PharmaCoNets of Butobarbital (SPCN: 5.55 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Butobarbitalhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Butobarbitalhsa00500Starch and sucrose metabolism2.86E-022O43451, P46976MGAM, GYG1More
Butobarbitalhsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Butobarbitalhsa00770Pantothenate and CoA biosynthesis1.78E-022O95498, O95497VNN2, VNN1More
Butobarbitalhsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Butobarbitalhsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Butobarbitalhsa03050Proteasome1.40E-021P55036PSMD4More
Butobarbitalhsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Butobarbitalhsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Butobarbitalhsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Butobarbitalhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Butobarbitalhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Butobarbitalhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Butobarbitalhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Butobarbitalhsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Butobarbitalhsa04640Hematopoietic cell lineage4.27E-024P08514, P14778, P01730, P13765ITGA2B, IL1R1, CD4, HLA-DOBMore
Butobarbitalhsa04659Th17 cell differentiation2.73E-024Q16539, P01730, P13765, P14778MAPK14, CD4, HLA-DOB, IL1R1More
Butobarbitalhsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Butobarbitalhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Butobarbitalhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Butobarbitalhsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Butobarbitalhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Butobarbitalhsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Butobarbitalhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Butobarbitalhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Butobarbitalhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Butobarbitalhsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Butobarbitalhsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Butobarbitalhsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Butobarbitalhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Butobarbitalhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Butobarbitalhsa05340Primary immunodeficiency1.58E-023P01730, P11912, Q8WV28CD4, CD79A, BLNKMore

Community members of Butobarbital (SDC: 1.59)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Predicted00.15590.43870.16951.1248
P48058GRIA4Glutamate receptor 4Predicted00.40370.12090.37480.8184
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonPredicted00.13940.40970.15791.0469
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Predicted00.15590.43870.16951.1248
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)