PharmaCoNets

PharmaCoNets of Betrixaban (S_PCN: 187.77 )

Betrixaban regulated-network (S_DN: 26.33)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Betrixaban

hsa00030

Pentose phosphate pathway

7.84E-03

P06744, P37837

GPI, TALDO1

Betrixaban

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Betrixaban

hsa00071

Fatty acid degradation

3.65E-03

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Betrixaban

hsa00190

Oxidative phosphorylation

1.94E-02

Q16718, P36542, O14521

NDUFA5, ATP5C1, SDHD

Betrixaban

hsa00220

Arginine biosynthesis

1.21E-02

P15104

GLUL

Betrixaban

hsa00250

Alanine, aspartate and glutamate metabolism

2.42E-02

P15104

GLUL

Betrixaban

hsa00500

Starch and sucrose metabolism

1.54E-06

O43451, P46976, P06737

MGAM, GYG1, PYGL

Betrixaban

hsa00513

Various types of N-glycan biosynthesis

4.83E-02

Q9NR34

MAN1C1

Betrixaban

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Betrixaban

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Betrixaban

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Betrixaban

hsa00730

Thiamine metabolism

1.13E-04

P05186, P24666

ALPL, ACP1

Betrixaban

hsa00760

Nicotinate and nicotinamide metabolism

3.52E-02

P21589

NT5E

Betrixaban

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Betrixaban

hsa00830

Retinol metabolism

2.20E-02

P00325, P11766, Q9BPW9, O75911

ADH1B, ADH5, DHRS9, DHRS3

Betrixaban

hsa00910

Nitrogen metabolism

2.42E-02

P15104

GLUL

Betrixaban

hsa00920

Sulfur metabolism

5.99E-04

Q16762

TST

Betrixaban

hsa00970

Aminoacyl-tRNA biosynthesis

1.17E-02

O95363, P14868, Q15046

FARS2, DARS, KARS

Betrixaban

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Betrixaban

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Betrixaban

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Betrixaban

hsa01200

Carbon metabolism

7.69E-03

P06744, P37837, P40926

GPI, TALDO1, MDH2

Betrixaban

hsa01230

Biosynthesis of amino acids

5.53E-03

P15104, P37837

GLUL, TALDO1

Betrixaban

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P04049

RAF1

Betrixaban

hsa01522

Endocrine resistance

8.48E-04

P22694, P04049, Q9UM47, P10415, Q13323

PRKACB, RAF1, NOTCH3, BCL2, BIK

Betrixaban

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Betrixaban

hsa03013

RNA transport

2.82E-06

P62826, O14980, Q09161, O14893, P38919, Q9UBU9, P37198, Q7Z3B4, P35658, P63279, P68104, P47813, Q14152, P55884, O75822, Q14240, Q9BZI7, Q14232, Q06787, P51114

RAN, XPO1, NCBP1, GEMIN2, EIF4A3, NXF1, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF3A, EIF3B, EIF3J, EIF4A2, UPF3B, EIF2B1, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14980	XPO1	Exportin-1	0.799
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14893	GEMIN2	Gem-associated protein 2	0.72
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.844
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.869
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.77
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.849
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.764
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q06787	FMR1	Synaptic functional regulator FMR1	0.863
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.798

Betrixaban

hsa03020

RNA polymerase

6.21E-04

P30876, P24928, P62487, Q9Y535

POLR2B, POLR2A, POLR2G, POLR3H

Betrixaban

hsa03022

Basal transcription factors

3.50E-02

P20226, O00268, Q15544

TBP, TAF4, TAF11

Betrixaban

hsa03040

Spliceosome

1.26E-02

P17844, P51991, P61978, Q15365, Q01130, P11142

DDX5, HNRPA3, HNRPK, PCBP1, SFRS2, HSPA8

Betrixaban

hsa03060

Protein export

1.10E-03

Q15070, P37108, O76094, Q15005

OXA1L, SRP14, SRP72, SPCS2

Betrixaban

hsa03460

Fanconi anemia pathway

1.85E-02

P40692, Q9UNA4

MLH1, POLI

Betrixaban

hsa04010

MAPK signaling pathway

1.23E-03

P04049, Q9H2K8, Q12933

RAF1, TAOK3, TRAF2

Betrixaban

hsa04012

ErbB signaling pathway

1.82E-02

P04049

RAF1

Betrixaban

hsa04014

Ras signaling pathway

2.60E-03

P04049, Q15283, P61586, P62873

RAF1, RASA2, RHOA, GNB1

Betrixaban

hsa04015

Rap1 signaling pathway

7.23E-03

P04049, P25116, Q8TEU7, P08514

RAF1, F2R, RAPGEF6, ITGA2B

Betrixaban

hsa04020

Calcium signaling pathway

4.83E-02

Q08828, P0DP23, P05141, P51828

ADCY1, CALM1, SLC25A5, ADCY7

Betrixaban

hsa04022

cGMP-PKG signaling pathway

1.31E-03

P04049, P18848, P31751, Q08828, P51828, P05141, P0DP23

RAF1, ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1

Betrixaban

hsa04024

cAMP signaling pathway

1.09E-02

Q08828, P51828, P31751, P0DP23, P04049

ADCY1, ADCY7, AKT2, CALM1, RAF1

Betrixaban

hsa04060

Cytokine-cytokine receptor interaction

4.71E-02

P78552, O75509

IL13RA1, TNFRSF21

Betrixaban

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.79E-03

Q8NHW4, P09341, P19875, P25024, P25025, Q13651, P14784

CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, IL10RA, IL2RB

Betrixaban

hsa04062

Chemokine signaling pathway

7.67E-03

P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151, P04049

CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10, RAF1

Betrixaban

hsa04064

NF-kappa B signaling pathway

4.41E-08

P10415, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.807
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	1
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.741
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.801
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753

Betrixaban

hsa04068

FoxO signaling pathway

1.99E-02

P04049

RAF1

Betrixaban

hsa04070

Phosphatidylinositol signaling system

9.86E-03

P0DP23, O14986, Q16760, P48426

CALM1, PIP5K1B, DGKD, PIP4K2A

Betrixaban

hsa04071

Sphingolipid signaling pathway

1.04E-03

P04049, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2, Q12933, Q02156

RAF1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2, TRAF2, PRKCE

Betrixaban

hsa04072

Phospholipase D signaling pathway

1.75E-05

P04049, P31751, P42338, Q92529, P43657, P25024, P25025, P19174, O14986, Q14344, Q15438, Q08828, P51828, Q16760

RAF1, AKT2, PIK3CB, SHC3, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNA13, PSCD1, ADCY1, ADCY7, DGKD

Betrixaban

hsa04080

Neuroactive ligand-receptor interaction

8.49E-04

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550, P35318

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2, ADM

Betrixaban

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Betrixaban

hsa04114

Oocyte meiosis

1.35E-02

P0DP23, Q08828, P51828, Q13362, Q14738

CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5D

Betrixaban

hsa04120

Ubiquitin mediated proteolysis

1.08E-03

Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669

SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12

Betrixaban

hsa04122

Sulfur relay system

5.99E-04

Q16762

TST

Betrixaban

hsa04136

Autophagy - other

3.53E-02

O94817

ATG12

Betrixaban

hsa04140

Autophagy - animal

9.33E-04

P31751, P04049, Q7L523, O75460, P22694, Q14643, P10415, Q96GC9, Q8TEV9

AKT2, RAF1, RRAGA, ERN1, PRKACB, ITPR1, BCL2, TMEM49, SMCR8

Betrixaban

hsa04141

Protein processing in endoplasmic reticulum

6.04E-03

P18848, Q15437, Q99941, O75460, P11142, Q9H3Z4, P07900, Q9NR31

ATF4, SEC23B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, SAR1A

Betrixaban

hsa04142

Lysosome

2.64E-02

Q99437, P25774

ATP6V0B, CTSS

Betrixaban

hsa04145

Phagosome

3.11E-02

Q99437, P25774

ATP6V0B, CTSS

Betrixaban

hsa04146

Peroxisome

4.83E-02

O96011, P56589, Q9UKG9, O75521

PEX11B, PEX3, CROT, ECI2

Betrixaban

hsa04150

mTOR signaling pathway

2.32E-02

P04049

RAF1

Betrixaban

hsa04151

PI3K-Akt signaling pathway

9.80E-03

O43521, P27348, Q13362, P07900, P22105, P23458, Q99941, P18848, O00141, Q6ZUJ8

BCL2L11, YWHAQ, PPP2R5C, HSP90AA1, TNXB, JAK1, CREBL1, ATF4, SGK, PIK3AP1

Betrixaban

hsa04210

Apoptosis

2.16E-02

P04049

RAF1

Betrixaban

hsa04211

Longevity regulating pathway

2.32E-03

P31751, Q08828, P51828, Q99941, P18848, Q96RR4

AKT2, ADCY1, ADCY7, CREBL1, ATF4, CAMKK2

Betrixaban

hsa04213

Longevity regulating pathway - multiple species

4.29E-03

P31751, P42338, Q9Y4H2, Q08828, P51828, P11142, Q13547

AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA8, HDAC1

Betrixaban

hsa04217

Necroptosis

3.81E-04

P01375, P23458, P48023, Q9NQC7, Q14765, P07900, P05141, P01584, Q99878, Q9H444, O75351

TNF, JAK1, FASLG, CYLD, STAT4, HSP90AA1, SLC25A5, IL1B, H2AC14, CHMP4B, VPS4B

Betrixaban

hsa04218

Cellular senescence

2.49E-02

P04049

RAF1

Betrixaban

hsa04261

Adrenergic signaling in cardiomyocytes

2.69E-05

P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, P23634

TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, ATP2B4

Betrixaban

hsa04270

Vascular smooth muscle contraction

2.32E-02

P04049

RAF1

Betrixaban

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Betrixaban

hsa04340

Hedgehog signaling pathway

4.70E-04

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Betrixaban

hsa04360

Axon guidance

2.49E-02

P04049

RAF1

Betrixaban

hsa04370

VEGF signaling pathway

8.29E-03

P04049

RAF1

Betrixaban

hsa04371

Apelin signaling pathway

1.24E-02

P31751, P04049, Q08828, P51828, P0DP23

AKT2, RAF1, ADCY1, ADCY7, CALM1

Betrixaban

hsa04380

Osteoclast differentiation

5.22E-06

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P49841	GSK3B	Glycogen synthase kinase-3 beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.83
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832

Betrixaban

hsa04510

Focal adhesion

3.48E-02

P04049

RAF1

Betrixaban

hsa04512

ECM-receptor interaction

3.73E-02

P07359, P08514

GP1BA, ITGA2B

Betrixaban

hsa04514

Cell adhesion molecules

4.65E-04

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Betrixaban

hsa04530

Tight junction

2.65E-06

Q8TEU7, P16989, P56750, O00501, Q14247, P24844

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9

Betrixaban

hsa04540

Gap junction

5.06E-03

P22694, P68371, P04049, Q14643

PRKACB, TUBB2C, RAF1, ITPR1

Betrixaban

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P04049

RAF1

Betrixaban

hsa04610

Complement and coagulation cascades

1.26E-03

P25116, P09871, P00734, P0C0L4

F2R, C1S, F2, C4A

Betrixaban

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Betrixaban

hsa04612

Antigen processing and presentation

1.51E-02

P13765, P48382, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Betrixaban

hsa04613

Neutrophil extracellular trap formation

9.74E-06

P04049, P16109, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P08514, P21462, P07359, O43315, Q16539

RAF1, SELP, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Betrixaban

hsa04614

Renin-angiotensin system

2.74E-02

P15144, P08311, O75787

ANPEP, CTSG, ATP6AP2

Betrixaban

hsa04620

Toll-like receptor signaling pathway

2.54E-03

P01584, P31751, Q8NHW4

IL1B, AKT2, CCL4L2

Betrixaban

hsa04621

NOD-like receptor signaling pathway

2.35E-03

P01584, P07900, Q16539, Q14643, P23458, Q9H3M7, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P12838

IL1B, HSP90AA1, MAPK14, ITPR1, JAK1, TXNIP, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA4

Betrixaban

hsa04622

RIG-I-like receptor signaling pathway

2.47E-02

Q12933

TRAF2

Betrixaban

hsa04623

Cytosolic DNA-sensing pathway

2.21E-04

P01584, Q9Y535, Q8NHW4

IL1B, POLR3H, CCL4L2

Betrixaban

hsa04625

C-type lectin receptor signaling pathway

8.86E-06

Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539

CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14

Betrixaban

hsa04630

JAK-STAT signaling pathway

8.73E-03

P31751, P23458, Q13651, P04049

AKT2, JAK1, IL10RA, RAF1

Betrixaban

hsa04640

Hematopoietic cell lineage

6.79E-04

P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1B

Betrixaban

hsa04650

Natural killer cell mediated cytotoxicity

3.22E-07

P19174, P01375, P78314, P06239, O60880, P20963, P42338, P04049, Q13241, P26718, O14931, O75015, P26717, P26715

PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
P13612	ITGA4	Integrin alpha-4	Q13241	KLRD1	Natural killer cells antigen CD94	0.814
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P13612	ITGA4	Integrin alpha-4	P26718	KLRK1	NKG2-D type II integral membrane protein	0.818
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P13612	ITGA4	Integrin alpha-4	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.729
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P13612	ITGA4	Integrin alpha-4	P26717	KLRC2	NKG2-C type II integral membrane protein	0.772
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P13612	ITGA4	Integrin alpha-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.772
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714

Betrixaban

hsa04657

IL-17 signaling pathway

6.23E-06

O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P06737	PYGL	Glycogen phosphorylase, liver form	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Betrixaban

hsa04658

Th1 and Th2 cell differentiation

6.63E-09

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P42226, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P13612	ITGA4	Integrin alpha-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P13612	ITGA4	Integrin alpha-4	Q9UL17	TBX21	T-box transcription factor TBX21	0.822
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P13612	ITGA4	Integrin alpha-4	Q13761	RUNX3	Runt-related transcription factor 3	0.78
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Betrixaban

hsa04659

Th17 cell differentiation

1.46E-05

Q04759, Q16539, P19174, P06239, P42226, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458

PRKCQ, MAPK14, PLCG1, LCK, STAT6, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Betrixaban

hsa04660

T cell receptor signaling pathway

2.06E-09

P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, P04049, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P13612	ITGA4	Integrin alpha-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.834
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P13612	ITGA4	Integrin alpha-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
P13612	ITGA4	Integrin alpha-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.7
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P13612	ITGA4	Integrin alpha-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.83
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861

Betrixaban

hsa04662

B cell receptor signaling pathway

9.95E-03

P04049

RAF1

Betrixaban

hsa04664

Fc epsilon RI signaling pathway

7.50E-03

P01375, Q16539, Q9UQC2, P04049

TNF, MAPK14, GAB2, RAF1

Betrixaban

hsa04666

Fc gamma R-mediated phagocytosis

2.32E-02

P04049

RAF1

Betrixaban

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Betrixaban

hsa04710

Circadian rhythm

2.43E-02

O15516

CLOCK

Betrixaban

hsa04713

Circadian entrainment

4.54E-02

P0DP23, Q08828, P51828

CALM1, ADCY1, ADCY7

Betrixaban

hsa04720

Long-term potentiation

1.06E-02

P0DP23, P18848, Q08828, P04049

CALM1, ATF4, ADCY1, RAF1

Betrixaban

hsa04722

Neurotrophin signaling pathway

7.90E-04

P04049, P49841, O43524, P48023, P51617, P10415, P0DP23

RAF1, GSK3B, FOXO3, FASLG, IRAK1, BCL2, CALM1

Betrixaban

hsa04723

Retrograde endocannabinoid signaling

2.68E-02

P48169, P62873

GABRA4, GNB1

Betrixaban

hsa04725

Cholinergic synapse

1.20E-03

Q08828, P51828, P22694, Q14643, P18848, P31751, P10415

ADCY1, ADCY7, PRKACB, ITPR1, ATF4, AKT2, BCL2

Betrixaban

hsa04726

Serotonergic synapse

1.33E-02

P04049

RAF1

Betrixaban

hsa04727

GABAergic synapse

3.69E-02

P62873, P48169

GNB1, GABRA4

Betrixaban

hsa04728

Dopaminergic synapse

7.83E-03

P31751, P18848, Q13362, Q14738, P0DP23

AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Betrixaban

hsa04730

Long-term depression

1.55E-03

Q14344, P04049

GNA13, RAF1

Betrixaban

hsa04740

Olfactory transduction

2.07E-02

P62873, P0DP23

GNB1, CALM1

Betrixaban

hsa04742

Taste transduction

4.80E-02

P48169

GABRA4

Betrixaban

hsa04744

Phototransduction

2.27E-03

P62873, P0DP23

GNB1, CALM1

Betrixaban

hsa04750

Inflammatory mediator regulation of TRP channels

1.30E-05

P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1

Betrixaban

hsa04810

Regulation of actin cytoskeleton

7.86E-03

Q15746, P04049, P08514, P25116

MYLK, RAF1, ITGA2B, F2R

Betrixaban

hsa04910

Insulin signaling pathway

1.49E-02

P04049

RAF1

Betrixaban

hsa04911

Insulin secretion

2.75E-03

Q08828, P51828, Q99941, P18848

ADCY1, ADCY7, CREBL1, ATF4

Betrixaban

hsa04912

GnRH signaling pathway

1.73E-03

Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P04049

ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, RAF1

Betrixaban

hsa04913

Ovarian steroidogenesis

2.72E-02

P42330, P22694

AKR1C3, PRKACB

Betrixaban

hsa04914

Progesterone-mediated oocyte maturation

2.16E-02

P04049

RAF1

Betrixaban

hsa04915

Estrogen signaling pathway

3.37E-04

P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P11142, P0DP23, Q15788

RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA8, CALM1, NCOA1

Betrixaban

hsa04916

Melanogenesis

4.54E-03

P0DP23, Q08828, P51828, P04049

CALM1, ADCY1, ADCY7, RAF1

Betrixaban

hsa04917

Prolactin signaling pathway

6.63E-03

P04049

RAF1

Betrixaban

hsa04918

Thyroid hormone synthesis

2.50E-02

P51828, Q99941, P18848, P05543

ADCY7, CREBL1, ATF4, SERPINA7

Betrixaban

hsa04919

Thyroid hormone signaling pathway

1.82E-02

P04049

RAF1

Betrixaban

hsa04921

Oxytocin signaling pathway

2.32E-02

P04049

RAF1

Betrixaban

hsa04923

Regulation of lipolysis in adipocytes

2.89E-04

Q08828, P51828, P07550, P42338, Q9Y4H2, P31751

ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2

Betrixaban

hsa04924

Renin secretion

3.09E-03

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Betrixaban

hsa04925

Aldosterone synthesis and secretion

6.67E-04

Q99941, P18848, Q08828, P51828, P0DP23, P23634

CREBL1, ATF4, ADCY1, ADCY7, CALM1, ATP2B4

Betrixaban

hsa04926

Relaxin signaling pathway

6.96E-03

P31751, P18848, Q08828, P51828, P04049

AKT2, ATF4, ADCY1, ADCY7, RAF1

Betrixaban

hsa04927

Cortisol synthesis and secretion

6.22E-05

Q14643, Q99941, P18848, Q08828, P51828, P22694

ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACB

Betrixaban

hsa04928

Parathyroid hormone synthesis, secretion and action

2.75E-03

Q14643, P22694, P23771, P04049, P10415

ITPR1, PRKACB, GATA3, RAF1, BCL2

Betrixaban

hsa04929

GnRH secretion

4.98E-03

P04049

RAF1

Betrixaban

hsa04930

Type II diabetes mellitus

2.47E-02

Q02156

PRKCE

Betrixaban

hsa04932

Non-alcoholic fatty liver disease

5.87E-04

P31751, P01375, P49841, P18848, P48023, O75460, P01584, O95298

AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFC2

Betrixaban

hsa04934

Cushing syndrome

5.04E-03

Q14643, P18848, Q08828, P51828, P22694, P04628

ITPR1, ATF4, ADCY1, ADCY7, PRKACB, WNT1

Betrixaban

hsa04935

Growth hormone synthesis, secretion and action

5.00E-03

Q08828, P51828, P04049, P18848, P31751

ADCY1, ADCY7, RAF1, ATF4, AKT2

Betrixaban

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Betrixaban

hsa04960

Aldosterone-regulated sodium reabsorption

4.38E-02

P48048

KCNJ1

Betrixaban

hsa04970

Salivary secretion

7.97E-04

P07550, Q08828, P51828, P22694, Q14643, P0DP23

ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM1

Betrixaban

hsa04971

Gastric acid secretion

2.54E-03

Q08828, P51828, P15311, P0DP23

ADCY1, ADCY7, VIL2, CALM1

Betrixaban

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Betrixaban

hsa04974

Protein digestion and absorption

2.47E-02

Q7Z2H8

SLC36A1

Betrixaban

hsa04975

Fat digestion and absorption

4.83E-02

O14494

PLPP1

Betrixaban

hsa04976

Bile secretion

1.59E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Betrixaban

hsa05010

Alzheimer disease

4.94E-03

O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070

NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4

Betrixaban

hsa05014

Amyotrophic lateral sclerosis

2.72E-02

P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629

TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7

Betrixaban

hsa05016

Huntington disease

2.24E-02

O95298, P24928, P30876, P62487, P05141, O75460, P28070

NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4

Betrixaban

hsa05017

Spinocerebellar ataxia

3.94E-02

O75460, P31751, P28070, P05141

ERN1, AKT2, PSMB4, SLC25A5

Betrixaban

hsa05022

Pathways of neurodegeneration - multiple diseases

1.67E-02

O95298, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070

NDUFC2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4

Betrixaban

hsa05032

Morphine addiction

1.42E-02

P62873, P48169

GNB1, GABRA4

Betrixaban

hsa05033

Nicotine addiction

2.43E-02

P48169

GABRA4

Betrixaban

hsa05034

Alcoholism

2.78E-04

P04049, Q93077, P62807, O60814, P68431

RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Betrixaban

hsa05110

Vibrio cholerae infection

4.78E-02

Q99437

ATP6V0B

Betrixaban

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.96E-04

Q16539, P09341, P19875, P19174, P25024, P25025

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Betrixaban

hsa05130

Pathogenic Escherichia coli infection

7.39E-03

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Betrixaban

hsa05131

Shigellosis

1.65E-02

Q12933, Q02156

TRAF2, PRKCE

Betrixaban

hsa05132

Salmonella infection

1.24E-03

P51617, P04049, Q9UJU2, P10415, O75369, Q9BQS8, Q13509

IRAK1, RAF1, LEF1, BCL2, FLNB, FYCO1, TUBB3

Betrixaban

hsa05133

Pertussis

1.26E-03

P0DP23, P09871, P0C0L4, Q02556

CALM1, C1S, C4A, IRF8

Betrixaban

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Betrixaban

hsa05140

Leishmaniasis

1.93E-03

P13612, O75015, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, Q15080

ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, NCF4

Betrixaban

hsa05143

African trypanosomiasis

3.01E-03

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Betrixaban

hsa05144

Malaria

2.14E-03

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Betrixaban

hsa05146

Amoebiasis

2.17E-05

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Betrixaban

hsa05150

Staphylococcus aureus infection

8.11E-04

P21730, P21462, O75015, P13765, Q16581, Q14532, P59665, P59666, P12838

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4

Betrixaban

hsa05152

Tuberculosis

2.00E-04

P04049, Q99437, P0DP23, P48382, P10415, P25774, Q9UDY8, P51617

RAF1, ATP6V0B, CALM1, RFX5, BCL2, CTSS, MALT1, IRAK1

Betrixaban

hsa05160

Hepatitis C

1.40E-03

P60033, P04049, P49841, P01375, P48023

CD81, RAF1, GSK3B, TNF, FASLG

Betrixaban

hsa05161

Hepatitis B

1.99E-02

P04049

RAF1

Betrixaban

hsa05163

Human cytomegalovirus infection

8.88E-07

P31751, P04049, P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463

AKT2, RAF1, TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P22891	PROZ	Vitamin K-dependent protein Z	P51828	ADCY7	Adenylate cyclase type 7	0.797
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
P22891	PROZ	Vitamin K-dependent protein Z	P23458	JAK1	Tyrosine-protein kinase JAK1	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P22891	PROZ	Vitamin K-dependent protein Z	P01584	IL1B	Interleukin-1 beta	0.804
P22891	PROZ	Vitamin K-dependent protein Z	P61073	CXCR4	C-X-C chemokine receptor type 4	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
P22891	PROZ	Vitamin K-dependent protein Z	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P22891	PROZ	Vitamin K-dependent protein Z	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.712
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P22891	PROZ	Vitamin K-dependent protein Z	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734

Betrixaban

hsa05164

Influenza A

1.49E-02

P31751, P01584, P23458, P05141, P04049, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1

Betrixaban

hsa05166

Human T-cell leukemia virus 1 infection

3.90E-02

P23458, P05141, P62826, Q08828, P51828, P18848, P31751

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2

Betrixaban

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.15E-02

P04049

RAF1

Betrixaban

hsa05169

Epstein-Barr virus infection

4.32E-02

P13765, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P01375, O60603, P09693, P20963

HLA-DOB, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, TNF, TLR2, CD3G, CD247

Betrixaban

hsa05170

Human immunodeficiency virus 1 infection

3.46E-03

P04049, P62873, P0DP23, P51617, P10415, Q9Y6Q5

RAF1, GNB1, CALM1, IRAK1, BCL2, AP1M2

Betrixaban

hsa05200

Pathways in cancer

4.99E-02

Q9UJU2, P14923, P10415, Q13077, P62873, Q9UM47, P0DP23

LEF1, JUP, BCL2, TRAF1, GNB1, NOTCH3, CALM1

Betrixaban

hsa05202

Transcriptional misregulation in cancer

2.61E-05

Q15532, P17844, P14780, P27930, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

SS18, DDX5, MMP9, IL1R2, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819

Betrixaban

hsa05203

Viral carcinogenesis

4.22E-03

Q99941, P18848, P23458, P27348, Q7KZF4, Q15283, P61978, P62807, O60814

CREBL1, ATF4, JAK1, YWHAQ, SND1, RASA2, HNRPK, HIST1H2BC, H2BC12

Betrixaban

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Betrixaban

hsa05205

Proteoglycans in cancer

1.03E-02

Q13009, Q12955, O75369, P04049, P08962

TIAM1, ANK3, FLNB, RAF1, CD63

Betrixaban

hsa05206

MicroRNAs in cancer

3.15E-02

P04049

RAF1

Betrixaban

hsa05210

Colorectal cancer

1.66E-02

P04049

RAF1

Betrixaban

hsa05211

Renal cell carcinoma

1.16E-02

P04049

RAF1

Betrixaban

hsa05212

Pancreatic cancer

3.52E-03

P31751, P04049, Q15311, P23458

AKT2, RAF1, RALBP1, JAK1

Betrixaban

hsa05213

Endometrial cancer

9.95E-03

P04049

RAF1

Betrixaban

hsa05214

Glioma

9.95E-03

P04049

RAF1

Betrixaban

hsa05215

Prostate cancer

1.33E-02

P04049

RAF1

Betrixaban

hsa05217

Basal cell carcinoma

1.30E-03

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Betrixaban

hsa05218

Melanoma

6.63E-03

P04049

RAF1

Betrixaban

hsa05219

Bladder cancer

5.65E-03

P14780, P04637, P04049

MMP9, TP53, RAF1

Betrixaban

hsa05220

Chronic myeloid leukemia

9.95E-03

P04049

RAF1

Betrixaban

hsa05221

Acute myeloid leukemia

8.29E-03

P04049

RAF1

Betrixaban

hsa05223

Non-small cell lung cancer

6.63E-03

P04049

RAF1

Betrixaban

hsa05224

Breast cancer

1.24E-02

P04049, P49841, Q92837, P04637, P24522

RAF1, GSK3B, FRAT1, TP53, GADD45A

Betrixaban

hsa05225

Hepatocellular carcinoma

6.30E-04

P04049, Q92529, P51531

RAF1, SHC3, SMARCA2

Betrixaban

hsa05226

Gastric cancer

8.29E-03

P04049

RAF1

Betrixaban

hsa05230

Central carbon metabolism in cancer

9.95E-03

P04049

RAF1

Betrixaban

hsa05231

Choline metabolism in cancer

5.74E-03

P04049, P31751, Q16760, O14986

RAF1, AKT2, DGKD, PIP5K1B

Betrixaban

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

5.38E-05

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707

Betrixaban

hsa05321

Inflammatory bowel disease

3.75E-05

O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771, P01584

TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3, IL1B

Betrixaban

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Betrixaban

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Betrixaban

hsa05332

Graft-versus-host disease

3.70E-02

P48023, P01375

FASLG, TNF

Betrixaban

hsa05414

Dilated cardiomyopathy

2.68E-02

P09493, P26678

TPM1, PLN

Betrixaban

hsa05418

Fluid shear stress and atherosclerosis

1.26E-04

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Community members of Betrixaban (S_DC: 7.13)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

KCNJ1

ATPNonesensitive inward rectifier potassium channel 1

Predicted

0.0042

0.282

0.1274

0.6935

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P10619

CTSA

Lysosomal protective protein

Predicted

0.1226

0.1531

0.1901

0.5575

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

Q96EB6

SIRT1

NADNonedependent protein deacetylase sirtuinNone1

Predicted

0.2865

0.4571

0.5784

1.6358

P25774

CTSS

Cathepsin S

Predicted

0.3185

0.4932

0.5168

1.6625

P13612

ITGA4

Integrin alphaNone4

Predicted

0.1165

0.2386

0.6862

1.2217

Q02156

PRKCE

Protein kinase C epsilon type

Predicted

0.1175

0.5287

0.5377

1.6539

Q16513

PKN2

Serine/threonineNoneprotein kinase N2

Predicted

0.0421

0.2778

0.3391

0.9157

P06737

PYGL

Glycogen phosphorylase, liver form

Predicted

0.3733

0.2211

0.3169

0.9457

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P61586

RHOA

Transforming protein RhoA

Predicted

0.3541

0.0689

1.3149

P21453

S1PR1

Sphingosine 1Nonephosphate receptor 1

Predicted

0.1434

0.3847

0.221

1.0621

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

Q00535

CDK5

CyclinNonedependentNonelike kinase 5

Predicted

0.1992

0.6633

0.2994

1.7256

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P51617

IRAK1

InterleukinNone1 receptorNoneassociated kinase 1

Predicted

0.0238

0.3

0.9444

1.5563

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

P18054

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

Predicted

0.0075

0.3703

0.2416

0.986

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

P04049

RAF1

RAF protoNoneoncogene serine/threonineNoneprotein kinase

Predicted

0.557

0.7572

2.7929

P49768

PSEN1

PresenilinNone1

Predicted

0.2677

0.6599

0.3308

1.7845

P22891

PROZ

Vitamin KNonedependent protein Z

Predicted

0.7981

0.0168

0.4327

PharmaCoNets of Betrixaban (SPCN: 187.77 )

Betrixaban regulated-network (SDN: 26.33)

Community members of Betrixaban (SDC: 7.13)

PharmaCoNets of Betrixaban (S_PCN: 187.77 )

Betrixaban regulated-network (S_DN: 26.33)

Community members of Betrixaban (S_DC: 7.13)