PharmaCoNets of Candesartan-cilexetil (SPCN: 38.27 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Candesartan-cilexetilhsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Candesartan-cilexetilhsa00220Arginine biosynthesis2.86E-022P15104, P05089GLUL, ARG1More
Candesartan-cilexetilhsa00500Starch and sucrose metabolism9.22E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Candesartan-cilexetilhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Candesartan-cilexetilhsa00591Linoleic acid metabolism1.29E-031P11712CYP2C9More
Candesartan-cilexetilhsa00670One carbon pool by folate1.63E-022O95954, Q99707FTCD, MTRMore
Candesartan-cilexetilhsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Candesartan-cilexetilhsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Candesartan-cilexetilhsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Candesartan-cilexetilhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Candesartan-cilexetilhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Candesartan-cilexetilhsa01524Platinum drug resistance1.13E-025P10415, Q13489, P78417, P23025, P43246BCL2, BIRC3, GSTO1, XPA, MSH2More
Candesartan-cilexetilhsa03008Ribosome biogenesis in eukaryotes2.60E-035Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0UTP6, RPP38, GNL3, NVL, NXF2; NXF2BMore
Candesartan-cilexetilhsa03013RNA transport2.29E-0413O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Candesartan-cilexetilhsa03020RNA polymerase4.40E-022P24928, P62487POLR2A, POLR2GMore
Candesartan-cilexetilhsa03040Spliceosome5.79E-037Q14562, O43143, O60508, Q99633, Q13595, Q01130, Q9UMS4DHX8, DHX15, CDC40, PRPF18, TRA2A, SFRS2, PRPF19More
Candesartan-cilexetilhsa03050Proteasome4.83E-021P55036PSMD4More
Candesartan-cilexetilhsa04015Rap1 signaling pathway1.58E-026P20827, P49767, P63261, P25116, P0DP23, P17252EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCAMore
Candesartan-cilexetilhsa04020Calcium signaling pathway1.16E-037Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFCMore
Candesartan-cilexetilhsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Candesartan-cilexetilhsa04024cAMP signaling pathway2.84E-025P0DP23, P23634, Q16566, O15399, P25116CALM1, ATP2B4, CAMK4, GRIN2D, F2RMore
Candesartan-cilexetilhsa04060Cytokine-cytokine receptor interaction9.80E-0416P27930, P14778, P26842, Q9UHF4, Q13651, P16871, P25024, Q9UBD3, P47992, P02775, P09341, P32248, P51684, P18510, P09603, P01730IL1R2, IL1R1, CD27, IL20RA, IL10RA, IL7R, CXCR1, XCL2, XCL1, PPBP, CXCL1, CCR7, CCR6, IL1RN, CSF1, CD4More
Candesartan-cilexetilhsa04061Viral protein interaction with cytokine and cytokine receptor7.74E-046P51684, P32248, P02775, P47992, Q9UBD3, Q9UHF4CCR6, CCR7, PPBP, XCL1, XCL2, IL20RAMore
Candesartan-cilexetilhsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Candesartan-cilexetilhsa04064NF-kappa B signaling pathway4.92E-026P10415, P51617, Q13546, Q9UDY8, Q13077, P24522BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45AMore
Candesartan-cilexetilhsa04066HIF-1 signaling pathway3.40E-023Q09472, P07195, P10415EP300, LDHB, BCL2More
Candesartan-cilexetilhsa04068FoxO signaling pathway3.52E-021Q96BR1SGK3More
Candesartan-cilexetilhsa04070Phosphatidylinositol signaling system4.07E-024P0DP23, Q14643, O14732, P17252CALM1, ITPR1, IMPA2, PRKCAMore
Candesartan-cilexetilhsa04071Sphingolipid signaling pathway1.90E-038P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Candesartan-cilexetilhsa04110Cell cycle2.06E-026Q9UJX4, O60566, Q09472, P24522, P04637, P49918ANAPC5, BUB1B, EP300, GADD45A, TP53, CDKN1CMore
Candesartan-cilexetilhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Candesartan-cilexetilhsa04145Phagosome1.86E-025P63261, Q15080, Q13509, P68371, P27824ACTG1, NCF4, TUBB3, TUBB2C, CANXMore
Candesartan-cilexetilhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Candesartan-cilexetilhsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Candesartan-cilexetilhsa04210Apoptosis2.44E-0410P04637, P10415, O75460, P24522, Q13077, O43521, P43234, Q9UBR2, P18848, Q14643TP53, BCL2, ERN1, GADD45A, TRAF1, BCL2L11, CTSO, CTSZ, ATF4, ITPR1More
Candesartan-cilexetilhsa04217Necroptosis5.66E-035P15104, P05141, P01584, P0C0S5, Q9H444GLUL, SLC25A5, IL1B, H2AFZ, CHMP4BMore
Candesartan-cilexetilhsa04261Adrenergic signaling in cardiomyocytes3.44E-025Q16537, P0DP23, P17252, P10415, P20020PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Candesartan-cilexetilhsa04270Vascular smooth muscle contraction2.89E-022P35579, P35318MYH9, ADMMore
Candesartan-cilexetilhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Candesartan-cilexetilhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Candesartan-cilexetilhsa04390Hippo signaling pathway1.47E-025P63261, Q13485, Q9UJU2, O43623, Q13489ACTG1, SMAD4, LEF1, SNAI2, BIRC3More
Candesartan-cilexetilhsa04510Focal adhesion3.21E-026Q15942, P17252, Q13489, P10415, P49767, P63261ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1More
Candesartan-cilexetilhsa04520Adherens junction3.36E-024Q13485, Q9UJU2, O43623, P63261SMAD4, LEF1, SNAI2, ACTG1More
Candesartan-cilexetilhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Candesartan-cilexetilhsa04540Gap junction4.76E-023P17252, Q13509, P68371PRKCA, TUBB3, TUBB2CMore
Candesartan-cilexetilhsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Candesartan-cilexetilhsa04613Neutrophil extracellular trap formation1.29E-0414P17252, P11215, O60603, P08246, Q92769, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P21462PRKCA, ITGAM, TLR2, ELA2, HDAC2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1More
Candesartan-cilexetilhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Candesartan-cilexetilhsa04640Hematopoietic cell lineage7.16E-037P13612, P14778, P27930, P07766, P01730, P09564, P09603ITGA4, IL1R1, IL1R2, CD3E, CD4, CD7, CSF1More
Candesartan-cilexetilhsa04650Natural killer cell mediated cytotoxicity3.53E-0613P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Candesartan-cilexetilhsa04658Th1 and Th2 cell differentiation4.54E-036P07766, P20963, P01730, P06239, Q9UL17, Q13761CD3E, CD247, CD4, LCK, TBX21, RUNX3More
Candesartan-cilexetilhsa04659Th17 cell differentiation1.43E-026P01730, P06239, P14778, Q9UL17, P07766, P20963CD4, LCK, IL1R1, TBX21, CD3E, CD247More
Candesartan-cilexetilhsa04660T cell receptor signaling pathway1.49E-0310P01375, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Candesartan-cilexetilhsa04664Fc epsilon RI signaling pathway7.22E-032Q9UQC2, P20292GAB2, ALOX5APMore
Candesartan-cilexetilhsa04666Fc gamma R-mediated phagocytosis2.22E-024P49006, P06396, P14598, P17252MARCKSL1, GSN, NCF1, PRKCAMore
Candesartan-cilexetilhsa04668TNF signaling pathway2.91E-023P18848, P01584, P20333ATF4, IL1B, TNFRSF1BMore
Candesartan-cilexetilhsa04720Long-term potentiation2.27E-058P17252, Q16566, P16298, P0DP23, P51812, O15399, Q02750, Q14643PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1, ITPR1More
Candesartan-cilexetilhsa04724Glutamatergic synapse2.72E-035P48058, P43003, P63218, P50151, P15104GRIA4, SLC1A3, GNG5, GNG10, GLULMore
Candesartan-cilexetilhsa04727GABAergic synapse3.89E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Candesartan-cilexetilhsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Candesartan-cilexetilhsa04912GnRH signaling pathway4.42E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Candesartan-cilexetilhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Candesartan-cilexetilhsa04916Melanogenesis3.55E-023P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Candesartan-cilexetilhsa04921Oxytocin signaling pathway4.19E-024P0DP23, P17252, Q16566, P63261CALM1, PRKCA, CAMK4, ACTG1More
Candesartan-cilexetilhsa04925Aldosterone synthesis and secretion2.90E-046Q14643, P0DP23, P17252, Q16566, P20020, P23634ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4More
Candesartan-cilexetilhsa04932Non-alcoholic fatty liver disease2.05E-035O43521, P18848, O75460, P01584, P13073BCL2L11, ATF4, ERN1, IL1B, COX4I1More
Candesartan-cilexetilhsa04933AGE-RAGE signaling pathway in diabetic complications3.36E-024Q13485, P10415, P49767, P17252SMAD4, BCL2, VEGFC, PRKCAMore
Candesartan-cilexetilhsa04962Vasopressin-regulated water reabsorption7.22E-032P52566, P62491ARHGDIB, RAB11AMore
Candesartan-cilexetilhsa04966Collecting duct acid secretion3.15E-022P02730, Q9Y666SLC4A1, SLC12A7More
Candesartan-cilexetilhsa04970Salivary secretion8.71E-045Q14643, P20020, P23634, P17252, P0DP23ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1More
Candesartan-cilexetilhsa04971Gastric acid secretion4.76E-023P17252, P63261, P0DP23PRKCA, ACTG1, CALM1More
Candesartan-cilexetilhsa04972Pancreatic secretion1.00E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Candesartan-cilexetilhsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Candesartan-cilexetilhsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Candesartan-cilexetilhsa05012Parkinson disease3.89E-025P13073, P05141, O75460, P18848, P0DP24COX4I1, SLC25A5, ERN1, ATF4, CALM2More
Candesartan-cilexetilhsa05014Amyotrophic lateral sclerosis4.31E-027O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2BMore
Candesartan-cilexetilhsa05016Huntington disease4.87E-025P13073, P24928, P62487, P05141, O75460COX4I1, POLR2A, POLR2G, SLC25A5, ERN1More
Candesartan-cilexetilhsa05022Pathways of neurodegeneration - multiple diseases1.98E-027P13073, O75460, P18848, P05141, P20333, P01584, P0DP24COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2More
Candesartan-cilexetilhsa05031Amphetamine addiction1.49E-024O15399, P0DP23, Q16566, P17252GRIN2D, CALM1, CAMK4, PRKCAMore
Candesartan-cilexetilhsa05034Alcoholism3.11E-056Q96RR4, Q93077, P62807, O60814, P84243, P68431CAMKK2, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Candesartan-cilexetilhsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Candesartan-cilexetilhsa05132Salmonella infection2.12E-0413P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2CMore
Candesartan-cilexetilhsa05133Pertussis2.52E-023P0DP23, P23528, P09871CALM1, CFL1, C1SMore
Candesartan-cilexetilhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Candesartan-cilexetilhsa05140Leishmaniasis1.56E-025P14598, O60603, P49006, P51617, Q15080NCF1, TLR2, MARCKSL1, IRAK1, NCF4More
Candesartan-cilexetilhsa05144Malaria1.64E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Candesartan-cilexetilhsa05146Amoebiasis4.54E-036Q13751, P09341, P14778, P27930, P05089, P12814LAMB3, CXCL1, IL1R1, IL1R2, ARG1, ACTN1More
Candesartan-cilexetilhsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Candesartan-cilexetilhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Candesartan-cilexetilhsa05168Herpes simplex virus 1 infection1.94E-029Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2More
Candesartan-cilexetilhsa05169Epstein-Barr virus infection2.15E-0310P13765, Q92769, P04637, Q13546, P10415, P24522, O60603, P29728, P51617, P09693HLA-DOB, HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, OAS2, IRAK1, CD3GMore
Candesartan-cilexetilhsa05170Human immunodeficiency virus 1 infection1.24E-0414Q02750, P62879, P16298, P0DP23, Q05397, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5, P20333MAP2K1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2, TNFRSF1BMore
Candesartan-cilexetilhsa05200Pathways in cancer2.37E-0318P04637, Q9UJU2, P17252, Q09472, P43246, Q13485, P14923, P10415, Q13489, Q13077, P49767, P25116, O95267, P78417, P24522, P0DP23, P01568, P16871TP53, LEF1, PRKCA, EP300, MSH2, SMAD4, JUP, BCL2, BIRC3, TRAF1, VEGFC, F2R, RASGRP1, GSTO1, GADD45A, CALM1, IFNA21, IL7RMore
Candesartan-cilexetilhsa05202Transcriptional misregulation in cancer1.98E-027Q15532, P14923, Q13077, O15550, P04637, Q9C0K0, P24522SS18, JUP, TRAF1, UTX, TP53, BCL11B, GADD45AMore
Candesartan-cilexetilhsa05203Viral carcinogenesis2.93E-033Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Candesartan-cilexetilhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Candesartan-cilexetilhsa05210Colorectal cancer2.41E-024P10415, P04637, Q9UJU2, P24522BCL2, TP53, LEF1, GADD45AMore
Candesartan-cilexetilhsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Candesartan-cilexetilhsa05213Endometrial cancer1.53E-035O15169, Q9UJU2, Q02750, P04637, P24522AXIN1, LEF1, MAP2K1, TP53, GADD45AMore
Candesartan-cilexetilhsa05214Glioma8.71E-045P0DP23, Q16566, P17252, P04637, P24522CALM1, CAMK4, PRKCA, TP53, GADD45AMore
Candesartan-cilexetilhsa05215Prostate cancer1.94E-024P10415, Q9UJU2, Q09472, P04637BCL2, LEF1, EP300, TP53More
Candesartan-cilexetilhsa05216Thyroid cancer2.42E-043Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Candesartan-cilexetilhsa05217Basal cell carcinoma1.56E-033Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Candesartan-cilexetilhsa05222Small cell lung cancer1.94E-024P10415, Q13077, P04637, P24522BCL2, TRAF1, TP53, GADD45AMore
Candesartan-cilexetilhsa05224Breast cancer4.32E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Candesartan-cilexetilhsa05226Gastric cancer7.13E-047Q02750, Q9UJU2, O15169, P04637, P24522, P14923, P10415MAP2K1, LEF1, AXIN1, TP53, GADD45A, JUP, BCL2More
Candesartan-cilexetilhsa05230Central carbon metabolism in cancer4.04E-022P07195, P04637LDHB, TP53More
Candesartan-cilexetilhsa05322Systemic lupus erythematosus1.49E-055P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Candesartan-cilexetilhsa05418Fluid shear stress and atherosclerosis2.49E-0311Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2More

Community members of Candesartan-cilexetil (SDC: 2.54)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)