PharmaCoNets

PharmaCoNets of Bezafibrate (S_PCN: 115.86 )

Bezafibrate regulated-network (S_DN: 22.63)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Bezafibrate

hsa00020

Citrate cycle (TCA cycle)

2.78E-02

O75390, P40926

CS, MDH2

Bezafibrate

hsa00040

Pentose and glucuronate interconversions

9.59E-03

P15121, P14550

AKR1B1, AKR1A1

Bezafibrate

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Bezafibrate

hsa00061

Fatty acid biosynthesis

4.83E-02

P33121

ACSL1

Bezafibrate

hsa00190

Oxidative phosphorylation

1.00E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Bezafibrate

hsa00220

Arginine biosynthesis

1.54E-02

P05089, P49448

ARG1, GLUD2

Bezafibrate

hsa00480

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Bezafibrate

hsa00513

Various types of N-glycan biosynthesis

4.83E-02

Q9NR34

MAN1C1

Bezafibrate

hsa00520

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Bezafibrate

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Bezafibrate

hsa00561

Glycerolipid metabolism

7.94E-03

P15121, P14550, Q86XP1

AKR1B1, AKR1A1, DGKH

Bezafibrate

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Bezafibrate

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Bezafibrate

hsa00591

Linoleic acid metabolism

1.95E-03

P11712

CYP2C9

Bezafibrate

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Bezafibrate

hsa00630

Glyoxylate and dicarboxylate metabolism

1.32E-02

P40925, P15104

MDH1, GLUL

Bezafibrate

hsa00830

Retinol metabolism

4.09E-02

O75911, P11712

DHRS3, CYP2C9

Bezafibrate

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Bezafibrate

hsa00920

Sulfur metabolism

5.99E-04

Q16762

TST

Bezafibrate

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Bezafibrate

hsa00982

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Bezafibrate

hsa00983

Drug metabolism - other enzymes

1.78E-03

P04183, P32320, P05164, Q16772, P09211

TK1, CDA, MPO, GSTA3, GSTP1

Bezafibrate

hsa01100

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Bezafibrate

hsa01524

Platinum drug resistance

4.74E-03

P10415, Q13489, Q16772, P09211, P23025

BCL2, BIRC3, GSTA3, GSTP1, XPA

Bezafibrate

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Bezafibrate

hsa03010

Ribosome

1.60E-02

P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396

RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3

Bezafibrate

hsa03013

RNA transport

2.53E-02

P62826, Q15287, Q9UBU9, P63279, Q13310, P20042

RAN, RNPS1, NXF1, UBE2I, PABPC4, EIF2S2

Bezafibrate

hsa03015

mRNA surveillance pathway

4.25E-02

Q13310, Q13362, Q15287, Q9UBU9

PABPC4, PPP2R5C, RNPS1, NXF1

Bezafibrate

hsa03020

RNA polymerase

9.86E-07

Q9GZM3, P52435

POLR2J2, POLR2J

Bezafibrate

hsa03030

DNA replication

1.48E-02

P49005, P33993, P15927

POLD2, MCM7, RPA2

Bezafibrate

hsa03040

Spliceosome

4.19E-04

Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1

Bezafibrate

hsa03050

Proteasome

1.21E-02

P28074

PSMB5

Bezafibrate

hsa03060

Protein export

1.90E-02

Q15070, O76094

OXA1L, SRP72

Bezafibrate

hsa03320

PPAR signaling pathway

3.78E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Bezafibrate

hsa04012

ErbB signaling pathway

1.34E-02

P16333, P19174, P42338, P01106

NCK1, PLCG1, PIK3CB, MYC

Bezafibrate

hsa04014

Ras signaling pathway

2.92E-04

P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174

PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Bezafibrate

hsa04015

Rap1 signaling pathway

6.14E-05

P20827, Q9NRA1, P49767, P11215, P25116, Q8TEU7, Q13009, P42338, P0DP23, P08514, P19174

EFNA1, PDGFC, VEGFC, ITGAM, F2R, RAPGEF6, TIAM1, PIK3CB, CALM1, ITGA2B, PLCG1

Bezafibrate

hsa04020

Calcium signaling pathway

1.14E-06

P27987, Q96DU7, Q08828, P21796, Q13557, P21860, P19174, P61073, P0DP23, P05141, P12236, P51828, P26678, P63092, Q9NRA1, P49767

ITPKB, ITPKC, ADCY1, VDAC1, CAMK2D, ERBB3, PLCG1, CXCR4, CALM1, SLC25A5, SLC25A6, ADCY7, PLN, GNAS, PDGFC, VEGFC

Bezafibrate

hsa04022

cGMP-PKG signaling pathway

2.71E-04

P24844, P61586, P26678, Q99941, P18848, Q8WYR1, P05141, P12236, Q15746

MYL9, RHOA, PLN, CREBL1, ATF4, PIK3R5, SLC25A5, SLC25A6, MYLK

Bezafibrate

hsa04024

cAMP signaling pathway

1.40E-02

P48058, P25116, P24844

GRIA4, F2R, MYL9

Bezafibrate

hsa04060

Cytokine-cytokine receptor interaction

5.39E-03

P27930, P08476, Q13651, Q9HBE5, Q9UBD3, P47992, P01375, P09341, P18510, Q93038

IL1R2, INHBA, IL10RA, IL21R, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25

Bezafibrate

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.81E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF

Bezafibrate

hsa04062

Chemokine signaling pathway

2.81E-05

P25024, P25025, P09341, P19875, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P25963

CXCR1, CXCR2, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711

Bezafibrate

hsa04064

NF-kappa B signaling pathway

7.26E-07

P10415, Q13489, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643

BCL2, BIRC3, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.832
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16548	BCL2A1	Bcl-2-related protein A1	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q8WV28	BLNK	B-cell linker protein	-0.746
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Bezafibrate

hsa04070

Phosphatidylinositol signaling system

1.12E-02

P19174, P0DP23, P42338, P23743, P27987

PLCG1, CALM1, PIK3CB, DGKA, ITPKB

Bezafibrate

hsa04071

Sphingolipid signaling pathway

1.57E-04

P21453, Q9H228, Q13362, Q9BX95, Q16539, P10415, Q9UQC2, P01042

S1PR1, EDG8, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2, KNG1

Bezafibrate

hsa04072

Phospholipase D signaling pathway

5.49E-03

P42338, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFC

Bezafibrate

hsa04080

Neuroactive ligand-receptor interaction

7.92E-04

P08311, Q15722, P21453, Q9H228, O00398, P25116, P21730, Q16581, P07550, P01042

CTSG, LTB4R, S1PR1, EDG8, P2RY10, F2R, C5AR1, C3AR1, ADRB2, KNG1

Bezafibrate

hsa04114

Oocyte meiosis

4.54E-04

Q9Y6D9, P51812, Q02750, Q13557, P16298, Q17RY0, Q08828, P51828, P27348, Q13362

MAD1L1, RPS6KA3, MAP2K1, CAMK2D, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQ, PPP2R5C

Bezafibrate

hsa04122

Sulfur relay system

5.99E-04

Q16762

TST

Bezafibrate

hsa04136

Autophagy - other

3.53E-02

O94817

ATG12

Bezafibrate

hsa04140

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Bezafibrate

hsa04145

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Bezafibrate

hsa04151

PI3K-Akt signaling pathway

2.62E-04

P42338, P21860, P01106, P27348, P20827, O14944, Q9NRA1, P49767, P07900, P08238, Q15831, P62873, P63218, P50151, O15335, P22105, P14784, P01568, Q99941, P18848, O95988

PIK3CB, ERBB3, MYC, YWHAQ, EFNA1, EREG, PDGFC, VEGFC, HSP90AA1, HSP90AB1, STK11, GNB1, GNG5, GNG10, CHAD, TNXB, IL2RB, IFNA21, CREBL1, ATF4, TCL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40926	MDH2	Malate dehydrogenase, mitochondrial	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40926	MDH2	Malate dehydrogenase, mitochondrial	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P40926	MDH2	Malate dehydrogenase, mitochondrial	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.718
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15831	STK11	Serine/threonine-protein kinase STK11	0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O15335	CHAD	Chondroadherin	-0.704
P40926	MDH2	Malate dehydrogenase, mitochondrial	P22105	TNXB	Tenascin-X	0.802
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	O95988	TCL1B	T-cell leukemia/lymphoma protein 1B	0.719

Bezafibrate

hsa04210

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Bezafibrate

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Bezafibrate

hsa04215

Apoptosis - multiple species

1.02E-03

Q13489, P10415

BIRC3, BCL2

Bezafibrate

hsa04217

Necroptosis

2.87E-03

P01568, Q13489, P42224, P08238, Q6FI13, Q93077, O43633, Q08752

IFNA21, BIRC3, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, CHMP2A, PPID

Bezafibrate

hsa04261

Adrenergic signaling in cardiomyocytes

2.78E-03

P63092, Q08828, P51828, Q99941, P18848, P26678, Q13362, Q13557

GNAS, ADCY1, ADCY7, CREBL1, ATF4, PLN, PPP2R5C, CAMK2D

Bezafibrate

hsa04270

Vascular smooth muscle contraction

4.65E-02

Q15746, P24844

MYLK, MYL9

Bezafibrate

hsa04340

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Bezafibrate

hsa04360

Axon guidance

2.87E-02

P16333, P20827, O95631, P42338, P19174

NCK1, EFNA1, NTN1, PIK3CB, PLCG1

Bezafibrate

hsa04370

VEGF signaling pathway

2.47E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Bezafibrate

hsa04371

Apelin signaling pathway

2.41E-03

P62873, P63218, P50151, Q13370, Q14814, Q14344, P0DP23

GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, CALM1

Bezafibrate

hsa04380

Osteoclast differentiation

1.81E-02

Q9UQC2, Q16539, Q8WV28, Q15080

GAB2, MAPK14, BLNK, NCF4

Bezafibrate

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Bezafibrate

hsa04510

Focal adhesion

4.41E-03

P16144, P08514, Q15746, P24844, Q15942, Q13489, P10415

ITGB4, ITGA2B, MYLK, MYL9, ZYX, BIRC3, BCL2

Bezafibrate

hsa04512

ECM-receptor interaction

2.02E-03

P07359, P08514

GP1BA, ITGA2B

Bezafibrate

hsa04514

Cell adhesion molecules

5.78E-05

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Bezafibrate

hsa04530

Tight junction

7.89E-09

Q8TEU7, P16989, P56750, O00501, Q14247, P24844

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9

Bezafibrate

hsa04610

Complement and coagulation cascades

3.19E-06

P25116, P01042, P09871, P0C0L4, P10909, Q16581

F2R, KNG1, C1S, C4A, CLU, C3AR1

Bezafibrate

hsa04611

Platelet activation

2.54E-09

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Bezafibrate

hsa04612

Antigen processing and presentation

1.36E-03

P13765, P48382, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Bezafibrate

hsa04613

Neutrophil extracellular trap formation

5.05E-05

P42338, P19174, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q93077, P62807, Q93079, O60814, P68431, P21796, P14598, Q15080, P20160, P08311, P21730, P08514, P07359

PIK3CB, PLCG1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, C5AR1, ITGA2B, GP1BA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876

Bezafibrate

hsa04620

Toll-like receptor signaling pathway

4.00E-02

P01568, P42224, P25963, P42338

IFNA21, STAT1, NFKBIA, PIK3CB

Bezafibrate

hsa04623

Cytosolic DNA-sensing pathway

1.85E-03

P01568, P25963

IFNA21, NFKBIA

Bezafibrate

hsa04625

C-type lectin receptor signaling pathway

2.17E-02

Q9ULY5, P42224, P25963, P42338, P0DP23

CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1

Bezafibrate

hsa04640

Hematopoietic cell lineage

2.01E-03

P14778, P27930, P11215, P25063, P07766, P09693, P01732, P09564, P13765, P01375

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF

Bezafibrate

hsa04650

Natural killer cell mediated cytotoxicity

2.28E-08

P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P08311	CTSG	Cathepsin G	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.92
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P13612	ITGA4	Integrin alpha-4	Q13241	KLRD1	Natural killer cells antigen CD94	0.814
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P13612	ITGA4	Integrin alpha-4	P26718	KLRK1	NKG2-D type II integral membrane protein	0.818
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P08311	CTSG	Cathepsin G	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P13612	ITGA4	Integrin alpha-4	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.729
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P13612	ITGA4	Integrin alpha-4	P26717	KLRC2	NKG2-C type II integral membrane protein	0.772
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P13612	ITGA4	Integrin alpha-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.772
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Bezafibrate

hsa04657

IL-17 signaling pathway

2.29E-02

O00463, P09341, P14780, P80188, P01375

TRAF5, CXCL1, MMP9, LCN2, TNF

Bezafibrate

hsa04658

Th1 and Th2 cell differentiation

4.42E-12

P25963, Q04759, P07766, P20963, P09693, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

NFKBIA, PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P13612	ITGA4	Integrin alpha-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.764
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P13612	ITGA4	Integrin alpha-4	Q9UL17	TBX21	T-box transcription factor TBX21	0.822
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
P13612	ITGA4	Integrin alpha-4	Q13761	RUNX3	Runt-related transcription factor 3	0.78
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Bezafibrate

hsa04659

Th17 cell differentiation

1.60E-08

P25963, Q04759, P19174, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Bezafibrate

hsa04660

T cell receptor signaling pathway

4.18E-08

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P13612	ITGA4	Integrin alpha-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.834
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P13612	ITGA4	Integrin alpha-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P13612	ITGA4	Integrin alpha-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.7
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P13612	ITGA4	Integrin alpha-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.83
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816

Bezafibrate

hsa04662

B cell receptor signaling pathway

1.12E-02

P25963, P42338, P07948, P21854, Q8N149

NFKBIA, PIK3CB, LYN, CD72, LILRA2

Bezafibrate

hsa04664

Fc epsilon RI signaling pathway

1.34E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Bezafibrate

hsa04666

Fc gamma R-mediated phagocytosis

2.92E-02

P07948, P42338, P19174, P14598

LYN, PIK3CB, PLCG1, NCF1

Bezafibrate

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Bezafibrate

hsa04713

Circadian entrainment

4.00E-02

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Bezafibrate

hsa04720

Long-term potentiation

2.35E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Bezafibrate

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Bezafibrate

hsa04724

Glutamatergic synapse

3.15E-03

P48058, P62873, P63218, P50151, P15104, Q9NSB8

GRIA4, GNB1, GNG5, GNG10, GLUL, HOMER2

Bezafibrate

hsa04725

Cholinergic synapse

1.91E-03

Q08828, P51828, P62873, P63218, P50151, P18848, Q13557, P42338

ADCY1, ADCY7, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB

Bezafibrate

hsa04727

GABAergic synapse

8.14E-03

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Bezafibrate

hsa04744

Phototransduction

1.32E-02

P62873, P0DP23

GNB1, CALM1

Bezafibrate

hsa04750

Inflammatory mediator regulation of TRP channels

4.29E-05

P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1

Bezafibrate

hsa04810

Regulation of actin cytoskeleton

3.78E-05

P12814, P24844, Q15746, Q13009, P42338, P08514, P11215, Q14344, Q9NRA1, P25116

ACTN1, MYL9, MYLK, TIAM1, PIK3CB, ITGA2B, ITGAM, GNA13, PDGFC, F2R

Bezafibrate

hsa04911

Insulin secretion

5.02E-05

Q08828, P51828, P63092, Q99941, P18848, Q13557

ADCY1, ADCY7, GNAS, CREBL1, ATF4, CAMK2D

Bezafibrate

hsa04912

GnRH signaling pathway

2.45E-02

Q08828, P51828, P18848, Q13557

ADCY1, ADCY7, ATF4, CAMK2D

Bezafibrate

hsa04914

Progesterone-mediated oocyte maturation

1.37E-03

Q17RY0, P42338, Q13370, Q9Y6D9, P30304, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1

Bezafibrate

hsa04916

Melanogenesis

3.73E-02

Q13557, Q08828, P51828

CAMK2D, ADCY1, ADCY7

Bezafibrate

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Bezafibrate

hsa04921

Oxytocin signaling pathway

6.37E-03

Q15746, P24844, Q8WYR1

MYLK, MYL9, PIK3R5

Bezafibrate

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Bezafibrate

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Bezafibrate

hsa04924

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Bezafibrate

hsa04925

Aldosterone synthesis and secretion

7.42E-04

Q99941, P18848, Q08828, P51828, P63092, Q13557

CREBL1, ATF4, ADCY1, ADCY7, GNAS, CAMK2D

Bezafibrate

hsa04926

Relaxin signaling pathway

8.74E-03

P25963, P42338, P62873, P63218, P50151, P49767

NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFC

Bezafibrate

hsa04927

Cortisol synthesis and secretion

1.32E-03

Q99941, P18848, Q08828, P51828, P63092

CREBL1, ATF4, ADCY1, ADCY7, GNAS

Bezafibrate

hsa04928

Parathyroid hormone synthesis, secretion and action

2.59E-03

Q14643, P63092, P22694, P23771, P61586, Q99941, P18848, P10415

ITPR1, GNAS, PRKACB, GATA3, RHOA, CREBL1, ATF4, BCL2

Bezafibrate

hsa04932

Non-alcoholic fatty liver disease

2.07E-02

P18848, O75460, P01584, P12074, O15239

ATF4, ERN1, IL1B, COX6A1, NDUFA1

Bezafibrate

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Bezafibrate

hsa04934

Cushing syndrome

4.71E-05

Q99941, P18848, Q08828, P51828, P63092, O15169, Q13557

CREBL1, ATF4, ADCY1, ADCY7, GNAS, AXIN1, CAMK2D

Bezafibrate

hsa04964

Proximal tubule bicarbonate reclamation

2.74E-03

P22748, P00918, P49448

CA4, CA2, GLUD2

Bezafibrate

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Bezafibrate

hsa04971

Gastric acid secretion

4.73E-03

Q08828, P51828, P15311, Q13557

ADCY1, ADCY7, VIL2, CAMK2D

Bezafibrate

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Bezafibrate

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Bezafibrate

hsa05010

Alzheimer disease

6.56E-04

Q92542, O15239, P05496, P12074, Q00535, O75460, P01584, P18848, O15169, P05141, P12236, P28070, P43686, P62195

NCSTN, NDUFA1, ATP5G1, COX6A1, CDK5, ERN1, IL1B, ATF4, AXIN1, SLC25A5, SLC25A6, PSMB4, PSMC4, PSMC5

Bezafibrate

hsa05012

Parkinson disease

2.31E-05

O15239, P12074, P05496, P05141, P12236, P21796, P60604, P63092, O75460, P18848, P28070, P43686, P62195, P19174, P0DP23, Q13557, Q71U36, Q13509

NDUFA1, COX6A1, ATP5G1, SLC25A5, SLC25A6, VDAC1, UBE2G2, GNAS, ERN1, ATF4, PSMB4, PSMC4, PSMC5, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P63279	UBE2I	SUMO-conjugating enzyme UBC9	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.736
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.752
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.768
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P05141	SLC25A5	ADP/ATP translocase 2	0.755
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P60604	UBE2G2	Ubiquitin-conjugating enzyme E2 G2	0.82
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P63279	UBE2I	SUMO-conjugating enzyme UBC9	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.737
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P28070	PSMB4	Proteasome subunit beta type-4	0.733
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P63279	UBE2I	SUMO-conjugating enzyme UBC9	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.743
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777

Bezafibrate

hsa05014

Amyotrophic lateral sclerosis

3.92E-02

P20333, O15239, P05496, P18848, P43686, P62195, P51991, P35658

TNFRSF1B, NDUFA1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214

Bezafibrate

hsa05016

Huntington disease

4.51E-05

O15239, P12074, P05496, Q9GZM3, P30876, P62487, P52435, P05141, Q9NYC9, O75460, P28070

NDUFA1, COX6A1, ATP5G1, POLR2J2, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1, PSMB4

Bezafibrate

hsa05017

Spinocerebellar ataxia

2.43E-02

P28074

PSMB5

Bezafibrate

hsa05020

Prion disease

1.39E-03

P01584, P46531, O15239, P05496, P12074, P18848, P05141, P12236, P28070, P43686, P62195, Q99941

IL1B, NOTCH1, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, PSMC5, CREBL1

Bezafibrate

hsa05022

Pathways of neurodegeneration - multiple diseases

8.85E-04

O15239, P12074, P05496, O75460, P18848, P05141, P12236, P20333, Q00535, O15169, P01584, Q13557, P28070, P43686, P62195

NDUFA1, COX6A1, ATP5G1, ERN1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, CDK5, AXIN1, IL1B, CAMK2D, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P63279	UBE2I	SUMO-conjugating enzyme UBC9	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.736
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.752
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.768
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P63279	UBE2I	SUMO-conjugating enzyme UBC9	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.737
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P05141	SLC25A5	ADP/ATP translocase 2	0.755
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.772
P63279	UBE2I	SUMO-conjugating enzyme UBC9	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.739
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15169	AXIN1	Axin-1	0.795
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P01584	IL1B	Interleukin-1 beta	0.815
P63279	UBE2I	SUMO-conjugating enzyme UBC9	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.743
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P28070	PSMB4	Proteasome subunit beta type-4	0.733
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721

Bezafibrate

hsa05030

Cocaine addiction

2.40E-02

P63092, Q99941, P18848

GNAS, CREBL1, ATF4

Bezafibrate

hsa05031

Amphetamine addiction

4.47E-03

Q13557, P63092, Q99941, P18848

CAMK2D, GNAS, CREBL1, ATF4

Bezafibrate

hsa05032

Morphine addiction

7.60E-03

P62873, P63218, P50151, Q13370, P43250

GNB1, GNG5, GNG10, PDE3B, GRK6

Bezafibrate

hsa05034

Alcoholism

9.92E-05

Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431

HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Bezafibrate

hsa05100

Bacterial invasion of epithelial cells

4.50E-02

Q92529

SHC3

Bezafibrate

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Bezafibrate

hsa05130

Pathogenic Escherichia coli infection

4.91E-04

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Bezafibrate

hsa05132

Salmonella infection

2.07E-03

P25963, P08238, P01106, P42338, Q13489, P10415, O75369, Q9BQS8, Q71U36, Q13509, P49754

NFKBIA, HSP90AB1, MYC, PIK3CB, BIRC3, BCL2, FLNB, FYCO1, TUBA1A, TUBB3, VPS41

Bezafibrate

hsa05133

Pertussis

1.86E-03

P09871, P0C0L4, Q02556

C1S, C4A, IRF8

Bezafibrate

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Bezafibrate

hsa05135

Yersinia infection

2.58E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Bezafibrate

hsa05140

Leishmaniasis

1.42E-03

P14598, P42224, P13765, P25963, P29350, Q16539, Q15080

NCF1, STAT1, HLA-DOB, NFKBIA, PTPN6, MAPK14, NCF4

Bezafibrate

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Bezafibrate

hsa05144

Malaria

3.09E-02

P69905, P68871

HBA2, HBB

Bezafibrate

hsa05145

Toxoplasmosis

9.35E-04

P25963, Q16539, P10415, Q13489, P13765

NFKBIA, MAPK14, BCL2, BIRC3, HLA-DOB

Bezafibrate

hsa05146

Amoebiasis

1.01E-05

P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Bezafibrate

hsa05152

Tuberculosis

1.81E-02

P48382, P10415, P13765, Q16539

RFX5, BCL2, HLA-DOB, MAPK14

Bezafibrate

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Bezafibrate

hsa05162

Measles

1.84E-02

P01568, P25963, P42224, P14784, P07766, P42338, P11142

IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8

Bezafibrate

hsa05163

Human cytomegalovirus infection

6.53E-05

P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, Q08828, P51828, P23458, P01106, P01584, P61073, Q13651, P18848, P30101, P01568

PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, ADCY1, ADCY7, JAK1, MYC, IL1B, CXCR4, IL10RA, ATF4, PDIA3, IFNA21

Bezafibrate

hsa05167

Kaposi sarcoma-associated herpesvirus infection

7.49E-05

P01568, P42224, P25963, P42338, P62873, P63218, P50151, P19174, P07948, P01106, P0DP23

IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, PLCG1, LYN, MYC, CALM1

Bezafibrate

hsa05168

Herpes simplex virus 1 infection

6.47E-04

P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.866
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.835
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.908
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13398	ZNF211	Zinc finger protein 211	0.891
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75820	ZNF189	Zinc finger protein 189	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824

Bezafibrate

hsa05169

Epstein-Barr virus infection

1.08E-03

P01106, Q13547, P25963, P42338, P07948, P30101, Q13761, O75293, P42224, P01568, P07766

MYC, HDAC1, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, STAT1, IFNA21, CD3E

Bezafibrate

hsa05170

Human immunodeficiency virus 1 infection

3.27E-04

P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P07766

PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E

Bezafibrate

hsa05200

Pathways in cancer

1.82E-03

P42338, P08238, P42224, P25963, P19174, P01106, P43246, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784

PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB

Bezafibrate

hsa05202

Transcriptional misregulation in cancer

3.33E-05

Q12778, Q15532, Q13315, P14780, P27930, Q15744, Q16548, Q13489, O15550, P05164, P12838, P08246, Q9C0K0, P68431, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, CEBPE, BCL2A1, BIRC3, UTX, MPO, DEFA4, ELA2, BCL11B, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q15532	SS18	Protein SSXT	-0.829
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16548	BCL2A1	Bcl-2-related protein A1	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.832
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	O15550	UTX	Lysine-specific demethylase 6A	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P05164	MPO	Myeloperoxidase	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	-0.79
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Bezafibrate

hsa05203

Viral carcinogenesis

3.72E-07

Q12933, Q99941, P18848, P23458, P42229, P42338, P06746, P07948, P27348, P29083, Q7KZF4, Q13547, Q15283, P61586, P12814, P25963, P61978, P62807, Q93079, O60814

TRAF2, CREBL1, ATF4, JAK1, STAT5A, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, SND1, HDAC1, RASA2, RHOA, ACTN1, NFKBIA, HNRPK, HIST1H2BC, H2BC9, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P23458	JAK1	Tyrosine-protein kinase JAK1	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P06746	POLB	DNA polymerase beta	0.837
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P27348	YWHAQ	14-3-3 protein theta	0.759
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P29083	GTF2E1	General transcription factor IIE subunit 1	0.786
P63279	UBE2I	SUMO-conjugating enzyme UBC9	Q7KZF4	SND1	Staphylococcal nuclease domain-containing protein 1	0.74
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15283	RASA2	Ras GTPase-activating protein 2	-0.815
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P12814	ACTN1	Alpha-actinin-1	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.7
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.878
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Bezafibrate

hsa05204

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Bezafibrate

hsa05206

MicroRNAs in cancer

1.34E-03

P30304, P09493, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P61586, P20827, P19174

CDC25A, TPM1, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, RHOA, EFNA1, PLCG1

Bezafibrate

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Bezafibrate

hsa05212

Pancreatic cancer

3.52E-02

P84022, Q13485

SMAD3, SMAD4

Bezafibrate

hsa05214

Glioma

1.34E-02

P0DP23, P42338, P19174, O75293

CALM1, PIK3CB, PLCG1, GADD45B

Bezafibrate

hsa05218

Melanoma

2.31E-02

Q9NRA1, P42338, O75293

PDGFC, PIK3CB, GADD45B

Bezafibrate

hsa05220

Chronic myeloid leukemia

1.14E-03

Q13547, P01106, Q13485, P25963, P84022, P42338, O75293

HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Bezafibrate

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Bezafibrate

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Bezafibrate

hsa05231

Choline metabolism in cancer

2.92E-03

P42338, Q9NRA1, Q9Y259, P19174, P23743

PIK3CB, PDGFC, CHKB, PLCG1, DGKA

Bezafibrate

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.14E-05

P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759

NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Bezafibrate

hsa05310

Asthma

3.20E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Bezafibrate

hsa05321

Inflammatory bowel disease

5.69E-06

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Bezafibrate

hsa05322

Systemic lupus erythematosus

1.18E-04

P08246, P08311, P09871, P01375, P13765, Q93077, P62807, Q16778, O60814, P68431, P12814

ELA2, CTSG, C1S, TNF, HLA-DOB, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1

Bezafibrate

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Bezafibrate

hsa05332

Graft-versus-host disease

4.20E-04

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Bezafibrate

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Bezafibrate

hsa05415

Diabetic cardiomyopathy

6.60E-04

P17252, P05141, P12236, P14598, Q15080, O15239, Q16718, O14521, P05496, Q13557, P04406, P26678

PRKCA, SLC25A5, SLC25A6, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, ATP5G1, CAMK2D, GAPDH, PLN

Community members of Bezafibrate (S_DC: 5.12)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

NR1I2

Nuclear receptor subfamily 1 group I member 2

Reported

0.0315

0.9493

1.9143

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P10619

CTSA

Lysosomal protective protein

Predicted

0.1226

0.1531

0.1901

0.5575

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P40926

MDH2

Malate dehydrogenase, mitochondrial

Predicted

0.4721

0.1611

0.2474

0.8055

P40925

MDH1

Malate dehydrogenase, cytoplasmic

Predicted

0.3566

0.2746

0.2426

0.97

P63279

UBE2I

SUMONoneconjugating enzyme UBC9

Predicted

0.2332

0.0512

0.4983

0.7173

P13612

ITGA4

Integrin alphaNone4

Predicted

0.1165

0.2386

0.6862

1.2217

P28074

PSMB5

Proteasome subunit beta typeNone5

Predicted

0.2839

0.4723

0.5439

1.6305

P15121

AKR1B1

AldoNoneketo reductase family 1 member B1

Predicted

0.5683

0.629

0.214

1.7562

P18054

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

Predicted

0.0075

0.3703

0.2416

0.986

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

Q16581

C3AR1

C3a anaphylatoxin chemotactic receptor

Predicted

0.1388

0.0385

0.3428

0.4892

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P42330

AKR1C3

AldoNoneketo reductase family 1 member C3

Predicted

0.4017

0.8348

0.1748

2.0453

P08514

ITGA2B

Integrin alphaNoneIIb

Predicted

0.0782

0.3248

0.779

1.4677

P08311

CTSG

Cathepsin G

Predicted

0.4949

0.1874

0.6478

1.2701

P10588

NR2F6

Nuclear receptor subfamily 2 group F member 6

Predicted

0.3923

0.068

0.3321

P10826

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

PharmaCoNets of Bezafibrate (SPCN: 115.86 )

Bezafibrate regulated-network (SDN: 22.63)

Community members of Bezafibrate (SDC: 5.12)

PharmaCoNets of Bezafibrate (S_PCN: 115.86 )

Bezafibrate regulated-network (S_DN: 22.63)

Community members of Bezafibrate (S_DC: 5.12)