| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Brimonidine | hsa00052 | Galactose metabolism | 4.27E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Brimonidine | hsa00190 | Oxidative phosphorylation | 8.71E-03 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Brimonidine | hsa00500 | Starch and sucrose metabolism | 6.17E-03 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Brimonidine | hsa00640 | Propanoate metabolism | 3.83E-02 | 2 | Q02252, Q9P2R7 | ALDH6A1, SUCLA2 | More | | | Brimonidine | hsa00730 | Thiamine metabolism | 2.27E-02 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Brimonidine | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Brimonidine | hsa00790 | Folate biosynthesis | 1.04E-02 | 3 | Q92820, P05186, P42330 | GGH, ALPL, AKR1C3 | More | | | Brimonidine | hsa00830 | Retinol metabolism | 4.25E-02 | 1 | P00325 | ADH1B | More | | | Brimonidine | hsa00983 | Drug metabolism - other enzymes | 4.16E-02 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Brimonidine | hsa01523 | Antifolate resistance | 2.54E-03 | 4 | P41440, Q92820, P04818, P01375 | SLC19A1, GGH, TYMS, TNF | More | | | Brimonidine | hsa03013 | RNA transport | 4.49E-02 | 5 | P62826, Q9UBU9, P63279, P68104, Q14232 | RAN, NXF1, UBE2I, EEF1A1, EIF2B1 | More | | | Brimonidine | hsa03015 | mRNA surveillance pathway | 1.83E-02 | 3 | Q13362, Q14738, Q9UBU9 | PPP2R5C, PPP2R5D, NXF1 | More | | | Brimonidine | hsa03020 | RNA polymerase | 6.21E-04 | 4 | P30876, P24928, P62487, Q9Y535 | POLR2B, POLR2A, POLR2G, POLR3H | More | | | Brimonidine | hsa04020 | Calcium signaling pathway | 4.83E-02 | 4 | Q08828, P0DP23, P05141, P51828 | ADCY1, CALM1, SLC25A5, ADCY7 | More | | | Brimonidine | hsa04022 | cGMP-PKG signaling pathway | 4.38E-03 | 6 | P18848, P31751, Q08828, P51828, P05141, P0DP23 | ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1 | More | | | Brimonidine | hsa04024 | cAMP signaling pathway | 3.94E-02 | 4 | Q08828, P51828, P31751, P0DP23 | ADCY1, ADCY7, AKT2, CALM1 | More | | | Brimonidine | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 3.16E-03 | 8 | Q8NHW4, P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P01375 | CCL4L2, CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, TNF | More | | | Brimonidine | hsa04064 | NF-kappa B signaling pathway | 7.24E-04 | 10 | P10415, Q13489, P01584, P29965, Q9UDY8, Q8WV28, Q13315, P63279, Q8NHW4, Q9NQC7 | BCL2, BIRC3, IL1B, CD40LG, MALT1, BLNK, ATM, UBE2I, CCL4L2, CYLD | More | | | Brimonidine | hsa04070 | Phosphatidylinositol signaling system | 1.00E-03 | 7 | P0DP23, Q14643, O14986, P23743, Q16760, P48426, P17252 | CALM1, ITPR1, PIP5K1B, DGKA, DGKD, PIP4K2A, PRKCA | More | | | Brimonidine | hsa04071 | Sphingolipid signaling pathway | 4.49E-02 | 4 | P17252, Q13362, Q9BX95, P10415 | PRKCA, PPP2R5C, SGPP1, BCL2 | More | | | Brimonidine | hsa04072 | Phospholipase D signaling pathway | 2.40E-03 | 6 | P31751, O14986, Q15438, Q08828, P51828, Q16760 | AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD | More | | | Brimonidine | hsa04080 | Neuroactive ligand-receptor interaction | 1.40E-02 | 8 | P08311, Q15722, P21453, Q9H228, P43657, P21730, P07550, P35318 | CTSG, LTB4R, S1PR1, EDG8, P2RY5, C5AR1, ADRB2, ADM | More | | | Brimonidine | hsa04110 | Cell cycle | 6.63E-04 | 6 | P06493, O60566, P30304, P33981, P42773, P01106 | CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC | More | | | Brimonidine | hsa04114 | Oocyte meiosis | 1.36E-03 | 5 | P0DP23, Q08828, P51828, Q13362, Q14738 | CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5D | More | | | Brimonidine | hsa04120 | Ubiquitin mediated proteolysis | 1.08E-03 | 6 | Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669 | SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12 | More | | | Brimonidine | hsa04140 | Autophagy - animal | 1.71E-02 | 5 | P31751, Q7L523, O75460, Q96GC9, Q8TEV9 | AKT2, RRAGA, ERN1, TMEM49, SMCR8 | More | | | Brimonidine | hsa04145 | Phagosome | 1.59E-03 | 7 | Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765 | NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB | More | | | Brimonidine | hsa04151 | PI3K-Akt signaling pathway | 4.50E-02 | 9 | P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252 | F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCA | More | | | Brimonidine | hsa04152 | AMPK signaling pathway | 1.83E-02 | 3 | Q96RR4, Q13362, Q14738 | CAMKK2, PPP2R5C, PPP2R5D | More | | | Brimonidine | hsa04211 | Longevity regulating pathway | 1.88E-02 | 4 | P31751, Q08828, P51828, P18848 | AKT2, ADCY1, ADCY7, ATF4 | More | | | Brimonidine | hsa04213 | Longevity regulating pathway - multiple species | 4.54E-02 | 3 | P31751, Q08828, P51828 | AKT2, ADCY1, ADCY7 | More | | | Brimonidine | hsa04217 | Necroptosis | 6.91E-04 | 11 | P01375, P01568, P48023, Q13489, P42224, Q14765, Q6FI13, Q99878, P10415, O43633, Q08752 | TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, H2AC18; H2AC19, H2AC14, BCL2, CHMP2A, PPID | More | | | Brimonidine | hsa04261 | Adrenergic signaling in cardiomyocytes | 1.22E-05 | 10 | P09493, Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23, P17252, P10415 | TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, PRKCA, BCL2 | More | | | Brimonidine | hsa04270 | Vascular smooth muscle contraction | 3.82E-02 | 5 | P24723, Q04759, Q14643, P22694, P35318 | PRKCH, PRKCQ, ITPR1, PRKACB, ADM | More | | | Brimonidine | hsa04310 | Wnt signaling pathway | 1.79E-02 | 2 | P17612, P67870 | PRKACA, CSNK2B | More | | | Brimonidine | hsa04340 | Hedgehog signaling pathway | 3.91E-02 | 1 | P17612 | PRKACA | More | | | Brimonidine | hsa04371 | Apelin signaling pathway | 3.94E-02 | 4 | P31751, Q08828, P51828, P0DP23 | AKT2, ADCY1, ADCY7, CALM1 | More | | | Brimonidine | hsa04380 | Osteoclast differentiation | 5.27E-04 | 10 | Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149 | CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2 | More | | | Brimonidine | hsa04540 | Gap junction | 1.29E-02 | 4 | P17252, Q13509, P68371, Q14643 | PRKCA, TUBB3, TUBB2C, ITPR1 | More | | | Brimonidine | hsa04611 | Platelet activation | 2.12E-02 | 2 | Q9Y490, P17612 | TLN1, PRKACA | More | | | Brimonidine | hsa04612 | Antigen processing and presentation | 1.19E-02 | 7 | P13765, P26715, P26717, Q07444, Q13241, P01732, P01375 | HLA-DOB, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, TNF | More | | | Brimonidine | hsa04613 | Neutrophil extracellular trap formation | 3.58E-02 | 8 | P17252, O60603, P08246, Q6FI13, P68431, P14598, Q15080, P21462 | PRKCA, TLR2, ELA2, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1 | More | | | Brimonidine | hsa04620 | Toll-like receptor signaling pathway | 2.54E-03 | 3 | P01584, P31751, Q8NHW4 | IL1B, AKT2, CCL4L2 | More | | | Brimonidine | hsa04623 | Cytosolic DNA-sensing pathway | 2.21E-04 | 3 | P01584, Q9Y535, Q8NHW4 | IL1B, POLR3H, CCL4L2 | More | | | Brimonidine | hsa04625 | C-type lectin receptor signaling pathway | 1.14E-03 | 8 | Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539 | CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14 | More | | | Brimonidine | hsa04630 | JAK-STAT signaling pathway | 4.54E-02 | 3 | P31751, P23458, Q13651 | AKT2, JAK1, IL10RA | More | | | Brimonidine | hsa04640 | Hematopoietic cell lineage | 2.50E-03 | 11 | P13612, P27930, P15144, P25063, P09693, P01732, P01730, P06127, P09564, P13765, P01375 | ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF | More | | | Brimonidine | hsa04650 | Natural killer cell mediated cytotoxicity | 5.65E-04 | 10 | P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q07444, P26715 | TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC3, KLRC1 | More | | | Brimonidine | hsa04657 | IL-17 signaling pathway | 1.36E-02 | 5 | O00463, Q16539, P49841, P14780, P01375 | TRAF5, MAPK14, GSK3B, MMP9, TNF | More | | | Brimonidine | hsa04658 | Th1 and Th2 cell differentiation | 1.71E-04 | 9 | Q04759, P20963, P09693, P06239, Q14765, P23771, Q9UL17, P13765, Q13761 | PRKCQ, CD247, CD3G, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3 | More | | | Brimonidine | hsa04659 | Th17 cell differentiation | 2.15E-02 | 7 | Q04759, P06239, P13765, Q9UL17, P23771, P09693, P20963 | PRKCQ, LCK, HLA-DOB, TBX21, GATA3, CD3G, CD247 | More | | | Brimonidine | hsa04660 | T cell receptor signaling pathway | 1.40E-02 | 8 | P01375, Q04759, Q08881, P20963, P09693, P01732, Q13191, P06239 | TNF, PRKCQ, ITK, CD247, CD3G, CD8A, CBLB, LCK | More | | | Brimonidine | hsa04664 | Fc epsilon RI signaling pathway | 3.98E-02 | 3 | P01375, Q16539, Q9UQC2 | TNF, MAPK14, GAB2 | More | | | Brimonidine | hsa04668 | TNF signaling pathway | 2.21E-02 | 5 | P01375, O00463, Q16539, P20749, P14780 | TNF, TRAF5, MAPK14, BCL3, MMP9 | More | | | Brimonidine | hsa04672 | Intestinal immune network for IgA production | 3.76E-03 | 3 | P29965, P10747, P13765 | CD40LG, CD28, HLA-DOB | More | | | Brimonidine | hsa04713 | Circadian entrainment | 2.85E-03 | 6 | P0DP23, P17252, P62873, Q14643, Q08828, P51828 | CALM1, PRKCA, GNB1, ITPR1, ADCY1, ADCY7 | More | | | Brimonidine | hsa04720 | Long-term potentiation | 4.45E-03 | 5 | P17252, P0DP23, P18848, Q08828, Q14643 | PRKCA, CALM1, ATF4, ADCY1, ITPR1 | More | | | Brimonidine | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Brimonidine | hsa04723 | Retrograde endocannabinoid signaling | 1.88E-02 | 4 | Q14643, P17252, P62873, Q16718 | ITPR1, PRKCA, GNB1, NDUFA5 | More | | | Brimonidine | hsa04725 | Cholinergic synapse | 7.24E-04 | 8 | Q08828, P51828, Q14643, P17252, P62873, P18848, P31751, P10415 | ADCY1, ADCY7, ITPR1, PRKCA, GNB1, ATF4, AKT2, BCL2 | More | | | Brimonidine | hsa04728 | Dopaminergic synapse | 8.46E-05 | 8 | Q14643, P17252, P62873, P31751, P18848, Q13362, Q14738, P0DP23 | ITPR1, PRKCA, GNB1, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1 | More | | | Brimonidine | hsa04740 | Olfactory transduction | 2.52E-02 | 1 | Q9H255 | OR51E2 | More | | | Brimonidine | hsa04742 | Taste transduction | 7.70E-04 | 2 | P30939, P17612 | HTR1F, PRKACA | More | | | Brimonidine | hsa04744 | Phototransduction | 1.02E-02 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Brimonidine | hsa04750 | Inflammatory mediator regulation of TRP channels | 9.86E-03 | 4 | P01584, Q08828, P51828, P0DP23 | IL1B, ADCY1, ADCY7, CALM1 | More | | | Brimonidine | hsa04911 | Insulin secretion | 2.40E-02 | 3 | Q08828, P51828, P18848 | ADCY1, ADCY7, ATF4 | More | | | Brimonidine | hsa04912 | GnRH signaling pathway | 1.52E-03 | 6 | P17252, Q08828, P51828, P18848, Q14643, P0DP23 | PRKCA, ADCY1, ADCY7, ATF4, ITPR1, CALM1 | More | | | Brimonidine | hsa04915 | Estrogen signaling pathway | 2.13E-02 | 5 | P18848, Q08828, P51828, P31751, P0DP23 | ATF4, ADCY1, ADCY7, AKT2, CALM1 | More | | | Brimonidine | hsa04916 | Melanogenesis | 2.40E-02 | 3 | P0DP23, Q08828, P51828 | CALM1, ADCY1, ADCY7 | More | | | Brimonidine | hsa04921 | Oxytocin signaling pathway | 3.13E-02 | 3 | P0DP23, Q96RR4, Q13469 | CALM1, CAMKK2, NFATC2 | More | | | Brimonidine | hsa04922 | Glucagon signaling pathway | 3.47E-02 | 4 | Q12778, Q13370, P0DP23, Q14643 | FOXO1, PDE3B, CALM1, ITPR1 | More | | | Brimonidine | hsa04923 | Regulation of lipolysis in adipocytes | 5.15E-03 | 3 | Q08828, P51828, P31751 | ADCY1, ADCY7, AKT2 | More | | | Brimonidine | hsa04924 | Renin secretion | 4.33E-04 | 5 | P22694, P07550, Q14643, Q13370, P0DP23 | PRKACB, ADRB2, ITPR1, PDE3B, CALM1 | More | | | Brimonidine | hsa04925 | Aldosterone synthesis and secretion | 9.86E-03 | 4 | P18848, Q08828, P51828, P0DP23 | ATF4, ADCY1, ADCY7, CALM1 | More | | | Brimonidine | hsa04926 | Relaxin signaling pathway | 2.46E-02 | 4 | P31751, P18848, Q08828, P51828 | AKT2, ATF4, ADCY1, ADCY7 | More | | | Brimonidine | hsa04927 | Cortisol synthesis and secretion | 1.59E-02 | 3 | P18848, Q08828, P51828 | ATF4, ADCY1, ADCY7 | More | | | Brimonidine | hsa04932 | Non-alcoholic fatty liver disease | 5.87E-04 | 8 | P31751, P01375, P49841, P18848, P48023, O75460, P01584, O95298 | AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFC2 | More | | | Brimonidine | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.27E-02 | 5 | P42224, P10415, Q12778, P49767, P17252 | STAT1, BCL2, FOXO1, VEGFC, PRKCA | More | | | Brimonidine | hsa04934 | Cushing syndrome | 4.54E-02 | 3 | P18848, Q08828, P51828 | ATF4, ADCY1, ADCY7 | More | | | Brimonidine | hsa04935 | Growth hormone synthesis, secretion and action | 1.88E-02 | 4 | Q08828, P51828, P18848, P31751 | ADCY1, ADCY7, ATF4, AKT2 | More | | | Brimonidine | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Brimonidine | hsa04966 | Collecting duct acid secretion | 2.86E-02 | 2 | Q13488, Q9Y666 | TCIRG1, SLC12A7 | More | | | Brimonidine | hsa04970 | Salivary secretion | 1.59E-02 | 3 | Q08828, P51828, P0DP23 | ADCY1, ADCY7, CALM1 | More | | | Brimonidine | hsa04971 | Gastric acid secretion | 2.54E-03 | 4 | Q08828, P51828, P15311, P0DP23 | ADCY1, ADCY7, VIL2, CALM1 | More | | | Brimonidine | hsa04976 | Bile secretion | 1.59E-02 | 3 | Q08828, P51828, Q14032 | ADCY1, ADCY7, BAAT | More | | | Brimonidine | hsa04979 | Cholesterol metabolism | 1.61E-02 | 2 | P38571, P61916 | LIPA, NPC2 | More | | | Brimonidine | hsa05010 | Alzheimer disease | 7.57E-04 | 15 | Q16718, O95298, O14521, Q14643, Q00535, O75460, P0DP23, P01584, P18848, Q13509, P68371, P31751, P05141, Q08752, P28070 | NDUFA5, NDUFC2, SDHD, ITPR1, CDK5, ERN1, CALM1, IL1B, ATF4, TUBB3, TUBB2C, AKT2, SLC25A5, PPID, PSMB4 | More | | | Brimonidine | hsa05012 | Parkinson disease | 2.25E-02 | 6 | Q16718, O14521, Q14643, P0DP23, Q13509, P68371 | NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C | More | | | Brimonidine | hsa05016 | Huntington disease | 2.24E-02 | 7 | O95298, P24928, P30876, P62487, P05141, O75460, P28070 | NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4 | More | | | Brimonidine | hsa05017 | Spinocerebellar ataxia | 3.94E-02 | 4 | O75460, P31751, P28070, P05141 | ERN1, AKT2, PSMB4, SLC25A5 | More | | | Brimonidine | hsa05020 | Prion disease | 1.15E-02 | 7 | Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080 | NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4 | More | | | Brimonidine | hsa05022 | Pathways of neurodegeneration - multiple diseases | 3.36E-04 | 18 | Q14643, Q13509, P68371, P10415, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, P17252, Q00535, P01584, Q08752, P0DP23, P28070 | ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, CDK5, IL1B, PPID, CALM1, PSMB4 | More | | | Brimonidine | hsa05110 | Vibrio cholerae infection | 2.11E-03 | 2 | Q99437, P17612 | ATP6V0B, PRKACA | More | | | Brimonidine | hsa05131 | Shigellosis | 2.27E-02 | 8 | P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID | More | | | Brimonidine | hsa05132 | Salmonella infection | 1.11E-02 | 8 | Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371 | LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C | More | | | Brimonidine | hsa05140 | Leishmaniasis | 2.17E-03 | 6 | P14598, P42224, P13765, O60603, P29350, Q15080 | NCF1, STAT1, HLA-DOB, TLR2, PTPN6, NCF4 | More | | | Brimonidine | hsa05143 | African trypanosomiasis | 2.72E-02 | 2 | P01375, P48023 | TNF, FASLG | More | | | Brimonidine | hsa05145 | Toxoplasmosis | 1.11E-02 | 6 | P10415, Q13489, P42224, P13765, O60603, P29965 | BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG | More | | | Brimonidine | hsa05146 | Amoebiasis | 5.91E-03 | 7 | P09341, P27930, P01375, P05089, P22694, P12814, P08311 | CXCL1, IL1R2, TNF, ARG1, PRKACB, ACTN1, CTSG | More | | | Brimonidine | hsa05150 | Staphylococcus aureus infection | 1.91E-02 | 4 | Q14532, P59665, P59666, P49913 | KRT32, DEFA1; DEFA1B, DEFA3, CAMP | More | | | Brimonidine | hsa05152 | Tuberculosis | 7.93E-04 | 8 | Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8 | TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1 | More | | | Brimonidine | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Brimonidine | hsa05163 | Human cytomegalovirus infection | 1.64E-05 | 15 | P31751, P01375, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, O00463 | AKT2, TNF, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TRAF5 | More | | | Brimonidine | hsa05164 | Influenza A | 4.49E-02 | 5 | P31751, P01584, P23458, P05141, Q9UBU9 | AKT2, IL1B, JAK1, SLC25A5, NXF1 | More | | | Brimonidine | hsa05165 | Human papillomavirus infection | 3.10E-02 | 8 | P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315 | ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM | More | | | Brimonidine | hsa05166 | Human T-cell leukemia virus 1 infection | 3.90E-02 | 7 | P23458, P05141, P62826, Q08828, P51828, P18848, P31751 | JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2 | More | | | Brimonidine | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 6.35E-03 | 8 | P01568, P42224, P23458, P62873, Q13469, Q14643, P0DP23, Q9UJU2 | IFNA21, STAT1, JAK1, GNB1, NFATC2, ITPR1, CALM1, LEF1 | More | | | Brimonidine | hsa05168 | Herpes simplex virus 1 infection | 4.79E-02 | 8 | P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820 | NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189 | More | | | Brimonidine | hsa05170 | Human immunodeficiency virus 1 infection | 4.67E-03 | 9 | P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5 | GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2 | More | | | Brimonidine | hsa05200 | Pathways in cancer | 4.99E-02 | 12 | P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568 | STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21 | More | | | Brimonidine | hsa05202 | Transcriptional misregulation in cancer | 2.78E-02 | 11 | P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522 | MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45A | More | | | Brimonidine | hsa05212 | Pancreatic cancer | 2.33E-03 | 3 | P31751, Q15311, P23458 | AKT2, RALBP1, JAK1 | More | | | Brimonidine | hsa05231 | Choline metabolism in cancer | 3.38E-02 | 3 | P31751, Q16760, O14986 | AKT2, DGKD, PIP5K1B | More | | | Brimonidine | hsa05310 | Asthma | 1.04E-02 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Brimonidine | hsa05320 | Autoimmune thyroid disease | 1.27E-03 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | | Brimonidine | hsa05321 | Inflammatory bowel disease | 4.38E-03 | 5 | P01375, P13765, Q14765, Q9UL17, P23771 | TNF, HLA-DOB, STAT4, TBX21, GATA3 | More | | | Brimonidine | hsa05322 | Systemic lupus erythematosus | 4.37E-04 | 12 | O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q16778, P68431, P12814 | FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1 | More | | | Brimonidine | hsa05323 | Rheumatoid arthritis | 1.29E-02 | 4 | P13765, Q13488, P10747, O60603 | HLA-DOB, TCIRG1, CD28, TLR2 | More | | | Brimonidine | hsa05330 | Allograft rejection | 1.04E-03 | 5 | P13765, P29965, P48023, P10747, P01375 | HLA-DOB, CD40LG, FASLG, CD28, TNF | More | | | Brimonidine | hsa05332 | Graft-versus-host disease | 1.03E-03 | 5 | P13765, P48023, P01375, P26715, Q13241 | HLA-DOB, FASLG, TNF, KLRC1, KLRD1 | More | | | Brimonidine | hsa05415 | Diabetic cardiomyopathy | 3.55E-02 | 5 | P17252, P14598, Q15080, Q16718, O14521 | PRKCA, NCF1, NCF4, NDUFA5, SDHD | More | | | Brimonidine | hsa05416 | Viral myocarditis | 2.62E-02 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | | | Brimonidine | hsa05418 | Fluid shear stress and atherosclerosis | 1.08E-03 | 7 | Q16539, Q14145, P10599, P14780, P01375, P14778, P27930 | MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2 | More | |
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