| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Bortezomib | hsa00030 | Pentose phosphate pathway | 8.52E-04 | 4 | P60891, P51854, P08237, P37837 | PRPS1, TKTL1, PFKM, TALDO1 | More | | | Bortezomib | hsa00052 | Galactose metabolism | 4.27E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Bortezomib | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Bortezomib | hsa00220 | Arginine biosynthesis | 8.30E-04 | 2 | P05089, P49448 | ARG1, GLUD2 | More | | | Bortezomib | hsa00500 | Starch and sucrose metabolism | 6.17E-03 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Bortezomib | hsa00520 | Amino sugar and nucleotide sugar metabolism | 2.24E-02 | 3 | Q16222, Q9Y223, P06865 | UAP1, GNE, HEXA | More | | | Bortezomib | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 1.91E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Bortezomib | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Bortezomib | hsa00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 3.78E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Bortezomib | hsa00670 | One carbon pool by folate | 3.15E-02 | 2 | O95954, Q99707 | FTCD, MTR | More | | | Bortezomib | hsa00730 | Thiamine metabolism | 2.27E-02 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Bortezomib | hsa00750 | Vitamin B6 metabolism | 3.56E-02 | 1 | O00764 | PDXK | More | | | Bortezomib | hsa00830 | Retinol metabolism | 3.93E-02 | 3 | P00352, Q9BPW9, O75911 | ALDH1A1, DHRS9, DHRS3 | More | | | Bortezomib | hsa00860 | Porphyrin and chlorophyll metabolism | 8.96E-04 | 2 | P36551, P30043 | CPOX, BLVRB | More | | | Bortezomib | hsa00910 | Nitrogen metabolism | 2.93E-02 | 2 | P22748, P49448 | CA4, GLUD2 | More | | | Bortezomib | hsa00920 | Sulfur metabolism | 1.78E-02 | 1 | Q16762 | TST | More | | | Bortezomib | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.12E-02 | 1 | P14868 | DARS | More | | | Bortezomib | hsa00983 | Drug metabolism - other enzymes | 3.20E-02 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Bortezomib | hsa01100 | Metabolic pathways | 1.03E-02 | 28 | Q9Y234, P35790, Q16772, P15144, P30041, O14732, Q02153, Q16774, P20839, P00918, P10768, P55809, P06280, Q9Y6K0, P08237, P21399, Q9UHK6, P51854, Q86VZ5, Q9BVK2, P15907, O96024, P37837, P50213, P43490, Q969G6, Q13029, Q9NVH6 | LIPT1, CHKA, GSTA3, ANPEP, PRDX6, IMPA2, GUCY1B3, GUK1, IMPDH1, CA2, ESD, OXCT1, GLA, CEPT1, PFKM, ACO1, AMACR, TKTL1, SGMS1, ALG8, ST6GAL1, B3GALT4, TALDO1, IDH3A, PBEF1, RFK, PRDM2, TMLHE | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9Y234 | LIPT1 | Lipoyltransferase 1, mitochondrial | 0.778 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P35790 | CHKA | Choline kinase alpha | -0.856 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q16772 | GSTA3 | Glutathione S-transferase A3 | -0.768 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P15144 | ANPEP | Aminopeptidase N | 0.846 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P30041 | PRDX6 | Peroxiredoxin-6 | 0.785 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | O14732 | IMPA2 | Inositol monophosphatase 2 | 0.738 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q02153 | GUCY1B3 | Guanylate cyclase soluble subunit beta-1 | -0.774 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q16774 | GUK1 | Guanylate kinase | 0.757 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | 1 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P00918 | CA2 | Carbonic anhydrase 2 | 0.772 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P10768 | ESD | S-formylglutathione hydrolase | -0.701 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P55809 | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | -0.744 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P06280 | GLA | Alpha-galactosidase A | 0.728 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9Y6K0 | CEPT1 | Choline/ethanolaminephosphotransferase 1 | 0.771 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P08237 | PFKM | ATP-dependent 6-phosphofructokinase, muscle type | 0.868 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P21399 | ACO1 | Cytoplasmic aconitate hydratase | -0.739 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9UHK6 | AMACR | Alpha-methylacyl-CoA racemase | -0.784 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P51854 | TKTL1 | Transketolase-like protein 1 | -0.753 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q86VZ5 | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | -0.81 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9BVK2 | ALG8 | Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase | -0.726 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P15907 | ST6GAL1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | -0.827 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | O96024 | B3GALT4 | Beta-1,3-galactosyltransferase 4 | 0.797 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P37837 | TALDO1 | Transaldolase | 0.732 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P50213 | IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | -0.732 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.702 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q969G6 | RFK | Riboflavin kinase | 0.705 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q13029 | PRDM2 | PR domain zinc finger protein 2 | 0.744 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9NVH6 | TMLHE | Trimethyllysine dioxygenase, mitochondrial | -0.721 |
| | Bortezomib | hsa01200 | Carbon metabolism | 1.81E-02 | 6 | P51854, P08237, P37837, P50213, P21399, P10768 | TKTL1, PFKM, TALDO1, IDH3A, ACO1, ESD | More | | | Bortezomib | hsa01210 | 2-Oxocarboxylic acid metabolism | 3.09E-05 | 2 | P21399, P50213 | ACO1, IDH3A | More | | | Bortezomib | hsa01230 | Biosynthesis of amino acids | 7.09E-04 | 7 | P08237, P51854, P60891, Q99707, P21399, P50213, P37837 | PFKM, TKTL1, PRPS1, MTR, ACO1, IDH3A, TALDO1 | More | | | Bortezomib | hsa01522 | Endocrine resistance | 4.55E-02 | 5 | P14780, P22694, Q9UM47, P10415, Q13323 | MMP9, PRKACB, NOTCH3, BCL2, BIK | More | | | Bortezomib | hsa02010 | ABC transporters | 4.93E-02 | 1 | Q8IZY2 | ABCA7 | More | | | Bortezomib | hsa03008 | Ribosome biogenesis in eukaryotes | 1.37E-03 | 4 | O14980, O60832, P78345, Q9BVP2 | XPO1, DKC1, RPP38, GNL3 | More | | | Bortezomib | hsa03013 | RNA transport | 5.57E-09 | 16 | O14980, P52298, Q09161, O14893, P61326, Q9H307, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, Q06787, P51114 | XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, PNN, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FMR1, FXR1 | More | | | Bortezomib | hsa03050 | Proteasome | 1.21E-02 | 1 | P28074 | PSMB5 | More | | | Bortezomib | hsa03450 | Non-homologous end-joining | 4.21E-02 | 1 | P13010 | XRCC5 | More | | | Bortezomib | hsa04060 | Cytokine-cytokine receptor interaction | 7.03E-05 | 16 | P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P01375, P09341, P18510, P01730, Q93038 | IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNF, CXCL1, IL1RN, CD4, TNFRSF25 | More | | | Bortezomib | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 2.07E-04 | 9 | P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375 | CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF | More | | | Bortezomib | hsa04062 | Chemokine signaling pathway | 4.01E-04 | 13 | P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881 | CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK | More | | | Bortezomib | hsa04064 | NF-kappa B signaling pathway | 3.68E-10 | 19 | P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q13315, P24522, P09341, P19875, Q06643 | BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, ATM, GADD45A, CXCL1, CXCL2, LTB | More | | | Bortezomib | hsa04071 | Sphingolipid signaling pathway | 2.24E-06 | 8 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2 | More | | | Bortezomib | hsa04072 | Phospholipase D signaling pathway | 4.48E-02 | 5 | P42338, P43657, P25024, P25025, P19174 | PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1 | More | | | Bortezomib | hsa04080 | Neuroactive ligand-receptor interaction | 1.11E-03 | 8 | P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1 | More | | | Bortezomib | hsa04115 | p53 signaling pathway | 3.57E-02 | 5 | P24522, Q13315, Q53FA7, O95067, P10415 | GADD45A, ATM, TP53I3, CCNB2, BCL2 | More | | | Bortezomib | hsa04122 | Sulfur relay system | 1.78E-02 | 1 | Q16762 | TST | More | | | Bortezomib | hsa04136 | Autophagy - other | 4.02E-04 | 2 | O94817, Q9H1Y0 | ATG12, ATG5 | More | | | Bortezomib | hsa04140 | Autophagy - animal | 4.55E-02 | 5 | P22694, Q14643, P10415, Q9H1Y0, Q04759 | PRKACB, ITPR1, BCL2, ATG5, PRKCQ | More | | | Bortezomib | hsa04145 | Phagosome | 8.88E-04 | 9 | O75015, Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765 | FCGR3B, NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB | More | | | Bortezomib | hsa04146 | Peroxisome | 2.42E-02 | 5 | O43933, P56589, Q9UKG9, O75521, P33121 | PEX1, PEX3, CROT, ECI2, ACSL1 | More | | | Bortezomib | hsa04210 | Apoptosis | 1.52E-02 | 9 | Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643 | ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1 | More | | | Bortezomib | hsa04213 | Longevity regulating pathway - multiple species | 3.85E-02 | 4 | P42338, Q9Y4H2, P11142, Q13547 | PIK3CB, IRS2, HSPA8, HDAC1 | More | | | Bortezomib | hsa04330 | Notch signaling pathway | 3.28E-03 | 4 | Q92542, P49768, Q92830, P78504 | NCSTN, PSEN1, KAT2A, JAG1 | More | | | Bortezomib | hsa04340 | Hedgehog signaling pathway | 3.46E-02 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Bortezomib | hsa04360 | Axon guidance | 1.66E-02 | 3 | P20827, P23528, Q06124 | EFNA1, CFL1, PTPN11 | More | | | Bortezomib | hsa04380 | Osteoclast differentiation | 1.02E-02 | 6 | Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149 | GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2 | More | | | Bortezomib | hsa04390 | Hippo signaling pathway | 2.41E-03 | 4 | P63261, O15105, P04628, O43623 | ACTG1, SMAD7, WNT1, SNAI2 | More | | | Bortezomib | hsa04514 | Cell adhesion molecules | 2.37E-02 | 2 | P16109, O00501 | SELP, CLDN5 | More | | | Bortezomib | hsa04530 | Tight junction | 3.64E-03 | 4 | P63261, O00501, Q92974, P24844 | ACTG1, CLDN5, ARHGEF2, MYL9 | More | | | Bortezomib | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.96E-02 | 3 | P04628, P40189, P14653 | WNT1, IL6ST, HOXB1 | More | | | Bortezomib | hsa04610 | Complement and coagulation cascades | 1.07E-05 | 3 | P00734, P0C0L4, P21730 | F2, C4A, C5AR1 | More | | | Bortezomib | hsa04612 | Antigen processing and presentation | 6.32E-05 | 9 | P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Bortezomib | hsa04613 | Neutrophil extracellular trap formation | 6.83E-08 | 16 | P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539 | PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | | Bortezomib | hsa04621 | NOD-like receptor signaling pathway | 2.68E-04 | 14 | Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838 | MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4 | More | | | Bortezomib | hsa04625 | C-type lectin receptor signaling pathway | 3.87E-02 | 4 | Q9ULY5, P20749, P01375, Q16539 | CLEC4E, BCL3, TNF, MAPK14 | More | | | Bortezomib | hsa04630 | JAK-STAT signaling pathway | 4.43E-02 | 3 | P48551, P40189, Q06124 | IFNAR2, IL6ST, PTPN11 | More | | | Bortezomib | hsa04640 | Hematopoietic cell lineage | 2.57E-06 | 12 | P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375 | ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF | More | | | Bortezomib | hsa04650 | Natural killer cell mediated cytotoxicity | 2.42E-07 | 11 | P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, P26715 | PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC1 | More | | | Bortezomib | hsa04657 | IL-17 signaling pathway | 1.65E-05 | 8 | O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF | More | | | Bortezomib | hsa04658 | Th1 and Th2 cell differentiation | 1.14E-12 | 14 | Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P08311 | CTSG | Cathepsin G | Q04759 | PRKCQ | Protein kinase C theta type | -0.913 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P08311 | CTSG | Cathepsin G | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.888 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P08311 | CTSG | Cathepsin G | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.706 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P08311 | CTSG | Cathepsin G | P06239 | LCK | Tyrosine-protein kinase Lck | -0.816 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.861 | | P08311 | CTSG | Cathepsin G | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.81 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.747 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | P08311 | CTSG | Cathepsin G | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.866 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.808 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P08311 | CTSG | Cathepsin G | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.795 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P08311 | CTSG | Cathepsin G | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.863 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 |
| | Bortezomib | hsa04659 | Th17 cell differentiation | 8.70E-10 | 13 | Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963 | PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247 | More | | | Bortezomib | hsa04660 | T cell receptor signaling pathway | 4.00E-10 | 18 | P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841 | TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P08311 | CTSG | Cathepsin G | P01375 | TNF | Tumor necrosis factor | 0.733 | | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.767 | | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | | P08311 | CTSG | Cathepsin G | Q04759 | PRKCQ | Protein kinase C theta type | -0.913 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P08246 | ELA2 | Neutrophil elastase | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | -0.854 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.792 | | P08246 | ELA2 | Neutrophil elastase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.724 | | P08311 | CTSG | Cathepsin G | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.705 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.855 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | P08246 | ELA2 | Neutrophil elastase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.782 | | P08311 | CTSG | Cathepsin G | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.866 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P08311 | CTSG | Cathepsin G | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.888 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P08311 | CTSG | Cathepsin G | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.706 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.742 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | P08311 | CTSG | Cathepsin G | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.826 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.793 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.714 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P08311 | CTSG | Cathepsin G | P06239 | LCK | Tyrosine-protein kinase Lck | -0.816 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.75 |
| | Bortezomib | hsa04664 | Fc epsilon RI signaling pathway | 3.98E-02 | 3 | P01375, Q16539, Q9UQC2 | TNF, MAPK14, GAB2 | More | | | Bortezomib | hsa04666 | Fc gamma R-mediated phagocytosis | 3.08E-02 | 5 | O75015, P06396, O14494, P14598, P17252 | FCGR3B, GSN, PLPP1, NCF1, PRKCA | More | | | Bortezomib | hsa04668 | TNF signaling pathway | 1.83E-03 | 8 | P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780 | TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9 | More | | | Bortezomib | hsa04670 | Leukocyte transendothelial migration | 4.20E-02 | 7 | P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681 | MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK | More | | | Bortezomib | hsa04750 | Inflammatory mediator regulation of TRP channels | 7.24E-03 | 5 | P14778, P19174, P42338, P24723, Q04759 | IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ | More | | | Bortezomib | hsa04920 | Adipocytokine signaling pathway | 4.49E-02 | 4 | P25963, P33121, Q04759, P01375 | NFKBIA, ACSL1, PRKCQ, TNF | More | | | Bortezomib | hsa04923 | Regulation of lipolysis in adipocytes | 2.24E-02 | 3 | P07550, P42338, Q9Y4H2 | ADRB2, PIK3CB, IRS2 | More | | | Bortezomib | hsa04940 | Type I diabetes mellitus | 4.18E-02 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | | | Bortezomib | hsa04964 | Proximal tubule bicarbonate reclamation | 2.74E-03 | 3 | P22748, P00918, P49448 | CA4, CA2, GLUD2 | More | | | Bortezomib | hsa04966 | Collecting duct acid secretion | 4.93E-02 | 1 | P00918 | CA2 | More | | | Bortezomib | hsa04970 | Salivary secretion | 4.49E-02 | 4 | P22694, Q14643, P17252, P49913 | PRKACB, ITPR1, PRKCA, CAMP | More | | | Bortezomib | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Bortezomib | hsa05017 | Spinocerebellar ataxia | 2.43E-02 | 1 | P28074 | PSMB5 | More | | | Bortezomib | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.78E-03 | 5 | P09341, P19875, P19174, P25024, P25025 | CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | | Bortezomib | hsa05131 | Shigellosis | 3.34E-02 | 11 | P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32 | TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF | More | | | Bortezomib | hsa05132 | Salmonella infection | 2.98E-02 | 11 | P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509 | IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3 | More | | | Bortezomib | hsa05133 | Pertussis | 2.64E-03 | 2 | P0DP23, P0C0L4 | CALM1, C4A | More | | | Bortezomib | hsa05134 | Legionellosis | 1.29E-02 | 4 | P11215, P11142, P09341, P19875 | ITGAM, HSPA8, CXCL1, CXCL2 | More | | | Bortezomib | hsa05140 | Leishmaniasis | 2.56E-05 | 10 | P13612, O75015, P14598, P13765, O60603, P25963, P01375, Q16539, P51617, Q15080 | ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MAPK14, IRAK1, NCF4 | More | | | Bortezomib | hsa05143 | African trypanosomiasis | 1.74E-03 | 2 | P69905, P68871 | HBA2, HBB | More | | | Bortezomib | hsa05144 | Malaria | 3.32E-03 | 4 | P69905, P68871, O60603, P10145 | HBA2, HBB, TLR2, IL8 | More | | | Bortezomib | hsa05145 | Toxoplasmosis | 3.07E-02 | 7 | P51617, P25963, P01375, P10415, Q13489, P13765, O60603 | IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2 | More | | | Bortezomib | hsa05146 | Amoebiasis | 1.14E-07 | 12 | P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | | | Bortezomib | hsa05150 | Staphylococcus aureus infection | 3.25E-03 | 8 | P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, P49913 | C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, CAMP | More | | | Bortezomib | hsa05152 | Tuberculosis | 8.50E-04 | 10 | Q13488, O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617 | TCIRG1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1 | More | | | Bortezomib | hsa05161 | Hepatitis B | 2.33E-02 | 8 | P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765 | PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4 | More | | | Bortezomib | hsa05163 | Human cytomegalovirus infection | 2.80E-02 | 6 | P01375, P49841, P14778, P25025, Q16539, O00463 | TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5 | More | | | Bortezomib | hsa05169 | Epstein-Barr virus infection | 4.84E-03 | 10 | P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963 | HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247 | More | | | Bortezomib | hsa05170 | Human immunodeficiency virus 1 infection | 1.06E-03 | 13 | P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5 | TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2 | More | | | Bortezomib | hsa05202 | Transcriptional misregulation in cancer | 1.62E-09 | 20 | Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522 | FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P22894 | MMP8 | Neutrophil collagenase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.72 | | P08246 | ELA2 | Neutrophil elastase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.75 | | P22894 | MMP8 | Neutrophil collagenase | Q15532 | SS18 | Protein SSXT | -0.867 | | P08246 | ELA2 | Neutrophil elastase | Q15532 | SS18 | Protein SSXT | -0.806 | | P22748 | CA4 | Carbonic anhydrase 4 | Q15532 | SS18 | Protein SSXT | -0.862 | | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | | P08311 | CTSG | Cathepsin G | Q13315 | ATM | Serine-protein kinase ATM | -0.709 | | P22748 | CA4 | Carbonic anhydrase 4 | P41732 | TSPAN7 | Tetraspanin-7 | 0.706 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | P22894 | MMP8 | Neutrophil collagenase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.882 | | P08246 | ELA2 | Neutrophil elastase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.859 | | P08311 | CTSG | Cathepsin G | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.79 | | P22748 | CA4 | Carbonic anhydrase 4 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.925 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | P08311 | CTSG | Cathepsin G | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.726 | | P22748 | CA4 | Carbonic anhydrase 4 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.708 | | P22894 | MMP8 | Neutrophil collagenase | P14923 | JUP | Junction plakoglobin | -0.809 | | P08246 | ELA2 | Neutrophil elastase | P14923 | JUP | Junction plakoglobin | -0.811 | | P22748 | CA4 | Carbonic anhydrase 4 | P14923 | JUP | Junction plakoglobin | -0.772 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | | P08311 | CTSG | Cathepsin G | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.909 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | | P22894 | MMP8 | Neutrophil collagenase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.843 | | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | | P08311 | CTSG | Cathepsin G | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.79 | | P22748 | CA4 | Carbonic anhydrase 4 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.833 | | P22894 | MMP8 | Neutrophil collagenase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.765 | | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | | P22894 | MMP8 | Neutrophil collagenase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.806 | | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | | P22748 | CA4 | Carbonic anhydrase 4 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.718 | | P22748 | CA4 | Carbonic anhydrase 4 | O15550 | UTX | Lysine-specific demethylase 6A | 0.714 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | | P22748 | CA4 | Carbonic anhydrase 4 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.834 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | | P22748 | CA4 | Carbonic anhydrase 4 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.834 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | | P08311 | CTSG | Cathepsin G | P05164 | MPO | Myeloperoxidase | 0.956 | | P22748 | CA4 | Carbonic anhydrase 4 | P05164 | MPO | Myeloperoxidase | 0.826 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | P08246 | ELA2 | Neutrophil elastase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.709 | | P08311 | CTSG | Cathepsin G | P12838 | DEFA4 | Neutrophil defensin 4 | 0.817 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | | P08311 | CTSG | Cathepsin G | P08246 | ELA2 | Neutrophil elastase | 0.792 | | P22748 | CA4 | Carbonic anhydrase 4 | P08246 | ELA2 | Neutrophil elastase | 0.921 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | | P22894 | MMP8 | Neutrophil collagenase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.778 | | P08246 | ELA2 | Neutrophil elastase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.75 | | P08311 | CTSG | Cathepsin G | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.853 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 | | P22894 | MMP8 | Neutrophil collagenase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.766 | | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 | | P08311 | CTSG | Cathepsin G | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.799 | | P22748 | CA4 | Carbonic anhydrase 4 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.769 |
| | Bortezomib | hsa05222 | Small cell lung cancer | 2.79E-02 | 6 | Q13489, P10415, P25963, Q13077, O00463, P24522 | BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A | More | | | Bortezomib | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 3.63E-05 | 9 | P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759, P01730 | PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, CD4 | More | | | Bortezomib | hsa05310 | Asthma | 2.50E-05 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Bortezomib | hsa05321 | Inflammatory bowel disease | 4.57E-08 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R | More | | | Bortezomib | hsa05322 | Systemic lupus erythematosus | 4.18E-04 | 10 | O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, Q16778, P12814, P05455 | FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST2H2BE, ACTN1, SSB | More | | | Bortezomib | hsa05332 | Graft-versus-host disease | 1.08E-06 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Bortezomib | hsa05340 | Primary immunodeficiency | 2.19E-02 | 4 | P01730, P01732, P07766, P06239 | CD4, CD8A, CD3E, LCK | More | | | Bortezomib | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.93E-02 | 1 | P54284 | CACNB3 | More | | | Bortezomib | hsa05416 | Viral myocarditis | 2.30E-02 | 2 | P10747, P63261 | CD28, ACTG1 | More | | | Bortezomib | hsa05418 | Fluid shear stress and atherosclerosis | 1.08E-03 | 7 | Q16539, Q14145, P10599, P14780, P01375, P14778, P27930 | MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2 | More | |
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