PharmaCoNets of Calcifediol (SPCN: 70.03 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Calcifediolhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Calcifediolhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Calcifediolhsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Calcifediolhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Calcifediolhsa00561Glycerolipid metabolism2.51E-022P51648, P23743ALDH3A2, DGKAMore
Calcifediolhsa00562Inositol phosphate metabolism7.30E-044P27987, Q96PE3, P19174, P42338ITPKB, INPP4A, PLCG1, PIK3CBMore
Calcifediolhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Calcifediolhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Calcifediolhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Calcifediolhsa00620Pyruvate metabolism2.51E-022P40925, P51648MDH1, ALDH3A2More
Calcifediolhsa00630Glyoxylate and dicarboxylate metabolism2.78E-032P40925, P15104MDH1, GLULMore
Calcifediolhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Calcifediolhsa01100Metabolic pathways3.67E-0319Q9Y259, P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, Q13956, P40925, P23743, P49619, O95954, Q02318, P43034, P09917, Q9UBX8, Q53FZ2, P35573CHKB, GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, PDE6H, MDH1, DGKA, DGKG, FTCD, CYP27A1, PAFAH1B1, ALOX5, B4GALT6, ACSM3, AGLMore
Calcifediolhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Calcifediolhsa01521EGFR tyrosine kinase inhibitor resistance2.46E-045Q92529, P19174, P42338, P08069, Q9NRA1SHC3, PLCG1, PIK3CB, IGF1R, PDGFCMore
Calcifediolhsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Calcifediolhsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Calcifediolhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Calcifediolhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Calcifediolhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Calcifediolhsa03320PPAR signaling pathway2.42E-034Q6PCB7, Q9UNU6, Q13133, Q02318SLC27A1, CYP8B1, NR1H3, CYP27A1More
Calcifediolhsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Calcifediolhsa04012ErbB signaling pathway8.14E-045P16333, Q92529, P19174, P42338, P01106NCK1, SHC3, PLCG1, PIK3CB, MYCMore
Calcifediolhsa04014Ras signaling pathway6.46E-058P42338, Q92529, Q9NRA1, P49767, P08069, P63218, P50151, P19174PIK3CB, SHC3, PDGFC, VEGFC, IGF1R, GNG5, GNG10, PLCG1More
Calcifediolhsa04015Rap1 signaling pathway8.98E-035Q9NRA1, P49767, P08069, P42338, P19174PDGFC, VEGFC, IGF1R, PIK3CB, PLCG1More
Calcifediolhsa04020Calcium signaling pathway2.16E-024P27987, P19174, Q9NRA1, P49767ITPKB, PLCG1, PDGFC, VEGFCMore
Calcifediolhsa04062Chemokine signaling pathway4.35E-036P07948, P42338, P19174, Q92529, P63218, P50151LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10More
Calcifediolhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Calcifediolhsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Calcifediolhsa04070Phosphatidylinositol signaling system3.67E-056P19174, P42338, P23743, P49619, Q96PE3, P27987PLCG1, PIK3CB, DGKA, DGKG, INPP4A, ITPKBMore
Calcifediolhsa04072Phospholipase D signaling pathway1.85E-046P42338, Q92529, P19174, Q14344, P23743, Q9NRA1PIK3CB, SHC3, PLCG1, GNA13, DGKA, PDGFCMore
Calcifediolhsa04110Cell cycle1.65E-048Q9UBD5, P06493, O75293, P30304, P33981, P42773, P01106, Q13547ORC3, CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Calcifediolhsa04114Oocyte meiosis1.45E-046Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Calcifediolhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Calcifediolhsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Calcifediolhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Calcifediolhsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Calcifediolhsa04151PI3K-Akt signaling pathway2.55E-038P42338, Q9NRA1, P49767, P08238, P63218, P50151, O15335, P14784PIK3CB, PDGFC, VEGFC, HSP90AB1, GNG5, GNG10, CHAD, IL2RBMore
Calcifediolhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Calcifediolhsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Calcifediolhsa04213Longevity regulating pathway - multiple species1.66E-021P08069IGF1RMore
Calcifediolhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Calcifediolhsa04370VEGF signaling pathway2.44E-065P19174, P16298, P42338, Q05397, Q02750PLCG1, PPP3CB, PIK3CB, PTK2, MAP2K1More
Calcifediolhsa04371Apelin signaling pathway1.24E-024P63218, P50151, Q13370, Q14344GNG5, GNG10, PDE3B, GNA13More
Calcifediolhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Calcifediolhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Calcifediolhsa04510Focal adhesion3.52E-036P42338, O15335, P08069, Q9NRA1, P49767, Q92529PIK3CB, CHAD, IGF1R, PDGFC, VEGFC, SHC3More
Calcifediolhsa04520Adherens junction8.29E-031P08069IGF1RMore
Calcifediolhsa04550Signaling pathways regulating pluripotency of stem cells9.61E-034Q13873, Q02750, P08069, Q86SE9BMPR2, MAP2K1, IGF1R, PCGF5More
Calcifediolhsa04611Platelet activation4.11E-023P42338, Q14344, P07948PIK3CB, GNA13, LYNMore
Calcifediolhsa04613Neutrophil extracellular trap formation1.56E-025P19174, P11215, Q13547, P62807, Q16778PLCG1, ITGAM, HDAC1, HIST1H2BC, HIST2H2BEMore
Calcifediolhsa04630JAK-STAT signaling pathway3.20E-024P01106, P42224, P14784, Q13651MYC, STAT1, IL2RB, IL10RAMore
Calcifediolhsa04650Natural killer cell mediated cytotoxicity3.73E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Calcifediolhsa04658Th1 and Th2 cell differentiation4.17E-097P07766, P19174, P01730, P06239, P42224, P14784, Q13761CD3E, PLCG1, CD4, LCK, STAT1, IL2RB, RUNX3More
Calcifediolhsa04659Th17 cell differentiation4.89E-0710P25963, P19174, P01730, P06239, P42224, P14784, P84022, Q13485, P08238, P07766NFKBIA, PLCG1, CD4, LCK, STAT1, IL2RB, SMAD3, SMAD4, HSP90AB1, CD3EMore
Calcifediolhsa04660T cell receptor signaling pathway4.08E-025P19174, P16333, P07766, P01730, P06239PLCG1, NCK1, CD3E, CD4, LCKMore
Calcifediolhsa04662B cell receptor signaling pathway2.78E-023P42338, P07948, Q8N149PIK3CB, LYN, LILRA2More
Calcifediolhsa04664Fc epsilon RI signaling pathway7.30E-044P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Calcifediolhsa04666Fc gamma R-mediated phagocytosis1.73E-023P07948, P42338, P19174LYN, PIK3CB, PLCG1More
Calcifediolhsa04720Long-term potentiation2.85E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Calcifediolhsa04722Neurotrophin signaling pathway4.87E-023P42338, P19174, Q92529PIK3CB, PLCG1, SHC3More
Calcifediolhsa04724Glutamatergic synapse1.73E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Calcifediolhsa04725Cholinergic synapse1.73E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Calcifediolhsa04726Serotonergic synapse3.41E-023P63218, P50151, P09917GNG5, GNG10, ALOX5More
Calcifediolhsa04727GABAergic synapse6.57E-033P63218, P50151, P15104GNG5, GNG10, GLULMore
Calcifediolhsa04730Long-term depression3.83E-033Q14344, P08069, P07948GNA13, IGF1R, LYNMore
Calcifediolhsa04910Insulin signaling pathway4.11E-023Q92529, Q13370, P42338SHC3, PDE3B, PIK3CBMore
Calcifediolhsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Calcifediolhsa04914Progesterone-mediated oocyte maturation1.40E-058P08069, Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750IGF1R, CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1More
Calcifediolhsa04915Estrogen signaling pathway4.76E-034P42338, Q92529, P08238, P11142PIK3CB, SHC3, HSP90AB1, HSPA8More
Calcifediolhsa04919Thyroid hormone signaling pathway1.64E-024P19174, P42224, Q13547, P01106PLCG1, STAT1, HDAC1, MYCMore
Calcifediolhsa04923Regulation of lipolysis in adipocytes3.64E-022Q13370, P42338PDE3B, PIK3CBMore
Calcifediolhsa04926Relaxin signaling pathway1.31E-035P42338, P63218, P50151, P49767, Q92529PIK3CB, GNG5, GNG10, VEGFC, SHC3More
Calcifediolhsa04933AGE-RAGE signaling pathway in diabetic complications1.47E-036P84022, Q13485, P10415, P42338, P49767, P19174SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1More
Calcifediolhsa04935Growth hormone synthesis, secretion and action2.78E-023P19174, P42338, Q92529PLCG1, PIK3CB, SHC3More
Calcifediolhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Calcifediolhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Calcifediolhsa05022Pathways of neurodegeneration - multiple diseases2.95E-022Q06055, O15020ATP5G2, SPTBN2More
Calcifediolhsa05032Morphine addiction2.22E-023P63218, P50151, Q13370GNG5, GNG10, PDE3BMore
Calcifediolhsa05034Alcoholism4.79E-023Q13547, P62807, Q16778HDAC1, HIST1H2BC, HIST2H2BEMore
Calcifediolhsa05100Bacterial invasion of epithelial cells1.94E-035Q14141, Q05397, P42338, Q92529, Q96JJ3SEPT6, PTK2, PIK3CB, SHC3, ELMO2More
Calcifediolhsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Calcifediolhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Calcifediolhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Calcifediolhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Calcifediolhsa05162Measles3.91E-024P14784, P07766, P42338, P11142IL2RB, CD3E, PIK3CB, HSPA8More
Calcifediolhsa05163Human cytomegalovirus infection1.14E-025P42338, P63218, P50151, Q14344, P30101PIK3CB, GNG5, GNG10, GNA13, PDIA3More
Calcifediolhsa05167Kaposi sarcoma-associated herpesvirus infection1.14E-025P42338, P63218, P50151, P19174, P07948PIK3CB, GNG5, GNG10, PLCG1, LYNMore
Calcifediolhsa05169Epstein-Barr virus infection3.39E-038P01106, Q13547, P42338, P07948, P30101, Q13761, P42224, P07766MYC, HDAC1, PIK3CB, LYN, PDIA3, RUNX3, STAT1, CD3EMore
Calcifediolhsa05170Human immunodeficiency virus 1 infection7.03E-036P42338, P63218, P50151, P30101, P19174, P07766PIK3CB, GNG5, GNG10, PDIA3, PLCG1, CD3EMore
Calcifediolhsa05200Pathways in cancer3.05E-028P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RBMore
Calcifediolhsa05202Transcriptional misregulation in cancer2.82E-021P08069IGF1RMore
Calcifediolhsa05203Viral carcinogenesis9.16E-035Q13547, P12814, P06493, P62807, Q16778HDAC1, ACTN1, CDK1, HIST1H2BC, HIST2H2BEMore
Calcifediolhsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Calcifediolhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Calcifediolhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Calcifediolhsa05214Glioma8.47E-044P08069, Q92529, P42338, P19174IGF1R, SHC3, PIK3CB, PLCG1More
Calcifediolhsa05215Prostate cancer5.38E-034P08069, Q9NRA1, P08238, P42338IGF1R, PDGFC, HSP90AB1, PIK3CBMore
Calcifediolhsa05218Melanoma2.85E-033P08069, Q9NRA1, P42338IGF1R, PDGFC, PIK3CBMore
Calcifediolhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Calcifediolhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Calcifediolhsa05223Non-small cell lung cancer4.24E-023P19174, Q9HC35, O75293PLCG1, EML4, GADD45BMore
Calcifediolhsa05224Breast cancer1.49E-021P08069IGF1RMore
Calcifediolhsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Calcifediolhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Calcifediolhsa05231Choline metabolism in cancer5.46E-076P42338, Q9NRA1, Q9Y259, P19174, P23743, P49619PIK3CB, PDGFC, CHKB, PLCG1, DGKA, DGKGMore
Calcifediolhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer7.21E-066P19174, P07766, P06239, P42224, Q9HC35, P01730PLCG1, CD3E, LCK, STAT1, EML4, CD4More
Calcifediolhsa05322Systemic lupus erythematosus2.75E-023P62807, Q16778, P12814HIST1H2BC, HIST2H2BE, ACTN1More
Calcifediolhsa05340Primary immunodeficiency4.24E-023P01730, P07766, P06239CD4, CD3E, LCKMore

Community members of Calcifediol (SDC: 4.75)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P06746POLBDNA polymerase betaPredicted00.45730.18680.48561.0878
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)