PharmaCoNets of Bromodiphenhydramine (SPCN: 30.92 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Bromodiphenhydraminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Bromodiphenhydraminehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Bromodiphenhydraminehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Bromodiphenhydraminehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Bromodiphenhydraminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Bromodiphenhydraminehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Bromodiphenhydraminehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Bromodiphenhydraminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Bromodiphenhydraminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Bromodiphenhydraminehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Bromodiphenhydraminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Bromodiphenhydraminehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Bromodiphenhydraminehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Bromodiphenhydraminehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Bromodiphenhydraminehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Bromodiphenhydraminehsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Bromodiphenhydraminehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Bromodiphenhydraminehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Bromodiphenhydraminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Bromodiphenhydraminehsa04613Neutrophil extracellular trap formation2.15E-0511P11215, Q13547, P04908, Q93077, P58876, P62807, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Bromodiphenhydraminehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Bromodiphenhydraminehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Bromodiphenhydraminehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Bromodiphenhydraminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Bromodiphenhydraminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Bromodiphenhydraminehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Bromodiphenhydraminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Bromodiphenhydraminehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Bromodiphenhydraminehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Bromodiphenhydraminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Bromodiphenhydraminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Bromodiphenhydraminehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Bromodiphenhydraminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Bromodiphenhydraminehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Bromodiphenhydraminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Bromodiphenhydraminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Bromodiphenhydraminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Bromodiphenhydraminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Bromodiphenhydraminehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Bromodiphenhydraminehsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Bromodiphenhydraminehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Bromodiphenhydraminehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Bromodiphenhydraminehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Bromodiphenhydraminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Bromodiphenhydraminehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Bromodiphenhydraminehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Bromodiphenhydraminehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Bromodiphenhydraminehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Bromodiphenhydraminehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Bromodiphenhydraminehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Bromodiphenhydraminehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Bromodiphenhydraminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Bromodiphenhydraminehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Bromodiphenhydraminehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Bromodiphenhydramine (SDC: 4.53)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
O14786NRP1NeuropilinNone1Predicted10.38340.20260.51531.1123
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)