucleoporin p54	0.774
P21462	FPR1	fMet-Leu-Phe receptor	Q7Z3B4	NUP54	Nucleoporin p54	-0.903
P51684	CCR6	C-C chemokine receptor type 6	Q7Z3B4	NUP54	Nucleoporin p54	0.811
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P10415	BCL2	Apoptosis regulator Bcl-2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.751
P21462	FPR1	fMet-Leu-Phe receptor	P35658	NUP214	Nuclear pore complex protein Nup214	0.971
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P10415	BCL2	Apoptosis regulator Bcl-2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.734
P21462	FPR1	fMet-Leu-Phe receptor	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.89
P51684	CCR6	C-C chemokine receptor type 6	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.701
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P10415	BCL2	Apoptosis regulator Bcl-2	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.837
P21462	FPR1	fMet-Leu-Phe receptor	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.953
P51684	CCR6	C-C chemokine receptor type 6	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.711
P10415	BCL2	Apoptosis regulator Bcl-2	P78345	RPP38	Ribonuclease P protein subunit p38	0.852
P51684	CCR6	C-C chemokine receptor type 6	P78345	RPP38	Ribonuclease P protein subunit p38	0.861
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P21462	FPR1	fMet-Leu-Phe receptor	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	-0.721
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.812
P21462	FPR1	fMet-Leu-Phe receptor	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.904
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.732
P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.703
P21462	FPR1	fMet-Leu-Phe receptor	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	-0.713

Cannabidiol

hsa03015

mRNA surveillance pathway

7.29E-03

O60942, O43148, Q15287, Q9UBU9, P52298, Q53GS7

RNGTT, RNMT, RNPS1, NXF1, NCBP2, GLE1

Cannabidiol

hsa03020

RNA polymerase

1.31E-02

P24928, P62487

POLR2A, POLR2G

Cannabidiol

hsa03040

Spliceosome

2.14E-09

Q14562, O43143, O60508, Q99633, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, Q9UMS4, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, PRPF18, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, PRPF19, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P46091	GPR1	Chemerin-like receptor 2	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.819
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P46091	GPR1	Chemerin-like receptor 2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P46091	GPR1	Chemerin-like receptor 2	O60508	CDC40	Pre-mRNA-processing factor 17	-0.778
P46091	GPR1	Chemerin-like receptor 2	Q99633	PRPF18	Pre-mRNA-splicing factor 18	-0.711
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.793
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	0.772
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	Q13595	TRA2A	Transformer-2 protein homolog alpha	0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P46091	GPR1	Chemerin-like receptor 2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.753
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P46091	GPR1	Chemerin-like receptor 2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.746
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P46091	GPR1	Chemerin-like receptor 2	Q9UMS4	PRPF19	Pre-mRNA-processing factor 19	0.703
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Cannabidiol

hsa03050

Proteasome

1.40E-02

P55036

PSMD4

Cannabidiol

hsa03060

Protein export

9.84E-06

P37108, Q15005

SRP14, SPCS2

Cannabidiol

hsa04012

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Cannabidiol

hsa04014

Ras signaling pathway

3.06E-03

P42338, P20827, P49767, Q13009, Q7LDG7, Q14644, P0DP23, P62873, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, RASA3, CALM1, GNB1, GNG5, GNG10, PLCG1

Cannabidiol

hsa04015

Rap1 signaling pathway

1.45E-04

P20827, P49767, P63261, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P0DP23, P08514, P17252, P19174

EFNA1, VEGFC, ACTG1, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, CALM1, ITGA2B, PRKCA, PLCG1

Cannabidiol

hsa04020

Calcium signaling pathway

2.59E-06

Q96DU7, P45880, Q16566, Q13557, P17252, P21860, O15399, P25116, P0DP23, P51828, P23634, P49767

ITPKC, VDAC2, CAMK4, CAMK2D, PRKCA, ERBB3, GRIN2D, F2R, CALM1, ADCY7, ATP2B4, VEGFC

Cannabidiol

hsa04022

cGMP-PKG signaling pathway

4.72E-02

Q99941, P23634, P51828, P45880

CREBL1, ATP2B4, ADCY7, VDAC2

Cannabidiol

hsa04024

cAMP signaling pathway

3.11E-03

P63092, P26678, P0DP23, P23634, P61586, Q16566, O15399, P25116

GNAS, PLN, CALM1, ATP2B4, RHOA, CAMK4, GRIN2D, F2R

Cannabidiol

hsa04060

Cytokine-cytokine receptor interaction

3.17E-05

P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, P25024, P25025, Q9UBD3, P47992, P01375, P09341, P18510, P09603, P01730, Q93038

IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, CXCR1, CXCR2, XCL2, XCL1, TNF, CXCL1, IL1RN, CSF1, CD4, TNFRSF25

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43657	P2RY5	Lysophosphatidic acid receptor 6	P27930	IL1R2	Interleukin-1 receptor type 2	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P08476	INHBA	Inhibin beta A chain	-0.798
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P43657	P2RY5	Lysophosphatidic acid receptor 6	P26842	CD27	CD27 antigen	0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.774
P43657	P2RY5	Lysophosphatidic acid receptor 6	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.794
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.774
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.836
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P47992	XCL1	Lymphotactin	0.836
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P01375	TNF	Tumor necrosis factor	-0.856
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P09341	CXCL1	Growth-regulated alpha protein	-0.762
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09341	CXCL1	Growth-regulated alpha protein	-0.839
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P18510	IL1RN	Interleukin-1 receptor antagonist protein	-0.743
P43657	P2RY5	Lysophosphatidic acid receptor 6	P18510	IL1RN	Interleukin-1 receptor antagonist protein	-0.787
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.715
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	Q93038	TNFRSF25	Tumor necrosis factor receptor superfamily member 25	0.795

Cannabidiol

hsa04061

Viral protein interaction with cytokine and cytokine receptor

5.72E-05

Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P14784, P01375

CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, IL2RB, TNF

Cannabidiol

hsa04062

Chemokine signaling pathway

3.74E-06

P25024, P25025, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1

CXCR1, CXCR2, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Cannabidiol

hsa04064

NF-kappa B signaling pathway

2.71E-05

P10415, P51617, O00463, Q13546, P14778, P01584, Q04759, Q9UDY8, Q13077, P67870, P07948, P06239, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7

BCL2, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, PRKCQ, MALT1, TRAF1, CSNK2B, LYN, LCK, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P51684	CCR6	C-C chemokine receptor type 6	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.869
P51684	CCR6	C-C chemokine receptor type 6	Q13077	TRAF1	TNF receptor-associated factor 1	0.768
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763

Cannabidiol

hsa04070

Phosphatidylinositol signaling system

4.07E-02

P0DP23, Q14643, O14732, P17252

CALM1, ITPR1, IMPA2, PRKCA

Cannabidiol

hsa04071

Sphingolipid signaling pathway

9.73E-05

P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2

Cannabidiol

hsa04072

Phospholipase D signaling pathway

2.75E-02

P61586, O14986, P63092

RHOA, PIP5K1B, GNAS

Cannabidiol

hsa04080

Neuroactive ligand-receptor interaction

6.43E-06

P08311, P28472, Q15722, P21453, Q9H228, O00398, Q01726, P41968, P21462, P21730, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, MC1R, MC3R, FPR1, C5AR1, ADRB2

Cannabidiol

hsa04110

Cell cycle

4.67E-03

Q09472, P24522, P49918, P42773, P01106

EP300, GADD45A, CDKN1C, CDKN2C, MYC

Cannabidiol

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Cannabidiol

hsa04120

Ubiquitin mediated proteolysis

4.91E-05

Q14145, Q13042, Q13191, P62837, Q15751, O95071, Q7Z6Z7, P0CG47

KEAP1, CDC16, CBLB, UBE2D2, HERC1, UBR5, HUWE1, UBB

Cannabidiol

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Cannabidiol

hsa04137

Mitophagy - animal

6.72E-04

P19784, P67870, Q07817, P0CG47

CSNK2A2, CSNK2B, BCL2L1, UBB

Cannabidiol

hsa04140

Autophagy - animal

4.74E-02

P22694, Q14643, P10415

PRKACB, ITPR1, BCL2

Cannabidiol

hsa04141

Protein processing in endoplasmic reticulum

3.64E-02

Q99941, O75460, P11142, Q9H3Z4, P07900

CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1

Cannabidiol

hsa04142

Lysosome

1.96E-02

Q9UBR2, P34059, P17900

CTSZ, GALNS, GM2A

Cannabidiol

hsa04144

Endocytosis

2.62E-04

Q13191, P0DMV8, P11142, Q9H444, O75351, Q9NZZ3, P62491, P42566, P61073, P43250, P84022, Q9Y5X3

CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, CHMP5, RAB11A, EPS15, CXCR4, GRK6, SMAD3, SNX5

Cannabidiol

hsa04145

Phagosome

9.60E-06

P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P27824, P13765

ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, CANX, HLA-DOB

Cannabidiol

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Cannabidiol

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Cannabidiol

hsa04213

Longevity regulating pathway - multiple species

4.34E-02

P51828, P0DMV8

ADCY7, HSPA1A

Cannabidiol

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Cannabidiol

hsa04217

Necroptosis

7.97E-06

P01375, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, Q14765, P07384, P0C0S5, Q6FI13, Q99878, P10415, Q9H444, O43633, Q9NZZ3, O75351

TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT4, CAPN1, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CHMP4B, CHMP2A, CHMP5, VPS4B

Cannabidiol

hsa04260

Cardiac muscle contraction

4.49E-02

P67936, P13073, P12074

TPM4, COX4I1, COX6A1

Cannabidiol

hsa04261

Adrenergic signaling in cardiomyocytes

3.69E-04

P07550, P51828, P22694, Q99941, P18848, Q13362, Q16537, P0DP23, Q13557, P17252, P10415, P20020, P23634

ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, PPP2R5E, CALM1, CAMK2D, PRKCA, BCL2, ATP2B1, ATP2B4

Cannabidiol

hsa04270

Vascular smooth muscle contraction

2.96E-02

P0DP24, P51828, P35579, P35318

CALM2, ADCY7, MYH9, ADM

Cannabidiol

hsa04310

Wnt signaling pathway

9.34E-04

P84022, P61586, P30279, Q13485, O43318, P19784, P67870

SMAD3, RHOA, CCND2, SMAD4, MAP3K7, CSNK2A2, CSNK2B

Cannabidiol

hsa04330

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Cannabidiol

hsa04340

Hedgehog signaling pathway

4.20E-04

P22694, Q13635, Q9Y496, P10415

PRKACB, PTCH1, KIF3A, BCL2

Cannabidiol

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Cannabidiol

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Cannabidiol

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Cannabidiol

hsa04371

Apelin signaling pathway

2.07E-06

P62873, P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.767
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.911
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.776
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.832
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.842
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.749
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.788
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.708
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	-0.792
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	P0DP23	CALM1	Calmodulin-1	0.739

Cannabidiol

hsa04390

Hippo signaling pathway

9.73E-04

P63261, P84022, Q13485, Q9UJU2, O43623, Q13489

ACTG1, SMAD3, SMAD4, LEF1, SNAI2, BIRC3

Cannabidiol

hsa04510

Focal adhesion

5.93E-04

O75369, Q15942, O14986, P17252, P61586, Q16363, Q13489, P10415, P49767, P63261

FLNB, ZYX, PIP5K1B, PRKCA, RHOA, LAMA4, BIRC3, BCL2, VEGFC, ACTG1

Cannabidiol

hsa04512

ECM-receptor interaction

3.73E-02

P07359, P08514

GP1BA, ITGA2B

Cannabidiol

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Cannabidiol

hsa04520

Adherens junction

1.66E-04

Q13485, Q9UJU2, O43623, P19784, P67870, P61586, P63261

SMAD4, LEF1, SNAI2, CSNK2A2, CSNK2B, RHOA, ACTG1

Cannabidiol

hsa04530

Tight junction

2.47E-05

Q8TEU7, P16989, P56750, O00501, Q14247

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN

Cannabidiol

hsa04540

Gap junction

3.27E-03

P17252, P22694, Q13509, P68371, Q14643

PRKCA, PRKACB, TUBB3, TUBB2C, ITPR1

Cannabidiol

hsa04610

Complement and coagulation cascades

1.03E-03

P25116, P09871, P0C0L4

F2R, C1S, C4A

Cannabidiol

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Cannabidiol

hsa04612

Antigen processing and presentation

5.26E-07

P13765, P48382, P01730, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P48382	RFX5	DNA-binding protein RFX5	0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.8
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P26717	KLRC2	NKG2-C type II integral membrane protein	0.8
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	Q13241	KLRD1	Natural killer cells antigen CD94	0.85
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.813
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P01375	TNF	Tumor necrosis factor	-0.856
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755

Cannabidiol

hsa04613

Neutrophil extracellular trap formation

3.77E-06

P17252, P16109, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, Q6FI13, Q93077, P62807, P33778, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359

PRKCA, SELP, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P05164	MPO	Myeloperoxidase	-0.876
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P08246	ELA2	Neutrophil elastase	-0.797
P51684	CCR6	C-C chemokine receptor type 6	P08246	ELA2	Neutrophil elastase	-0.706
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.91
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	Q13547	HDAC1	Histone deacetylase 1	0.786
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P51684	CCR6	C-C chemokine receptor type 6	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.86
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P51684	CCR6	C-C chemokine receptor type 6	P33778	H2BC3	Histone H2B type 1-B	0.704
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.704
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P20160	AZU1	Azurocidin	-0.853
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P08311	CTSG	Cathepsin G	-0.866
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P49913	CAMP	Cathelicidin antimicrobial peptide	-0.736
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.766
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.823
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P21462	FPR1	fMet-Leu-Phe receptor	-0.716
P51684	CCR6	C-C chemokine receptor type 6	P21462	FPR1	fMet-Leu-Phe receptor	-0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876

Cannabidiol

hsa04614

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Cannabidiol

hsa04621

NOD-like receptor signaling pathway

4.31E-02

P01375, P59665, P59666, P12838

TNF, DEFA1; DEFA1B, DEFA3, DEFA4

Cannabidiol

hsa04623

Cytosolic DNA-sensing pathway

5.88E-04

P01584, P01568, Q13546, Q8NHW4

IL1B, IFNA21, RIPK1, CCL4L2

Cannabidiol

hsa04630

JAK-STAT signaling pathway

4.43E-02

P01106, Q09472, P16871

MYC, EP300, IL7R

Cannabidiol

hsa04640

Hematopoietic cell lineage

6.36E-09

P13612, P14778, P27930, P20023, P25063, P04234, P07766, P09693, P01732, P01730, P09564, P16871, P13765, P20036, P09603

ITGA4, IL1R1, IL1R2, CR2, CD24, CD3D, CD3E, CD3G, CD8A, CD4, CD7, IL7R, HLA-DOB, HLA-DPA1, CSF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P43657	P2RY5	Lysophosphatidic acid receptor 6	P13612	ITGA4	Integrin alpha-4	0.764
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P43657	P2RY5	Lysophosphatidic acid receptor 6	P27930	IL1R2	Interleukin-1 receptor type 2	-0.726
Q14376	GALE	UDP-glucose 4-epimerase	P20023	CR2	Complement receptor type 2	0.716
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
Q9Y5S1	TRPV2	Transient receptor potential cation channel subfamily V member 2	P04234	CD3D	T-cell surface glycoprotein CD3 delta chain	0.704
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P43657	P2RY5	Lysophosphatidic acid receptor 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.777
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q14376	GALE	UDP-glucose 4-epimerase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.735
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q14376	GALE	UDP-glucose 4-epimerase	P01730	CD4	T-cell surface glycoprotein CD4	0.729
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09564	CD7	T-cell antigen CD7	0.735
Q14376	GALE	UDP-glucose 4-epimerase	P16871	IL7R	Interleukin-7 receptor subunit alpha	0.846
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q9Y5S1	TRPV2	Transient receptor potential cation channel subfamily V member 2	P20036	HLA-DPA1	HLA class II histocompatibility antigen, DP alpha 1 chain	0.714
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.715

Cannabidiol

hsa04650

Natural killer cell mediated cytotoxicity

3.14E-12

P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715

PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P01375	TNF	Tumor necrosis factor	-0.856
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	O60880	SH2D1A	SH2 domain-containing protein 1A	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	Q13241	KLRD1	Natural killer cells antigen CD94	0.85
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P26718	KLRK1	NKG2-D type II integral membrane protein	0.824
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.766
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P26717	KLRC2	NKG2-C type II integral membrane protein	0.8
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.8
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Cannabidiol

hsa04657

IL-17 signaling pathway

2.31E-03

P08238, Q07955, P19875, P14780, Q9UJX4, P04141, P80188, P01375

HSP90AB1, SFRS1, CXCL2, MMP9, ANAPC5, CSF2, LCN2, TNF

Cannabidiol

hsa04658

Th1 and Th2 cell differentiation

2.21E-09

Q04759, P07766, P04234, P20963, P09693, P01730, P06239, P23771, Q9UL17, P14784, P13765, P20036, Q13761

PRKCQ, CD3E, CD3D, CD247, CD3G, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, HLA-DPA1, RUNX3

Cannabidiol

hsa04659

Th17 cell differentiation

5.59E-10

P25963, Q04759, P19174, P01730, P06239, P14784, P13765, P20036, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P04234, P20963

NFKBIA, PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, HLA-DPA1, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD3D, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P43657	P2RY5	Lysophosphatidic acid receptor 6	P06239	LCK	Tyrosine-protein kinase Lck	0.788
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q9Y5S1	TRPV2	Transient receptor potential cation channel subfamily V member 2	P20036	HLA-DPA1	HLA class II histocompatibility antigen, DP alpha 1 chain	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q9UL17	TBX21	T-box transcription factor TBX21	0.731
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P43657	P2RY5	Lysophosphatidic acid receptor 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.777
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q9Y5S1	TRPV2	Transient receptor potential cation channel subfamily V member 2	P04234	CD3D	T-cell surface glycoprotein CD3 delta chain	0.704
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P43657	P2RY5	Lysophosphatidic acid receptor 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.758

Cannabidiol

hsa04660

T cell receptor signaling pathway

7.54E-06

P01375, Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Cannabidiol

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Cannabidiol

hsa04664

Fc epsilon RI signaling pathway

2.47E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Cannabidiol

hsa04666

Fc gamma R-mediated phagocytosis

1.44E-03

P23528, P49006, P06396, O14494, P14598, P17252

CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCA

Cannabidiol

hsa04668

TNF signaling pathway

4.29E-03

P01375, Q99941, P18848, P19875, P01584, P14780, O95429

TNF, CREBL1, ATF4, CXCL2, IL1B, MMP9, BAG4

Cannabidiol

hsa04672

Intestinal immune network for IgA production

1.43E-02

P29965, P10747, P13765, P20036

CD40LG, CD28, HLA-DOB, HLA-DPA1

Cannabidiol

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Cannabidiol

hsa04713

Circadian entrainment

4.94E-02

P62873, P63092

GNB1, GNAS

Cannabidiol

hsa04720

Long-term potentiation

2.27E-05

P17252, Q16566, P16298, P0DP23, P51812, O15399, Q02750, Q14643

PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1, ITPR1

Cannabidiol

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Cannabidiol

hsa04723

Retrograde endocannabinoid signaling

4.94E-02

P48169, P62873

GABRA4, GNB1

Cannabidiol

hsa04724

Glutamatergic synapse

4.63E-06

P48058, O15399, P43003, P63092, P62873, P63218, P50151, P15104

GRIA4, GRIN2D, SLC1A3, GNAS, GNB1, GNG5, GNG10, GLUL

Cannabidiol

hsa04725

Cholinergic synapse

3.74E-02

P22694, Q14643, P10415

PRKACB, ITPR1, BCL2

Cannabidiol

hsa04726

Serotonergic synapse

2.52E-02

P63092, P62873

GNAS, GNB1

Cannabidiol

hsa04727

GABAergic synapse

1.69E-03

P63218, P50151, P15104

GNG5, GNG10, GLUL

Cannabidiol

hsa04728

Dopaminergic synapse

2.82E-02

P14416, P63218, P50151, P49841, Q16539, P49407

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1

Cannabidiol

hsa04730

Long-term depression

3.10E-02

Q14344, P07948

GNA13, LYN

Cannabidiol

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Cannabidiol

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Cannabidiol

hsa04744

Phototransduction

2.20E-04

P62873, P0DP23

GNB1, CALM1

Cannabidiol

hsa04750

Inflammatory mediator regulation of TRP channels

8.09E-03

P01584, P51828, Q13557, Q9Y5S1

IL1B, ADCY7, CAMK2D, TRPV2

Cannabidiol

hsa04810

Regulation of actin cytoskeleton

2.58E-02

Q15746, P08514, P25116

MYLK, ITGA2B, F2R

Cannabidiol

hsa04911

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Cannabidiol

hsa04912

GnRH signaling pathway

4.42E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Cannabidiol

hsa04913

Ovarian steroidogenesis

1.27E-03

P42330, P22694

AKR1C3, PRKACB

Cannabidiol

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Cannabidiol

hsa04915

Estrogen signaling pathway

2.52E-03

Q99941, P51828, P07900, P0DMV8, P11142, P0DP24, Q15788

CREBL1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM2, NCOA1

Cannabidiol

hsa04916

Melanogenesis

4.89E-04

P0DP23, Q9UJU2, P17252, P49841, Q01726, P04628

CALM1, LEF1, PRKCA, GSK3B, MC1R, WNT1

Cannabidiol

hsa04918

Thyroid hormone synthesis

3.62E-02

P22352

GPX3

Cannabidiol

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Cannabidiol

hsa04921

Oxytocin signaling pathway

4.19E-02

P0DP23, P17252, Q16566, P63261

CALM1, PRKCA, CAMK4, ACTG1

Cannabidiol

hsa04924

Renin secretion

2.90E-04

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Cannabidiol

hsa04925

Aldosterone synthesis and secretion

5.60E-06

Q14643, Q99941, P51828, P0DP23, P17252, Q16566, Q13557, P20020, P23634

ITPR1, CREBL1, ADCY7, CALM1, PRKCA, CAMK4, CAMK2D, ATP2B1, ATP2B4

Cannabidiol

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Cannabidiol

hsa04927

Cortisol synthesis and secretion

1.27E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Cannabidiol

hsa04928

Parathyroid hormone synthesis, secretion and action

1.02E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Cannabidiol

hsa04932

Non-alcoholic fatty liver disease

6.66E-04

P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, O15239

TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1

Cannabidiol

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.45E-05

P84022, Q13485, P10415, P42338, Q12778, P49767, P17252, P19174

SMAD3, SMAD4, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1

Cannabidiol

hsa04934

Cushing syndrome

5.32E-04

Q14643, Q99941, P51828, P22694, O15169, Q13557, P04628

ITPR1, CREBL1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1

Cannabidiol

hsa04940

Type I diabetes mellitus

3.01E-04

P48023, P20036, P01375

FASLG, HLA-DPA1, TNF

Cannabidiol

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Cannabidiol

hsa04966

Collecting duct acid secretion

2.32E-03

P02730, P00918, Q9Y666

SLC4A1, CA2, SLC12A7

Cannabidiol

hsa04970

Salivary secretion

2.77E-06

P07550, P22694, Q14643, P20020, P23634, P17252, P0DP23, P49913

ADRB2, PRKACB, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1, CAMP

Cannabidiol

hsa04971

Gastric acid secretion

1.87E-03

P51828, P17252, P15311, P63261, P0DP23, Q13557

ADCY7, PRKCA, VIL2, ACTG1, CALM1, CAMK2D

Cannabidiol

hsa04972

Pancreatic secretion

6.98E-05

Q14643, P20020, P17252, P63092, Q08828, P62491, P61586

ITPR1, ATP2B1, PRKCA, GNAS, ADCY1, RAB11A, RHOA

Cannabidiol

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Cannabidiol

hsa04978

Mineral absorption

3.94E-02

P23634, Q9BXS9

ATP2B4, SLC26A6

Cannabidiol

hsa05010

Alzheimer disease

1.32E-04

Q92542, O15239, P05496, Q06055, P13073, P12074, Q00535, O75460, P0DP23, P04406, P01584, O95197, O15169, P67870, P45880, P28070, P62195

NCSTN, NDUFA1, ATP5G1, ATP5G2, COX4I1, COX6A1, CDK5, ERN1, CALM1, GAPDH, IL1B, RTN3, AXIN1, CSNK2B, VDAC2, PSMB4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P36969	GPX4	Phospholipid hydroperoxide glutathione peroxidase	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.831
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P36969	GPX4	Phospholipid hydroperoxide glutathione peroxidase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.732
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778
P36969	GPX4	Phospholipid hydroperoxide glutathione peroxidase	P62195	PSMC5	26S proteasome regulatory subunit 8	0.712

Cannabidiol

hsa05012

Parkinson disease

2.95E-03

P19404, P12074, Q06055, P45880, P62195

NDUFV2, COX6A1, ATP5G2, VDAC2, PSMC5

Cannabidiol

hsa05014

Amyotrophic lateral sclerosis

1.64E-02

O15399, P10415, Q06055, Q13509, P68371, P62195, Q53GS7, P63261, Q9GZY0

GRIN2D, BCL2, ATP5G2, TUBB3, TUBB2C, PSMC5, GLE1, ACTG1, NXF2; NXF2B

Cannabidiol

hsa05016

Huntington disease

3.83E-03

P19404, P12074, Q06055, P45880, P62195

NDUFV2, COX6A1, ATP5G2, VDAC2, PSMC5

Cannabidiol

hsa05020

Prion disease

9.09E-05

P01584, P46531, P11142, P19404, P05496, Q06055, P12074, O15399, Q9NZJ5, P21796, P45880, P62195, Q71U36, Q99941

IL1B, NOTCH1, HSPA8, NDUFV2, ATP5G1, ATP5G2, COX6A1, GRIN2D, EIF2AK3, VDAC1, VDAC2, PSMC5, TUBA1A, CREBL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.803
P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	P19404	NDUFV2	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P36969	GPX4	Phospholipid hydroperoxide glutathione peroxidase	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.831
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.716
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.765
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.744
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	1
P36969	GPX4	Phospholipid hydroperoxide glutathione peroxidase	P62195	PSMC5	26S proteasome regulatory subunit 8	0.712
P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.887
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769

Cannabidiol

hsa05022

Pathways of neurodegeneration - multiple diseases

1.97E-02

O15399, Q13509, P68371, P10415, Q06055, Q13561, P07384, P04628, P0DP23, P62195

GRIN2D, TUBB3, TUBB2C, BCL2, ATP5G2, DCTN2, CAPN1, WNT1, CALM1, PSMC5

Cannabidiol

hsa05031

Amphetamine addiction

1.61E-03

O15399, P0DP23, Q16566, P22694, P18848, P17252, Q13547

GRIN2D, CALM1, CAMK4, PRKACB, ATF4, PRKCA, HDAC1

Cannabidiol

hsa05032

Morphine addiction

3.27E-08

P62873, Q07343, P48169, P78334, P63092, P32298, P43250

GNB1, PDE4B, GABRA4, GABRE, GNAS, GRK4, GRK6

Cannabidiol

hsa05034

Alcoholism

3.96E-06

P07101, Q16566, P0DP24, P0DP23, Q96RR4, P62873, P0C0S5, Q93077, P62807, P33778, O60814, P84243, P68431

TH, CAMK4, CALM2, CALM1, CAMKK2, GNB1, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Cannabidiol

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

3.11E-02

Q16539, P25024, P25025, P07948

MAPK14, CXCR1, CXCR2, LYN

Cannabidiol

hsa05130

Pathogenic Escherichia coli infection

7.39E-03

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Cannabidiol

hsa05132

Salmonella infection

9.92E-08

P51617, P25963, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371

IRAK1, NFKBIA, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P10415	BCL2	Apoptosis regulator Bcl-2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.908
P46091	GPR1	Chemerin-like receptor 2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.736
P51684	CCR6	C-C chemokine receptor type 6	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.835
P46091	GPR1	Chemerin-like receptor 2	P63261	ACTG1	Actin, cytoplasmic 2	0.776
P33260	CYP2C18	Cytochrome P450 2C18	P63261	ACTG1	Actin, cytoplasmic 2	0.845
P33260	CYP2C18	Cytochrome P450 2C18	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.765
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
P46091	GPR1	Chemerin-like receptor 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.759
P33260	CYP2C18	Cytochrome P450 2C18	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.752
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
P46091	GPR1	Chemerin-like receptor 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.808
P33260	CYP2C18	Cytochrome P450 2C18	P10415	BCL2	Apoptosis regulator Bcl-2	0.784
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P10415	BCL2	Apoptosis regulator Bcl-2	O75369	FLNB	Filamin-B	-0.762
P33260	CYP2C18	Cytochrome P450 2C18	O75369	FLNB	Filamin-B	-0.726
P51684	CCR6	C-C chemokine receptor type 6	O75369	FLNB	Filamin-B	-0.717
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P10415	BCL2	Apoptosis regulator Bcl-2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.929
P51684	CCR6	C-C chemokine receptor type 6	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.721
P51684	CCR6	C-C chemokine receptor type 6	P51808	DYNLT3	Dynein light chain Tctex-type 3	0.731
P10415	BCL2	Apoptosis regulator Bcl-2	Q13561	DCTN2	Dynactin subunit 2	-0.843
P33260	CYP2C18	Cytochrome P450 2C18	Q13561	DCTN2	Dynactin subunit 2	-0.716
P51684	CCR6	C-C chemokine receptor type 6	Q13561	DCTN2	Dynactin subunit 2	-0.781
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
P46091	GPR1	Chemerin-like receptor 2	Q13509	TUBB3	Tubulin beta-3 chain	-0.748
P33260	CYP2C18	Cytochrome P450 2C18	Q13509	TUBB3	Tubulin beta-3 chain	-0.816
P51684	CCR6	C-C chemokine receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	-0.835
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766
P46091	GPR1	Chemerin-like receptor 2	P68371	TUBB2C	Tubulin beta-4B chain	-0.751
P33260	CYP2C18	Cytochrome P450 2C18	P68371	TUBB2C	Tubulin beta-4B chain	-0.707

Cannabidiol

hsa05133

Pertussis

1.02E-05

P11215, P0DP23, P23528, P09871, P0C0L4, Q02556

ITGAM, CALM1, CFL1, C1S, C4A, IRF8

Cannabidiol

hsa05134

Legionellosis

4.34E-02

Q9NR31, P0DMV8

SAR1A, HSPA1A

Cannabidiol

hsa05135

Yersinia infection

4.65E-02

P13612, P06239, Q16539, P01375, P49841

ITGA4, LCK, MAPK14, TNF, GSK3B

Cannabidiol

hsa05140

Leishmaniasis

1.56E-02

P14598, O60603, P49006, P51617, Q15080

NCF1, TLR2, MARCKSL1, IRAK1, NCF4

Cannabidiol

hsa05142

Chagas disease

3.80E-03

P01375, P30679, P48023, P04234

TNF, GNA15, FASLG, CD3D

Cannabidiol

hsa05143

African trypanosomiasis

4.76E-05

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Cannabidiol

hsa05144

Malaria

1.30E-05

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Cannabidiol

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Cannabidiol

hsa05146

Amoebiasis

5.29E-07

Q13751, P09341, P19875, P14778, P27930, P01375, P05089, P30679, P22694, P12814, P08311

LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, ARG1, GNA15, PRKACB, ACTN1, CTSG

Cannabidiol

hsa05150

Staphylococcus aureus infection

1.04E-03

P21730, P21462, O75015, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Cannabidiol

hsa05152

Tuberculosis

5.68E-03

Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617

TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1

Cannabidiol

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Cannabidiol

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Cannabidiol

hsa05162

Measles

3.10E-03

P23458, P0DMV8, P11142, Q13191, Q9NZJ5, Q9NP90, P30279, O43318

JAK1, HSPA1A, HSPA8, CBLB, EIF2AK3, RAB9B, CCND2, MAP3K7

Cannabidiol

hsa05163

Human cytomegalovirus infection

2.08E-04

P01375, P62873, P63218, P50151, P0DP23, P61586, Q8NHW4, Q08828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, P63092, O00463, P61769

TNF, GNB1, GNG5, GNG10, CALM1, RHOA, CCL4L2, ADCY1, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, GNAS, TRAF5, B2M

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711

Cannabidiol

hsa05166

Human T-cell leukemia virus 1 infection

1.68E-03

P01106, P04234, P09693, P20036, Q09472, P42773, P01730

MYC, CD3D, CD3G, HLA-DPA1, EP300, CDKN2C, CD4

Cannabidiol

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Cannabidiol

hsa05168

Herpes simplex virus 1 infection

7.40E-04

Q9UKJ0, Q06124, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q9NR11, Q03923, Q9UDV6, P10415

PILRB, PTPN11, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF302, ZNF85, ZNF212, BCL2

Cannabidiol

hsa05169

Epstein-Barr virus infection

1.01E-06

P20023, P13765, P20036, P01106, Q13547, Q92769, P04637, Q13546, O00463, P10415, P07948, Q13761, P24522, O60603, P51617, Q14790, P04234, P07766, P09693, P20963

CR2, HLA-DOB, HLA-DPA1, MYC, HDAC1, HDAC2, TP53, RIPK1, TRAF5, BCL2, LYN, RUNX3, GADD45A, TLR2, IRAK1, CASP8, CD3D, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q14376	GALE	UDP-glucose 4-epimerase	P20023	CR2	Complement receptor type 2	0.716
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q9Y5S1	TRPV2	Transient receptor potential cation channel subfamily V member 2	P20036	HLA-DPA1	HLA class II histocompatibility antigen, DP alpha 1 chain	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
Q14376	GALE	UDP-glucose 4-epimerase	P01106	MYC	Myc proto-oncogene protein	0.747
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P51684	CCR6	C-C chemokine receptor type 6	P04637	TP53	Cellular tumor antigen p53	0.728
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q14376	GALE	UDP-glucose 4-epimerase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.723
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
Q14376	GALE	UDP-glucose 4-epimerase	Q14790	CASP8	Caspase-8	-0.704
Q9Y5S1	TRPV2	Transient receptor potential cation channel subfamily V member 2	P04234	CD3D	T-cell surface glycoprotein CD3 delta chain	0.704
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q14376	GALE	UDP-glucose 4-epimerase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.735
P51684	CCR6	C-C chemokine receptor type 6	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.753
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927

Cannabidiol

hsa05170

Human immunodeficiency virus 1 infection

3.18E-06

Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q13546, O00463, Q14643, P01568, P51617, O60603, P23528, P09693, P10415, Q93034, Q9Y6Q5, P20333

MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, RIPK1, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, CD3G, BCL2, CUL5, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10415	BCL2	Apoptosis regulator Bcl-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.777
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10415	BCL2	Apoptosis regulator Bcl-2	P0DP23	CALM1	Calmodulin-1	-0.772
P51684	CCR6	C-C chemokine receptor type 6	P0DP23	CALM1	Calmodulin-1	-0.734
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10415	BCL2	Apoptosis regulator Bcl-2	P17252	PRKCA	Protein kinase C alpha type	0.844
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P10415	BCL2	Apoptosis regulator Bcl-2	O00463	TRAF5	TNF receptor-associated factor 5	0.773
P10415	BCL2	Apoptosis regulator Bcl-2	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.858
P51684	CCR6	C-C chemokine receptor type 6	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.81
P10415	BCL2	Apoptosis regulator Bcl-2	P01568	IFNA21	Interferon alpha-21	0.721
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P10415	BCL2	Apoptosis regulator Bcl-2	P23528	CFL1	Cofilin-1	0.741
P51684	CCR6	C-C chemokine receptor type 6	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.753
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P10415	BCL2	Apoptosis regulator Bcl-2	Q93034	CUL5	Cullin-5	0.704
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.901
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.86
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Cannabidiol

hsa05171

Coronavirus disease - COVID-19

4.47E-02

Q9UHA3, O14786

RSL24D1, NRP1

Cannabidiol

hsa05200

Pathways in cancer

1.48E-05

Q13751, P42338, P08238, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P98170, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, BIRC4, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	Q13751	LAMB3	Laminin subunit beta-3	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P46091	GPR1	Chemerin-like receptor 2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.736
P46091	GPR1	Chemerin-like receptor 2	P17252	PRKCA	Protein kinase C alpha type	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P46091	GPR1	Chemerin-like receptor 2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.838
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	P43246	MSH2	DNA mismatch repair protein Msh2	0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.708
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P46091	GPR1	Chemerin-like receptor 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.809
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P46091	GPR1	Chemerin-like receptor 2	P14923	JUP	Junction plakoglobin	0.883
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P46091	GPR1	Chemerin-like receptor 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.808
P46091	GPR1	Chemerin-like receptor 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.759
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.741
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	-0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P46091	GPR1	Chemerin-like receptor 2	P49767	VEGFC	Vascular endothelial growth factor C	0.718
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	P49767	VEGFC	Vascular endothelial growth factor C	-0.811
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	Q12778	FOXO1	Forkhead box protein O1	-0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P46091	GPR1	Chemerin-like receptor 2	P25116	F2R	Proteinase-activated receptor 1	0.76
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P46091	GPR1	Chemerin-like receptor 2	P78417	GSTO1	Glutathione S-transferase omega-1	0.738
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	P78417	GSTO1	Glutathione S-transferase omega-1	-0.913
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P46091	GPR1	Chemerin-like receptor 2	P0DP23	CALM1	Calmodulin-1	-0.846
O75832	PSMD10	26S proteasome non-ATPase regulatory subunit 10	P0DP23	CALM1	Calmodulin-1	0.739
P46091	GPR1	Chemerin-like receptor 2	P01568	IFNA21	Interferon alpha-21	0.724
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Cannabidiol

hsa05202

Transcriptional misregulation in cancer

3.43E-03

Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P24522

FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, GADD45A

Cannabidiol

hsa05203

Viral carcinogenesis

9.67E-04

Q14790, Q09472, Q15283, P62807, P33778, O60814

CASP8, EP300, RASA2, HIST1H2BC, H2BC3, H2BC12

Cannabidiol

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Cannabidiol

hsa05205

Proteoglycans in cancer

1.39E-03

Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962

TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63

Cannabidiol

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Cannabidiol

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Cannabidiol

hsa05212

Pancreatic cancer

9.87E-04

P42338, P37173, P84022, Q13485, O75293

PIK3CB, TGFBR2, SMAD3, SMAD4, GADD45B

Cannabidiol

hsa05213

Endometrial cancer

3.30E-03

O15169, P01106, Q02750, P24522

AXIN1, MYC, MAP2K1, GADD45A

Cannabidiol

hsa05214

Glioma

8.71E-04

P0DP23, Q16566, P17252, P04637, P24522

CALM1, CAMK4, PRKCA, TP53, GADD45A

Cannabidiol

hsa05216

Thyroid cancer

8.83E-04

P01106, Q9UJU2, P04637, P24522

MYC, LEF1, TP53, GADD45A

Cannabidiol

hsa05217

Basal cell carcinoma

4.42E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Cannabidiol

hsa05220

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Cannabidiol

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Cannabidiol

hsa05226

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Cannabidiol

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.70E-03

P07766, P04234, P20963, P09693, P06239, Q04759, P01730

CD3E, CD3D, CD247, CD3G, LCK, PRKCQ, CD4

Cannabidiol

hsa05310

Asthma

2.71E-02

P20036

HLA-DPA1

Cannabidiol

hsa05320

Autoimmune thyroid disease

6.60E-03

P13765, P20036, P29965, P01568, P10747

HLA-DOB, HLA-DPA1, CD40LG, IFNA21, CD28

Cannabidiol

hsa05321

Inflammatory bowel disease

3.51E-04

P01375, P20036, Q14765, Q9UL17, P23771

TNF, HLA-DPA1, STAT4, TBX21, GATA3

Cannabidiol

hsa05322

Systemic lupus erythematosus

2.30E-05

P09871, Q93077, P62807, P33778, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Cannabidiol

hsa05330

Allograft rejection

3.91E-04

P20036, P48023, P01375

HLA-DPA1, FASLG, TNF

Cannabidiol

hsa05332

Graft-versus-host disease

8.73E-07

P13765, P20036, P48023, P01375, P26715, Q13241

HLA-DOB, HLA-DPA1, FASLG, TNF, KLRC1, KLRD1

Cannabidiol

hsa05340

Primary immunodeficiency

2.16E-04

P01730, P01732, P16871, P04234, P07766, P06239

CD4, CD8A, IL7R, CD3D, CD3E, LCK

Cannabidiol

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Cannabidiol

hsa05415

Diabetic cardiomyopathy

5.56E-04

P45880, P19404, Q06055, P12074, P04406

VDAC2, NDUFV2, ATP5G2, COX6A1, GAPDH

Cannabidiol

hsa05416

Viral myocarditis

4.49E-02

P20036

HLA-DPA1

Cannabidiol

hsa05418

Fluid shear stress and atherosclerosis

2.49E-03

Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974

MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2

Community members of Cannabidiol (S_DC: 4.55)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

TRPV2

Transient receptor potential cation channel subfamily V member 2

Reported

0.6291

0.0388

0.2402

0.6324

P21796

VDAC1

VoltageNonedependent anionNoneselective channel protein 1

Reported

0.1417

0.0067

0.9284

1.0125

P00441

SOD1

Superoxide dismutase [CuNoneZn]

Reported

0.5385

0.0713

0.4871

0.8991

F1T0I5

AANAT

Arylalkylamine NNoneacetyltransferase

Reported

0.0166

0.0067

0.0216

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Predicted

0.0315

0.9493

1.9143

Q14376

GALE

UDPNoneglucose 4Noneepimerase

Predicted

0.0046

0.0309

0.2313

0.2953

P18054

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

Predicted

0.0075

0.3703

0.2416

0.986

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

P62942

FKBP1A

PeptidylNoneprolyl cisNonetrans isomerase FKBP1A

Predicted

0.432

0.2695

0.7551

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P10415

BCL2

Apoptosis regulator BclNone2

Predicted

0.0341

0.5271

2.0714

Q07817

BCL2L1

BclNone2Nonelike protein 1

Predicted

0.0872

0.4349

1.9134

P45880

VDAC2

VoltageNonedependent anionNoneselective channel protein 2

Predicted

0.1502

0.005

0.8425

0.9276

Q16613

AANAT

Serotonin NNoneacetyltransferase

Predicted

0.0166

0.0123

0.1541

0.1869

P33260

CYP2C18

Cytochrome P450 2C18

Predicted

0.0239

0.0756

0.1528

0.316

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P28472

GABRB3

GammaNoneaminobutyric acid receptor subunit betaNone3

Predicted

0.1559

0.4387

0.1695

1.1248

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P78334

GABRE

GammaNoneaminobutyric acid receptor subunit epsilon

Predicted

0.1394

0.4097

0.1579

1.0469

P48169

GABRA4

GammaNoneaminobutyric acid receptor subunit alphaNone4

Predicted

0.3253

0.565

0.1579

1.4506

P16083

NQO2

Ribosyldihydronicotinamide dehydrogenase [quinone]

Predicted

0.2958

0.3134

0.7747

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

Q13510

ASAH1

Acid ceramidase

Predicted

0.4064

0.0423

0.2802

0.568

P22352

GPX3

Glutathione peroxidase 3

Predicted

0.3246

0.0164

0.3617

0.5568

P10826

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P21462

FPR1

fMetNoneLeuNonePhe receptor

Predicted

0.1205

0.3492

0.4378

1.1964

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

Q9H228

EDG8

Sphingosine 1Nonephosphate receptor 5

Predicted

0.0925

0.0552

0.1003

0.2569

P43657

P2RY5

Lysophosphatidic acid receptor 6

Predicted

0.7539

0.0448

0.3708

0.8373

P50052

AGTR2

TypeNone2 angiotensin II receptor

Predicted

0.0604

0.4365

0.1541

1.0572

P21453

S1PR1

Sphingosine 1Nonephosphate receptor 1

Predicted

0.1434

0.3847

0.221

1.0621

P51684

CCR6

CNoneC chemokine receptor type 6

Predicted

0.085

0.1741

0.3304

0.7212

P46091

GPR1

ChemerinNonelike receptor 2

Predicted

0.2476

0.1372

0.3982

P36969

GPX4

Phospholipid hydroperoxide glutathione peroxidase

Predicted

0.6691

0.0157

0.2519

0.6179

P41968

MC3R

Melanocortin receptor 3

Predicted

0.2235

0.2637

0.6392

Q01726

MC1R

MelanocyteNonestimulating hormone receptor

Predicted

0.047

0.2375

0.011

0.5095

O75832

PSMD10

26S proteasome nonNoneATPase regulatory subunit 10

Predicted

0.2103

0.0185

0.1422

PharmaCoNets of Cannabidiol (SPCN: 120.88 )

Cannabidiol regulated-network (SDN: 26.57)

Community members of Cannabidiol (SDC: 4.55)

PharmaCoNets of Cannabidiol (S_PCN: 120.88 )

Cannabidiol regulated-network (S_DN: 26.57)

Community members of Cannabidiol (S_DC: 4.55)