PharmaCoNets of Bosentan (SPCN: 37.13 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Bosentanhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Bosentanhsa00190Oxidative phosphorylation3.56E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Bosentanhsa00220Arginine biosynthesis4.40E-021P15104GLULMore
Bosentanhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Bosentanhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Bosentanhsa02010ABC transporters2.17E-031Q8IZY2ABCA7More
Bosentanhsa03010Ribosome7.34E-036P62753, P62829, P62888, P61927, P61513, P36578RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4More
Bosentanhsa03013RNA transport3.98E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Bosentanhsa03020RNA polymerase2.06E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Bosentanhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Bosentanhsa04064NF-kappa B signaling pathway2.35E-024P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Bosentanhsa04120Ubiquitin mediated proteolysis2.38E-035Q14145, Q13042, Q93034, P62837, Q15751KEAP1, CDC16, CUL5, UBE2D2, HERC1More
Bosentanhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Bosentanhsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Bosentanhsa04145Phagosome1.66E-039Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Bosentanhsa04213Longevity regulating pathway - multiple species2.82E-023Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Bosentanhsa04217Necroptosis1.26E-049P01375, P48023, Q9NQC7, Q14765, P07900, P15104, P01584, Q99878, Q9H444TNF, FASLG, CYLD, STAT4, HSP90AA1, GLUL, IL1B, H2AC14, CHMP4BMore
Bosentanhsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Bosentanhsa04610Complement and coagulation cascades4.27E-061P0C0L4C4AMore
Bosentanhsa04612Antigen processing and presentation4.12E-023O43908, P30511, P01375KLRC4, HLA-F, TNFMore
Bosentanhsa04621NOD-like receptor signaling pathway2.70E-037P01584, P07900, P52630, P10599, P43490, P01375, P12838IL1B, HSP90AA1, STAT2, TXN, PBEF1, TNF, DEFA4More
Bosentanhsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Bosentanhsa04625C-type lectin receptor signaling pathway2.17E-023P52630, P20749, P01375STAT2, BCL3, TNFMore
Bosentanhsa04657IL-17 signaling pathway2.79E-035P07900, P49841, P80188, P01375, P01584HSP90AA1, GSK3B, LCN2, TNF, IL1BMore
Bosentanhsa04666Fc gamma R-mediated phagocytosis2.42E-025P23528, P06396, O14494, P14598, P17252CFL1, GSN, PLPP1, NCF1, PRKCAMore
Bosentanhsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Bosentanhsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Bosentanhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Bosentanhsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Bosentanhsa04750Inflammatory mediator regulation of TRP channels4.01E-024P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Bosentanhsa04915Estrogen signaling pathway3.17E-025Q08828, P51828, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Bosentanhsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Bosentanhsa04932Non-alcoholic fatty liver disease9.52E-0510P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, O15239, O95298TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2More
Bosentanhsa04940Type I diabetes mellitus5.82E-043P48023, P30511, P01375FASLG, HLA-F, TNFMore
Bosentanhsa04960Aldosterone-regulated sodium reabsorption4.40E-021O00141SGKMore
Bosentanhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Bosentanhsa04966Collecting duct acid secretion2.17E-031P00918CA2More
Bosentanhsa04970Salivary secretion4.78E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Bosentanhsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Bosentanhsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Bosentanhsa05132Salmonella infection2.93E-0210P51617, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Bosentanhsa05133Pertussis3.02E-031P0C0L4C4AMore
Bosentanhsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Bosentanhsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Bosentanhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Bosentanhsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Bosentanhsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Bosentanhsa05160Hepatitis C3.24E-045P52630, P60033, P49841, P01375, P48023STAT2, CD81, GSK3B, TNF, FASLGMore
Bosentanhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Bosentanhsa05163Human cytomegalovirus infection3.31E-027P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RAMore
Bosentanhsa05165Human papillomavirus infection1.76E-025P49841, P24821, P01375, P52630, P30511GSK3B, TNC, TNF, STAT2, HLA-FMore
Bosentanhsa05170Human immunodeficiency virus 1 infection5.94E-0312P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2More
Bosentanhsa05171Coronavirus disease - COVID-193.18E-037P01584, P62753, P36578, P62888, P61927, P61513, P62829IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23More
Bosentanhsa05202Transcriptional misregulation in cancer3.51E-0211Q12778, Q15532, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0FOXO1, SS18, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11BMore
Bosentanhsa05205Proteoglycans in cancer1.09E-0210Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Bosentanhsa05310Asthma9.71E-032P12724, P01375RNASE3, TNFMore
Bosentanhsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Bosentanhsa05330Allograft rejection1.28E-033P30511, P48023, P01375HLA-F, FASLG, TNFMore
Bosentanhsa05332Graft-versus-host disease2.43E-033P48023, P30511, P01375FASLG, HLA-F, TNFMore
Bosentanhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Bosentanhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Bosentanhsa05418Fluid shear stress and atherosclerosis4.70E-023Q14145, P10599, P01375KEAP1, TXN, TNFMore

Community members of Bosentan (SDC: 4.27)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q14145KEAP1KelchNonelike ECHNoneassociated protein 1Predicted10.02350.08370.40730.5864
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
O15164TRIM24Transcription intermediary factor 1NonealphaPredicted00.28070.105500.3514
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)