PharmaCoNets

PharmaCoNets of Butabarbital (S_PCN: 7.78 )

Butabarbital regulated-network (S_DN: 3.49)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Butabarbital

Tryptophan metabolism

4.14E-02

1

Q16613

AANAT

Butabarbital

Starch and sucrose metabolism

2.86E-02

2

O43451, P46976

MGAM, GYG1

Butabarbital

Thiamine metabolism

1.75E-04

3

Q9Y6K8, P05186, P24666

AK5, ALPL, ACP1

Butabarbital

Pantothenate and CoA biosynthesis

1.78E-02

2

O95498, O95497

VNN2, VNN1

Butabarbital

Biosynthesis of cofactors

3.34E-02

3

P05186, Q9Y6K8, O75911

ALPL, AK5, DHRS3

Butabarbital

Ribosome biogenesis in eukaryotes

4.94E-02

2

P19784, P67870

CSNK2A2, CSNK2B

Butabarbital

Proteasome

1.40E-02

1

P55036

PSMD4

Butabarbital

cAMP signaling pathway

3.37E-02

3

P63092, P26678, P61586

GNAS, PLN, RHOA

Butabarbital

Phospholipase D signaling pathway

2.75E-02

3

P61586, O14986, P63092

RHOA, PIP5K1B, GNAS

Butabarbital

Ubiquitin mediated proteolysis

6.89E-03

5

Q14145, Q13042, Q13191, Q15751, Q7Z6Z7

KEAP1, CDC16, CBLB, HERC1, HUWE1

Butabarbital

Mitophagy - animal

2.52E-02

2

P19784, P67870

CSNK2A2, CSNK2B

Butabarbital

Wnt signaling pathway

4.17E-03

3

P61586, P19784, P67870

RHOA, CSNK2A2, CSNK2B

Butabarbital

Focal adhesion

4.07E-02

3

O14986, P61586, Q16363

PIP5K1B, RHOA, LAMA4

Butabarbital

Adherens junction

1.38E-04

3

P19784, P67870, P61586

CSNK2A2, CSNK2B, RHOA

Butabarbital

NOD-like receptor signaling pathway

4.31E-02

4

P01375, P59665, P59666, P12838

TNF, DEFA1; DEFA1B, DEFA3, DEFA4

Butabarbital

Hematopoietic cell lineage

4.27E-02

4

P08514, P14778, P01730, P13765

ITGA2B, IL1R1, CD4, HLA-DOB

Butabarbital

Th17 cell differentiation

2.73E-02

4

Q16539, P01730, P13765, P14778

MAPK14, CD4, HLA-DOB, IL1R1

Butabarbital

Circadian entrainment

4.94E-02

2

P62873, P63092

GNB1, GNAS

Butabarbital

Retrograde endocannabinoid signaling

4.94E-02

2

P48169, P62873

GABRA4, GNB1

Butabarbital

Glutamatergic synapse

3.65E-02

2

P63092, P62873

GNAS, GNB1

Butabarbital

Serotonergic synapse

2.52E-02

2

P63092, P62873

GNAS, GNB1

Butabarbital

Type I diabetes mellitus

1.87E-02

2

P48023, P01375

FASLG, TNF

Butabarbital

Pancreatic secretion

3.65E-02

2

P63092, P61586

GNAS, RHOA

Butabarbital

Morphine addiction

9.04E-05

5

P62873, P48169, P78334, P63092, P32298

GNB1, GABRA4, GABRE, GNAS, GRK4

Butabarbital

Chagas disease

2.26E-02

3

P01375, P30679, P48023

TNF, GNA15, FASLG

Butabarbital

African trypanosomiasis

2.72E-02

2

P01375, P48023

TNF, FASLG

Butabarbital

Staphylococcus aureus infection

1.83E-02

3

P59665, P59666, P12838

DEFA1; DEFA1B, DEFA3, DEFA4

Butabarbital

Human cytomegalovirus infection

2.09E-02

4

P62873, P61586, P63092, P61769

GNB1, RHOA, GNAS, B2M

Butabarbital

Coronavirus disease - COVID-19

4.47E-02

2

Q9UHA3, O14786

RSL24D1, NRP1

Butabarbital

Allograft rejection

2.72E-02

2

P48023, P01375

FASLG, TNF

Butabarbital

Graft-versus-host disease

3.70E-02

2

P48023, P01375

FASLG, TNF

Butabarbital

Primary immunodeficiency

1.58E-02

3

P01730, P11912, Q8WV28

CD4, CD79A, BLNK

Community members of Butabarbital (S_DC: 2.23)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

GABRA4

GammaNoneaminobutyric acid receptor subunit alphaNone4

0

0.3253

0.565

0.1579

1.4506

GABRB3

GammaNoneaminobutyric acid receptor subunit betaNone3

0

0.1559

0.4387

0.1695

1.1248

GABRE

GammaNoneaminobutyric acid receptor subunit epsilon

0

0.1394

0.4097

0.1579

1.0469

GRIA4

Glutamate receptor 4

0

0.4037

0.1209

0.3748

0.8184

This pair is Reported in Drugbank.

Gene name	UniProt_ID	Bioactivity	Value (nM)