PharmaCoNets of Calcitriol (SPCN: 74.19 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Calcitriolhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Calcitriolhsa00190Oxidative phosphorylation3.56E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Calcitriolhsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Calcitriolhsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Calcitriolhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Calcitriolhsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Calcitriolhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Calcitriolhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Calcitriolhsa00565Ether lipid metabolism3.94E-021Q8N661TMEM86BMore
Calcitriolhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Calcitriolhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Calcitriolhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Calcitriolhsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Calcitriolhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Calcitriolhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Calcitriolhsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Calcitriolhsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Calcitriolhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Calcitriolhsa03013RNA transport1.21E-0719O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, P23588, Q9Y6A5XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, EIF4B, TACC3More
Calcitriolhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Calcitriolhsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Calcitriolhsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Calcitriolhsa03320PPAR signaling pathway2.42E-034Q6PCB7, Q9UNU6, Q13133, Q02318SLC27A1, CYP8B1, NR1H3, CYP27A1More
Calcitriolhsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Calcitriolhsa04012ErbB signaling pathway2.98E-036P21860, P16333, Q13557, P19174, O14944, P01106ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYCMore
Calcitriolhsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Calcitriolhsa04015Rap1 signaling pathway2.99E-021P08069IGF1RMore
Calcitriolhsa04020Calcium signaling pathway6.50E-046Q96DU7, P45880, Q13557, P21860, P51828, P23634ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4More
Calcitriolhsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Calcitriolhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Calcitriolhsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Calcitriolhsa04070Phosphatidylinositol signaling system2.96E-023P19174, P49619, P27987PLCG1, DGKG, ITPKBMore
Calcitriolhsa04110Cell cycle1.65E-048Q9UBD5, P06493, O75293, P30304, P33981, P42773, P01106, Q13547ORC3, CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Calcitriolhsa04114Oocyte meiosis1.45E-046Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Calcitriolhsa04120Ubiquitin mediated proteolysis2.89E-022O95071, P0CG47UBR5, UBBMore
Calcitriolhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Calcitriolhsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Calcitriolhsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Calcitriolhsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Calcitriolhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Calcitriolhsa04145Phagosome1.66E-039Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Calcitriolhsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Calcitriolhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Calcitriolhsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Calcitriolhsa04213Longevity regulating pathway - multiple species1.66E-021P08069IGF1RMore
Calcitriolhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Calcitriolhsa04261Adrenergic signaling in cardiomyocytes3.98E-024P51828, Q99941, Q13557, P23634ADCY7, CREBL1, CAMK2D, ATP2B4More
Calcitriolhsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Calcitriolhsa04370VEGF signaling pathway9.46E-053P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Calcitriolhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Calcitriolhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Calcitriolhsa04510Focal adhesion3.48E-021P08069IGF1RMore
Calcitriolhsa04520Adherens junction8.29E-031P08069IGF1RMore
Calcitriolhsa04550Signaling pathways regulating pluripotency of stem cells9.61E-034Q13873, Q02750, P08069, Q86SE9BMPR2, MAP2K1, IGF1R, PCGF5More
Calcitriolhsa04613Neutrophil extracellular trap formation1.56E-025P19174, P11215, Q13547, P62807, Q16778PLCG1, ITGAM, HDAC1, HIST1H2BC, HIST2H2BEMore
Calcitriolhsa04630JAK-STAT signaling pathway3.20E-024P01106, P42224, P14784, Q13651MYC, STAT1, IL2RB, IL10RAMore
Calcitriolhsa04650Natural killer cell mediated cytotoxicity3.73E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Calcitriolhsa04658Th1 and Th2 cell differentiation1.01E-077P07766, P19174, P01730, P06239, P42224, P14784, Q13761CD3E, PLCG1, CD4, LCK, STAT1, IL2RB, RUNX3More
Calcitriolhsa04659Th17 cell differentiation6.83E-069P25963, P19174, P01730, P06239, P42224, P14784, P84022, Q13485, P07766NFKBIA, PLCG1, CD4, LCK, STAT1, IL2RB, SMAD3, SMAD4, CD3EMore
Calcitriolhsa04660T cell receptor signaling pathway4.08E-025P19174, P16333, P07766, P01730, P06239PLCG1, NCK1, CD3E, CD4, LCKMore
Calcitriolhsa04666Fc gamma R-mediated phagocytosis2.42E-025P23528, P06396, O14494, P14598, P17252CFL1, GSN, PLPP1, NCF1, PRKCAMore
Calcitriolhsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Calcitriolhsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Calcitriolhsa04720Long-term potentiation2.85E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Calcitriolhsa04730Long-term depression1.16E-021P08069IGF1RMore
Calcitriolhsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Calcitriolhsa04750Inflammatory mediator regulation of TRP channels3.74E-023P01584, P51828, Q13557IL1B, ADCY7, CAMK2DMore
Calcitriolhsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Calcitriolhsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Calcitriolhsa04914Progesterone-mediated oocyte maturation2.23E-045P08069, Q17RY0, Q9Y6D9, P51812, Q02750IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Calcitriolhsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Calcitriolhsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Calcitriolhsa04919Thyroid hormone signaling pathway1.64E-024P19174, P42224, Q13547, P01106PLCG1, STAT1, HDAC1, MYCMore
Calcitriolhsa04925Aldosterone synthesis and secretion5.19E-034Q99941, P51828, Q13557, P23634CREBL1, ADCY7, CAMK2D, ATP2B4More
Calcitriolhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Calcitriolhsa04934Cushing syndrome3.48E-034Q99941, P51828, O15169, Q13557CREBL1, ADCY7, AXIN1, CAMK2DMore
Calcitriolhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Calcitriolhsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Calcitriolhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Calcitriolhsa05010Alzheimer disease2.07E-027Q92542, P05496, P12074, O75460, P01584, O15169, P45880NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2More
Calcitriolhsa05020Prion disease1.81E-027P01584, P46531, P11142, P05496, P12074, P45880, Q99941IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1More
Calcitriolhsa05022Pathways of neurodegeneration - multiple diseases2.95E-022Q06055, O15020ATP5G2, SPTBN2More
Calcitriolhsa05034Alcoholism4.79E-023Q13547, P62807, Q16778HDAC1, HIST1H2BC, HIST2H2BEMore
Calcitriolhsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Calcitriolhsa05132Salmonella infection3.44E-0311P51617, P25963, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, NFKBIA, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Calcitriolhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Calcitriolhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Calcitriolhsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Calcitriolhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Calcitriolhsa05169Epstein-Barr virus infection3.66E-025P01106, Q13547, Q13761, P42224, P07766MYC, HDAC1, RUNX3, STAT1, CD3EMore
Calcitriolhsa05170Human immunodeficiency virus 1 infection5.94E-0312P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2More
Calcitriolhsa05202Transcriptional misregulation in cancer2.68E-0312Q12778, Q15532, P14780, P14923, Q16548, Q13489, Q13077, P08069, P35226, P05164, P08246, Q9C0K0FOXO1, SS18, MMP9, JUP, BCL2A1, BIRC3, TRAF1, IGF1R, BMI1, MPO, ELA2, BCL11BMore
Calcitriolhsa05203Viral carcinogenesis9.16E-035Q13547, P12814, P06493, P62807, Q16778HDAC1, ACTN1, CDK1, HIST1H2BC, HIST2H2BEMore
Calcitriolhsa05205Proteoglycans in cancer4.93E-0311Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P08069, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, IGF1R, WNT1, PTCH1, CD63More
Calcitriolhsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Calcitriolhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Calcitriolhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Calcitriolhsa05214Glioma9.95E-031P08069IGF1RMore
Calcitriolhsa05215Prostate cancer1.33E-021P08069IGF1RMore
Calcitriolhsa05218Melanoma6.63E-031P08069IGF1RMore
Calcitriolhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Calcitriolhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Calcitriolhsa05223Non-small cell lung cancer4.24E-023P19174, Q9HC35, O75293PLCG1, EML4, GADD45BMore
Calcitriolhsa05224Breast cancer1.49E-021P08069IGF1RMore
Calcitriolhsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Calcitriolhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Calcitriolhsa05231Choline metabolism in cancer1.14E-043Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Calcitriolhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer7.21E-066P19174, P07766, P06239, P42224, Q9HC35, P01730PLCG1, CD3E, LCK, STAT1, EML4, CD4More
Calcitriolhsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Calcitriolhsa05322Systemic lupus erythematosus2.75E-023P62807, Q16778, P12814HIST1H2BC, HIST2H2BE, ACTN1More
Calcitriolhsa05340Primary immunodeficiency4.24E-023P01730, P07766, P06239CD4, CD3E, LCKMore

Community members of Calcitriol (SDC: 5.32)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)