PharmaCoNets of Brinzolamide (SPCN: 9.85 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Brinzolamidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Brinzolamidehsa00520Amino sugar and nucleotide sugar metabolism3.76E-021Q13231CHIT1More
Brinzolamidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Brinzolamidehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Brinzolamidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Brinzolamidehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Brinzolamidehsa04071Sphingolipid signaling pathway1.87E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Brinzolamidehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Brinzolamidehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Brinzolamidehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Brinzolamidehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Brinzolamidehsa04613Neutrophil extracellular trap formation7.32E-0313O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Brinzolamidehsa04614Renin-angiotensin system2.52E-021P50052AGTR2More
Brinzolamidehsa04657IL-17 signaling pathway4.98E-026O00463, Q16539, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, MMP9, ANAPC5, LCN2, TNFMore
Brinzolamidehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Brinzolamidehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Brinzolamidehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Brinzolamidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Brinzolamidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Brinzolamidehsa05133Pertussis4.20E-021P0C0L4C4AMore
Brinzolamidehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Brinzolamidehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Brinzolamidehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Brinzolamidehsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Brinzolamidehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Brinzolamidehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Brinzolamidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Brinzolamide (SDC: 3.09)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Reported10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Reported00.00560.82670.16091.8171
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
O75493CA11Carbonic anhydraseNonerelated protein 11Predicted00.07450.061200.1597
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
CA2P00918IC503.2
CA2P00918IC5045
CA2P00918Ki0.125893
CA2P00918Ki0.13
CA2P00918Ki3
CA2P00918Kd0.089
CA2P00918Kd0.128825
CA2P00918Kd0.13
CA4P22748IC5045
CA4P22748IC5045.3
CA4P22748Ki3950