PharmaCoNets of Butamben (SPCN: 35.25 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Butambenhsa00061Fatty acid biosynthesis4.07E-021P33121ACSL1More
Butambenhsa00071Fatty acid degradation2.52E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Butambenhsa00190Oxidative phosphorylation3.73E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Butambenhsa00500Starch and sucrose metabolism1.07E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Butambenhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Butambenhsa00514Other types of O-glycan biosynthesis3.20E-022O15294, Q9NY28OGT, GALNT8More
Butambenhsa00531Glycosaminoglycan degradation8.18E-042P15586, P34059GNS, GALNSMore
Butambenhsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate1.29E-031Q9Y2C2USTMore
Butambenhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Butambenhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Butambenhsa00604Glycosphingolipid biosynthesis - ganglio series1.34E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Butambenhsa00630Glyoxylate and dicarboxylate metabolism4.12E-032P40925, P15104MDH1, GLULMore
Butambenhsa00730Thiamine metabolism8.96E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Butambenhsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Butambenhsa00770Pantothenate and CoA biosynthesis2.27E-022O95498, O95497VNN2, VNN1More
Butambenhsa00970Aminoacyl-tRNA biosynthesis2.77E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Butambenhsa00980Metabolism of xenobiotics by cytochrome P4503.20E-022P78417, P11712GSTO1, CYP2C9More
Butambenhsa00982Drug metabolism - cytochrome P4503.20E-022P11712, P78417CYP2C9, GSTO1More
Butambenhsa01100Metabolic pathways2.61E-0332P05089, O14521, O95455, P21953, P32320, Q13370, P11766, P06280, Q16875, O43286, O43451, P11712, P05186, P24666, P23743, O60701, Q9HCC0, P33121, Q08477, P15907, Q9NY28, Q9UNP4, P09960, P37837, P32321, Q9BPW9, Q9UHY7, P43490, Q9Y2B2, P46976, P06737, Q16718ARG1, SDHD, TGDS, BCKDHB, CDA, PDE3B, ADH5, GLA, PFKFB3, B4GALT5, MGAM, CYP2C9, ALPL, ACP1, DGKA, UGDH, MCCC2, ACSL1, CYP4F3, ST6GAL1, GALNT8, ST3GAL5, LTA4H, TALDO1, DCTD, DHRS9, ENOPH1, PBEF1, PIGL, GYG1, PYGL, NDUFA5More
Butambenhsa01524Platinum drug resistance3.62E-024Q13489, P98170, P78417, P43246BIRC3, BIRC4, GSTO1, MSH2More
Butambenhsa03008Ribosome biogenesis in eukaryotes2.06E-022Q9NYH9, Q9BVP2UTP6, GNL3More
Butambenhsa03010Ribosome1.03E-022P46777, P50914RPL5, RPL14More
Butambenhsa03022Basal transcription factors2.17E-022O00268, Q15544TAF4, TAF11More
Butambenhsa03040Spliceosome3.17E-026Q14562, O43143, Q07955, Q13243, P11142, O75643DHX8, DHX15, SFRS1, SFRS5, HSPA8, ASCC3L1More
Butambenhsa03050Proteasome3.93E-021P62195PSMC5More
Butambenhsa04012ErbB signaling pathway4.28E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Butambenhsa04014Ras signaling pathway4.38E-025P20827, P49767, Q14644, P0DP23, P62873EFNA1, VEGFC, RASA3, CALM1, GNB1More
Butambenhsa04020Calcium signaling pathway4.93E-023P17252, P25116, P20020PRKCA, F2R, ATP2B1More
Butambenhsa04024cAMP signaling pathway4.93E-023P20020, Q13370, P25116ATP2B1, PDE3B, F2RMore
Butambenhsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Butambenhsa04064NF-kappa B signaling pathway2.63E-0311P10415, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341BCL2, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1More
Butambenhsa04070Phosphatidylinositol signaling system2.56E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Butambenhsa04072Phospholipase D signaling pathway1.54E-035Q92529, P25116, P17252, Q14344, P23743SHC3, F2R, PRKCA, GNA13, DGKAMore
Butambenhsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Butambenhsa04141Protein processing in endoplasmic reticulum3.07E-025P30101, P60604, P11142, P08238, Q9UNL2PDIA3, UBE2G2, HSPA8, HSP90AB1, SSR3More
Butambenhsa04142Lysosome1.14E-023P43234, P15586, P34059CTSO, GNS, GALNSMore
Butambenhsa04145Phagosome3.69E-027O75015, Q15080, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Butambenhsa04150mTOR signaling pathway4.38E-045P42338, Q9NQL2, Q13322, P49841, Q93098PIK3CB, RRAGD, GRB10, GSK3B, WNT8BMore
Butambenhsa04210Apoptosis9.18E-034P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Butambenhsa04217Necroptosis2.87E-038P01568, Q13489, P42224, P08238, Q6FI13, Q93077, O43633, Q08752IFNA21, BIRC3, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, CHMP2A, PPIDMore
Butambenhsa04261Adrenergic signaling in cardiomyocytes3.29E-023P09493, P17252, P20020TPM1, PRKCA, ATP2B1More
Butambenhsa04371Apelin signaling pathway5.32E-048P62873, P63218, Q13370, Q14814, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, PDE3B, MEF2D, SMAD4, SMAD3, CAMK4, CALM1More
Butambenhsa04380Osteoclast differentiation4.80E-024P06239, P42338, P14778, Q8N149LCK, PIK3CB, IL1R1, LILRA2More
Butambenhsa04610Complement and coagulation cascades4.69E-031P0C0L4C4AMore
Butambenhsa04612Antigen processing and presentation3.69E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Butambenhsa04613Neutrophil extracellular trap formation2.16E-027P19174, P11215, Q13547, Q93077, P62807, O60814, P60709PLCG1, ITGAM, HDAC1, HIST1H2AC, HIST1H2BC, H2BC12, ACTBMore
Butambenhsa04621NOD-like receptor signaling pathway1.93E-028Q16539, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838MAPK14, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4More
Butambenhsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Butambenhsa04640Hematopoietic cell lineage4.09E-0310P13612, P27930, P15144, P25063, P04234, P09693, P01732, P13765, P20036, P01375ITGA4, IL1R2, ANPEP, CD24, CD3D, CD3G, CD8A, HLA-DOB, HLA-DPA1, TNFMore
Butambenhsa04650Natural killer cell mediated cytotoxicity1.19E-029P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Butambenhsa04657IL-17 signaling pathway1.05E-0310P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, Q9UJX4, P04141, P01375HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, CSF2, TNFMore
Butambenhsa04658Th1 and Th2 cell differentiation5.05E-0515Q04759, P07766, P04234, P20963, P09693, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, P20036, Q13761PRKCQ, CD3E, CD3D, CD247, CD3G, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, HLA-DPA1, RUNX3More
Butambenhsa04659Th17 cell differentiation3.43E-0516Q04759, P19174, P06239, P42224, P14784, P13765, P20036, P14778, Q9HBE5, Q9UL17, P23771, P08238, P07766, P09693, P04234, P20963PRKCQ, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, HLA-DPA1, IL1R1, IL21R, TBX21, GATA3, HSP90AB1, CD3E, CD3G, CD3D, CD247More
Butambenhsa04660T cell receptor signaling pathway4.75E-0310P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCKMore
Butambenhsa04662B cell receptor signaling pathway7.25E-034P49841, P42338, P21854, Q8N149GSK3B, PIK3CB, CD72, LILRA2More
Butambenhsa04672Intestinal immune network for IgA production3.16E-021P20036HLA-DPA1More
Butambenhsa04714Thermogenesis1.99E-023P33121, Q16718, O14521ACSL1, NDUFA5, SDHDMore
Butambenhsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Butambenhsa04726Serotonergic synapse1.64E-023P17252, P31645, P11712PRKCA, SLC6A4, CYP2C9More
Butambenhsa04730Long-term depression3.52E-021Q14344GNA13More
Butambenhsa04744Phototransduction5.04E-052P62873, P0DP23GNB1, CALM1More
Butambenhsa04750Inflammatory mediator regulation of TRP channels9.08E-034P14778, P42338, Q9Y5S1, P24723IL1R1, PIK3CB, TRPV2, PRKCHMore
Butambenhsa04919Thyroid hormone signaling pathway2.48E-025P19174, P42224, P60709, Q13547, P01106PLCG1, STAT1, ACTB, HDAC1, MYCMore
Butambenhsa04929GnRH secretion3.63E-022P42338, P49407PIK3CB, ARRB1More
Butambenhsa04933AGE-RAGE signaling pathway in diabetic complications2.33E-024P84022, Q13485, Q12778, P49767SMAD3, SMAD4, FOXO1, VEGFCMore
Butambenhsa04940Type I diabetes mellitus4.05E-021P20036HLA-DPA1More
Butambenhsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Butambenhsa04961Endocrine and other factor-regulated calcium reabsorption1.48E-022P20020, P17252ATP2B1, PRKCAMore
Butambenhsa04970Salivary secretion4.83E-022P20020, P17252ATP2B1, PRKCAMore
Butambenhsa04972Pancreatic secretion1.48E-022P20020, P17252ATP2B1, PRKCAMore
Butambenhsa04973Carbohydrate digestion and absorption4.12E-032O43451, P42338MGAM, PIK3CBMore
Butambenhsa05010Alzheimer disease1.23E-022P17861, P62195XBP1, PSMC5More
Butambenhsa05012Parkinson disease7.44E-032P17861, P62195XBP1, PSMC5More
Butambenhsa05014Amyotrophic lateral sclerosis2.32E-043P17861, P62195, Q53GS7XBP1, PSMC5, GLE1More
Butambenhsa05016Huntington disease2.93E-024Q16718, O14521, O00268, Q13561NDUFA5, SDHD, TAF4, DCTN2More
Butambenhsa05017Spinocerebellar ataxia1.95E-032P17861, P62195XBP1, PSMC5More
Butambenhsa05022Pathways of neurodegeneration - multiple diseases4.41E-037Q16718, O14521, P17861, Q13561, P17252, Q08752, P62195NDUFA5, SDHD, XBP1, DCTN2, PRKCA, PPID, PSMC5More
Butambenhsa05032Morphine addiction1.90E-024P62873, P63218, Q13370, P43250GNB1, GNG5, PDE3B, GRK6More
Butambenhsa05034Alcoholism2.43E-049Q16566, Q13547, P0DP23, P62873, P63218, Q93077, P62807, O60814, P68431CAMK4, HDAC1, CALM1, GNB1, GNG5, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Butambenhsa05120Epithelial cell signaling in Helicobacter pylori infection2.27E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Butambenhsa05133Pertussis1.88E-023P11215, P0DP23, P23528ITGAM, CALM1, CFL1More
Butambenhsa05134Legionellosis4.28E-023P11215, P11142, P19875ITGAM, HSPA8, CXCL2More
Butambenhsa05140Leishmaniasis1.29E-0412P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Butambenhsa05142Chagas disease4.93E-021P04234CD3DMore
Butambenhsa05144Malaria1.14E-025P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Butambenhsa05146Amoebiasis2.30E-038P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Butambenhsa05150Staphylococcus aureus infection4.36E-022P0C0L4, P13646C4A, KRT13More
Butambenhsa05163Human cytomegalovirus infection3.28E-027P01375, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Butambenhsa05166Human T-cell leukemia virus 1 infection9.87E-032P04234, P20036CD3D, HLA-DPA1More
Butambenhsa05167Kaposi sarcoma-associated herpesvirus infection8.64E-037P42224, P62873, P63218, P19875, P19174, P01106, P0DP23STAT1, GNB1, GNG5, CXCL2, PLCG1, MYC, CALM1More
Butambenhsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Butambenhsa05169Epstein-Barr virus infection2.48E-039P20036, P01106, Q13547, P30101, Q13761, O75293, P42224, P04234, P07766HLA-DPA1, MYC, HDAC1, PDIA3, RUNX3, GADD45B, STAT1, CD3D, CD3EMore
Butambenhsa05200Pathways in cancer6.13E-0420Q13751, P08238, P42224, P19174, P01106, P43246, P84022, Q13485, P20585, Q13547, Q13489, P98170, P49767, Q12778, P62873, P63218, P78417, O75293, P0DP23, P14784LAMB3, HSP90AB1, STAT1, PLCG1, MYC, MSH2, SMAD3, SMAD4, MSH3, HDAC1, BIRC3, BIRC4, VEGFC, FOXO1, GNB1, GNG5, GSTO1, GADD45B, CALM1, IL2RBMore
Butambenhsa05202Transcriptional misregulation in cancer2.35E-0212Q13315, P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522ATM, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Butambenhsa05203Viral carcinogenesis3.56E-026P06746, P29083, Q13547, P12814, P62807, O60814POLB, GTF2E1, HDAC1, ACTN1, HIST1H2BC, H2BC12More
Butambenhsa05205Proteoglycans in cancer4.43E-023P63261, P04637, Q06124ACTG1, TP53, PTPN11More
Butambenhsa05206MicroRNAs in cancer3.17E-026P30304, P09493, P01106, Q9Y4H2, Q13547, P19174CDC25A, TPM1, MYC, IRS2, HDAC1, PLCG1More
Butambenhsa05211Renal cell carcinoma7.75E-032Q06124, Q99814PTPN11, EPAS1More
Butambenhsa05212Pancreatic cancer2.60E-022P04637, P24522TP53, GADD45AMore
Butambenhsa05213Endometrial cancer2.60E-022P04637, P24522TP53, GADD45AMore
Butambenhsa05214Glioma3.46E-047P09619, P0DP23, Q02750, P04637, P19174, P24522, O75293PDGFRB, CALM1, MAP2K1, TP53, PLCG1, GADD45A, GADD45BMore
Butambenhsa05216Thyroid cancer1.14E-022P04637, P24522TP53, GADD45AMore
Butambenhsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Butambenhsa05218Melanoma3.52E-044P09619, P04637, Q02750, P24522PDGFRB, TP53, MAP2K1, GADD45AMore
Butambenhsa05220Chronic myeloid leukemia7.90E-033Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Butambenhsa05223Non-small cell lung cancer3.19E-022P04637, P24522TP53, GADD45AMore
Butambenhsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Butambenhsa05225Hepatocellular carcinoma2.06E-035Q92529, P04637, P24522, P51531, P63261SHC3, TP53, GADD45A, SMARCA2, ACTG1More
Butambenhsa05230Central carbon metabolism in cancer4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Butambenhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.93E-021P04234CD3DMore
Butambenhsa05310Asthma1.20E-024P13765, P20036, P12724, P01375HLA-DOB, HLA-DPA1, RNASE3, TNFMore
Butambenhsa05320Autoimmune thyroid disease3.60E-021P20036HLA-DPA1More
Butambenhsa05321Inflammatory bowel disease1.40E-048O60603, P01375, P13765, P20036, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, HLA-DPA1, STAT4, TBX21, GATA3, IL21RMore
Butambenhsa05322Systemic lupus erythematosus4.50E-024Q93077, P62807, O60814, P12814HIST1H2AC, HIST1H2BC, H2BC12, ACTN1More
Butambenhsa05330Allograft rejection3.60E-021P20036HLA-DPA1More
Butambenhsa05332Graft-versus-host disease1.57E-025P13765, P20036, P01375, P26715, Q13241HLA-DOB, HLA-DPA1, TNF, KLRC1, KLRD1More
Butambenhsa05340Primary immunodeficiency1.81E-021P04234CD3DMore
Butambenhsa05415Diabetic cardiomyopathy1.24E-036P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore
Butambenhsa05416Viral myocarditis4.49E-021P20036HLA-DPA1More
Butambenhsa05418Fluid shear stress and atherosclerosis2.43E-037Q16539, P42338, P10599, P14780, P01375, P14778, P27930MAPK14, PIK3CB, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Butamben (SDC: 2.34)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q8IZS8CACNA2D3VoltageNonedependent calcium channel subunit alphaNone2/deltaNone3Reported00.09430.040.32910.4562
P54284CACNB3VoltageNonedependent LNonetype calcium channel subunit betaNone3Reported00.10260.15390.32910.6881
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Reported00.00420.2820.12740.6935
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Reported00.07310.08780.20670.4189
Q99712KCNJ15ATPNonesensitive inward rectifier potassium channel 15Reported00.15870.07790.12670.3619
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P19174PLCG11Nonephosphatidylinositol 4,5Nonebisphosphate phosphodiesterase gammaNone1Predicted00.06960.039711.1142
P17861XBP1XNoneboxNonebinding protein 1Predicted00.29140.06510.46080.7367
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
Q08752PPIDPeptidylNoneprolyl cisNonetrans isomerase DPredicted00.20150.03360.51080.6787
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
Q9Y5S1TRPV2Transient receptor potential cation channel subfamily V member 2Predicted00.62910.03880.24020.6324
O75832PSMD1026S proteasome nonNoneATPase regulatory subunit 10Predicted00.21030.018500.1422
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)