PharmaCoNets of Bethanidine (SPCN: 35.52 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Bethanidinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Bethanidinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Bethanidinehsa00071Fatty acid degradation2.52E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Bethanidinehsa00500Starch and sucrose metabolism1.07E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Bethanidinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Bethanidinehsa00590Arachidonic acid metabolism2.95E-033P11712, P18054, P09960CYP2C9, ALOX12, LTA4HMore
Bethanidinehsa00591Linoleic acid metabolism1.58E-031P11712CYP2C9More
Bethanidinehsa00630Glyoxylate and dicarboxylate metabolism4.12E-032P40925, P15104MDH1, GLULMore
Bethanidinehsa00730Thiamine metabolism8.96E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Bethanidinehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Bethanidinehsa00770Pantothenate and CoA biosynthesis5.15E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Bethanidinehsa00970Aminoacyl-tRNA biosynthesis2.77E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Bethanidinehsa00980Metabolism of xenobiotics by cytochrome P4501.45E-042P78417, P11712GSTO1, CYP2C9More
Bethanidinehsa00982Drug metabolism - cytochrome P4501.45E-042P11712, P78417CYP2C9, GSTO1More
Bethanidinehsa01100Metabolic pathways3.52E-0223P05089, O95455, P21953, P32320, P11766, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, Q08477, P15907, Q9UNP4, P37837, P32321, Q9BPW9, Q9UHY7, P43490, P46976, P06737ARG1, TGDS, BCKDHB, CDA, ADH5, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, CYP4F3, ST6GAL1, ST3GAL5, TALDO1, DCTD, DHRS9, ENOPH1, PBEF1, GYG1, PYGLMore
Bethanidinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Bethanidinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Bethanidinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Bethanidinehsa04014Ras signaling pathway1.60E-024P49767, P17252, Q14644, P0DP23VEGFC, PRKCA, RASA3, CALM1More
Bethanidinehsa04020Calcium signaling pathway8.12E-056P17252, Q93086, Q15746, P0DP23, P23634, P49767PRKCA, P2RX5, MYLK, CALM1, ATP2B4, VEGFCMore
Bethanidinehsa04022cGMP-PKG signaling pathway3.50E-023P23634, Q15746, P0DP23ATP2B4, MYLK, CALM1More
Bethanidinehsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Bethanidinehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Bethanidinehsa04072Phospholipase D signaling pathway9.70E-032Q92529, Q14344SHC3, GNA13More
Bethanidinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Bethanidinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Bethanidinehsa04150mTOR signaling pathway2.23E-023P42338, Q13322, P49841PIK3CB, GRB10, GSK3BMore
Bethanidinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Bethanidinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Bethanidinehsa04261Adrenergic signaling in cardiomyocytes2.43E-037P07550, P22694, P18848, Q13362, P0DP23, P17252, P23634ADRB2, PRKACB, ATF4, PPP2R5C, CALM1, PRKCA, ATP2B4More
Bethanidinehsa04270Vascular smooth muscle contraction1.50E-023Q15746, P17252, P0DP23MYLK, PRKCA, CALM1More
Bethanidinehsa04380Osteoclast differentiation4.80E-024P06239, P42338, P14778, Q8N149LCK, PIK3CB, IL1R1, LILRA2More
Bethanidinehsa04510Focal adhesion2.35E-024Q15746, P17252, Q13489, P49767MYLK, PRKCA, BIRC3, VEGFCMore
Bethanidinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Bethanidinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Bethanidinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Bethanidinehsa04613Neutrophil extracellular trap formation1.02E-048P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Bethanidinehsa04621NOD-like receptor signaling pathway1.93E-028Q16539, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838MAPK14, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4More
Bethanidinehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Bethanidinehsa04657IL-17 signaling pathway7.22E-048O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Bethanidinehsa04659Th17 cell differentiation4.12E-024P06239, P14784, P14778, P07766LCK, IL2RB, IL1R1, CD3EMore
Bethanidinehsa04662B cell receptor signaling pathway7.25E-034P49841, P42338, P21854, Q8N149GSK3B, PIK3CB, CD72, LILRA2More
Bethanidinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Bethanidinehsa04720Long-term potentiation3.63E-022P17252, P0DP23PRKCA, CALM1More
Bethanidinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Bethanidinehsa04726Serotonergic synapse1.50E-023P17252, P11712, P18054PRKCA, CYP2C9, ALOX12More
Bethanidinehsa04730Long-term depression3.52E-021Q14344GNA13More
Bethanidinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Bethanidinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Bethanidinehsa04750Inflammatory mediator regulation of TRP channels1.05E-036P14778, P18054, P42338, P17252, P24723, P0DP23IL1R1, ALOX12, PIK3CB, PRKCA, PRKCH, CALM1More
Bethanidinehsa04912GnRH signaling pathway3.63E-022P17252, P0DP23PRKCA, CALM1More
Bethanidinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Bethanidinehsa04916Melanogenesis3.97E-033P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Bethanidinehsa04921Oxytocin signaling pathway2.19E-023Q15746, P0DP23, P17252MYLK, CALM1, PRKCAMore
Bethanidinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Bethanidinehsa04925Aldosterone synthesis and secretion5.51E-033P0DP23, P17252, P23634CALM1, PRKCA, ATP2B4More
Bethanidinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Bethanidinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Bethanidinehsa04929GnRH secretion3.63E-022P42338, P49407PIK3CB, ARRB1More
Bethanidinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Bethanidinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Bethanidinehsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Bethanidinehsa04961Endocrine and other factor-regulated calcium reabsorption1.40E-022P23634, P17252ATP2B4, PRKCAMore
Bethanidinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Bethanidinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Bethanidinehsa04970Salivary secretion2.29E-046P07550, P22694, P23634, P17252, P0DP23, P49913ADRB2, PRKACB, ATP2B4, PRKCA, CALM1, CAMPMore
Bethanidinehsa04971Gastric acid secretion5.51E-033P17252, P0DP23, Q15746PRKCA, CALM1, MYLKMore
Bethanidinehsa04972Pancreatic secretion1.40E-022P23634, P17252ATP2B4, PRKCAMore
Bethanidinehsa04973Carbohydrate digestion and absorption4.12E-032O43451, P42338MGAM, PIK3CBMore
Bethanidinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Bethanidinehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Bethanidinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.27E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Bethanidinehsa05133Pertussis2.92E-033P0DP23, P09871, P0C0L4CALM1, C1S, C4AMore
Bethanidinehsa05140Leishmaniasis2.47E-025P13612, O75015, P01375, P49006, Q16539ITGA4, FCGR3B, TNF, MARCKSL1, MAPK14More
Bethanidinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Bethanidinehsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Bethanidinehsa05146Amoebiasis3.03E-038P09341, P19875, P14778, P27930, P01375, P05089, P30679, P22694CXCL1, CXCL2, IL1R1, IL1R2, TNF, ARG1, GNA15, PRKACBMore
Bethanidinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Bethanidinehsa05163Human cytomegalovirus infection3.28E-027P01375, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Bethanidinehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Bethanidinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Bethanidinehsa05204Chemical carcinogenesis4.09E-042P78417, P11712GSTO1, CYP2C9More
Bethanidinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Bethanidinehsa05214Glioma4.55E-022P0DP23, P17252CALM1, PRKCAMore
Bethanidinehsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Bethanidinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Bethanidinehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Bethanidinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Bethanidinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Bethanidinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Bethanidinehsa05418Fluid shear stress and atherosclerosis2.43E-037Q16539, P42338, P10599, P14780, P01375, P14778, P27930MAPK14, PIK3CB, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Bethanidine (SDC: 3.43)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Reported00.00420.2820.12740.6935
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P09871C1SComplement C1s subcomponentPredicted10.09720.02820.54030.6452
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Predicted00.07310.08780.20670.4189
Q99712KCNJ15ATPNonesensitive inward rectifier potassium channel 15Predicted00.15870.07790.12670.3619
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)