PharmaCoNets of Brigatinib (SPCN: 258.14 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Brigatinibhsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Brigatinibhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Brigatinibhsa00030Pentose phosphate pathway1.80E-094P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Brigatinibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Brigatinibhsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Brigatinibhsa00052Galactose metabolism4.25E-056P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Brigatinibhsa00071Fatty acid degradation2.38E-023P11310, O75521, P33121ACADM, ECI2, ACSL1More
Brigatinibhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Brigatinibhsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Brigatinibhsa00190Oxidative phosphorylation4.36E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Brigatinibhsa00220Arginine biosynthesis2.76E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Brigatinibhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Brigatinibhsa00250Alanine, aspartate and glutamate metabolism6.84E-053Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Brigatinibhsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Brigatinibhsa00280Valine, leucine and isoleucine degradation1.93E-066P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Brigatinibhsa00310Lysine degradation2.14E-057Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Brigatinibhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Brigatinibhsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Brigatinibhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Brigatinibhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Brigatinibhsa00500Starch and sucrose metabolism3.15E-084O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Brigatinibhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Brigatinibhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Brigatinibhsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Brigatinibhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Brigatinibhsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Brigatinibhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Brigatinibhsa00564Glycerophospholipid metabolism1.25E-046P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Brigatinibhsa00590Arachidonic acid metabolism2.48E-033P11712, P09917, P09960CYP2C9, ALOX5, LTA4HMore
Brigatinibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Brigatinibhsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Brigatinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Brigatinibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Brigatinibhsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Brigatinibhsa00630Glyoxylate and dicarboxylate metabolism7.49E-124P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Brigatinibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Brigatinibhsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Brigatinibhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Brigatinibhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Brigatinibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Brigatinibhsa00770Pantothenate and CoA biosynthesis3.98E-021Q6ZQY3GADL1More
Brigatinibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Brigatinibhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Brigatinibhsa00830Retinol metabolism3.35E-045P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Brigatinibhsa00860Porphyrin and chlorophyll metabolism2.26E-033P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Brigatinibhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Brigatinibhsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Brigatinibhsa00970Aminoacyl-tRNA biosynthesis2.84E-034O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Brigatinibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Brigatinibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Brigatinibhsa00983Drug metabolism - other enzymes1.07E-065P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Brigatinibhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Brigatinibhsa01100Metabolic pathways8.01E-0769Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q96RQ9, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, IL4I1, MCCC2, ACSL1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Brigatinibhsa01200Carbon metabolism2.13E-022P52209, P37837PGD, TALDO1More
Brigatinibhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Brigatinibhsa01230Biosynthesis of amino acids1.89E-046P51854, P60891, Q99707, P50213, P05089, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, TALDO1More
Brigatinibhsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Brigatinibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Brigatinibhsa01522Endocrine resistance1.02E-047P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Brigatinibhsa01523Antifolate resistance2.88E-033P41440, Q92820, P01375SLC19A1, GGH, TNFMore
Brigatinibhsa01524Platinum drug resistance5.43E-0610Q13489, P98170, Q14790, P48023, P78417, P40692, P23025, P43246, P52701, P31751BIRC3, BIRC4, CASP8, FASLG, GSTO1, MLH1, XPA, MSH2, MSH6, AKT2More
Brigatinibhsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Brigatinibhsa03010Ribosome2.33E-1118P26373, P62753, P42677, P25398, P32969, P62917, P46776, Q9H0U6, Q07020, P62899, P62910, P18077, P61927, Q02878, P36578, P27635, P05386, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL27A, MRPL18, RPL18, RPL31, RPL32, RPL35A, RPL37, RPL6, RPL4, RPL10, RPLP1, RPS3More
Brigatinibhsa03013RNA transport1.97E-1829P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Brigatinibhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Brigatinibhsa03020RNA polymerase7.29E-084P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Brigatinibhsa03040Spliceosome1.48E-0815Q14562, O43143, O60508, P08579, P26368, O75940, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Brigatinibhsa03060Protein export3.67E-094Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Brigatinibhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Brigatinibhsa03430Mismatch repair4.38E-021P20585MSH3More
Brigatinibhsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Brigatinibhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Brigatinibhsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Brigatinibhsa04012ErbB signaling pathway3.61E-057Q13153, P16333, Q13191, P19174, P42338, P01106, P04049PAK1, NCK1, CBLB, PLCG1, PIK3CB, MYC, RAF1More
Brigatinibhsa04014Ras signaling pathway2.30E-054P04049, P31751, P08069, P0DP23RAF1, AKT2, IGF1R, CALM1More
Brigatinibhsa04015Rap1 signaling pathway3.20E-076P04049, P08069, P06213, O00522, P31751, P0DP23RAF1, IGF1R, INSR, KRIT1, AKT2, CALM1More
Brigatinibhsa04020Calcium signaling pathway2.78E-0612Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P30679, P0DP24, P0DP23, P05141, P51828, P23634ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, GNA15, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4More
Brigatinibhsa04022cGMP-PKG signaling pathway1.32E-0712Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Brigatinibhsa04024cAMP signaling pathway1.08E-046Q08828, P51828, P31751, P0DP23, P04049, Q13153ADCY1, ADCY7, AKT2, CALM1, RAF1, PAK1More
Brigatinibhsa04060Cytokine-cytokine receptor interaction8.92E-0621P14784, P27930, P14778, P37173, P08476, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, P25025, Q9UBD3, P47992, P01375, P09341, P19875, P80075, P18510, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, INHBA, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, CXCR2, XCL2, XCL1, TNF, CXCL1, CXCL2, CCL8, IL1RN, CD4, TNFRSF25More
Brigatinibhsa04061Viral protein interaction with cytokine and cytokine receptor2.14E-069Q8NHW4, P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Brigatinibhsa04062Chemokine signaling pathway9.37E-0719P25024, P25025, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963CXCR1, CXCR2, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIAMore
Brigatinibhsa04064NF-kappa B signaling pathway1.10E-1523P10415, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Brigatinibhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Brigatinibhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Brigatinibhsa04070Phosphatidylinositol signaling system5.07E-059P19174, P0DP23, O14986, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7PLCG1, CALM1, PIP5K1B, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKCMore
Brigatinibhsa04071Sphingolipid signaling pathway7.65E-059P04049, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, Q12933, Q02156RAF1, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, TRAF2, PRKCEMore
Brigatinibhsa04072Phospholipase D signaling pathway4.96E-058P04049, P31751, Q9UQC2, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, GAB2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Brigatinibhsa04080Neuroactive ligand-receptor interaction1.86E-0511P08311, P78334, Q15722, P21453, Q9H228, P43657, P21462, P21730, P30939, P07550, P35318CTSG, GABRE, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, HTR1F, ADRB2, ADMMore
Brigatinibhsa04110Cell cycle9.34E-0511Q9UBD5, P30260, P06493, Q14683, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, SMC1A, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Brigatinibhsa04114Oocyte meiosis5.73E-1011Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Brigatinibhsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Brigatinibhsa04136Autophagy - other7.59E-032O94817, Q9H1Y0ATG12, ATG5More
Brigatinibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Brigatinibhsa04140Autophagy - animal3.90E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Brigatinibhsa04141Protein processing in endoplasmic reticulum1.13E-0412P18848, Q12933, P30101, Q15436, P60604, Q99941, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SSR3More
Brigatinibhsa04142Lysosome1.11E-0511O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Brigatinibhsa04144Endocytosis8.76E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Brigatinibhsa04145Phagosome4.61E-0410O75015, Q15080, P14598, Q13509, P68371, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Brigatinibhsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Brigatinibhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Brigatinibhsa04151PI3K-Akt signaling pathway1.09E-0621P62753, P21860, O43521, P04637, P27348, Q13362, P07900, P62873, P61952, P02452, P24821, Q16363, P22105, P23458, P01568, Q99941, P18848, Q96BR1, O00141, Q6ZUJ8, P56279RPS6, ERBB3, BCL2L11, TP53, YWHAQ, PPP2R5C, HSP90AA1, GNB1, GNG11, COL1A1, TNC, LAMA4, TNXB, JAK1, IFNA21, CREBL1, ATF4, SGK3, SGK, PIK3AP1, TCL1AMore
Brigatinibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Brigatinibhsa04210Apoptosis1.10E-034Q14790, P48023, P42575, P04049CASP8, FASLG, CASP2, RAF1More
Brigatinibhsa04211Longevity regulating pathway2.60E-046P31751, P08069, Q08828, P51828, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, ATF4, CAMKK2More
Brigatinibhsa04213Longevity regulating pathway - multiple species1.23E-079P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Brigatinibhsa04217Necroptosis1.77E-1019Q12933, P01568, P23458, Q13489, P98170, Q9NQC7, Q13546, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q13557, Q9H444, O75351, P21796, P45880TRAF2, IFNA21, JAK1, BIRC3, BIRC4, CYLD, RIPK1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, CAMK2D, CHMP4B, VPS4B, VDAC1, VDAC2More
Brigatinibhsa04218Cellular senescence1.96E-047P31751, P04049, P30281, P0DP23, P01889, P10321, P12236AKT2, RAF1, CCND3, CALM1, HLA-B, HLA-C, SLC25A6More
Brigatinibhsa04260Cardiac muscle contraction4.20E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Brigatinibhsa04261Adrenergic signaling in cardiomyocytes4.78E-0812P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP24, P0DP23, Q13557, P23634TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, CAMK2D, ATP2B4More
Brigatinibhsa04270Vascular smooth muscle contraction1.84E-0711P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Brigatinibhsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Brigatinibhsa04330Notch signaling pathway4.54E-044Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Brigatinibhsa04340Hedgehog signaling pathway2.58E-034P17612, P22694, Q13635, P10415PRKACA, PRKACB, PTCH1, BCL2More
Brigatinibhsa04360Axon guidance4.12E-047P16298, Q05397, Q13873, P42338, P04049, O14639, P24844PPP3CB, PTK2, BMPR2, PIK3CB, RAF1, ABLIM1, MYL9More
Brigatinibhsa04370VEGF signaling pathway6.18E-137P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Brigatinibhsa04371Apelin signaling pathway3.11E-0714P62873, P63218, P50151, P61952, P31751, P04049, Q08828, P51828, Q13485, P84022, P62753, Q16566, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, AKT2, RAF1, ADCY1, ADCY7, SMAD4, SMAD3, RPS6, CAMK4, CALM1, CALM2More
Brigatinibhsa04380Osteoclast differentiation2.25E-0710Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Brigatinibhsa04390Hippo signaling pathway3.37E-055O95835, P04628, Q9UJU2, O43623, Q13489LATS1, WNT1, LEF1, SNAI2, BIRC3More
Brigatinibhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Brigatinibhsa04510Focal adhesion1.63E-035Q15942, P51636, P30281, P04049, P08069ZYX, CAV2, CCND3, RAF1, IGF1RMore
Brigatinibhsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Brigatinibhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Brigatinibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Brigatinibhsa04540Gap junction8.97E-044Q13509, P68371, P04049, Q9NRA1TUBB3, TUBB2C, RAF1, PDGFCMore
Brigatinibhsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Brigatinibhsa04610Complement and coagulation cascades1.45E-084P09871, P0C0L4, P20023, P05107C1S, C4A, CR2, ITGB2More
Brigatinibhsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Brigatinibhsa04612Antigen processing and presentation1.30E-0911P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNFMore
Brigatinibhsa04613Neutrophil extracellular trap formation5.25E-0723P19174, P04049, P16109, P11215, P05164, P08246, Q9UM07, Q13547, Q99878, Q93077, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359PLCG1, RAF1, SELP, ITGAM, MPO, ELA2, PADI4, HDAC1, H2AC14, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BAMore
Brigatinibhsa04620Toll-like receptor signaling pathway2.48E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Brigatinibhsa04621NOD-like receptor signaling pathway2.55E-0312P01584, P07900, Q14643, P23458, P45880, P10599, P43490, O00463, P29728, P01375, P09341, P12838IL1B, HSP90AA1, ITPR1, JAK1, VDAC2, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Brigatinibhsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Brigatinibhsa04623Cytosolic DNA-sensing pathway1.82E-105P01584, P01568, Q13546, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, POLR3H, CCL4L2More
Brigatinibhsa04625C-type lectin receptor signaling pathway4.61E-0810Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Brigatinibhsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Brigatinibhsa04640Hematopoietic cell lineage1.09E-1016P13612, P07359, P08514, P14778, P27930, P11215, P15144, P20023, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNFMore
Brigatinibhsa04650Natural killer cell mediated cytotoxicity7.62E-2018P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Brigatinibhsa04657IL-17 signaling pathway3.80E-0613P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, P80188, P01375, P06702NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, S100A9More
Brigatinibhsa04658Th1 and Th2 cell differentiation1.05E-3417P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, RUNX3More
Brigatinibhsa04659Th17 cell differentiation1.07E-2418P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Brigatinibhsa04660T cell receptor signaling pathway1.13E-2219P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Brigatinibhsa04662B cell receptor signaling pathway2.42E-1313P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Brigatinibhsa04664Fc epsilon RI signaling pathway1.57E-068P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P04049, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, RAF1, ALOX5More
Brigatinibhsa04666Fc gamma R-mediated phagocytosis4.61E-034P08637, O75015, P04049, P06396FCGR3A, FCGR3B, RAF1, GSNMore
Brigatinibhsa04668TNF signaling pathway4.51E-0511P01375, Q12933, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Brigatinibhsa04710Circadian rhythm4.86E-021O15516CLOCKMore
Brigatinibhsa04713Circadian entrainment1.16E-0811O15399, P0DP23, P0DP24, Q13557, Q02153, P62873, P63218, P50151, P61952, Q08828, P51828GRIN2D, CALM1, CALM2, CAMK2D, GUCY1B3, GNB1, GNG5, GNG10, GNG11, ADCY1, ADCY7More
Brigatinibhsa04714Thermogenesis4.42E-024Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Brigatinibhsa04720Long-term potentiation4.74E-1112Q16566, Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, O15399, Q08828, Q02750, P04049CAMK4, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, GRIN2D, ADCY1, MAP2K1, RAF1More
Brigatinibhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Brigatinibhsa04722Neurotrophin signaling pathway9.79E-067Q05655, P31751, P04049, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, ARHGDIB, IRAK1, BCL2, CALM1More
Brigatinibhsa04723Retrograde endocannabinoid signaling3.71E-024P62873, P61952, Q08828, O15239GNB1, GNG11, ADCY1, NDUFA1More
Brigatinibhsa04724Glutamatergic synapse1.33E-077O15399, Q08828, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLULMore
Brigatinibhsa04725Cholinergic synapse1.65E-0711Q08828, P51828, P62873, P63218, P50151, P61952, P18848, Q16566, Q13557, P42338, P31751ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK4, CAMK2D, PIK3CB, AKT2More
Brigatinibhsa04726Serotonergic synapse3.11E-035P62873, P63218, P50151, P09917, P04049GNB1, GNG5, GNG10, ALOX5, RAF1More
Brigatinibhsa04727GABAergic synapse6.11E-119Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1More
Brigatinibhsa04728Dopaminergic synapse9.23E-0916P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP24, P0DP23, O15516, P48058GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM2, CALM1, CLOCK, GRIA4More
Brigatinibhsa04730Long-term depression3.10E-034Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Brigatinibhsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Brigatinibhsa04742Taste transduction1.18E-032P30939, P17612HTR1F, PRKACAMore
Brigatinibhsa04744Phototransduction6.33E-093P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Brigatinibhsa04750Inflammatory mediator regulation of TRP channels8.03E-0911P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM2, CALM1More
Brigatinibhsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Brigatinibhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Brigatinibhsa04911Insulin secretion1.04E-065Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Brigatinibhsa04912GnRH signaling pathway5.04E-067Q08828, P51828, P18848, Q9Y6R4, P0DP23, P04049, P45985ADCY1, ADCY7, ATF4, MAP3K4, CALM1, RAF1, MAP2K4More
Brigatinibhsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Brigatinibhsa04914Progesterone-mediated oocyte maturation1.58E-086P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Brigatinibhsa04915Estrogen signaling pathway8.54E-1012P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Brigatinibhsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Brigatinibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Brigatinibhsa04918Thyroid hormone synthesis2.47E-045Q08828, Q99941, P18848, P02768, P05543ADCY1, CREBL1, ATF4, ALB, SERPINA7More
Brigatinibhsa04919Thyroid hormone signaling pathway1.21E-047P19174, P04049, P42224, P60709, Q13547, Q9UM47, P01106PLCG1, RAF1, STAT1, ACTB, HDAC1, NOTCH3, MYCMore
Brigatinibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Brigatinibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Brigatinibhsa04922Glucagon signaling pathway4.86E-044P14618, P06737, P31751, P0DP23PKM2, PYGL, AKT2, CALM1More
Brigatinibhsa04923Regulation of lipolysis in adipocytes5.39E-064Q08828, P51828, P06213, P31751ADCY1, ADCY7, INSR, AKT2More
Brigatinibhsa04924Renin secretion3.14E-054P22694, P07550, Q14643, P0DP23PRKACB, ADRB2, ITPR1, CALM1More
Brigatinibhsa04925Aldosterone synthesis and secretion1.79E-088Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Brigatinibhsa04926Relaxin signaling pathway1.62E-0714P31751, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P30679, P49407AKT2, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Brigatinibhsa04927Cortisol synthesis and secretion2.32E-054Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Brigatinibhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Brigatinibhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Brigatinibhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Brigatinibhsa04932Non-alcoholic fatty liver disease3.31E-1112P31751, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298, P19404AKT2, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2, NDUFV2More
Brigatinibhsa04934Cushing syndrome5.10E-076Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Brigatinibhsa04935Growth hormone synthesis, secretion and action5.87E-046Q08828, P51828, P04049, P18848, P31751, P45985ADCY1, ADCY7, RAF1, ATF4, AKT2, MAP2K4More
Brigatinibhsa04940Type I diabetes mellitus1.55E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Brigatinibhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Brigatinibhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Brigatinibhsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Brigatinibhsa04970Salivary secretion2.10E-0910P07550, Q08828, P51828, P22694, Q14643, P23634, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, CALM2, CALM1, GUCY1B3, CAMPMore
Brigatinibhsa04971Gastric acid secretion3.36E-076Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Brigatinibhsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Brigatinibhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Brigatinibhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Brigatinibhsa04976Bile secretion1.97E-043Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Brigatinibhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Brigatinibhsa05010Alzheimer disease3.85E-0920P49768, Q92542, O15239, O95298, P19404, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, Q12933, P18848, O15169, P67870, P31751, P05141, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFC2, NDUFV2, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, AXIN1, CSNK2B, AKT2, SLC25A5, PSMB4, PSMC4More
Brigatinibhsa05012Parkinson disease5.92E-0414O15239, O95298, P13073, P12074, P05496, P05141, P12236, O75460, P18848, P28070, P43686, P0DP23, P0DP24, Q13557NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, ERN1, ATF4, PSMB4, PSMC4, CALM1, CALM2, CAMK2DMore
Brigatinibhsa05014Amyotrophic lateral sclerosis4.18E-025P19404, P12074, O75460, P28070, Q8TEV9NDUFV2, COX6A1, ERN1, PSMB4, SMCR8More
Brigatinibhsa05016Huntington disease1.51E-0612O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Brigatinibhsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Brigatinibhsa05020Prion disease1.31E-0516P01584, P46531, P0DMV8, P11142, O15239, O95298, P05496, P13073, P12074, P18848, P05141, P12236, P28070, P43686, P67870, Q99941IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFC2, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, CSNK2B, CREBL1More
Brigatinibhsa05022Pathways of neurodegeneration - multiple diseases1.42E-0826P67870, O15239, O95298, P19404, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, P05141, P45880, Q15078, Q00535, O15169, P01584, P49768, O15020, P0DP24, P0DP23, Q13557, P62987, P28070, P43686CSNK2B, NDUFA1, NDUFC2, NDUFV2, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, SLC25A5, VDAC2, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, SPTBN2, CALM2, CALM1, CAMK2D, UBA52, PSMB4, PSMC4More
Brigatinibhsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Brigatinibhsa05031Amphetamine addiction4.45E-055P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Brigatinibhsa05032Morphine addiction6.04E-046P62873, P63218, P50151, P78334, P32298, P43250GNB1, GNG5, GNG10, GABRE, GRK4, GRK6More
Brigatinibhsa05033Nicotine addiction4.01E-021P78334GABREMore
Brigatinibhsa05034Alcoholism8.63E-0819O15399, Q99941, P18848, Q16566, Q13547, P0DP23, P0DP24, P62873, P63218, P50151, P61952, P04049, P0C0S5, Q93077, P62807, Q93079, Q16778, O60814, P68431GRIN2D, CREBL1, ATF4, CAMK4, HDAC1, CALM1, CALM2, GNB1, GNG5, GNG10, GNG11, RAF1, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Brigatinibhsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Brigatinibhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Brigatinibhsa05120Epithelial cell signaling in Helicobacter pylori infection4.31E-1111Q16539, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240, P07948MAPK14, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Brigatinibhsa05130Pathogenic Escherichia coli infection2.77E-039P16333, Q13509, P60709, P25963, P04406, P29350, Q15438, P35579, P55061NCK1, TUBB3, ACTB, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Brigatinibhsa05131Shigellosis2.79E-0514Q12933, Q13546, Q05655, Q02156, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q12778, Q13315, P10415, P07737TRAF2, RIPK1, PRKCD, PRKCE, MALT1, RRAGD, UBB, SEPT6, ELMO2, PTK2, FOXO1, ATM, BCL2, PFN1More
Brigatinibhsa05132Salmonella infection1.34E-0819P51617, P25963, P08238, P04049, Q9UJU2, P01106, P84095, P60709, Q13546, Q13489, P10415, P04406, O75369, P07737, Q9BQS8, Q13561, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41More
Brigatinibhsa05133Pertussis1.43E-053P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Brigatinibhsa05134Legionellosis2.58E-089P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Brigatinibhsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Brigatinibhsa05140Leishmaniasis1.47E-0613P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Brigatinibhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Brigatinibhsa05143African trypanosomiasis2.11E-032P69905, P68871HBA2, HBBMore
Brigatinibhsa05144Malaria4.06E-069P60033, P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Brigatinibhsa05146Amoebiasis1.52E-1612P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Brigatinibhsa05150Staphylococcus aureus infection4.78E-0915P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Brigatinibhsa05152Tuberculosis1.04E-047P04049, P0DP23, P48382, P31751, P10415, Q9UDY8, P51617RAF1, CALM1, RFX5, AKT2, BCL2, MALT1, IRAK1More
Brigatinibhsa05160Hepatitis C2.32E-033Q13546, P01568, P04049RIPK1, IFNA21, RAF1More
Brigatinibhsa05161Hepatitis B4.32E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Brigatinibhsa05162Measles5.20E-046P23458, P31751, P0DMV8, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9BMore
Brigatinibhsa05163Human cytomegalovirus infection8.70E-1328P31751, P04049, P01375, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769, P01568AKT2, RAF1, TNF, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2M, IFNA21More
Brigatinibhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Brigatinibhsa05165Human papillomavirus infection2.80E-0410P02452, P24821, Q16363, P30281, Q9UM47, P01568, P01889, P10321, Q99437, P04628COL1A1, TNC, LAMA4, CCND3, NOTCH3, IFNA21, HLA-B, HLA-C, ATP6V0B, WNT1More
Brigatinibhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Brigatinibhsa05167Kaposi sarcoma-associated herpesvirus infection2.83E-0512P01568, P31751, P42224, P25963, P62873, P63218, P50151, P19174, P04049, P07948, P01106, P0DP23IFNA21, AKT2, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, RAF1, LYN, MYC, CALM1More
Brigatinibhsa05168Herpes simplex virus 1 infection6.80E-0424O00463, O60603, P25963, P01568, Q05823, Q07955, Q01130, P84103, Q13243, Q16629, Q13489, P30101, Q9Y2A4, Q13398, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9NZL3, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, SFRS1, SFRS2, SFRS3, SFRS5, SFRS7, BIRC3, PDIA3, ZNF443, ZNF211, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF224, ZNF212, BCL2More
Brigatinibhsa05169Epstein-Barr virus infection6.88E-0817P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Brigatinibhsa05170Human immunodeficiency virus 1 infection1.98E-0717P31751, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P51617, Q13315, P23528, P10415, Q9Y6Q5AKT2, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, IRAK1, ATM, CFL1, BCL2, AP1M2More
Brigatinibhsa05171Coronavirus disease - COVID-193.96E-0917P23396, P62753, P25398, P42677, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P46776, P62899, P62910, P18077, P61927, P05386RPS3, RPS6, RPS12, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPLP1More
Brigatinibhsa05200Pathways in cancer4.15E-0930Q13751, P08238, P42224, P25963, P19174, P01106, Q9UJU2, P43246, P84022, Q13485, P20585, P52701, P14923, P30279, P10415, Q13489, P98170, Q13077, P14921, P31751, P62873, P63218, P50151, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P01042LAMB3, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, MSH2, SMAD3, SMAD4, MSH3, MSH6, JUP, CCND2, BCL2, BIRC3, BIRC4, TRAF1, ETS1, AKT2, GNB1, GNG5, GNG10, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Brigatinibhsa05202Transcriptional misregulation in cancer7.90E-0919Q12778, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522FOXO1, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Brigatinibhsa05203Viral carcinogenesis8.79E-0615Q12933, Q99941, P18848, P30281, P27348, Q13547, Q15283, P06396, P12814, P01889, P10321, P06493, P62807, Q16778, O60814TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, RASA2, GSN, ACTN1, HLA-B, HLA-C, CDK1, HIST1H2BC, HIST2H2BE, H2BC12More
Brigatinibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Brigatinibhsa05205Proteoglycans in cancer6.79E-0510Q13009, Q12955, O75369, P60709, P04049, P01106, P08069, P19174, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MYC, IGF1R, PLCG1, PTPN6, CD63More
Brigatinibhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Brigatinibhsa05210Colorectal cancer2.62E-0510Q9UKG1, P84022, Q13485, P43246, P04049, P01106, P52701, P20585, P37173, O75293APPL1, SMAD3, SMAD4, MSH2, RAF1, MYC, MSH6, MSH3, TGFBR2, GADD45BMore
Brigatinibhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Brigatinibhsa05212Pancreatic cancer7.63E-057P31751, P04049, Q15311, P23458, P84022, Q13485, O75293AKT2, RAF1, RALBP1, JAK1, SMAD3, SMAD4, GADD45BMore
Brigatinibhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Brigatinibhsa05214Glioma1.15E-067P08069, P0DP23, Q16566, P04049, P31751, P19174, O75293IGF1R, CALM1, CAMK4, RAF1, AKT2, PLCG1, GADD45BMore
Brigatinibhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Brigatinibhsa05217Basal cell carcinoma4.31E-022P04628, Q9UJU2WNT1, LEF1More
Brigatinibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Brigatinibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Brigatinibhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Brigatinibhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Brigatinibhsa05222Small cell lung cancer4.77E-035P31751, Q13751, Q13489, P98170, O75293AKT2, LAMB3, BIRC3, BIRC4, GADD45BMore
Brigatinibhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Brigatinibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Brigatinibhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Brigatinibhsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Brigatinibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Brigatinibhsa05231Choline metabolism in cancer2.51E-069P04049, P31751, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494RAF1, AKT2, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1More
Brigatinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.14E-1517P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Brigatinibhsa05310Asthma1.21E-093P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Brigatinibhsa05321Inflammatory bowel disease5.48E-167O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Brigatinibhsa05322Systemic lupus erythematosus1.44E-0715P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q93077, P62807, Q16778, O60814, P68431, P14678, P12814FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SNRPB, ACTN1More
Brigatinibhsa05323Rheumatoid arthritis1.89E-047P01375, Q06643, P13765, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, CD28, CXCL1, CXCL2, TLR2More
Brigatinibhsa05330Allograft rejection2.83E-023P13765, P10747, P01375HLA-DOB, CD28, TNFMore
Brigatinibhsa05332Graft-versus-host disease6.42E-135P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Brigatinibhsa05340Primary immunodeficiency4.07E-056P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Brigatinibhsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Brigatinibhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Brigatinibhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Brigatinibhsa05415Diabetic cardiomyopathy4.10E-037P30405, Q15080, Q16718, O14521, Q16539, P14780, P37173PPIF, NCF4, NDUFA5, SDHD, MAPK14, MMP9, TGFBR2More
Brigatinibhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Brigatinib (SDC: 10.49)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08069IGF1RInsulinNonelike growth factor 1 receptorReported10.20820.95610.98833.0047
P06213INSRInsulin receptorReported00.27940.78130.72092.4232
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
Q15046KARSLysineNoneNonetRNA ligasePredicted00.10330.0580.00270.1702
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
P26358DNMT1DNAPredicted00.34040.28090.26590.998
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
O60880SH2D1ASH2 domainNonecontaining protein 1APredicted00.03520.01650.18070.2313
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
IGF1RP08069IC5025
INSRP06213IC50196