PharmaCoNets of Brexpiprazole (SPCN: 312.37 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Brexpiprazolehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Brexpiprazolehsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Brexpiprazolehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Brexpiprazolehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Brexpiprazolehsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Brexpiprazolehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Brexpiprazolehsa00220Arginine biosynthesis9.96E-042P05089, P49448ARG1, GLUD2More
Brexpiprazolehsa00230Purine metabolism1.74E-034P31350, P21589, P20839, Q16774RRM2, NT5E, IMPDH1, GUK1More
Brexpiprazolehsa00240Pyrimidine metabolism5.03E-054P31350, P21589, P04183, P04818RRM2, NT5E, TK1, TYMSMore
Brexpiprazolehsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Brexpiprazolehsa00310Lysine degradation1.87E-043Q96KQ7, Q02809, P51648EHMT2, PLOD1, ALDH3A2More
Brexpiprazolehsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Brexpiprazolehsa00500Starch and sucrose metabolism2.60E-114O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Brexpiprazolehsa00512Mucin type O-glycan biosynthesis3.19E-033O95395, Q8N4A0, Q9NY28GCNT3, GALNT4, GALNT8More
Brexpiprazolehsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Brexpiprazolehsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Brexpiprazolehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Brexpiprazolehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Brexpiprazolehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Brexpiprazolehsa00600Sphingolipid metabolism4.23E-033Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Brexpiprazolehsa00630Glyoxylate and dicarboxylate metabolism3.40E-093P40925, P40926, P15104MDH1, MDH2, GLULMore
Brexpiprazolehsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Brexpiprazolehsa00730Thiamine metabolism1.64E-082P05186, P24666ALPL, ACP1More
Brexpiprazolehsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Brexpiprazolehsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Brexpiprazolehsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Brexpiprazolehsa00970Aminoacyl-tRNA biosynthesis2.02E-054O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Brexpiprazolehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Brexpiprazolehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Brexpiprazolehsa00983Drug metabolism - other enzymes9.82E-043P04183, P32320, P05164TK1, CDA, MPOMore
Brexpiprazolehsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Brexpiprazolehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Brexpiprazolehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Brexpiprazolehsa012102-Oxocarboxylic acid metabolism1.40E-021P50213IDH3AMore
Brexpiprazolehsa01230Biosynthesis of amino acids2.92E-035P51854, P60891, P05089, P15104, P37837TKTL1, PRPS1, ARG1, GLUL, TALDO1More
Brexpiprazolehsa01240Biosynthesis of cofactors2.95E-022P13716, P14618ALAD, PKM2More
Brexpiprazolehsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Brexpiprazolehsa01522Endocrine resistance4.08E-036P22694, P04049, Q02750, Q9UM47, P46527, P08069PRKACB, RAF1, MAP2K1, NOTCH3, CDKN1B, IGF1RMore
Brexpiprazolehsa01523Antifolate resistance2.05E-042Q92820, P04818GGH, TYMSMore
Brexpiprazolehsa01524Platinum drug resistance4.74E-036Q13489, P98170, O15392, P78417, P11388, P43246BIRC3, BIRC4, BIRC5, GSTO1, TOP2A, MSH2More
Brexpiprazolehsa02010ABC transporters1.11E-053P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Brexpiprazolehsa03010Ribosome1.53E-058P62753, P62906, P46776, Q07020, P61513, P27635, P62249, P23396RPS6, RPL10A, RPL27A, RPL18, RPL37A, RPL10, RPS16, RPS3More
Brexpiprazolehsa03013RNA transport8.62E-0720P52298, Q09161, O14893, P38919, Q15287, Q9UBU9, P37198, Q7Z3B4, P35658, P63279, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, P20042, Q9Y6A5, P51114NCBP2, NCBP1, GEMIN2, EIF4A3, RNPS1, NXF1, NUP62, NUP54, NUP214, UBE2I, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, TACC3, FXR1More
Brexpiprazolehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Brexpiprazolehsa03020RNA polymerase3.03E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Brexpiprazolehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Brexpiprazolehsa03040Spliceosome1.49E-1419Q14562, O43143, O60508, P17844, P08579, Q15427, P26368, P51991, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, SF3B4, U2AF2, HNRPA3, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Brexpiprazolehsa03050Proteasome4.42E-033P55036, P28074, P40306PSMD4, PSMB5, PSMB10More
Brexpiprazolehsa03060Protein export1.20E-032P37108, Q15005SRP14, SPCS2More
Brexpiprazolehsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Brexpiprazolehsa03430Mismatch repair4.38E-021P20585MSH3More
Brexpiprazolehsa03450Non-homologous end-joining1.02E-032P78527, P13010PRKDC, XRCC5More
Brexpiprazolehsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Brexpiprazolehsa04012ErbB signaling pathway6.03E-047P21860, P16333, Q13557, P19174, O14944, P01106, P04049ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC, RAF1More
Brexpiprazolehsa04014Ras signaling pathway2.48E-0519Q02750, P04049, P42338, P20827, Q15389, Q9NRA1, P49767, P08069, Q13009, P17252, Q7LDG7, P21359, P0DP23, P62873, P62879, P63218, P50151, P19174, P22694MAP2K1, RAF1, PIK3CB, EFNA1, ANGPT1, PDGFC, VEGFC, IGF1R, TIAM1, PRKCA, RASGRP2, NF1, CALM1, GNB1, GNB2, GNG5, GNG10, PLCG1, PRKACBMore
Brexpiprazolehsa04015Rap1 signaling pathway1.98E-0516P04049, P20827, P49767, P08069, P06213, Q96FS4, P11215, P25116, Q8TEU7, Q13009, O00522, Q7LDG7, P42338, P08514, P17252, P19174RAF1, EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, KRIT1, RASGRP2, PIK3CB, ITGA2B, PRKCA, PLCG1More
Brexpiprazolehsa04020Calcium signaling pathway9.75E-057Q96DU7, P45880, Q13557, P21860, P0DP24, P51828, P23634ITPKC, VDAC2, CAMK2D, ERBB3, CALM2, ADCY7, ATP2B4More
Brexpiprazolehsa04022cGMP-PKG signaling pathway1.03E-039P04049, Q99941, P18848, P23634, Q8WYR1, P51828, P05141, P45880, P0DP24RAF1, CREBL1, ATF4, ATP2B4, PIK3R5, ADCY7, SLC25A5, VDAC2, CALM2More
Brexpiprazolehsa04024cAMP signaling pathway7.41E-034P51828, P0DP24, P23634, P04049ADCY7, CALM2, ATP2B4, RAF1More
Brexpiprazolehsa04060Cytokine-cytokine receptor interaction4.05E-0413P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, P25025, Q9UBD3, P47992, P09341, P18510, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, CXCR2, XCL2, XCL1, CXCL1, IL1RN, CD4More
Brexpiprazolehsa04061Viral protein interaction with cytokine and cytokine receptor1.18E-037P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Brexpiprazolehsa04062Chemokine signaling pathway6.76E-1123P25024, P25025, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P14598, P42224, P04049, P25963, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, NCF1, STAT1, RAF1, NFKBIA, GSK3B, PIK3R5More
Brexpiprazolehsa04064NF-kappa B signaling pathway6.60E-1223P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLDMore
Brexpiprazolehsa04066HIF-1 signaling pathway1.49E-025P08069, P17252, Q15389, Q02750, P46527IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Brexpiprazolehsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Brexpiprazolehsa04070Phosphatidylinositol signaling system1.91E-047P19174, P0DP23, P23743, P49619, Q86XP1, P27987, Q96DU7PLCG1, CALM1, DGKA, DGKG, DGKH, ITPKB, ITPKCMore
Brexpiprazolehsa04071Sphingolipid signaling pathway9.45E-0811P04049, P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2RAF1, PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Brexpiprazolehsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Brexpiprazolehsa04080Neuroactive ligand-receptor interaction1.08E-0411P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550, P35318CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2, ADMMore
Brexpiprazolehsa04110Cell cycle2.24E-0810Q9UBD5, P06493, O60566, P78527, Q14683, P30304, P33981, P42773, P01106, Q13547ORC3, CDK1, BUB1B, PRKDC, SMC1A, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Brexpiprazolehsa04114Oocyte meiosis3.90E-0510Q9Y6D9, P51812, Q02750, P0DP24, P16298, Q17RY0, P51828, P27348, Q13362, P08069MAD1L1, RPS6KA3, MAP2K1, CALM2, PPP3CB, CPEB4, ADCY7, YWHAQ, PPP2R5C, IGF1RMore
Brexpiprazolehsa04115p53 signaling pathway4.58E-048P24522, O15151, Q13315, P31350, Q53FA7, P06493, O95067, P10415GADD45A, MDM4, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2More
Brexpiprazolehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Brexpiprazolehsa04140Autophagy - animal7.72E-042P08069, P04049IGF1R, RAF1More
Brexpiprazolehsa04141Protein processing in endoplasmic reticulum3.89E-0615P18848, P30101, Q15437, Q15436, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, P14625, Q9H173, Q9UNL2ATF4, PDIA3, SEC23B, SEC23A, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, HSP90B1, SIL1, SSR3More
Brexpiprazolehsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Brexpiprazolehsa04144Endocytosis4.54E-0414Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5More
Brexpiprazolehsa04145Phagosome7.63E-0511P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Brexpiprazolehsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Brexpiprazolehsa04151PI3K-Akt signaling pathway5.91E-0623P62753, P42338, P43657, O43521, P27348, P20827, P49767, P07900, P08238, P14625, Q8WYR1, P63218, P50151, O15335, Q16363, Q13751, P22105, P14784, Q99941, P18848, O00141, Q6ZUJ8, P30281RPS6, PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, HSP90B1, PIK3R5, GNG5, GNG10, CHAD, LAMA4, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGK, PIK3AP1, CCND3More
Brexpiprazolehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Brexpiprazolehsa04210Apoptosis5.34E-0515Q13315, P10415, Q13489, O76075, P25963, P01375, Q9NR28, O75460, P24522, Q16548, Q13077, O43521, P18848, Q14643, P04049ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, DIABLO, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, ATF4, ITPR1, RAF1More
Brexpiprazolehsa04211Longevity regulating pathway5.33E-034P08069, P51828, Q99941, P18848IGF1R, ADCY7, CREBL1, ATF4More
Brexpiprazolehsa04213Longevity regulating pathway - multiple species8.54E-034P08069, Q08828, P51828, P0DMV8IGF1R, ADCY1, ADCY7, HSPA1AMore
Brexpiprazolehsa04217Necroptosis2.06E-0514P01375, P01568, P48023, Q13489, P98170, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q99878, Q9H444, P21796TNF, IFNA21, FASLG, BIRC3, BIRC4, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CHMP4B, VDAC1More
Brexpiprazolehsa04218Cellular senescence2.49E-021P04049RAF1More
Brexpiprazolehsa04261Adrenergic signaling in cardiomyocytes6.25E-069P07550, P51828, P22694, Q99941, P18848, Q13362, P0DP24, Q13557, P23634ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, CALM2, CAMK2D, ATP2B4More
Brexpiprazolehsa04270Vascular smooth muscle contraction2.27E-037P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Brexpiprazolehsa04330Notch signaling pathway2.46E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Brexpiprazolehsa04340Hedgehog signaling pathway1.76E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Brexpiprazolehsa04360Axon guidance1.51E-027P16333, P20827, O95631, P42338, P07332, P04049, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, RAF1, PLCG1More
Brexpiprazolehsa04370VEGF signaling pathway2.77E-044P16298, Q05397, Q02750, P04049PPP3CB, PTK2, MAP2K1, RAF1More
Brexpiprazolehsa04371Apelin signaling pathway3.56E-0812P62873, P63218, P50151, Q8WYR1, P04049, Q13370, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, PIK3R5, RAF1, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Brexpiprazolehsa04380Osteoclast differentiation8.48E-0614Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, P08637, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3A, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Brexpiprazolehsa04510Focal adhesion1.18E-032P04049, P08069RAF1, IGF1RMore
Brexpiprazolehsa04512ECM-receptor interaction1.94E-033Q16787, P26012, P16070LAMA3, ITGB8, CD44More
Brexpiprazolehsa04520Adherens junction8.29E-031P08069IGF1RMore
Brexpiprazolehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Brexpiprazolehsa04540Gap junction4.12E-068P17252, P22694, Q13509, P68371, Q71U36, Q02750, P04049, Q9NRA1PRKCA, PRKACB, TUBB3, TUBB2C, TUBA1A, MAP2K1, RAF1, PDGFCMore
Brexpiprazolehsa04550Signaling pathways regulating pluripotency of stem cells1.06E-047P04628, P40189, Q13873, P04049, Q02750, P08069, Q86SE9WNT1, IL6ST, BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Brexpiprazolehsa04610Complement and coagulation cascades4.27E-061P0C0L4C4AMore
Brexpiprazolehsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Brexpiprazolehsa04612Antigen processing and presentation5.76E-0811P13765, P48382, P01730, Q14953, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Brexpiprazolehsa04613Neutrophil extracellular trap formation2.95E-1129P19174, P17252, P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, P08637, O75015, P21730, P21462, O43315, Q16539PLCG1, PRKCA, RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3A, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Brexpiprazolehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Brexpiprazolehsa04621NOD-like receptor signaling pathway2.42E-0516Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P59665, P59666, P12838MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Brexpiprazolehsa04623Cytosolic DNA-sensing pathway6.63E-044P01584, P01568, P25963, Q8NHW4IL1B, IFNA21, NFKBIA, CCL4L2More
Brexpiprazolehsa04625C-type lectin receptor signaling pathway3.56E-0510Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Brexpiprazolehsa04630JAK-STAT signaling pathway4.80E-058P01106, P42224, O75925, P14784, P40189, Q13651, Q06124, P04049MYC, STAT1, PIAS1, IL2RB, IL6ST, IL10RA, PTPN11, RAF1More
Brexpiprazolehsa04640Hematopoietic cell lineage4.37E-0815P13612, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Brexpiprazolehsa04650Natural killer cell mediated cytotoxicity2.71E-1818P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, P04049, Q13241, P26718, O14931, P08637, O75015, P26717, Q07444, Q14953, P26715PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3A, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1More
Brexpiprazolehsa04657IL-17 signaling pathway1.17E-089O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1BMore
Brexpiprazolehsa04658Th1 and Th2 cell differentiation5.08E-2317Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P42226, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Brexpiprazolehsa04659Th17 cell differentiation2.16E-2021P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P42226, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, STAT6, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Brexpiprazolehsa04660T cell receptor signaling pathway4.23E-1617P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Brexpiprazolehsa04662B cell receptor signaling pathway1.46E-077P49841, P42338, P60033, P07948, P21854, Q8N149, P04049GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Brexpiprazolehsa04664Fc epsilon RI signaling pathway9.17E-079P01375, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917TNF, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5More
Brexpiprazolehsa04666Fc gamma R-mediated phagocytosis4.07E-033P08637, O75015, P04049FCGR3A, FCGR3B, RAF1More
Brexpiprazolehsa04668TNF signaling pathway2.74E-0614P01375, O00463, Q13489, Q16539, P25963, Q99941, P18848, P19875, P01584, P20749, Q13077, P14780, P20333, O95429TNF, TRAF5, BIRC3, MAPK14, NFKBIA, CREBL1, ATF4, CXCL2, IL1B, BCL3, TRAF1, MMP9, TNFRSF1B, BAG4More
Brexpiprazolehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Brexpiprazolehsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Brexpiprazolehsa04713Circadian entrainment1.24E-045O15399, P0DP23, P62873, P63218, P50151GRIN2D, CALM1, GNB1, GNG5, GNG10More
Brexpiprazolehsa04714Thermogenesis6.01E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Brexpiprazolehsa04720Long-term potentiation1.96E-059P17252, Q16566, P16298, P0DP23, P51812, O15399, P22694, Q02750, P04049PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, PRKACB, MAP2K1, RAF1More
Brexpiprazolehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Brexpiprazolehsa04724Glutamatergic synapse7.91E-085O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Brexpiprazolehsa04725Cholinergic synapse6.16E-0612P51828, P22694, P17252, P62873, P62879, P63218, P50151, P18848, Q16566, Q13557, P42338, Q02750ADCY7, PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, ATF4, CAMK4, CAMK2D, PIK3CB, MAP2K1More
Brexpiprazolehsa04726Serotonergic synapse2.69E-059P22694, P17252, P62873, P62879, P63218, P50151, P09917, P04049, Q02750PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, ALOX5, RAF1, MAP2K1More
Brexpiprazolehsa04727GABAergic synapse3.07E-088P62873, P62879, P63218, P50151, P15104, P22694, O60296, P17252GNB1, GNB2, GNG5, GNG10, GLUL, PRKACB, TRAK2, PRKCAMore
Brexpiprazolehsa04728Dopaminergic synapse4.12E-039P14416, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407DRD2, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1More
Brexpiprazolehsa04730Long-term depression4.37E-034Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Brexpiprazolehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Brexpiprazolehsa04742Taste transduction1.01E-021P30939HTR1FMore
Brexpiprazolehsa04744Phototransduction6.37E-052P62873, P0DP23GNB1, CALM1More
Brexpiprazolehsa04750Inflammatory mediator regulation of TRP channels1.73E-0411P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, Q14643, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ, CALM2, CALM1More
Brexpiprazolehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Brexpiprazolehsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Brexpiprazolehsa04911Insulin secretion2.03E-054P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Brexpiprazolehsa04912GnRH signaling pathway8.65E-049P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P22694, P04049ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB, RAF1More
Brexpiprazolehsa04913Ovarian steroidogenesis5.67E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Brexpiprazolehsa04914Progesterone-mediated oocyte maturation2.97E-046P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Brexpiprazolehsa04915Estrogen signaling pathway2.34E-0510P04049, Q99941, P18848, Q08828, P51828, P07900, P0DMV8, P11142, P0DP23, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1More
Brexpiprazolehsa04916Melanogenesis1.33E-021P04049RAF1More
Brexpiprazolehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Brexpiprazolehsa04918Thyroid hormone synthesis1.89E-057P51828, P17252, Q99941, P18848, P14625, P27824, P02768ADCY7, PRKCA, CREBL1, ATF4, HSP90B1, CANX, ALBMore
Brexpiprazolehsa04919Thyroid hormone signaling pathway5.27E-0613P17252, P49841, P19174, P04049, Q02750, P42224, P22694, Q13547, O60244, Q9NVC6, Q12778, Q9UM47, P01106PRKCA, GSK3B, PLCG1, RAF1, MAP2K1, STAT1, PRKACB, HDAC1, MED14, MED17, FOXO1, NOTCH3, MYCMore
Brexpiprazolehsa04920Adipocytokine signaling pathway4.82E-047P25963, Q06124, P33121, Q9Y478, Q04759, Q9Y4H2, P01375NFKBIA, PTPN11, ACSL1, PRKAB1, PRKCQ, IRS2, TNFMore
Brexpiprazolehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Brexpiprazolehsa04922Glucagon signaling pathway4.18E-022P14618, P06737PKM2, PYGLMore
Brexpiprazolehsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Brexpiprazolehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Brexpiprazolehsa04925Aldosterone synthesis and secretion9.59E-076Q99941, P18848, P51828, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY7, CALM2, CAMK2D, ATP2B4More
Brexpiprazolehsa04926Relaxin signaling pathway1.14E-0512P42338, P63218, P50151, Q99941, P18848, P22694, P49767, P14780, P51828, P04049, P30679, P49407PIK3CB, GNG5, GNG10, CREBL1, ATF4, PRKACB, VEGFC, MMP9, ADCY7, RAF1, GNA15, ARRB1More
Brexpiprazolehsa04927Cortisol synthesis and secretion2.72E-044Q99941, P18848, P51828, P22694CREBL1, ATF4, ADCY7, PRKACBMore
Brexpiprazolehsa04928Parathyroid hormone synthesis, secretion and action8.88E-048P51828, P22694, P04049, Q02750, P17252, Q99941, P18848, Q9Y5Q3ADCY7, PRKACB, RAF1, MAP2K1, PRKCA, CREBL1, ATF4, MAFBMore
Brexpiprazolehsa04929GnRH secretion3.50E-033P42338, P49407, P04049PIK3CB, ARRB1, RAF1More
Brexpiprazolehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Brexpiprazolehsa04931Insulin resistance9.16E-045P01375, P49841, Q06124, P06737, Q9Y478TNF, GSK3B, PTPN11, PYGL, PRKAB1More
Brexpiprazolehsa04932Non-alcoholic fatty liver disease6.81E-0712P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Brexpiprazolehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Brexpiprazolehsa04934Cushing syndrome1.09E-055Q99941, P18848, P51828, O15169, Q13557CREBL1, ATF4, ADCY7, AXIN1, CAMK2DMore
Brexpiprazolehsa04935Growth hormone synthesis, secretion and action5.33E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Brexpiprazolehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Brexpiprazolehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Brexpiprazolehsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Brexpiprazolehsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Brexpiprazolehsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Brexpiprazolehsa04966Collecting duct acid secretion2.17E-031P00918CA2More
Brexpiprazolehsa04970Salivary secretion1.05E-0610P07550, Q08828, P51828, P22694, Q14643, P23634, P17252, P0DP24, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CALM1, CAMPMore
Brexpiprazolehsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Brexpiprazolehsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Brexpiprazolehsa04973Carbohydrate digestion and absorption2.41E-021P13866SLC5A1More
Brexpiprazolehsa04976Bile secretion5.36E-057O43315, Q08828, P51828, P22694, P08183, P13866, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, SLC5A1, BAATMore
Brexpiprazolehsa05010Alzheimer disease1.70E-0311Q92542, P05496, P13073, P12074, O75460, P0DP24, P01584, P18848, O15169, P05141, P45880NCSTN, ATP5G1, COX4I1, COX6A1, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, VDAC2More
Brexpiprazolehsa05012Parkinson disease3.44E-0311P13073, P05141, P60604, O75460, P18848, P19174, P0DP23, P0DP24, Q71U36, Q13509, P68371COX4I1, SLC25A5, UBE2G2, ERN1, ATF4, PLCG1, CALM1, CALM2, TUBA1A, TUBB3, TUBB2CMore
Brexpiprazolehsa05016Huntington disease3.74E-0310O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Brexpiprazolehsa05017Spinocerebellar ataxia1.80E-025Q92915, O15399, P42338, P28074, P21796FGF14, GRIN2D, PIK3CB, PSMB5, VDAC1More
Brexpiprazolehsa05020Prion disease1.37E-0311P01584, P46531, P11142, Q16718, O14521, P05496, P12074, P45880, P49841, Q99941, Q16539IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, VDAC2, GSK3B, CREBL1, MAPK14More
Brexpiprazolehsa05022Pathways of neurodegeneration - multiple diseases6.94E-0413P49841, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, P0DP24GSK3B, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, CALM2More
Brexpiprazolehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Brexpiprazolehsa05031Amphetamine addiction8.84E-045Q13557, P22694, Q99941, P18848, Q13547CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Brexpiprazolehsa05032Morphine addiction7.62E-045P62873, P63218, P50151, Q13370, P43250GNB1, GNG5, GNG10, PDE3B, GRK6More
Brexpiprazolehsa05034Alcoholism1.08E-0614O15399, Q16566, Q13547, P0DP23, P62873, P63218, P50151, P04049, Q93077, P62807, Q93079, Q16778, O60814, P68431GRIN2D, CAMK4, HDAC1, CALM1, GNB1, GNG5, GNG10, RAF1, HIST1H2AC, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Brexpiprazolehsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Brexpiprazolehsa05120Epithelial cell signaling in Helicobacter pylori infection4.99E-0810Q16539, P25963, Q13488, Q99437, P09341, P19174, P25024, P25025, P41240, P07948MAPK14, NFKBIA, TCIRG1, ATP6V0B, CXCL1, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Brexpiprazolehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Brexpiprazolehsa05131Shigellosis3.05E-0312P01375, P25963, O00463, Q13546, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, RIPK1, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Brexpiprazolehsa05132Salmonella infection3.15E-0418P51617, P25963, P01375, P08238, P04049, Q9UJU2, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, TNF, HSP90AB1, RAF1, LEF1, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41More
Brexpiprazolehsa05133Pertussis3.02E-031P0C0L4C4AMore
Brexpiprazolehsa05134Legionellosis2.84E-036P01584, P25963, Q9NR31, P11215, P0DMV8, P11142IL1B, NFKBIA, SAR1A, ITGAM, HSPA1A, HSPA8More
Brexpiprazolehsa05135Yersinia infection3.91E-0411Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P49841, Q96JJ3, P01730, P01732PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, GSK3B, ELMO2, CD4, CD8AMore
Brexpiprazolehsa05140Leishmaniasis2.04E-0716P13612, P08637, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P49006, Q16539, P51617, Q15080ITGA4, FCGR3A, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, MARCKSL1, MAPK14, IRAK1, NCF4More
Brexpiprazolehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Brexpiprazolehsa05144Malaria3.55E-098P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Brexpiprazolehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Brexpiprazolehsa05146Amoebiasis8.64E-0812P01584, P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Brexpiprazolehsa05150Staphylococcus aureus infection6.55E-0713P0C0L4, P21730, P21462, P08637, O75015, P13765, Q16581, P13646, Q14532, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3A, FCGR3B, HLA-DOB, C3AR1, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Brexpiprazolehsa05152Tuberculosis1.41E-0210P04049, Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617RAF1, TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Brexpiprazolehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Brexpiprazolehsa05161Hepatitis B5.07E-0412P17252, P04049, P14780, Q99941, P18848, P25963, P01375, P10415, P27348, P51617, O60603, Q14765PRKCA, RAF1, MMP9, CREBL1, ATF4, NFKBIA, TNF, BCL2, YWHAQ, IRAK1, TLR2, STAT4More
Brexpiprazolehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Brexpiprazolehsa05163Human cytomegalovirus infection1.48E-0923P04049, P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463, P30101, P01568RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21More
Brexpiprazolehsa05164Influenza A3.65E-021P04049RAF1More
Brexpiprazolehsa05165Human papillomavirus infection4.71E-0310P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATMMore
Brexpiprazolehsa05167Kaposi sarcoma-associated herpesvirus infection2.26E-0611P01568, P42224, P25963, P62873, P63218, P50151, P19174, P04049, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, RAF1, LYN, CSF2, CALM1More
Brexpiprazolehsa05168Herpes simplex virus 1 infection5.00E-0312P25963, P01568, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P30101, Q13398, O75820, Q9NZL3NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF189, ZNF224More
Brexpiprazolehsa05169Epstein-Barr virus infection3.36E-0821P13765, P01106, Q13547, O00463, P16070, P10415, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, Q8WV28, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, CD44, BCL2, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, BLNK, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Brexpiprazolehsa05170Human immunodeficiency virus 1 infection1.35E-0727P04049, P62873, P63218, P50151, P0DP23, P01375, P17252, O00463, P30101, Q14643, P01568, P01730, Q16539, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P07766, P09693, P20963, P10415, Q13619, Q93034, Q9Y6Q5RAF1, GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, CD4, MAPK14, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, CD3E, CD3G, CD247, BCL2, CUL4A, CUL5, AP1M2More
Brexpiprazolehsa05171Coronavirus disease - COVID-194.36E-058P23396, P62753, P62249, P62906, P27635, Q07020, P46776, P61513RPS3, RPS6, RPS16, RPL10A, RPL10, RPL18, RPL27A, RPL37AMore
Brexpiprazolehsa05200Pathways in cancer2.40E-0727Q13751, P42338, P08238, P42224, P25963, P19174, P43246, P84022, Q13485, P20585, Q13547, P30281, Q13489, P98170, P49767, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P01042LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, SMAD4, MSH3, HDAC1, CCND3, BIRC3, BIRC4, VEGFC, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Brexpiprazolehsa05202Transcriptional misregulation in cancer2.88E-1226Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, Q15652, O15550, P08069, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, JMJD1C, UTX, IGF1R, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Brexpiprazolehsa05203Viral carcinogenesis7.37E-0511Q99941, P18848, P27348, Q13547, Q15283, P12814, P61978, P06493, P62807, Q16778, O60814CREBL1, ATF4, YWHAQ, HDAC1, RASA2, ACTN1, HNRPK, CDK1, HIST1H2BC, HIST2H2BE, H2BC12More
Brexpiprazolehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Brexpiprazolehsa05205Proteoglycans in cancer3.95E-0411Q12955, P04049, Q14247, P14780, P17252, P01375, P08069, P23588, Q13635, P22694, P08962ANK3, RAF1, CTTN, MMP9, PRKCA, TNF, IGF1R, EIF4B, PTCH1, PRKACB, CD63More
Brexpiprazolehsa05206MicroRNAs in cancer1.53E-0413P46527, P15311, P21860, P61978, P46531, Q9UM47, P16070, P63279, Q13315, P22105, P17252, P04049, Q02750CDKN1B, VIL2, ERBB3, HNRPK, NOTCH1, NOTCH3, CD44, UBE2I, ATM, TNXB, PRKCA, RAF1, MAP2K1More
Brexpiprazolehsa05210Colorectal cancer7.91E-035P84022, Q13485, P43246, P04049, O75293SMAD3, SMAD4, MSH2, RAF1, GADD45BMore
Brexpiprazolehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Brexpiprazolehsa05212Pancreatic cancer1.07E-046P42338, P04049, P42224, P84022, Q13485, O75293PIK3CB, RAF1, STAT1, SMAD3, SMAD4, GADD45BMore
Brexpiprazolehsa05213Endometrial cancer9.95E-031P04049RAF1More
Brexpiprazolehsa05214Glioma9.45E-056P08069, P0DP23, Q16566, P04049, P19174, O75293IGF1R, CALM1, CAMK4, RAF1, PLCG1, GADD45BMore
Brexpiprazolehsa05215Prostate cancer2.89E-057P10415, Q12778, P08069, P18848, Q9NRA1, P14625, P04049BCL2, FOXO1, IGF1R, ATF4, PDGFC, HSP90B1, RAF1More
Brexpiprazolehsa05217Basal cell carcinoma1.30E-034Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Brexpiprazolehsa05218Melanoma3.85E-052P08069, P04049IGF1R, RAF1More
Brexpiprazolehsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Brexpiprazolehsa05220Chronic myeloid leukemia3.00E-036Q13547, Q13485, P84022, P42338, P04049, O75293HDAC1, SMAD4, SMAD3, PIK3CB, RAF1, GADD45BMore
Brexpiprazolehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Brexpiprazolehsa05222Small cell lung cancer5.14E-0410Q16787, Q13751, Q13489, P98170, P10415, P25963, Q13077, O00463, P24522, O75293LAMA3, LAMB3, BIRC3, BIRC4, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A, GADD45BMore
Brexpiprazolehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Brexpiprazolehsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Brexpiprazolehsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Brexpiprazolehsa05226Gastric cancer1.02E-033P04049, P04628, P10826RAF1, WNT1, RARBMore
Brexpiprazolehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Brexpiprazolehsa05231Choline metabolism in cancer1.64E-044P04049, Q9Y259, P19174, P49619RAF1, CHKB, PLCG1, DGKGMore
Brexpiprazolehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.93E-1114O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, P42224, O60603, Q04759, Q16539, Q9HC35, P01730RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, STAT1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Brexpiprazolehsa05310Asthma1.70E-034P13765, P29965, P12724, P01375HLA-DOB, CD40LG, RNASE3, TNFMore
Brexpiprazolehsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Brexpiprazolehsa05321Inflammatory bowel disease1.09E-098O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3, IL1BMore
Brexpiprazolehsa05322Systemic lupus erythematosus1.39E-0716P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Brexpiprazolehsa05330Allograft rejection1.76E-034P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Brexpiprazolehsa05332Graft-versus-host disease3.35E-076P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Brexpiprazolehsa05340Primary immunodeficiency2.18E-034P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Brexpiprazolehsa05412Arrhythmogenic right ventricular cardiomyopathy3.28E-044P54284, P14923, P08514, Q9UJU2CACNB3, JUP, ITGA2B, LEF1More
Brexpiprazolehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Brexpiprazolehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Brexpiprazolehsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore
Brexpiprazolehsa05418Fluid shear stress and atherosclerosis1.79E-058Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Brexpiprazole (SDC: 11.04)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P11169SLC2A3Solute carrier family 2, facilitated glucose transporter member 3Predicted00.13570.065800.1995
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
O14786NRP1NeuropilinNone1Predicted10.38340.20260.51531.1123
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q9Y478PRKAB15'NoneAMPNoneactivated protein kinase subunit betaNone1Predicted10.14780.10880.55640.8479
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P40306PSMB10Proteasome subunit beta typeNone10Predicted00.26880.0510.01830.2548
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
P26358DNMT1DNAPredicted00.34040.28090.26590.998
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P14625HSP90B1EndoplasminPredicted00.23360.14970.53840.9546
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
Q96PH1NOX5NADPH oxidase 5Predicted00.23180.033200.1823
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)