PharmaCoNets of Budesonide (SPCN: 14.33 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Budesonidehsa00500Starch and sucrose metabolism3.56E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Budesonidehsa00970Aminoacyl-tRNA biosynthesis1.21E-021P14868DARSMore
Budesonidehsa03013RNA transport3.11E-022P68104, Q14232EEF1A1, EIF2B1More
Budesonidehsa04061Viral protein interaction with cytokine and cytokine receptor2.00E-027P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, TNFMore
Budesonidehsa04064NF-kappa B signaling pathway4.58E-034Q13489, Q13546, Q9UDY8, Q9UNE0BIRC3, RIPK1, MALT1, EDARMore
Budesonidehsa04140Autophagy - animal3.61E-025Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759RRAGD, PRKACB, ITPR1, ATG5, PRKCQMore
Budesonidehsa04141Protein processing in endoplasmic reticulum3.89E-022P17861, Q9NR31XBP1, SAR1AMore
Budesonidehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Budesonidehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Budesonidehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Budesonidehsa04612Antigen processing and presentation2.73E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Budesonidehsa04613Neutrophil extracellular trap formation6.66E-0415P11215, O60603, P05164, P08246, Q9UM07, Q13547, P58876, Q16778, O60814, P20160, P08311, O75015, P21730, O43315, Q16539ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2BC5, HIST2H2BE, H2BC12, AZU1, CTSG, FCGR3B, C5AR1, AQP9, MAPK14More
Budesonidehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Budesonidehsa04621NOD-like receptor signaling pathway3.95E-0313Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, P01375, P09341, P12838MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, TNF, CXCL1, DEFA4More
Budesonidehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Budesonidehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Budesonidehsa04640Hematopoietic cell lineage1.10E-029P13612, P14778, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Budesonidehsa04650Natural killer cell mediated cytotoxicity8.02E-039P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Budesonidehsa04657IL-17 signaling pathway1.42E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Budesonidehsa04658Th1 and Th2 cell differentiation5.94E-049Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOBMore
Budesonidehsa04659Th17 cell differentiation3.91E-039Q04759, Q16539, P06239, P13765, P14778, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3G, CD247More
Budesonidehsa04660T cell receptor signaling pathway6.95E-0411P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Budesonidehsa04750Inflammatory mediator regulation of TRP channels3.61E-025P14778, P22694, Q16539, Q14643, Q04759IL1R1, PRKACB, MAPK14, ITPR1, PRKCQMore
Budesonidehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Budesonidehsa05010Alzheimer disease1.01E-023Q06055, P17861, P62195ATP5G2, XBP1, PSMC5More
Budesonidehsa05012Parkinson disease5.41E-033Q06055, P17861, P62195ATP5G2, XBP1, PSMC5More
Budesonidehsa05014Amyotrophic lateral sclerosis1.01E-023Q06055, P17861, P62195ATP5G2, XBP1, PSMC5More
Budesonidehsa05017Spinocerebellar ataxia1.42E-022P17861, P62195XBP1, PSMC5More
Budesonidehsa05022Pathways of neurodegeneration - multiple diseases1.66E-023Q06055, P17861, P62195ATP5G2, XBP1, PSMC5More
Budesonidehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Budesonidehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Budesonidehsa05134Legionellosis5.53E-032Q9NR31, P68104SAR1A, EEF1A1More
Budesonidehsa05135Yersinia infection3.72E-026P13612, P06239, Q16539, P01375, P49841, P01732ITGA4, LCK, MAPK14, TNF, GSK3B, CD8AMore
Budesonidehsa05140Leishmaniasis2.69E-026P13612, O75015, P13765, O60603, P01375, Q16539ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14More
Budesonidehsa05144Malaria8.80E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Budesonidehsa05146Amoebiasis5.94E-049P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Budesonidehsa05163Human cytomegalovirus infection2.51E-029P01375, Q14643, P22694, P49841, P14778, Q13651, P25025, Q16539, O00463TNF, ITPR1, PRKACB, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5More
Budesonidehsa05202Transcriptional misregulation in cancer4.29E-0313P14780, P27930, Q15744, Q16548, P11215, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Budesonidehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Budesonidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.42E-027O95267, P20963, P09693, P06239, O60603, Q04759, Q16539RASGRP1, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14More
Budesonidehsa05310Asthma1.62E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Budesonidehsa05321Inflammatory bowel disease1.09E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Budesonidehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Budesonidehsa05332Graft-versus-host disease1.76E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More

Community members of Budesonide (SDC: 1.97)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P12429ANXA3Annexin A3Predicted00.44920.06300.3507
P08758ANXA5Annexin A5Predicted10.21280.054300.215
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)