PharmaCoNets of Calcium-levulinate (SPCN: 13.95 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Calcium-levulinatehsa00230Purine metabolism4.60E-024Q13370, P36959, Q13956, P27707PDE3B, GMPR, PDE6H, DCKMore
Calcium-levulinatehsa00240Pyrimidine metabolism4.50E-022P32320, P27707CDA, DCKMore
Calcium-levulinatehsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin4.77E-021Q7LGA3HS2ST1More
Calcium-levulinatehsa00670One carbon pool by folate3.99E-022O95954, Q99707FTCD, MTRMore
Calcium-levulinatehsa00920Sulfur metabolism3.01E-021O95571ETHE1More
Calcium-levulinatehsa01100Metabolic pathways3.95E-0223Q9Y234, Q99707, P29218, P11310, P27707, Q13370, P36959, Q13956, P30043, Q02252, O60701, O14772, O95954, Q02318, P04406, O15466, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809LIPT1, MTR, IMPA1, ACADM, DCK, PDE3B, GMPR, PDE6H, BLVRB, ALDH6A1, UGDH, FPGT, FTCD, CYP27A1, GAPDH, ST8SIA5, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1More
Calcium-levulinatehsa01524Platinum drug resistance4.45E-024P10415, Q13489, P78417, P43246BCL2, BIRC3, GSTO1, MSH2More
Calcium-levulinatehsa02010ABC transporters4.89E-021Q99758ABCA3More
Calcium-levulinatehsa03013RNA transport4.79E-022P62826, P63279RAN, UBE2IMore
Calcium-levulinatehsa03015mRNA surveillance pathway3.62E-023O43148, P61326, P52298RNMT, MAGOH, NCBP2More
Calcium-levulinatehsa03040Spliceosome1.11E-0718Q14562, O43143, O60508, P17844, O14776, P08579, O75940, P52298, P09651, Q15365, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, P61326DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, MAGOHMore
Calcium-levulinatehsa03050Proteasome5.53E-032P43686, P28070PSMC4, PSMB4More
Calcium-levulinatehsa03320PPAR signaling pathway2.18E-022O00767, Q02318SCD, CYP27A1More
Calcium-levulinatehsa03460Fanconi anemia pathway3.70E-033Q9NPI8, O60673, Q9UNA4FANCF, REV3L, POLIMore
Calcium-levulinatehsa04014Ras signaling pathway2.65E-039P31751, P20827, P49767, Q13009, P17252, Q15311, P0DP23, P62873, P19174AKT2, EFNA1, VEGFC, TIAM1, PRKCA, RALBP1, CALM1, GNB1, PLCG1More
Calcium-levulinatehsa04015Rap1 signaling pathway5.41E-039P20827, P49767, Q13009, Q08828, P51828, P31751, P0DP23, P17252, P19174EFNA1, VEGFC, TIAM1, ADCY1, ADCY7, AKT2, CALM1, PRKCA, PLCG1More
Calcium-levulinatehsa04020Calcium signaling pathway1.04E-0611P27987, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P51828, P23634, P49767ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, VEGFCMore
Calcium-levulinatehsa04024cAMP signaling pathway3.01E-039Q08828, P51828, P31751, P0DP23, P23634, Q13557, Q13370, O15399, Q13009ADCY1, ADCY7, AKT2, CALM1, ATP2B4, CAMK2D, PDE3B, GRIN2D, TIAM1More
Calcium-levulinatehsa04062Chemokine signaling pathway2.04E-0210P51684, Q8NHW4, P19174, P62873, Q08828, P51828, Q13009, P14598, P42224, P31751CCR6, CCL4L2, PLCG1, GNB1, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2More
Calcium-levulinatehsa04064NF-kappa B signaling pathway2.28E-049P10415, Q13489, P51617, P01584, P29965, P19174, O75293, Q8NHW4, Q9NQC7BCL2, BIRC3, IRAK1, IL1B, CD40LG, PLCG1, GADD45B, CCL4L2, CYLDMore
Calcium-levulinatehsa04070Phosphatidylinositol signaling system5.66E-046P19174, P0DP23, P23743, P48426, P27987, P17252PLCG1, CALM1, DGKA, PIP4K2A, ITPKB, PRKCAMore
Calcium-levulinatehsa04071Sphingolipid signaling pathway3.36E-026P17252, Q13510, Q13362, P10415, Q9UQC2, P01042PRKCA, ASAH1, PPP2R5C, BCL2, GAB2, KNG1More
Calcium-levulinatehsa04072Phospholipase D signaling pathway2.03E-028P31751, P19174, P17252, Q15438, Q08828, P51828, P23743, P00734AKT2, PLCG1, PRKCA, PSCD1, ADCY1, ADCY7, DGKA, F2More
Calcium-levulinatehsa04140Autophagy - animal2.58E-027P31751, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9AKT2, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8More
Calcium-levulinatehsa04144Endocytosis8.99E-0312P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6More
Calcium-levulinatehsa04145Phagosome5.56E-038P60709, P63261, Q15075, Q15080, P14598, Q13509, Q13488, O60603ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TCIRG1, TLR2More
Calcium-levulinatehsa04151PI3K-Akt signaling pathway4.68E-0318O43521, P27348, P20827, P49767, Q13362, P08238, P62873, P16144, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, Q6ZUJ8BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AB1, GNB1, ITGB4, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, PIK3AP1More
Calcium-levulinatehsa04210Apoptosis6.18E-033P07384, P60709, P63261CAPN1, ACTB, ACTG1More
Calcium-levulinatehsa04217Necroptosis3.39E-0815P01568, P23458, Q13489, Q9NQC7, P42224, P08238, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351IFNA21, JAK1, BIRC3, CYLD, STAT1, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4BMore
Calcium-levulinatehsa04261Adrenergic signaling in cardiomyocytes4.43E-0611P09493, Q08828, P51828, P31751, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Calcium-levulinatehsa04360Axon guidance8.44E-048P61073, P16333, P20827, O95631, P17252, Q13557, P23528, P19174CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, CFL1, PLCG1More
Calcium-levulinatehsa04371Apelin signaling pathway3.08E-027P62873, P31751, Q08828, P51828, Q13370, Q13485, P0DP23GNB1, AKT2, ADCY1, ADCY7, PDE3B, SMAD4, CALM1More
Calcium-levulinatehsa04380Osteoclast differentiation4.18E-027Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1More
Calcium-levulinatehsa04390Hippo signaling pathway2.80E-022P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa04510Focal adhesion3.76E-027P16144, O75369, Q15942, P17252, Q13489, P10415, P49767ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, VEGFCMore
Calcium-levulinatehsa04520Adherens junction1.58E-022P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa04530Tight junction3.88E-033P60709, P63261, P60660ACTB, ACTG1, MYL6More
Calcium-levulinatehsa04540Gap junction4.08E-025P17252, Q13509, P68371, Q08828, P51828PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7More
Calcium-levulinatehsa04611Platelet activation2.61E-022P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa04613Neutrophil extracellular trap formation2.86E-026O60603, P08246, Q9UM07, Q6FI13, Q15080, P49913TLR2, ELA2, PADI4, H2AC18; H2AC19, NCF4, CAMPMore
Calcium-levulinatehsa04620Toll-like receptor signaling pathway1.33E-025P51617, P01568, P31751, P42224, Q8NHW4IRAK1, IFNA21, AKT2, STAT1, CCL4L2More
Calcium-levulinatehsa04621NOD-like receptor signaling pathway3.16E-029P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, P43490, P10415IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, PBEF1, BCL2More
Calcium-levulinatehsa04623Cytosolic DNA-sensing pathway4.25E-022P01568, Q8NHW4IFNA21, CCL4L2More
Calcium-levulinatehsa04630JAK-STAT signaling pathway1.16E-028P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21More
Calcium-levulinatehsa04640Hematopoietic cell lineage2.82E-034P08514, P21926, P07766, P09564ITGA2B, CD9, CD3E, CD7More
Calcium-levulinatehsa04662B cell receptor signaling pathway3.68E-022P25963, P20023NFKBIA, CR2More
Calcium-levulinatehsa04666Fc gamma R-mediated phagocytosis2.78E-026P08575, P19174, P23528, Q9UQC2, P14598, P17252PTPRC, PLCG1, CFL1, GAB2, NCF1, PRKCAMore
Calcium-levulinatehsa04670Leukocyte transendothelial migration4.07E-022P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa04713Circadian entrainment5.61E-057O15399, P0DP23, Q13557, P17252, P62873, Q08828, P51828GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, ADCY1, ADCY7More
Calcium-levulinatehsa04714Thermogenesis3.64E-044P15336, P60709, P63261, P36542ATF2, ACTB, ACTG1, ATP5C1More
Calcium-levulinatehsa04720Long-term potentiation3.26E-036P17252, Q13557, P0DP23, P18848, O15399, Q08828PRKCA, CAMK2D, CALM1, ATF4, GRIN2D, ADCY1More
Calcium-levulinatehsa04724Glutamatergic synapse5.91E-037P48058, O15399, Q08828, P51828, P17252, P62873, P15104GRIA4, GRIN2D, ADCY1, ADCY7, PRKCA, GNB1, GLULMore
Calcium-levulinatehsa04725Cholinergic synapse4.42E-048Q08828, P51828, P17252, P62873, P18848, Q13557, P31751, P10415ADCY1, ADCY7, PRKCA, GNB1, ATF4, CAMK2D, AKT2, BCL2More
Calcium-levulinatehsa04727GABAergic synapse4.08E-025Q08828, P51828, P62873, P46459, P17252ADCY1, ADCY7, GNB1, NSF, PRKCAMore
Calcium-levulinatehsa04740Olfactory transduction2.61E-023P62873, Q13557, P0DP23GNB1, CAMK2D, CALM1More
Calcium-levulinatehsa04744Phototransduction1.30E-052P62873, P0DP23GNB1, CALM1More
Calcium-levulinatehsa04750Inflammatory mediator regulation of TRP channels4.32E-058P01584, Q08828, P51828, Q13557, P19174, P17252, P0DP23, P01042IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PRKCA, CALM1, KNG1More
Calcium-levulinatehsa04911Insulin secretion3.47E-024Q08828, P17252, P18848, Q13557ADCY1, PRKCA, ATF4, CAMK2DMore
Calcium-levulinatehsa04912GnRH signaling pathway2.85E-025P17252, Q08828, P18848, Q13557, P0DP23PRKCA, ADCY1, ATF4, CAMK2D, CALM1More
Calcium-levulinatehsa04914Progesterone-mediated oocyte maturation3.26E-026Q08828, P51828, P31751, Q13370, Q9UJX4, P08238ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, HSP90AB1More
Calcium-levulinatehsa04915Estrogen signaling pathway3.28E-039P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2More
Calcium-levulinatehsa04919Thyroid hormone signaling pathway3.20E-022P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa04921Oxytocin signaling pathway1.77E-033P60660, P60709, P63261MYL6, ACTB, ACTG1More
Calcium-levulinatehsa04923Regulation of lipolysis in adipocytes2.12E-024Q08828, P51828, Q13370, P31751ADCY1, ADCY7, PDE3B, AKT2More
Calcium-levulinatehsa04925Aldosterone synthesis and secretion6.45E-047P18848, Q08828, P51828, P0DP23, P17252, Q13557, P23634ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B4More
Calcium-levulinatehsa04933AGE-RAGE signaling pathway in diabetic complications2.04E-068Q13485, P01584, P42224, P10415, P31751, P49767, P17252, P19174SMAD4, IL1B, STAT1, BCL2, AKT2, VEGFC, PRKCA, PLCG1More
Calcium-levulinatehsa04935Growth hormone synthesis, secretion and action3.93E-026P19174, Q08828, P51828, P17252, P31751, P42224PLCG1, ADCY1, ADCY7, PRKCA, AKT2, STAT1More
Calcium-levulinatehsa04970Salivary secretion1.35E-035Q08828, P51828, P23634, P17252, P0DP23ADCY1, ADCY7, ATP2B4, PRKCA, CALM1More
Calcium-levulinatehsa04971Gastric acid secretion1.02E-022P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa04972Pancreatic secretion1.92E-035P23634, P17252, Q08828, P51828, P62491ATP2B4, PRKCA, ADCY1, ADCY7, RAB11AMore
Calcium-levulinatehsa05014Amyotrophic lateral sclerosis2.98E-023P36542, P60709, P63261ATP5C1, ACTB, ACTG1More
Calcium-levulinatehsa05017Spinocerebellar ataxia3.80E-038P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12More
Calcium-levulinatehsa05031Amphetamine addiction2.85E-025O15399, P0DP23, Q13557, P18848, P17252GRIN2D, CALM1, CAMK2D, ATF4, PRKCAMore
Calcium-levulinatehsa05032Morphine addiction4.08E-025Q08828, P51828, P62873, Q13370, P17252ADCY1, ADCY7, GNB1, PDE3B, PRKCAMore
Calcium-levulinatehsa05100Bacterial invasion of epithelial cells1.02E-022P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa05110Vibrio cholerae infection3.95E-032P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa05131Shigellosis1.91E-023P60709, P63261, P07384ACTB, ACTG1, CAPN1More
Calcium-levulinatehsa05132Salmonella infection3.99E-0413P51617, P01584, P08238, Q96RF0, Q13489, P10415, P08575, O75369, Q13561, Q13509, P68371, P49754, Q9NP90IRAK1, IL1B, HSP90AB1, SNAG1, BIRC3, BCL2, PTPRC, FLNB, DCTN2, TUBB3, TUBB2C, VPS41, RAB9BMore
Calcium-levulinatehsa05133Pertussis3.94E-045P0DP23, P01584, P23528, P09871, P51617CALM1, IL1B, CFL1, C1S, IRAK1More
Calcium-levulinatehsa05135Yersinia infection3.88E-033P60709, P63261, Q16513ACTB, ACTG1, PKN2More
Calcium-levulinatehsa05140Leishmaniasis2.58E-025P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Calcium-levulinatehsa05143African trypanosomiasis3.87E-023P01584, P17252, P01042IL1B, PRKCA, KNG1More
Calcium-levulinatehsa05145Toxoplasmosis5.28E-059P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RAMore
Calcium-levulinatehsa05152Tuberculosis4.22E-024Q13488, O60603, P49913, Q9UDY8TCIRG1, TLR2, CAMP, MALT1More
Calcium-levulinatehsa05161Hepatitis B1.31E-0410P17252, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617PRKCA, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1More
Calcium-levulinatehsa05162Measles1.74E-0410P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2More
Calcium-levulinatehsa05163Human cytomegalovirus infection2.59E-0314P31751, P62873, P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, P17252, Q13651, P18848, P61769, P01568AKT2, GNB1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, PRKCA, IL10RA, ATF4, B2M, IFNA21More
Calcium-levulinatehsa05164Influenza A7.10E-033P48551, P60709, P63261IFNAR2, ACTB, ACTG1More
Calcium-levulinatehsa05168Herpes simplex virus 1 infection2.45E-0518P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P61769, P31751, Q13398, Q6P280, Q03923, Q9UDV6, P10415, Q14232IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, B2M, AKT2, ZNF211, ZNF529, ZNF85, ZNF212, BCL2, EIF2B1More
Calcium-levulinatehsa05170Human immunodeficiency virus 1 infection4.12E-0512P31751, P62873, P0DP23, P61073, P17252, P61769, P01568, P51617, P19174, P23528, P10415, Q9Y6Q5AKT2, GNB1, CALM1, CXCR4, PRKCA, B2M, IFNA21, IRAK1, PLCG1, CFL1, BCL2, AP1M2More
Calcium-levulinatehsa05200Pathways in cancer4.30E-0928P23458, P08238, P42224, P19174, Q15311, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P31751, Q08828, P51828, P62873, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042JAK1, HSP90AB1, STAT1, PLCG1, RALBP1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, AKT2, ADCY1, ADCY7, GNB1, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1More
Calcium-levulinatehsa05204Chemical carcinogenesis3.70E-033P00325, P78417, P33260ADH1B, GSTO1, CYP2C18More
Calcium-levulinatehsa05206MicroRNAs in cancer4.07E-022P15311, P63279VIL2, UBE2IMore
Calcium-levulinatehsa05212Pancreatic cancer5.55E-036P31751, Q15311, P23458, P42224, Q13485, O75293AKT2, RALBP1, JAK1, STAT1, SMAD4, GADD45BMore
Calcium-levulinatehsa05214Glioma1.87E-056P0DP23, Q13557, P17252, P31751, P19174, O75293CALM1, CAMK2D, PRKCA, AKT2, PLCG1, GADD45BMore
Calcium-levulinatehsa05225Hepatocellular carcinoma4.07E-022P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa05322Systemic lupus erythematosus4.22E-024P08246, P10747, Q6FI13, P05455ELA2, CD28, H2AC18; H2AC19, SSBMore
Calcium-levulinatehsa05323Rheumatoid arthritis2.00E-023Q13488, P10747, O60603TCIRG1, CD28, TLR2More
Calcium-levulinatehsa05340Primary immunodeficiency2.68E-022P11912, P07766CD79A, CD3EMore
Calcium-levulinatehsa05410Hypertrophic cardiomyopathy1.02E-022P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa05412Arrhythmogenic right ventricular cardiomyopathy8.96E-032P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa05414Dilated cardiomyopathy1.73E-022P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa05416Viral myocarditis8.96E-032P60709, P63261ACTB, ACTG1More
Calcium-levulinatehsa05418Fluid shear stress and atherosclerosis3.64E-038P14598, P78417, P60709, P63261, P10415, P0DP23, P08238, Q92974NCF1, GSTO1, ACTB, ACTG1, BCL2, CALM1, HSP90AB1, ARHGEF2More

Community members of Calcium-levulinate (SDC: 0.96)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)