PharmaCoNets of Betamethasone (SPCN: 25.37 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Betamethasone-phosphatehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Betamethasone-phosphatehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Betamethasone-phosphatehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Betamethasone-phosphatehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Betamethasone-phosphatehsa00500Starch and sucrose metabolism2.00E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Betamethasone-phosphatehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Betamethasone-phosphatehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Betamethasone-phosphatehsa00970Aminoacyl-tRNA biosynthesis1.21E-021P14868DARSMore
Betamethasone-phosphatehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Betamethasone-phosphatehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Betamethasone-phosphatehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Betamethasone-phosphatehsa03013RNA transport3.11E-022P68104, Q14232EEF1A1, EIF2B1More
Betamethasone-phosphatehsa04061Viral protein interaction with cytokine and cytokine receptor2.00E-027P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, TNFMore
Betamethasone-phosphatehsa04064NF-kappa B signaling pathway4.58E-034Q13489, Q13546, Q9UDY8, Q9UNE0BIRC3, RIPK1, MALT1, EDARMore
Betamethasone-phosphatehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Betamethasone-phosphatehsa04140Autophagy - animal3.61E-025Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759RRAGD, PRKACB, ITPR1, ATG5, PRKCQMore
Betamethasone-phosphatehsa04141Protein processing in endoplasmic reticulum3.89E-022P17861, Q9NR31XBP1, SAR1AMore
Betamethasone-phosphatehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Betamethasone-phosphatehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Betamethasone-phosphatehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Betamethasone-phosphatehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Betamethasone-phosphatehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Betamethasone-phosphatehsa04612Antigen processing and presentation2.73E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Betamethasone-phosphatehsa04613Neutrophil extracellular trap formation1.96E-0212O60603, P05164, P08246, Q9UM07, Q13547, Q16778, P20160, P08311, O75015, P21730, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HIST2H2BE, AZU1, CTSG, FCGR3B, C5AR1, AQP9, MAPK14More
Betamethasone-phosphatehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Betamethasone-phosphatehsa04621NOD-like receptor signaling pathway3.95E-0313Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, P01375, P09341, P12838MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, TNF, CXCL1, DEFA4More
Betamethasone-phosphatehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Betamethasone-phosphatehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Betamethasone-phosphatehsa04640Hematopoietic cell lineage1.10E-029P13612, P14778, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Betamethasone-phosphatehsa04650Natural killer cell mediated cytotoxicity8.02E-039P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Betamethasone-phosphatehsa04657IL-17 signaling pathway1.80E-037O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Betamethasone-phosphatehsa04658Th1 and Th2 cell differentiation5.94E-049Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOBMore
Betamethasone-phosphatehsa04659Th17 cell differentiation3.91E-039Q04759, Q16539, P06239, P13765, P14778, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3G, CD247More
Betamethasone-phosphatehsa04660T cell receptor signaling pathway6.95E-0411P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Betamethasone-phosphatehsa04750Inflammatory mediator regulation of TRP channels3.61E-025P14778, P22694, Q16539, Q14643, Q04759IL1R1, PRKACB, MAPK14, ITPR1, PRKCQMore
Betamethasone-phosphatehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Betamethasone-phosphatehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Betamethasone-phosphatehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Betamethasone-phosphatehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Betamethasone-phosphatehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Betamethasone-phosphatehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Betamethasone-phosphatehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Betamethasone-phosphatehsa05010Alzheimer disease1.01E-023Q06055, P17861, P62195ATP5G2, XBP1, PSMC5More
Betamethasone-phosphatehsa05012Parkinson disease5.41E-033Q06055, P17861, P62195ATP5G2, XBP1, PSMC5More
Betamethasone-phosphatehsa05014Amyotrophic lateral sclerosis1.01E-023Q06055, P17861, P62195ATP5G2, XBP1, PSMC5More
Betamethasone-phosphatehsa05017Spinocerebellar ataxia1.42E-022P17861, P62195XBP1, PSMC5More
Betamethasone-phosphatehsa05022Pathways of neurodegeneration - multiple diseases1.66E-023Q06055, P17861, P62195ATP5G2, XBP1, PSMC5More
Betamethasone-phosphatehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Betamethasone-phosphatehsa05133Pertussis4.20E-021P0C0L4C4AMore
Betamethasone-phosphatehsa05134Legionellosis5.53E-032Q9NR31, P68104SAR1A, EEF1A1More
Betamethasone-phosphatehsa05135Yersinia infection3.72E-026P13612, P06239, Q16539, P01375, P49841, P01732ITGA4, LCK, MAPK14, TNF, GSK3B, CD8AMore
Betamethasone-phosphatehsa05140Leishmaniasis2.69E-026P13612, O75015, P13765, O60603, P01375, Q16539ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14More
Betamethasone-phosphatehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Betamethasone-phosphatehsa05144Malaria1.12E-037P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Betamethasone-phosphatehsa05146Amoebiasis5.94E-049P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Betamethasone-phosphatehsa05163Human cytomegalovirus infection2.51E-029P01375, Q14643, P22694, P49841, P14778, Q13651, P25025, Q16539, O00463TNF, ITPR1, PRKACB, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5More
Betamethasone-phosphatehsa05202Transcriptional misregulation in cancer3.51E-0212P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Betamethasone-phosphatehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Betamethasone-phosphatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.42E-027O95267, P20963, P09693, P06239, O60603, Q04759, Q16539RASGRP1, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14More
Betamethasone-phosphatehsa05310Asthma1.62E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Betamethasone-phosphatehsa05321Inflammatory bowel disease1.09E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Betamethasone-phosphatehsa05332Graft-versus-host disease1.76E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Betamethasone-phosphatehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Betamethasone-phosphatehsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore
Betamethasonehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Betamethasonehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Betamethasonehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Betamethasonehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Betamethasonehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Betamethasonehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Betamethasonehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Betamethasonehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Betamethasonehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Betamethasonehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Betamethasonehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Betamethasonehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Betamethasonehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Betamethasonehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Betamethasonehsa04064NF-kappa B signaling pathway4.58E-034Q13489, Q13546, Q9UDY8, Q9UNE0BIRC3, RIPK1, MALT1, EDARMore
Betamethasonehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Betamethasonehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Betamethasonehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Betamethasonehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Betamethasonehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Betamethasonehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Betamethasonehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Betamethasonehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Betamethasonehsa04612Antigen processing and presentation4.78E-026P48382, P26715, P26717, Q13241, O43908, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, TNFMore
Betamethasonehsa04613Neutrophil extracellular trap formation1.02E-048P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Betamethasonehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Betamethasonehsa04621NOD-like receptor signaling pathway4.48E-0312P01568, Q13489, Q9H1Y0, P43490, O00463, Q13546, Q05823, P01375, P49913, P59665, P59666, P12838IFNA21, BIRC3, ATG5, PBEF1, TRAF5, RIPK1, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Betamethasonehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Betamethasonehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Betamethasonehsa04650Natural killer cell mediated cytotoxicity1.25E-028P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Betamethasonehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Betamethasonehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Betamethasonehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Betamethasonehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Betamethasonehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Betamethasonehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Betamethasonehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Betamethasonehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Betamethasonehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Betamethasonehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Betamethasonehsa05133Pertussis4.20E-021P0C0L4C4AMore
Betamethasonehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Betamethasonehsa05144Malaria3.76E-036P60033, P69905, P68871, P01375, P35443, P26718CD81, HBA2, HBB, TNF, THBS4, KLRK1More
Betamethasonehsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Betamethasonehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Betamethasonehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Betamethasonehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Betamethasonehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Betamethasonehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Betamethasonehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Betamethasonehsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore

Community members of Betamethasone (SDC: 4.79)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)