PharmaCoNets

PharmaCoNets of Bexarotene (S_PCN: 98.72 )

Bexarotene regulated-network (S_DN: 18.59)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Bexarotene

hsa00190

Oxidative phosphorylation

8.71E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Bexarotene

hsa00500

Starch and sucrose metabolism

1.42E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Bexarotene

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Bexarotene

hsa00520

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Bexarotene

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Bexarotene

hsa00630

Glyoxylate and dicarboxylate metabolism

7.59E-03

P40925, P15104

MDH1, GLUL

Bexarotene

hsa00730

Thiamine metabolism

4.07E-02

P05186, P24666

ALPL, ACP1

Bexarotene

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Bexarotene

hsa00970

Aminoacyl-tRNA biosynthesis

2.76E-03

O95363, Q15046

FARS2, KARS

Bexarotene

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Bexarotene

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Bexarotene

hsa01524

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Bexarotene

hsa03013

RNA transport

2.99E-02

P38919, P37198, P35658, P55884

EIF4A3, NUP62, NUP214, EIF3B

Bexarotene

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Bexarotene

hsa03020

RNA polymerase

9.80E-05

Q9GZM3, P52435

POLR2J2, POLR2J

Bexarotene

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Bexarotene

hsa03050

Proteasome

3.05E-02

P55036

PSMD4

Bexarotene

hsa03060

Protein export

3.28E-02

Q15070, O76094

OXA1L, SRP72

Bexarotene

hsa03320

PPAR signaling pathway

3.78E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Bexarotene

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Bexarotene

hsa04010

MAPK signaling pathway

1.53E-02

Q9H2K8, Q12933

TAOK3, TRAF2

Bexarotene

hsa04012

ErbB signaling pathway

3.15E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Bexarotene

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Bexarotene

hsa04015

Rap1 signaling pathway

2.69E-03

P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P19174

EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PLCG1

Bexarotene

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Bexarotene

hsa04062

Chemokine signaling pathway

8.58E-05

P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q7LDG7, Q13009, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15046	KARS	Lysine--tRNA ligase	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.704
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q15046	KARS	Lysine--tRNA ligase	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.741
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
Q15046	KARS	Lysine--tRNA ligase	P07948	LYN	Tyrosine-protein kinase Lyn	-0.86
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q15046	KARS	Lysine--tRNA ligase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.749
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q15046	KARS	Lysine--tRNA ligase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.821
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q15046	KARS	Lysine--tRNA ligase	P49407	ARRB1	Beta-arrestin-1	0.791
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Bexarotene

hsa04064

NF-kappa B signaling pathway

2.43E-04

P10415, Q13489, O00463, P14778, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643

BCL2, BIRC3, TRAF5, IL1R1, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB

Bexarotene

hsa04070

Phosphatidylinositol signaling system

3.47E-02

P0DP23, Q14643, P23743, P17252

CALM1, ITPR1, DGKA, PRKCA

Bexarotene

hsa04071

Sphingolipid signaling pathway

1.48E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q12933, Q02156

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, TRAF2, PRKCE

Bexarotene

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Bexarotene

hsa04110

Cell cycle

1.44E-02

P06493, O75293, P30304, P33981, P42773, P01106, Q13547

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1

Bexarotene

hsa04114

Oocyte meiosis

1.62E-04

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Bexarotene

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Bexarotene

hsa04145

Phagosome

1.21E-04

O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Bexarotene

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Bexarotene

hsa04151

PI3K-Akt signaling pathway

5.33E-03

P42338, P43657, P25116, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252, P30281

PIK3CB, P2RY5, F2R, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Bexarotene

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Bexarotene

hsa04217

Necroptosis

9.14E-03

P01568, Q13489, P42224, Q6FI13, P10415, O43633, Q08752

IFNA21, BIRC3, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPID

Bexarotene

hsa04261

Adrenergic signaling in cardiomyocytes

2.84E-02

P09493, Q13362, P0DP23, P17252, P10415

TPM1, PPP2R5C, CALM1, PRKCA, BCL2

Bexarotene

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Bexarotene

hsa04340

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Bexarotene

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Bexarotene

hsa04370

VEGF signaling pathway

1.43E-05

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Bexarotene

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Bexarotene

hsa04512

ECM-receptor interaction

3.73E-02

P07359, P08514

GP1BA, ITGA2B

Bexarotene

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Bexarotene

hsa04530

Tight junction

1.38E-04

Q8TEU7, P16989, P56750, O00501, Q14247

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN

Bexarotene

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Bexarotene

hsa04610

Complement and coagulation cascades

1.21E-03

P25116, P09871, P0C0L4

F2R, C1S, C4A

Bexarotene

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Bexarotene

hsa04612

Antigen processing and presentation

2.40E-02

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Bexarotene

hsa04613

Neutrophil extracellular trap formation

3.60E-05

P17252, P16109, O60603, P05164, P08246, Q9UM07, Q6FI13, O60814, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P08514, P21462, P07359, O43315, Q16539

PRKCA, SELP, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.799
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
Q15722	LTB4R	Leukotriene B4 receptor 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.833
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
Q15722	LTB4R	Leukotriene B4 receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.875
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
Q15722	LTB4R	Leukotriene B4 receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.888
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
Q15722	LTB4R	Leukotriene B4 receptor 1	O43315	AQP9	Aquaporin-9	0.79
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721

Bexarotene

hsa04621

NOD-like receptor signaling pathway

2.50E-03

Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Bexarotene

hsa04622

RIG-I-like receptor signaling pathway

2.47E-02

Q12933

TRAF2

Bexarotene

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Bexarotene

hsa04650

Natural killer cell mediated cytotoxicity

4.85E-07

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O75475	PSIP1	PC4 and SFRS1-interacting protein	P01375	TNF	Tumor necrosis factor	-0.72
O75475	PSIP1	PC4 and SFRS1-interacting protein	P78314	SH3BP2	SH3 domain-binding protein 2	-0.731
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O75475	PSIP1	PC4 and SFRS1-interacting protein	O60880	SH2D1A	SH2 domain-containing protein 1A	0.734
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
O75475	PSIP1	PC4 and SFRS1-interacting protein	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.734
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
O75475	PSIP1	PC4 and SFRS1-interacting protein	Q13241	KLRD1	Natural killer cells antigen CD94	0.772
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
O75475	PSIP1	PC4 and SFRS1-interacting protein	P26718	KLRK1	NKG2-D type II integral membrane protein	0.83
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
O75475	PSIP1	PC4 and SFRS1-interacting protein	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.879
O75475	PSIP1	PC4 and SFRS1-interacting protein	P26717	KLRC2	NKG2-C type II integral membrane protein	0.783
O75475	PSIP1	PC4 and SFRS1-interacting protein	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.783

Bexarotene

hsa04657

IL-17 signaling pathway

5.02E-03

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Bexarotene

hsa04658

Th1 and Th2 cell differentiation

9.90E-10

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q15046	KARS	Lysine--tRNA ligase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.88
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
Q15046	KARS	Lysine--tRNA ligase	P01730	CD4	T-cell surface glycoprotein CD4	0.702
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q15046	KARS	Lysine--tRNA ligase	P06239	LCK	Tyrosine-protein kinase Lck	0.753
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q15046	KARS	Lysine--tRNA ligase	Q9UL17	TBX21	T-box transcription factor TBX21	0.72
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q15046	KARS	Lysine--tRNA ligase	Q13761	RUNX3	Runt-related transcription factor 3	0.744
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721

Bexarotene

hsa04659

Th17 cell differentiation

4.51E-08

Q04759, P19174, P01730, P06239, P42224, P14784, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P20963

PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q15046	KARS	Lysine--tRNA ligase	P01730	CD4	T-cell surface glycoprotein CD4	0.702
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q15046	KARS	Lysine--tRNA ligase	P06239	LCK	Tyrosine-protein kinase Lck	0.753
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
Q15046	KARS	Lysine--tRNA ligase	P14778	IL1R1	Interleukin-1 receptor type 1	-0.828
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q15046	KARS	Lysine--tRNA ligase	Q9UL17	TBX21	T-box transcription factor TBX21	0.72
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
Q15046	KARS	Lysine--tRNA ligase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
Q15046	KARS	Lysine--tRNA ligase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.88
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87

Bexarotene

hsa04660

T cell receptor signaling pathway

7.99E-06

P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Bexarotene

hsa04662

B cell receptor signaling pathway

1.00E-03

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Bexarotene

hsa04664

Fc epsilon RI signaling pathway

2.47E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Bexarotene

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Bexarotene

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Bexarotene

hsa04713

Circadian entrainment

2.60E-02

P0DP23, P17252, P62873, Q14643

CALM1, PRKCA, GNB1, ITPR1

Bexarotene

hsa04720

Long-term potentiation

1.34E-04

P17252, P16298, P0DP23, P51812, Q02750, Q14643

PRKCA, PPP3CB, CALM1, RPS6KA3, MAP2K1, ITPR1

Bexarotene

hsa04723

Retrograde endocannabinoid signaling

8.76E-04

Q14643, P17252, P62873, P22694, Q16539, Q16718

ITPR1, PRKCA, GNB1, PRKACB, MAPK14, NDUFA5

Bexarotene

hsa04725

Cholinergic synapse

1.88E-02

Q14643, P17252, P62873, P10415

ITPR1, PRKCA, GNB1, BCL2

Bexarotene

hsa04727

GABAergic synapse

2.62E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Bexarotene

hsa04728

Dopaminergic synapse

3.55E-02

Q14643, P17252, P62873, Q13362, P0DP23

ITPR1, PRKCA, GNB1, PPP2R5C, CALM1

Bexarotene

hsa04730

Long-term depression

4.05E-02

Q14344, P07948

GNA13, LYN

Bexarotene

hsa04744

Phototransduction

1.02E-02

P62873, P0DP23

GNB1, CALM1

Bexarotene

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Bexarotene

hsa04810

Regulation of actin cytoskeleton

2.58E-02

Q15746, P08514, P25116

MYLK, ITGA2B, F2R

Bexarotene

hsa04912

GnRH signaling pathway

3.31E-04

P17252, Q16539, Q9Y6R4, Q14643, P0DP23, P22694

PRKCA, MAPK14, MAP3K4, ITPR1, CALM1, PRKACB

Bexarotene

hsa04914

Progesterone-mediated oocyte maturation

5.67E-04

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Bexarotene

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Bexarotene

hsa04922

Glucagon signaling pathway

3.47E-02

Q12778, Q13370, P0DP23, Q14643

FOXO1, PDE3B, CALM1, ITPR1

Bexarotene

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Bexarotene

hsa04924

Renin secretion

8.71E-03

Q14643, Q13370, P0DP23

ITPR1, PDE3B, CALM1

Bexarotene

hsa04928

Parathyroid hormone synthesis, secretion and action

3.75E-02

Q14643, P22694, P23771, P17252, P10415

ITPR1, PRKACB, GATA3, PRKCA, BCL2

Bexarotene

hsa04930

Type II diabetes mellitus

2.47E-02

Q02156

PRKCE

Bexarotene

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.19E-03

P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1

Bexarotene

hsa04966

Collecting duct acid secretion

2.86E-02

Q13488, Q9Y666

TCIRG1, SLC12A7

Bexarotene

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Bexarotene

hsa04974

Protein digestion and absorption

2.47E-02

Q7Z2H8

SLC36A1

Bexarotene

hsa05010

Alzheimer disease

3.55E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPID

Bexarotene

hsa05012

Parkinson disease

2.25E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C

Bexarotene

hsa05016

Huntington disease

1.07E-02

Q9GZM3, P52435, P55036

POLR2J2, POLR2J, PSMD4

Bexarotene

hsa05020

Prion disease

1.15E-02

Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4

Bexarotene

hsa05022

Pathways of neurodegeneration - multiple diseases

4.48E-03

Q14643, Q13509, P68371, P10415, Q16718, O14521, Q13561, P17252, Q08752, P0DP23

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, PPID, CALM1

Bexarotene

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.84E-05

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Bexarotene

hsa05130

Pathogenic Escherichia coli infection

7.39E-03

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Bexarotene

hsa05131

Shigellosis

3.33E-03

Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752

TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID

Bexarotene

hsa05132

Salmonella infection

1.11E-02

Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371

LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Bexarotene

hsa05133

Pertussis

2.18E-03

P09871, P0C0L4, Q02556

C1S, C4A, IRF8

Bexarotene

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Bexarotene

hsa05135

Yersinia infection

2.58E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Bexarotene

hsa05140

Leishmaniasis

1.61E-05

P13612, O75015, P14598, P42224, P13765, O60603, P01375, P29350, P49006, Q16539, Q15080

ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, TNF, PTPN6, MARCKSL1, MAPK14, NCF4

Bexarotene

hsa05145

Toxoplasmosis

1.11E-02

P10415, Q13489, P42224, P13765, O60603, P29965

BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Bexarotene

hsa05146

Amoebiasis

1.22E-05

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Bexarotene

hsa05152

Tuberculosis

4.68E-05

Q13488, P0DP23, O75015, P42224, P48382, O60603, P10415, P13765, P01568, Q9UDY8, Q16539

TCIRG1, CALM1, FCGR3B, STAT1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, MAPK14

Bexarotene

hsa05163

Human cytomegalovirus infection

4.21E-04

P01375, P63218, P50151, Q14643, Q14344, P49841, P14778, P25025, Q16539, P04637, O00463, P30101

TNF, GNG5, GNG10, ITPR1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5, PDIA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75475	PSIP1	PC4 and SFRS1-interacting protein	P01375	TNF	Tumor necrosis factor	-0.72
O75475	PSIP1	PC4 and SFRS1-interacting protein	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.701
Q15046	KARS	Lysine--tRNA ligase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.749
O75475	PSIP1	PC4 and SFRS1-interacting protein	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.721
Q15046	KARS	Lysine--tRNA ligase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.821
O75475	PSIP1	PC4 and SFRS1-interacting protein	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
Q15046	KARS	Lysine--tRNA ligase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.81
O75475	PSIP1	PC4 and SFRS1-interacting protein	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.742
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
O75475	PSIP1	PC4 and SFRS1-interacting protein	P14778	IL1R1	Interleukin-1 receptor type 1	-0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q15046	KARS	Lysine--tRNA ligase	P14778	IL1R1	Interleukin-1 receptor type 1	-0.828
O75475	PSIP1	PC4 and SFRS1-interacting protein	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.903
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q15046	KARS	Lysine--tRNA ligase	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.741
O75475	PSIP1	PC4 and SFRS1-interacting protein	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
O75475	PSIP1	PC4 and SFRS1-interacting protein	O00463	TRAF5	TNF receptor-associated factor 5	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q15046	KARS	Lysine--tRNA ligase	P30101	PDIA3	Protein disulfide-isomerase A3	0.742

Bexarotene

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Bexarotene

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.04E-03

P01568, P42224, P62873, P62879, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2

IFNA21, STAT1, GNB1, GNB2, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1

Bexarotene

hsa05170

Human immunodeficiency virus 1 infection

1.09E-05

Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333

MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1B

Bexarotene

hsa05200

Pathways in cancer

1.55E-03

Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784

LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Bexarotene

hsa05202

Transcriptional misregulation in cancer

3.44E-04

Q12778, Q15532, P41732, P14780, P27930, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

FOXO1, SS18, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	Q12778	FOXO1	Forkhead box protein O1	-0.769
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15532	SS18	Protein SSXT	-0.803
Q15722	LTB4R	Leukotriene B4 receptor 1	P41732	TSPAN7	Tetraspanin-7	0.775
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
Q15722	LTB4R	Leukotriene B4 receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.861
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q15722	LTB4R	Leukotriene B4 receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.734
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.837
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.797
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
Q15722	LTB4R	Leukotriene B4 receptor 1	O15550	UTX	Lysine-specific demethylase 6A	0.789
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.808
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
Q15722	LTB4R	Leukotriene B4 receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.764

Bexarotene

hsa05212

Pancreatic cancer

3.94E-02

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Bexarotene

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Bexarotene

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Bexarotene

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Bexarotene

hsa05223

Non-small cell lung cancer

4.24E-02

P19174, Q9HC35, O75293

PLCG1, EML4, GADD45B

Bexarotene

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Bexarotene

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Bexarotene

hsa05231

Choline metabolism in cancer

4.24E-02

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Bexarotene

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

8.76E-06

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, Q04759, Q16539, Q9HC35, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, PRKCQ, MAPK14, EML4, CD4

Bexarotene

hsa05310

Asthma

2.81E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Bexarotene

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Bexarotene

hsa05321

Inflammatory bowel disease

3.31E-04

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Bexarotene

hsa05322

Systemic lupus erythematosus

4.18E-03

P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Bexarotene

hsa05323

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Bexarotene

hsa05330

Allograft rejection

1.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Bexarotene

hsa05332

Graft-versus-host disease

1.07E-03

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Bexarotene

hsa05340

Primary immunodeficiency

4.85E-03

P01730, P07766, P06239

CD4, CD3E, LCK

Bexarotene

hsa05415

Diabetic cardiomyopathy

3.55E-02

P17252, P14598, Q15080, Q16718, O14521

PRKCA, NCF1, NCF4, NDUFA5, SDHD

Bexarotene

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Bexarotene

hsa05418

Fluid shear stress and atherosclerosis

2.62E-02

Q16539, P10599, P14780, P04637, P14778, P27930

MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2

Community members of Bexarotene (S_DC: 5.31)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

Q13133

NR1H3

Oxysterols receptor LXRNonealpha

Predicted

0.0162

0.439

0.2086

1.0947

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P98170

BIRC4

E3 ubiquitinNoneprotein ligase XIAP

Predicted

0.2974

0.2298

0.79

1.3984

Q15722

LTB4R

Leukotriene B4 receptor 1

Predicted

0.0677

0.2199

0.4736

P30531

SLC6A1

SodiumNone and chlorideNonedependent GABA transporter 1

Predicted

0.0889

0.5202

0.1047

1.1894

P14780

MMP9

Matrix metalloproteinaseNone9

Predicted

0.1696

0.8424

0.7315

2.5012

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

Q15046

KARS

LysineNoneNonetRNA ligase

Predicted

0.1033

0.058

0.0027

0.1702

P30304

CDC25A

MNonephase inducer phosphatase 1

Predicted

0.1795

0.2347

0.4274

0.9865

P18054

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

Predicted

0.0075

0.3703

0.2416

0.986

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

Q02156

PRKCE

Protein kinase C epsilon type

Predicted

0.1175

0.5287

0.5377

1.6539

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

O75475

PSIP1

PC4 and SFRS1Noneinteracting protein

Predicted

0.3332

0.0638

0.2943

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P49768

PSEN1

PresenilinNone1

Predicted

0.2677

0.6599

0.3308

1.7845

P10588

NR2F6

Nuclear receptor subfamily 2 group F member 6

Predicted

0.3923

0.068

0.3321

P10826

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

PharmaCoNets of Bexarotene (SPCN: 98.72 )

Bexarotene regulated-network (SDN: 18.59)

Community members of Bexarotene (SDC: 5.31)

PharmaCoNets of Bexarotene (S_PCN: 98.72 )

Bexarotene regulated-network (S_DN: 18.59)

Community members of Bexarotene (S_DC: 5.31)